Patent application number | Description | Published |
20120262165 | RELAXOMETRY - Apparatus, methods, and other embodiments associated with multi-scale orthogonal matching pursuit (OMP) for magnetic resonance imaging (MRI) relaxometry are described. One example method includes controlling a nuclear magnetic resonance (NMR) apparatus to cause selected nuclei in an item to resonate by applying radio frequency (RF) energy to the item and then acquiring multiple series of magnetic resonance (MR) images of the item, the series of MR images having different scales. The example method includes controlling the NMR apparatus to produce a combined signal evolution from a first signal evolution associated with a first series of MR images and a second signal evolution associated with a second series of MR images and to characterize relaxation of the selected nuclei in the item as a function of an OMP that compares the combined signal evolution to a set of combined comparative signal evolutions. | 10-18-2012 |
20120268123 | RELAXOMETRY QUANTIFICATION SELF-JUSTIFICATION FITTING - Apparatus, methods, and other embodiments associated with self-justification fitting for magnetic resonance imaging (MRI) relaxation parameter quantification are described. One example nuclear magnetic resonance (NMR) apparatus includes a self-justification fitting logic configured to selectively include and exclude data points from a set of data points associated with NMR signals based, at least in part, on their impact on a fit attribute (e.g., standard deviation). In one embodiment, the self-justification is configured to select a subset of data points from the set of data points as a function of values for a fit attribute computed from fitting at least two different subsets of data points from the set of data points to a known NMR signal evolution. | 10-25-2012 |
20130265047 | Nuclear Magnetic Resonance (NMR) Fingerprinting - Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, and a characterization logic configured to characterize a resonant species in the object as a result of comparing acquired signals to reference signals. | 10-10-2013 |
20140167754 | Magnetic Resonance Fingerprinting (MRF) With Echo Splitting - Apparatus, methods, and other embodiments associated with nuclear magnetic resonance (NMR) fingerprinting using echo splitting are described. One example apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include the number of echo splitting pulses, spacings between echo splitting pulses, flip angle of echo splitting pulses, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, and a characterization logic configured to characterize a resonant species in the object as a result of comparing acquired signals to reference signals. | 06-19-2014 |
20140232399 | Nuclear Magnetic Resonance (NMR) Fingerprinting - Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, a matching logic configured to compare a signal evolution to a known, simulated or predicted signal evolution, and a characterization logic configured to characterize a resonant species in the object as a result of the signal evolution comparisons. | 08-21-2014 |
20140266199 | Nuclear Magnetic Resonance (NMR) Fingerprinting - Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, a matching logic configured to compare a signal evolution to a known, simulated or predicted signal evolution, and a characterization logic configured to characterize a resonant species in the object as a result of the signal evolution comparisons. | 09-18-2014 |
20150070012 | Magnetic Resonance Fingerprinting Exams With Optimized Sound - Apparatus, methods, and other embodiments associated with optimizing sounds produced during nuclear magnetic resonance (NMR) fingerprinting are described. One example NMR apparatus includes an NMR logic to repetitively and variably sample a (k, t, E) space associated with a patient to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include flip angle, echo time, RF amplitude, and other parameters. The parameters are varied in different acquisition blocks to facilitate matching sounds produced in response to the acquisition blocks to a desired set of sounds. The desired set of sounds may be a musical piece. | 03-12-2015 |
Patent application number | Description | Published |
20090089607 | Systems and methods for voltage regulator communication - Systems and method for providing a regulated voltage supply to an integrated circuit. In an embodiment of the invention, a voltage regulator in a system provides an integrated circuit in the system with information related to the voltage regulator providing a supply voltage to the integrated circuit. In another embodiment of the invention, the integrated circuit makes determinations about the operating characteristic of the system using information from the voltage regulator. | 04-02-2009 |
20090167092 | SIMULTANEOUS MULTI-VOLTAGE RAIL VOLTAGE REGULATION MESSAGES - Methods and mechanisms to simultaneously regulate two or more supply voltages provided to an integrated circuit by a voltage regulator. In an embodiment of the invention, a voltage regulation message exchanged between the integrated circuit and the voltage regulator includes an identifier indicating two or more supply voltages selected from a plurality of supply voltages provided to the integrated circuit by the voltage regulator, where the voltage regulation message relates to the indicated two or more supply voltages. In another embodiment, the voltage regulation message indicates a desired supply voltage level to which the indicated two or more supply voltages are to transition. | 07-02-2009 |
