Koff
Andrew Koff, Westbury, NY US
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20160030433 | COMPANION DIAGNOSTIC FOR CDK4 INHIBITORS - The present invention relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a subject. It is based, at least in part, on the discovery that cancer treatment with a CDK4 inhibitor is more effective where treated cancer cells undergo cellular senescence rather than a transient cell cycle arrest, where cellular senescence is associated with decreased MDM2 protein level. Accordingly, in non-limiting embodiments, the present invention provides for methods, compositions, and kits for a companion diagnostic for CDK4 inhibitors, and in particular, to the use of MDM2 expression as a biomarker for the likelihood that a cancer can be successfully treated by CDK4 inhibition. | 02-04-2016 |
Caroline N. Koff, Fort Collins, CO US
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20100088695 | SYSTEM AND METHOD FOR LOCALIZING A SERVER APPLICATION USING A CLIENT-SIDE TRANSLATOR - A method is provided for localizing a server application using a client-side translator. A client device selects a locale specific resource file using client locale information stored in a client operating system or provided by a user. The client locale information may be sent to a server. The client may download a locale specific resource file associated with the server application or install a locale specific resource file from a computer readable medium. The server application sends a displayable string to the client device. The displayable string may be a lookup key to mapping a locale specific string in the locale specific resource file to the displayable string. The displayable string may be replaced by the locale specific string corresponding to a translation of the displayable string. The locale specific string displays on the client device. | 04-08-2010 |
David Koff, Toronto CA
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20120243754 | SYSTEM AND METHOD FOR MANAGEMENT AND DISTRIBUTION OF DIAGNOSTIC IMAGING - A method of distributing an image study to a chosen image reader is disclosed having steps of receiving an image study from an image producer at a third party communication module, sending a receive notification message to a messaging layer, sending a study available notification message from the messaging layer to a workload distribution engine wherein the available notification message includes extracted image study information pulled from study headers of the image study, identifying image study rules from the extracted image study information, applying an image study complexity to the image study based on the image study rules, calculating image reader complexities for a plurality of image readers subscribed to receive image studies from the image producer, each of the image reader complexities calculated using the image study complexity and an Image reader profile assigned to each of the plurality of accredited image readers, selecting the chosen image reader from the plurality of image readers based on the image reader complexities, assigning the image study to the chosen image reader, and displaying the image study on a user interface to the chosen image reader. | 09-27-2012 |
Garry A. Koff, Grand Rapids, MI US
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20090252577 | Automatic load transfer device and method for automated material handling systems - An automatic load transfer device is provided for automated material handling systems of the type having a tow AGV pulling a train of trailers along a predetermined path between stations. The device has a base positioned adjacent to the path with spaced apart rails that support a movable carriage which shifts between retracted and extended positions. A conveyor having a plurality of side-by-side fingers with moving conveyor elements is supported on the carriage by a lift which shifts the conveyor between lowered and raised positions. The carriage, conveyor elements, and lift have separate drives that are operably connected with a controller which sequentially activates the same to load and/or unload loads onto and/or from the trailers. | 10-08-2009 |
20100138095 | POWER SOURCE MONITORING SYSTEM FOR AGVS AND METHOD - An automatic guided vehicle (AGV) and method has at least one AGV with a drive assembly, a rechargeable power source on-board the AGV configured to supply power to the drive assembly, and a controller on-board the AGV. The controller on-board the AGV is configured to substantially continuously monitor at least two conditions including an operating condition of the AGV, a state of charge of the power source, and an electrical power supplied for recharging the rechargeable power source, wherein the controller determines when the rechargeable power source of the AGV is to be recharged, and controls a recharging process of the power source based upon at least one of the monitored conditions. | 06-03-2010 |
Jeremy Koff, Studio City, CA US
