Patent application number | Description | Published |
20110136893 | OLIGONUCLEOTIDE-, PROTEIN AND/OR PEPTIDE-POLYMER CONJUGATES - A conjugate or compound comprising polyethyleneglycol and an oligonucleotide, wherein at least one polyethyleneglycol is linked to the 5′-end of the oligonucleotide and at least one polyethyleneglycol is linked to the 3′-end of the oligonucleotide, wherein the molecular weight of the polyethyleneglycol linked to the 5′- and 3′-end of the oligonucleotide is identical and is <5000 Da, or wherein the molecular weight of the polyethyleneglycol linked to the 5′- and 3′-end of the oligonucleotide is different. | 06-09-2011 |
20130172238 | METHOD FOR SELECTIVE OLIGONUCLEOTIDE MODIFICATION - Method for producing a modified oligonucleotide, wherein at least one polymer, preferably polyalkylene oxide, and/or a compound is covalently bound to the 5′-end or the 3′-end of the oligonucleotide via native ligation forming a native ligation site, with the proviso that the polymer and/or the compound is not a protein or peptide, if only the 5′-end of the oligonucleotide is modified by binding of the polymer or compound via native ligation. The invention is further directed to a modified oligonucleotide obtainable by the inventive method as well as the use of such modified oligonucleotide for the preparation of a medicament for preventing and/or treating a tumor, formation of metastasis, an immune disease or disorder, a cardiovascular disease or disorder, and/or a viral disease or disorder. | 07-04-2013 |
Patent application number | Description | Published |
20080308980 | HYDRAULICALLY PRESTRESSED ELASTOMER SPRING ELEMENT AND THE USE THEREOF IN WIND TURBINE BEARINGS - The invention relates to spring elements and bearings which contain these spring elements, the spring stiffness of the bearings and spring elements being individually adjustable by deformable elastomer bodies or elastomer layers by prestressing. The deformation of the elastomer layers and hence of the spring elements is achieved by an appropriately designed hydraulic device. The leak-tightness of the spring elements and bearing elements according to the invention is achieved through special hydraulically prestressed sealing elements, use of a pressure membrane and special structural features of the elastomer elements. | 12-18-2008 |
20110018181 | ELASTOMER COMPONENTS THAT CAN BE PRESTRESSED BY PRESSURE MEANS AND METHOD FOR THE PRODUCTION THEREOF - Elastomer components ( | 01-27-2011 |
20110150374 | HORIZONTALLY AND VERTICALLY ADJUSTABLE BEARING - A bearing ( | 06-23-2011 |
20110210490 | ASYMMETRICAL MOUNTING - An elastomeric bearing arrangement for the reduction of machine vibrations caused predominantly by externally acting forces. The bearing, due to its special design and construction symmetry, is capable of processing the forces occurring in all spatial directions with optimal material protection. The bearing is preferably suitable for a rotational connection of rotor/gearbox units to the support plate in wind turbines. The bearing has a sandwich element ( | 09-01-2011 |
20120248285 | ECCENTRIC CLAMPING BUSHING - A clamping bushing which, due to the particular eccentric geometry and composite materials used to manufacture the same, comprising elastomers ( | 10-04-2012 |
20120292840 | ELASTOMER SPRING WITH MECHANICALLY ADJUSTABLE STIFFNESS - A mechanically adjustable elastomer bearing based on a correspondingly arranged spring element whose spring stiffness can be adjusted or pretensioned individually by deformable elastomer bodies or elastomer layers. The deformation of the elastomer layers, and thus of the spring elements, is achieved by a pressure-generated device which is fully integrated into the spring element. The elastomer bearing are particularly suitable for use as bearings in rotor and gearbox for large wind turbines, but can also advantageously be employed in machine and vehicle construction, and in particular package clutches. | 11-22-2012 |
20130336606 | BUSHING WHICH CAN BE PRETENSIONED BY MATERIAL DISPLACEMENT AND BEARING EQUIPPED WITH SAID BUSHING - An elastomeric bushing and a bearing which is equipped with the bushing in question. The bushing can, even after installation in the bearing, be pretensioned or calibrated, by displacement of elastomeric material in the interior of the bushing, where the displacement is carried out by different pressing means and tensioning means in the bushing and/or in the surrounding bearing. | 12-19-2013 |
20140196999 | TEMPERATURE-INDEPENDENT VIBRATION DAMPER - A temperature-compensating damping element, which is suitable for the temperature-independent reduction of vibrations, which has a fixed, non-elastic outer part and a fixed, non-elastic inner part, which is either inserted fully or partly into a mating cut-out or opening of the outer part. The outer and inner parts have contact surfaces which are connected to one another by an elastic layer which comprises an elastomer material and which is, or can be, pre-tensioned with respect to a desired frequency by a tensioning element. The elastic layer which is responsible for the vibration damping is directly connected at one or more points to an additional elastic volume. The additional elastic volume is a multiple of the volume of the elastic layer, and has the effect that the excitation frequency of the damping element changes in the case of a temperature change within a temperature range. | 07-17-2014 |