20110199153 | Simultaneous Multi-Voltage Rail Voltage Regulation Messages - Methods and mechanisms to simultaneously regulate two or more supply voltages provided to an integrated circuit by a voltage regulator. In an embodiment of the invention, a voltage regulation message exchanged between the integrated circuit and the voltage regulator includes an identifier indicating two or more supply voltages selected from a plurality of supply voltages provided to the integrated circuit by the voltage regulator, where the voltage regulation message relates to the indicated two or more supply voltages. In another embodiment, the voltage regulation message indicates a desired supply voltage level to which the indicated two or more supply voltages are to transition. | 08-18-2011 |
20130015715 | SIMULTANEOUS MULTI-VOLTAGE RAIL VOLTAGE REGULATION MESSAGES - Methods and mechanisms to simultaneously regulate two or more supply voltages provided to an integrated circuit by a voltage regulator. In an embodiment of the invention, a voltage regulation message exchanged between the integrated circuit and the voltage regulator includes an identifier indicating two or more supply voltages selected from a plurality of supply voltages provided to the integrated circuit by the voltage regulator, where the voltage regulation message relates to the indicated two or more supply voltages. In another embodiment, the voltage regulation message indicates a desired supply voltage level to which the indicated two or more supply voltages are to transition. | 01-17-2013 |
20130047007 | DYNAMIC VOLTAGE TRANSITIONS - The operating voltage of an integrated circuit (e.g., a processor) is changed in response to one or more conditions (e.g., a laptop computer is connected to an AC power source). Both the operating frequency and the operating voltage of the integrated circuit are changed. The voltage regulator providing the operating voltage to the integrated circuit is caused to transition between voltage levels using one or more intermediate steps. The integrated circuit continues to operate in the normal manner both at the new voltage and throughout the voltage transition. | 02-21-2013 |
20130232351 | DYNAMIC VOLTAGE TRANSITIONS - The operating voltage of an integrated circuit (e.g., a processor) is changed in response to one or more conditions (e.g., a laptop computer is connected to an AC power source). Both the operating frequency and the operating voltage of the integrated circuit are changed. The voltage regulator providing the operating voltage to the integrated circuit is caused to transition between voltage levels using one or more intermediate steps. The integrated circuit continues to operate in the normal manner both at the new voltage and throughout the voltage transition. | 09-05-2013 |
Patent application number | Description | Published |
20120143237 | VASCULAR REMODELING DEVICE - Described herein are vascular remodeling devices that include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchors the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection. | 06-07-2012 |
20120143317 | VASCULAR REMODELING DEVICE - Described herein are vascular remodeling devices that include a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchors the device in an afferent vessel of a bifurcation. The distal section expands from the compressed delivery state to an expanded state that may be substantially planar, approximately semi-spherical, umbrella shaped, or reverse umbrella shaped. The distal section is positioned in a bifurcation junction across the neck of an aneurysm or within an aneurysm. The intermediate section allows perfusion to efferent vessels. Before or after the device is in position, embolic material may be used to treat the aneurysm. The distal section can act as a scaffolding to prevent herniation of the embolic material. The device can be used for clot retrieval with integral distal embolic protection. | 06-07-2012 |
20120290067 | VASCULAR REMODELING DEVICE - Described herein are flexible implantable devices or stents that can conform to the shape of vessels of the neurovasculature. In some embodiments, the devices can direct blood flow within a vessel away from an aneurysm or limit blood flow to the aneurysm. In some embodiments, a vascular remodeling device includes a first section and a protruding section. During deployment, the device expands from a compressed configuration to an expanded configuration. The first section anchors the device in an afferent vessel and/or in an efferent vessel of a bifurcation and the protruding section is positioned in the junction of the bifurcation having an aneurysm and across the neck of the aneurysm or at least partially within the aneurysm. | 11-15-2012 |
20120296361 | VASCULAR REMODELING DEVICE - A vascular remodeling device and methods for its use are provided. The device can be positionable at a junction of a bifurcation having an aneurysm and that defines afferent and efferent vessels. Ends of the device can be at least partially inserted into the aneurysm or can anchor the device by being at least partially inserted into efferent vessels. The device can act as a scaffolding to inhibit dislodging of objects out of the aneurysm. The device can permit perfusion to the efferent vessels. Embolic material can be inserted in the aneurysm before, during, and/or after positioning the device. | 11-22-2012 |
20120296362 | VASCULAR REMODELING DEVICE - A vascular remodeling device is provided that can comprise a proximal section, an intermediate section, and a distal section. During deployment, the proximal section can expand from a compressed delivery state to an expanded state and anchor the device in the afferent vessel of a bifurcation. The distal section can comprise at least one embolization coil that can be positioned within an aneurysm to treat the aneurysm and expand from the compressed delivery state to an expanded state upon deployment. The intermediate section can allow perfusion to efferent vessels. Before, during, and/or after the device is positioned, additional embolic material can be used to treat the aneurysm. | 11-22-2012 |