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20090259280 | ELECTRICAL STIMULATION LEAD WITH BIOERODIBLE ANCHORS AND ANCHOR STRAPS - An apparatus includes a coupling portion, a bioerodible anchor portion and a bioerodable retainer. The coupling portion is configured to be coupled to an electrical conductor. The bioerodible retention portion is adjacent to the coupling portion and is moveable from a collapsed configuration to an expanded configuration. The bioerodible retention portion is configured to anchor the electrical conductor with respect to body tissue when the bioerodible retention portion is in its expanded configuration. The bioerodible anchor portion is formulated to erode when disposed within the body tissue at a first rate. The bioerodible retainer is coupled to the bioerodible anchor portion and is configured to inhibit movement of the bioerodible anchor portion from the collapsed configuration to the expanded configuration. The bioerodible retainer is formulated to erode when disposed within the body tissue at a second rate greater than the first rate. | 10-15-2009 |
Jonathan L. Koff, San Francisco, CA US
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20110236349 | Use of Epidermal Growth Factor Inhibitors in the Treatment of Viral Infection - The present invention provides methods of treating a viral infection in an individual. The methods generally involve administering to an individual an effective amount of an epidermal growth factor receptor (EGF-R) inhibitor. | 09-29-2011 |
Matthew F. Koff, Livingston, NJ US
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20110030698 | MRI COMPATIBLE KNEE POSITIONING DEVICE - A device for positioning a subject's knee during an MRI scan. The device includes foot, knee, and thigh positioning apparatuses. Each of the positioning apparatuses can be translated and/or rotated to allow correct and consistent position of the subject's knee within the MRI magnetic bore. The device includes a user control to facilitate repeat measurements of knee characteristics with reduced intra- and inter-technologist variability. | 02-10-2011 |
Nadine Koff, Toronto CA
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20120243754 | SYSTEM AND METHOD FOR MANAGEMENT AND DISTRIBUTION OF DIAGNOSTIC IMAGING - A method of distributing an image study to a chosen image reader is disclosed having steps of receiving an image study from an image producer at a third party communication module, sending a receive notification message to a messaging layer, sending a study available notification message from the messaging layer to a workload distribution engine wherein the available notification message includes extracted image study information pulled from study headers of the image study, identifying image study rules from the extracted image study information, applying an image study complexity to the image study based on the image study rules, calculating image reader complexities for a plurality of image readers subscribed to receive image studies from the image producer, each of the image reader complexities calculated using the image study complexity and an Image reader profile assigned to each of the plurality of accredited image readers, selecting the chosen image reader from the plurality of image readers based on the image reader complexities, assigning the image study to the chosen image reader, and displaying the image study on a user interface to the chosen image reader. | 09-27-2012 |
Wayne Koff, Stony Brook, NY US
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20110044994 | HUMAN IMMUNODEFICIENCY VIRUS (HIV)-NEUTRALIZING ANTIBODIES - The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided. | 02-24-2011 |
20130251726 | NOVEL HIV -1 BROADLY NEUTRALIZING ANTIBODIES - The present application relates novel HIV-1 broadly neutralizing antibodies. The antibodies of the present invention are further characterized by their ability to bind epitopes from the Env proteins. The invention also provides light and heavy chain variable region sequences. Compositions for prophylaxis, diagnosis and treatment of HIV infection are provided. | 09-26-2013 |
20140205612 | HUMAN IMMUNODEFICIENCY VIRUS (HIV)-NEUTRALIZING ANTIBODIES - The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided. | 07-24-2014 |
20150218257 | MONOCLONAL ANTIBODIES DIRECTED AGAINST TRIMERIC FORMS OF THE HIV-1 ENVELOPE GLYCOPROTEIN WITH BROAD AND POTENT NEUTRALIZING ACTIVITY - The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided. | 08-06-2015 |
Wayne Koff, New York, NY US
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20150361160 | BROADLY NEUTRALIZING ANTIBODY AND USES THEREOF - The present invention relates to an exceptionally broad and potent neutralizing antibody which may comprise cross-clade neutralizing coverage of 83% at a median IC | 12-17-2015 |
Wayne C. Koff, Stony Brook, NY US
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20090123485 | Antigen Antibody Complexes as HIV-1 Vaccines - The present relation relates to antigen-antibody complexes for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic antibody-antigen complexes which are formulated into the vaccines of the present invention. | 05-14-2009 |
20110262488 | Novel HIV-1 Envelope Glycoprotein - The present application relates to a novel HIV-1 envelope glycoprotein which may be utilized as an HIV-1 vaccine immunogen, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention. | 10-27-2011 |
20120258124 | ANTIGEN-ANTIBODY COMPLEXES AS HIV-1 VACCINES - The present relation relates to antigen-antibody complexes for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The present invention encompasses the preparation and purification of immunogenic antibody-antigen complexes which are formulated into the vaccines of the present invention. | 10-11-2012 |