20150176671 | ELASTOMER COMPONENTS THAT CAN BE PRESTRESSED BY PRESSURE MEANS, AND METHOD FOR THE PRODUCTION THEREOF - Elastomer components, which are to have an elastomer volume with a sufficiently large prestress, as is required, for example, for use in wind energy plants. The elastomer components are substantially based on the incorporation and integration of separating elements into the elastomer body of the component, the elements are disposed either individually or in structures. The body may be compressed by pressure supplied into the region, between the separating elements and the surrounding elastomer material, or directly into the separating elements, such that the elastomer components are prestressed in a dynamically adjustable manner. | 06-25-2015 |
20150226186 | ELASTIC SELF-ALIGNING BEARING - A teeter bearing, preferably for use in wind turbines, which is built up from elastic, in particular conical multilayered spring elements, which can optionally be varied in their stiffness behaviour by hydraulic devices and are arranged constructively in the region of the rotor hub so that they are consequently highly suitable both for adjustment of the rotor blades and also for reduction of undesired forces transmitted to the turbine through the rotor blades. In particular, the teeter bearings are suitable for use in one- and two-bladed rotor wind turbines. | 08-13-2015 |
Patent application number | Description | Published |
20090256095 | Locomotive Air Compressor Crankcase with Oil Drain Valve - A crankcase for a locomotive air compressor including a body defining an interior space, a port in fluid communication with the interior space of the body, a valve receiving portion adjacent to and surrounding the port, and an oil drain valve engaged with the valve receiving portion and having a flow passageway in fluid communication with the port. The oil drain valve has an open position and a closed position, such that the oil drain valve in the open position allows oil to flow from the interior space of the body through the flow passageway, and the oil drain valve in the closed position prevents the flow of oil from the interior space of the body through the flow passageway. A method for installing a locomotive air compressor having the crankcase and oil drain valve is also disclosed. | 10-15-2009 |
20090297368 | Single Piece Water Over Air Intercooler for a Reciprocating Air Compressor - A water over air intercooler for use in a reciprocating air compressor includes a central core unit having an interior which contains a plurality of air passage tubes, a cooling water inlet and at least one cooling water outlet. A first manifold has at least one air inlet and is in communication with the plurality of air passage tubes so as to receive air from the at least one air inlet and direct the air to the plurality of air passage tubes. A second manifold has an air outlet and is in communication with the plurality of air passage tubes so as to receive air from the plurality of finned air passage tubes and direct the air to the at least one air outlet. The central core unit, the first manifold and the second manifold are integrally connected by welding to form a single piece. | 12-03-2009 |
20100050860 | Single-Acting Pneumatic Cylinder for Use on a Locomotive Platform - The pneumatic cylinder includes a cylinder body, a non-pressure head, a hollow piston rod, a piston head, and a push rod. The cylinder body has a mounting flange and an inlet port. The non-pressure head has a mounting flange. The hollow piston rod has an open end and a closed end. The piston head is secured to the hollow piston rod and defines the closed end of the hollow piston rod. The push rod has a socket end inserted within the hollow piston rod and a coupler end. The non-pressure head has a hollow rod guide bearing and a hollow rod seal and the piston head has a piston guide bearing and a piston seal. The hollow rod guide bearing and the hollow rod seal each slidably engage the hollow piston rod. The piston guide bearing and the piston seal each slidably engage the cylinder body. | 03-04-2010 |
20140234134 | Pressurized Oil Delivery System for a Reciprocating Air Compressor - A pressurized oil delivery system for a reciprocating air compressor includes an oil pump having an inlet port connected to an oil pickup tube and an outlet port connected to a filter inlet tube and a user interface panel mounted to a crankcase of the air compressor. The filter inlet tube may be connected to an oil filter assembly supported on an exterior face of the user interface panel. A pressure regulating valve may be provided in line in the filter inlet tube upstream of the oil filter assembly. An oil fill port may be located on the user interface panel. An oil level indicator may be connected to an oil level indicator tube passing through and supported by the user interface panel. An oil pressure measurement port may be provided on the user interface panel. | 08-21-2014 |