20140025154 | METHODS AND APPARATUS FOR LUMINAL STENTING - A stent delivery device includes a first retaining polymer disposed about and retaining a self-expanding stent at a proximal end portion, a second retaining polymer disposed about and retaining the self-expanding stent at a distal end portion, a first resistance member in thermal communication with the first retaining polymer, and a second resistance member in thermal communication with the second retaining polymer. The second retaining polymer and second resistance member are configured to allow release and expansion of the distal end portion of the self-expanding stent without expansion of the proximal end portion of the self-expanding stent. | 01-23-2014 |
20140243882 | DESIGN AND METHODS FOR A DEVICE WITH BLOOD FLOW RESTRICTION FEATURE FOR EMBOLUS REMOVAL IN HUMAN VASCULATURE - A mechanical thrombectomy device system is disclosed that is made from a single piece of biocompatible material, including a proximal flow block portion/feature, and/or, a flow block feature in the device body portion, a guidewire like delivery portion and an expandable, treatment portion. The construction of the device from a single piece allows for a seamless transition from the delivery portion to the treatment portion, thus removing any joints or bonding of the two portions together as separate pieces. This improves the strength of the system as a whole and greatly reduces the possibility of the two parts unintentionally detaching from each other. Likewise, the distal treatment portion is cut from a piece of material the same size as the proximal delivery portion, allowing the device to be compacted to a similar size profile giving it delivery advantages including a lower delivery force required and requiring small access systems, and the treatment portion's surface can be altered to enhance embolus affinity by either coating with a substance or changing the texture by mechanical or chemical means. | 08-28-2014 |
20140309673 | DEVICES FOR REMOVING VESSEL OCCLUSIONS - Described herein are thrombectomy devices and methods of using same for capturing or encapsulating and removal of a blood or vessel. | 10-16-2014 |
20150066073 | DETACHMENT MECHANISMS FOR IMPLANTABLE DEVICES - The present invention relates to detachment mechanisms for delivering and releasing implantable devices into a body lumen. According to certain aspects, systems of the invention include a junction that couples an implantable device to a delivery member. The junction includes an anodic portion and a cathodic portion galvanically coupled to the anodic portion such that the anodic portion corrodes when exposed to an electrolytic fluid, thereby detaching the implantable device from the delivery member without application of energy from an external power source. | 03-05-2015 |
Patent application number | Description | Published |
20110191414 | METHOD AND APPARATUS FOR EFFICIENT HTTP STREAMING - A method and apparatus provide streaming delivery of data such as media data (video, audio) using a non-streaming delivery mechanism such as HTTP along with server-side pacing of the delivery. An initial portion of the media data is preloaded to a client buffer in a bursting manner to minimize latency. The method may include client request verification, support for client self-pacing, and support for catch-up pacing reductions. A proxy server apparatus may also be used which employs both server-side and client-side pacing and may include caching and both cache and client preloading for minimized latency. A similar proxy server apparatus may be used to provide an efficient alternative to client polling for data from a polled data service, such as stock quotes etc., using streaming updates. The method may include support for stream modification through persistent client requests. | 08-04-2011 |
20120002717 | METHOD AND SYSTEM FOR LIVE STREAMING VIDEO WITH DYNAMIC RATE ADAPTATION - A live streaming system/method provides cross platform live streaming capabilities to mobile devices. A file format compatible with legacy HTTP infrastructure is used to deliver media over a persistent connection. Legacy client media players can dynamically change the encoded rate of the media delivered over a persistent connection. Standard HTTP servers may be used without modification, leveraging standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. | 01-05-2012 |
20120004960 | METHOD AND SYSTEM FOR EFFICIENT STREAMING VIDEO DYNAMIC RATE ADAPTATION - A streaming media system employs dynamic rate adaptation. The method includes a file format compatible with legacy HTTP infrastructure to deliver media over a persistent connection. The method further includes the ability for legacy client media players to dynamically change the encoded delivery rate of the media over a persistent connection. The method provided works transparently with standard HTTP servers, requiring no modification and leverages standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. A system is also specified for implementing a client and server in accordance with the method. | 01-05-2012 |
20120005364 | SYSTEM AND METHOD FOR NETWORK AWARE ADAPTIVE STREAMING FOR NOMADIC ENDPOINTS - In a system for streaming data over a network, the type and rate of streaming are automatically varied based on available network bandwidth. Video media is transcoded into different bit rate encodings that are divided into segment files. Segments are sent from a network-aware adaptive streaming (NAAS) server and reassembled and presented to a media player at a client device. The system may download additional segment files ahead of time from multiple NAAS servers to increase throughput. A playback status (“bookmark”) may be maintained to keep track of what the user has viewed and to allow the user to continue playing from where the user left off. The user may continue watching from the bookmark point on the same device or on a different device. | 01-05-2012 |
20120005365 | METHOD AND SYSTEM FOR EFFICIENT STREAMING VIDEO DYNAMIC RATE ADAPTATION - A streaming media system employs dynamic rate adaptation. The method includes a file format compatible with legacy HTTP infrastructure to deliver media over a persistent connection. The method further includes the ability for legacy client media players to dynamically change the encoded delivery rate of the media over a persistent connection. The method provided works transparently with standard HTTP servers, requiring no modification and leverages standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. A system is also specified for implementing a client and server in accordance with the method. | 01-05-2012 |
20120005366 | METHOD AND APPARATUS FOR RETRIEVING AND RENDERING LIVE STREAMING DATA - A live streaming system/method provides cross platform live streaming capabilities to mobile devices. A file format compatible with legacy HTTP infrastructure is used to deliver media over a persistent connection. Legacy client media players can dynamically change the encoded rate of the media delivered over a persistent connection. Standard HTTP servers may be used without modification, leveraging standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. | 01-05-2012 |
20120011267 | LIVE STREAMING MEDIA DELIVERY FOR MOBILE AUDIENCES - A live streaming system/method provides cross platform live streaming capabilities to mobile devices. The live streaming system includes a live streaming recorder operative to (1) capture a live media stream generated by a live media source and save the captured live media stream as a recorded stream in a recorded media file, and (2) transcode the recorded stream into a plurality of transcoded media files of respective different media encoding formats. The system further includes a stream distribution subsystem operative to generate a plurality of distributed media streams each generated from one or more of the transcoded media files, each distributed media stream being delivered to a corresponding set of the mobile endpoint devices. | 01-12-2012 |
20120240176 | METHOD AND SYSTEM FOR FEDERATED OVER-THE-TOP CONTENT DELIVERY - A method is provided for managing over-the-top delivery of content through a plurality of content delivery networks (CDN). The method provided works transparently with standard HTTP servers supporting an initial request for content from a client to a first preferred CDN. If the first CDN does not have the content, the method includes provisions for the first CDN to acquire the content from a second CDN, or for the client to request the content from a second CDN directly. A system is also specified for implementing a client and server infrastructure in accordance with the provisions of the method. | 09-20-2012 |
20120265892 | METHOD AND SYSTEM FOR SECURE AND RELIABLE VIDEO STREAMING WITH RATE ADAPTATION - A system for media delivery includes a server-side proxy for aggregating and encrypting stream data for efficient HTTP-based distribution over an unsecured network. A client-side proxy decrypts and distributes the encapsulated stream data to client devices. A multicast-based infrastructure may be used for increased scalability. The encoded rate of the media delivered over the persistent HTTP proxy connections may be dynamically adapted. The client-side proxy may be integrated within a mobile device for maximum network security and reliability. | 10-18-2012 |
20120331293 | METHOD AND SYSTEM FOR SECURE OVER-THE-TOP LIVE VIDEO DELIVERY - A method is provided for managing key rotation (use of series of keys) and secure key distribution in over-the-top content delivery. The method provided supports supplying a first content encryption key to a content packaging engine for encryption of a first portion of a video stream. Once the first content encryption key has expired, a second content encryption key is provided to the content packaging engine for encryption of a second portion of a video stream. The method further provides for notification of client devices of imminent key changes, as well as support for secure retrieval of new keys by client devices. A system is also specified for implementing a client and server infrastructure in accordance with the provisions of the method. | 12-27-2012 |
20130019273 | METHOD AND SYSTEM FOR TRICK PLAY IN OVER-THE-TOP VIDEO DELIVERY - A method for trick play (fast forward, rewind, etc.) in video streams using adaptive bitrate HTTP delivery protocols includes playing only portions of a video at a current bitrate to achieve the initial trick play functionality. A new trick play bitrate is selected based on a trick play playout rate, the trick play bitrate for the duration of the trick play is retrieved, and operation is switched back to a previous bitrate when normal playback resumes. A system is also specified for implementing a client and server infrastructure in accordance with the method. | 01-17-2013 |
20130097309 | METHOD AND APPARATUS FOR CARRIER CONTROLLED DYNAMIC RATE ADAPTATION AND CLIENT PLAYOUT RATE REDUCTION - A method and system is provided for controlling bandwidth rate limiting and client rendering rate limiting in a video delivery network. The method provides network service providers with a means for overriding video delivery data rates selected through dynamic client bitrate adaptation, as well as video data rendering rates of the clients, to limit the impact of network congestion. A system is also specified for implementing a client and a proxy computer in accordance with the method. The system works transparently with standard HTTP-based video delivery systems and includes an HTTP proxy cache infrastructure to support bandwidth rate limiting and client rending rate limiting. The system further provides for administrative overrides of client bitrate selection and client bandwidth usage. | 04-18-2013 |
20130152180 | DEVICE USING SECURE PROCESSING ZONE TO ESTABLISH TRUST FOR DIGITAL RIGHTS MANAGEMENT - A DRM client on a device establishes trust with a DRM server for playback of digital content. The client executes in a secure execution environment, and the process includes (1) securely loading loader code from secure programmable memory and verifying it using a digital signature scheme and first key securely stored in the device; (2) by the verified loader code, loading DRM client code from the memory and verifying it using a digital signature scheme and second key included in the loader code; (3) by the verified DRM client code (a) obtaining a domain key from the memory; (b) encrypting the domain key with a device identifier using a DRM system key included in the DRM client code; and (c) sending the encrypted domain key and device identifier to the DRM server, whereby the device becomes registered to receive content licenses via secure communications encrypted using the domain key. | 06-13-2013 |
20130282890 | IN-STREAM COLLECTION OF ANALYTICS INFORMATION IN A CONTENT DELIVERY SYSTEM - Analytics information is collected in a content delivery network when content requests are received by a content router. Analytics information may be gleaned from uniform resource identifiers, and additional augmented analytics information may be specified by either the client that issued the request or an intermediate network node that proxied the request. The augmented analytics information may be specified in proprietary HTTP header fields. Information collection includes intercepting content requests; correlating URIs with known content assets; associating content requests with session state; extracting downstream node augmented information from the content requests; updating session information in persistent storage; selecting target locations from which to retrieve the content assets; and redirecting the content requests to the target locations. | 10-24-2013 |
20130297815 | SERVER-SIDE CLASS-OF-SERVICE-BASED BANDWIDTH MANAGEMENT IN OVER-THE-TOP VIDEO DELIVERY - A server device delivers content to a client device by sending the content as a series of segments using chunked delivery. The sending is paced in accordance with a class of service for the client device, the class of service having an associated target chunk send time that decreases with higher classes of service. Pacing includes sending a chunk over an actual chunk send time and calculating an inter-chunk delay as a difference between the target chunk send time and the actual chunk send time. If the inter-chunk delay is positive, then the server waits the inter-chunk delay before beginning to send a next successive chunk, and otherwise it immediately begins sending the next successive chunk. The server also employs bitrate selection to manage client use of available bandwidth. | 11-07-2013 |
20140047069 | METHOD AND SYSTEM FOR FEDERATED OVER-THE-TOP CONTENT DELIVERY - A method is provided for managing over-the-top delivery of content through a plurality of content delivery networks (CDN). The method provided works transparently with standard HTTP servers supporting an initial request for content from a client to a first preferred CDN. If the first CDN does not have the content, the method includes provisions for the first CDN to acquire the content from a second CDN, or for the client to request the content from a second CDN directly. A system is also specified for implementing a client and server infrastructure in accordance with the provisions of the method. | 02-13-2014 |
20140095729 | CLIENT-SIDE CLASS-OF-SERVICE-BASED BANDWIDTH MANAGEMENT IN OVER-THE-TOP VIDEO DELIVERY - A client device downloads content from a content delivery network as segments encoded at respective bitrates selected from distinct encoding bitrates. Downloading is paced per a class of service having an associated abort timeout increasing with higher classes of service. Pacing includes downloading a segment encoded at a first bitrate and monitoring for the earlier of completing the downloading or aborting the downloading based on the abort timeout. Upon the downloading being aborted, a first backoff duration is calculated as a remainder of a playback interval and the first backoff duration is waited before downloading of the same segment is re-initiated at a second bitrate less than the first bitrate. Upon the downloading completing successfully, a second backoff duration is calculated and the second backoff duration is waited before downloading is initiated of a next segment encoded at either the first bitrate or at a greater third bitrate. | 04-03-2014 |
20140149210 | METHOD AND SYSTEM FOR AD INSERTION IN OVER-THE-TOP LIVE MEDIA DELIVERY - A method is provided for performing targeted ad insertion in over-the-top delivery of content by detecting ad replacement opportunities in a live content stream and preparing the content for seamless replacement with segmented HTTP adaptive streaming delivery. The method includes provisions for multi-stage proxy-based segment replacement for targeted ad delivery. The method provided works transparently with standard HTTP adaptive streaming clients. A system is also specified for implementing a client and server content delivery infrastructure in accordance with the provisions of the method. | 05-29-2014 |
20140150019 | METHOD AND SYSTEM FOR AD INSERTION IN OVER-THE-TOP LIVE MEDIA DELIVERY - A method is provided for performing targeted ad insertion in over-the-top delivery of content by detecting ad replacement opportunities in a live content stream and preparing the content for seamless replacement with segmented HTTP adaptive streaming delivery. The method includes provisions for multi-stage proxy-based segment replacement for targeted ad delivery. The method provided works transparently with standard HTTP adaptive streaming clients. A system is also specified for implementing a client and server content delivery infrastructure in accordance with the provisions of the method. | 05-29-2014 |
20140237243 | METHOD AND SYSTEM FOR SECURE OVER-THE-TOP LIVE VIDEO DELIVERY - A method is provided for managing key rotation (use of series of keys) and secure key distribution in over-the-top content delivery. The method provided supports supplying a first content encryption key to a content packaging engine for encryption of a first portion of a video stream. Once the first content encryption key has expired, a second content encryption key is provided to the content packaging engine for encryption of a second portion of a video stream. The method further provides for notification of client devices of imminent key changes, as well as support for secure retrieval of new keys by client devices. A system is also specified for implementing a client and server infrastructure in accordance with the provisions of the method. | 08-21-2014 |
20150074831 | Method and System for Federated Over-the-Top Content Delivery - A method is provided for managing over-the-top delivery of content through a plurality of content delivery networks (CDN). The method provided works transparently with standard HTTP servers supporting an initial request for content from a client to a first preferred CDN. If the first CDN does not have the content, the method includes provisions for the first CDN to acquire the content from a second CDN, or for the client to request the content from a second CDN directly. A system is also specified for implementing a client and server infrastructure in accordance with the provisions of the method. | 03-12-2015 |
Patent application number | Description | Published |
20120077667 | NON-PLATINUM GROUP METAL ELECTROCATALYSTS USING METAL ORGANIC FRAMEWORK MATERIALS AND METHOD OF PREPARATION - A method of preparing a nitrogen containing electrode catalyst by converting a high surface area metal-organic framework (MOF) material free of platinum group metals that includes a transition metal, an organic ligand, and an organic solvent via a high temperature thermal treatment to form catalytic active sites in the MOF. At least a portion of the contained organic solvent may be replaced with a nitrogen containing organic solvent or an organometallic compound or a transition metal salt to enhance catalytic performance. The electrode catalysts may be used in various electrochemical systems, including a proton exchange membrane fuel cell. | 03-29-2012 |
20140107333 | POLYHEDRAL CAGE-CONTAINING METALLOPORPHYRIN FRAMEWORKS, METHODS OF MAKING, AND METHODS OF USING - Embodiments of the present disclosure provide compositions including metal-organic polyhedrons, metalloporphyrin framework structures, methods of making these, methods of using these, and the like. | 04-17-2014 |
20150056536 | NON-PLATINUM GROUP METAL ELECTROCATALYSTS USING METAL ORGANIC FRAMEWORK MATERIALS AND METHOD OF PREPARATION - A method of preparing a nitrogen containing electrode catalyst by converting a high surface area metal-organic framework (MOF) material free of platinum group metals that includes a transition metal, an organic ligand, and an organic solvent via a high temperature thermal treatment to form catalytic active sites in the MOF. At least a portion of the contained organic solvent may be replaced with a nitrogen containing organic solvent or an organometallic compound or a transition metal salt to enhance catalytic performance. The electrode catalysts may be used in various electrochemical systems, including a proton exchange membrane fuel cell. | 02-26-2015 |
20150087044 | POLYHEDRAL CAGE-CONTAINING MESOPOROUS METAL-ORGANIC FRAMEWORKS AS PLATFORM FOR BIOCATALYSIS, METHODS OF MAKING THESE FRAMEWORKS, AND METHODS OF USING THESE FRAMEWORKS - Embodiments of the present disclosure provide compositions including polyhedral mesoporous metal-organic framework including a biomolecule (e.g., enzyme), methods of making these compositions, methods of use, and the like. | 03-26-2015 |
Patent application number | Description | Published |
20110229970 | DUAL-CHAMBER PERFUSION BIOREACTOR FOR ORTHOPEDIC TISSUE INTERFACES AND METHODS OF USE - The subject invention concerns a perfusion bioreactor device and methods of using the same. A bioreactor device of the invention can be used to grow cells and tissue in a controlled in vitro environment. A perfusion bioreactor device of the invention can have multiple perfusion chambers that can be controlled individually. Transverse or parallel flow of a fluid can be provided to each chamber. Cells can be seeded on a hydrogel and/or 3D scaffold to provide a 3D environment in the bioreactor device where the cells can adhere, proliferate, migrate, secrete growth and/or differentiation factors, and/or undergo differentiation, etc. The subject invention also concerns hydrogels and 3D scaffolds that can be used to grow and/or differentiate cells thereon. | 09-22-2011 |
20120020934 | MATERIALS AND METHODS FOR CRYOPRESERVED BONE CONSTRUCTS - The subject invention concern materials and methods for cryopreservation of HCG-cell constructs. In one embodiment, porous HCG scaffolds are provided in a perfusion bioreactor having perfusion chambers that can contain the HCG scaffolds, cells are then seeded in the HCG scaffolds in the perfusion bioreactor, cell culture media is perfused through and the bioreactor operated so as to allow for cell seeding and growth in the HCG scaffold. After a suitable period of time, the cell culture media is removed and the HCG containing cells (HCG-cell constructs) can be washed with a suitable buffer, such as phosphate-buffered saline (PBS). The HCG-cell constructs are then perfused in the bioreactor with a suitable cryopreservation fluid. The cryopreservant can comprise one or more of the following: DMSO, trehalose, glycerol, ethylene glycol, and serum for cell culture (e.g., fetal bovine serum (FBS)). In one embodiment, the HCG-cell constructs are perfused for a suitable period of time with cryopreservant fluid using transverse flow of the fluid in the bioreactor at a suitable flow rate. The HCG-cell constructs (or the perfusion chambers containing them) are then removed from the bioreactor and placed in a cryopreservant media and maintained at increasingly colder temperatures until temperatures reach about −80° C. The frozen HCG-cell constructs (or the chambers containing them) can then be stored at a suitable cryogenic temperature (e.g., in liquid nitrogen) until needed. When needed, frozen HCG-cell constructs can be removed from cold storage and thawed using suitable means (e.g., 37° C. water bath). Cells contemplated for use in the present invention include stem cells, such mesenchymal stem cells. Cells can be animal cells, such as mammalian cells. In one embodiment, the cells are human cells. | 01-26-2012 |
20120178159 | MESENCHYMAL STEM CELLS (MSC) EXPANSION METHODS AND MATERIALS - The subject invention concerns materials and methods for growing and expanding MSC while maintaining their undifferentiated phenotype, self-renewal ability, and/or multi-lineage potential. In one embodiment, a method of the invention comprises i) seeding freshly isolated MSC on a planar surface or a 3-D scaffold and growing the cells under physiological or low O | 07-12-2012 |
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20120029304 | CONFIGURABLE PATIENT MONITORING SYSTEM - A patient monitoring system is provided which includes a platform and one or more monitoring modules. Monitoring modules include parameter modules for monitoring physiological activity of a patient, and utility modules for providing additional functionality to the patient monitoring system. A platform and one or more monitoring modules may be coupled to form a communications bus, allowing communication between any of the plurality of coupled devices. Updates such as software upgrades may be provided by a monitoring module to a platform or other monitoring module to update functionality. | 02-02-2012 |
20120311219 | Patient Monitoring Platform Interface - Physical monitoring systems are disclosed which may include a platform interface between a platform device and a monitoring module. The platform interface may allow physiological information from a patient such as sensor signal data, physiological trend data, other suitable data, or combinations thereof to be communicated from the monitoring module to the platform device. The platform interface may include a connector with pins configured to receive UART communications, transmit UART communications, communicate diagnostic information, be coupled to a ground, be coupled to a serial clock, receive serial data, transmit serial data, be coupled to a regulated power supply, be coupled to an unregulated power supply, communicate using USB standard, communicate using any other suitable standards, perform any other suitable functions, or any combinations thereof. The monitoring module may connect directly to the platform device, or a wired cable with suitable connectors may be used to electrically couple the monitoring module to the platform device. | 12-06-2012 |
20140275873 | SENSOR CONNECTOR - Embodiments of the present disclosure relate to patient monitoring systems having a connector configured to couple a medical sensor to a monitor. According to certain embodiments, the connector may include a layered printed circuit board having a first surface comprising a plurality of electrical contacts and a second surface having a plurality of electrical contacts. The electrical contacts of the first surface and the electrical contacts of the second surface may be configured to enable the connector to be reversible and to electrically couple the medical sensor to the monitor when the connector is in a first orientation or in a second orientation with respect to the monitor. | 09-18-2014 |
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20120110024 | IDENTIFIERS FOR NON-SEARCHABLE ATTRIBUTES - An attribute is received for storage. Whether the attribute is searchable or non-searchable in storage is determined. Storing the attribute as a searchable attribute comprises storing the attribute in a database table corresponding to a hierarchical class-based object. Storing the attribute as a non-searchable attribute comprises storing the attribute together with one or more other non-searchable attributes as a set of attributes. The set of attributes is stored in a database location outside the database table corresponding to the hierarchical class-based object, and the database location is accessed before the database table. A unique attribute identifier is associated with the attribute to distinguish between a name of the attribute and a name of one of the one or more other non-searchable attributes in the event that the name of the attribute and the name of the one of the one or more other non-searchable attributes are assigned the same name. | 05-03-2012 |
20120185504 | RETRIEVAL OF SEARCHABLE AND NON-SEARCHABLE ATTRIBUTES - Retrieving stored data is disclosed. A retrieval request is received for an object. A retrieval response is generated that includes: 1) a first set of searchable attributes associated with the object, wherein an attribute of the first set of attributes is stored in a database in a manner that enables a database query to be performed against the attribute of the first set of attributes; and 2) a second set of non-searchable attributes associated with the object, wherein an attribute of the second set of attributes is stored in the database in a manner that does not enable a database query to be performed against the attribute of the second set of attributes. | 07-19-2012 |
20120185514 | OPTIMIZED FETCHING FOR CUSTOMIZATION OBJECT ATTRIBUTES - An attribute of a hierarchical class-based object is received. The attribute in a database is stored both in a first location in a first table at a first level of a hierarchy of database tables which table hierarchy is based at least in part on a class hierarchy associated with the hierarchical class-based object and in a second location in a second table at a second level of the table hierarchy which second level is higher than the first level. | 07-19-2012 |
20120290623 | EFFICIENT STORAGE OF NON-SEARCHABLE ATTRIBUTES - Storing data is disclosed. An attribute is included in a combined set of attributes. The combined set of attributes is stored in one or more database locations not specific to any one attribute in the combined set. | 11-15-2012 |
20130179463 | RETRIEVAL OF SEARCHABLE AND NON-SEARCHABLE ATTRIBUTES - Retrieving stored data is disclosed. A retrieval request is received for an object. A retrieval response is generated that includes: 1) a first set of searchable attributes associated with the object, wherein an attribute of the first set of attributes is stored in a database in a manner that enables a database query to be performed against the attribute of the first set of attributes; and 2) a second set of non-searchable attributes associated with the object, wherein an attribute of the second set of attributes is stored in the database in a manner that does not enable a database query to be performed against the attribute of the second set of attributes. | 07-11-2013 |
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20120071343 | BIOMARKERS FOR DIFFERENTIATING MELANOMA FROM BENIGN NEVUS IN THE SKIN - Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (PHACTR1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (SPP1), preferentially expressed antigen in melanoma (PRAME), growth differentiation factor 15 (GDF 15), and chemokine C-X-C motif ligand 10 (CXCL10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of PHACTR1, or fragments thereof, either alone or in combination with the detection of SPP1, PRAME, GDF15, and CXCL10, for the diagnosis or prognosis of melanoma. | 03-22-2012 |
20120214152 | RNASCOPE.RTM. HPV ASSAY FOR DETERMINING HPV STATUS IN HEAD AND NECK CANCERS AND CERVICAL LESIONS - The present invention provides a method and a kit for determining whether a head and neck cancer is HPV-related. In one embodiment, an RNAscope® HPV assay was designed to detect the presence of E6/E7 mRNA of certain high-risk HPV subtypes related to head and neck cancer. The present invention also provides a method and a kit for determining whether a cervical lesion is a benign lesion or a cervical intraepithethial neoplasm lesion. The present invention further provides a method for determining the progression of cervical intraepithethial neoplasm based on the spatial pattern and levels of the E6/E7 mRNA of certain high-risk HPV subtypes. The present invention also provides a method for determining the risk of developing cervical cancer in a human diagnosed with cervical intraepithethial neoplasm based on presence and absence of the certain subgroups of high-risk HPV subtypes. | 08-23-2012 |
20120258442 | DETERMINING TUMOR ORIGIN - The disclosure provides methods for the use of gene expression measurements to classify or identify among 54 cancer types in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples. | 10-11-2012 |
20140178869 | DETECTION OF IMMUNOGLOBULIN LIGHT CHAIN RESTRICTION BY RNA IN SITU HYBRIDIZATION - The invention provides a method for detecting immunoglobulin light chain restriction and clonality in B cells by obtaining a sample of B cells from a subject; conducting a duplex in situ hybridization assay on the sample using (i) at least one probe set which is designed to specifically hybridize to immunoglobulin kappa chain constant region (IGKCR) RNA; and (ii) at least one probe set which is designed to specifically hybridize to immunoglobulin lambda chain constant region (IGLCR) RNA; detecting signal associated with hybridized IGKCR probe and signal associated with hybridized IGLCR probe in a population of B cells in the sample; and determining a pattern of signal associated with hybridized IGKCR probe and hybridized IGLCR probe within individual cells in the B cell population, wherein the pattern of signal within individual cells indicates the presence or absence of light chain restriction and clonality of the B cells. | 06-26-2014 |
20140357509 | DIFFERENTIATION BETWEEN TRANSIENT AND PERSISTENT HIGH-RISK HPV INFECTION BY IN SITU HYBRIDIZATION - The invention relates to methods of categorizing a cervical tissue or cytology sample by performing an in situ hybridization assay using an antisense E6 or E7 probe on a cervical tissue sample, wherein the antisense E6 or E7 probe can simultaneously detect HPV DNA and HPV RNA; detecting the presence of HPV nucleic acid; and categorizing the cervical tissue sample based on HPV nucleic acid expression. | 12-04-2014 |
20150045251 | DUPLEX CHROMOGENIC ASSAY FOR IN SITU DETECTION OF NUCLEIC ACIDS - The disclosure provides methods of detecting two or more target nucleic acids. The methods can include the steps of contacting a sample with two or more label probes having distinct enzyme labels and targeting distinct nucleic acid targets, binding the two or more label probes to the target nucleic acids by hybridization; contacting the sample with a first substrate for the first enzyme of the first label probe; reacting the first substrate with the first enzyme, thereby producing a first detectable signal; contacting the sample with a second substrate for the second enzyme of the second label probe; reacting the second substrate with the second enzyme, thereby producing a second detectable signal; and detecting the first detectable signal and the second detectable signal, thereby detecting the first and second target nucleic acids in the sample. | 02-12-2015 |
Patent application number | Description | Published |
20120159122 | SYSTEMS AND METHODS FOR LATTICE REDUCTION - Disclosed herein are lattice reduction systems and methods for a MIMO communication system. One such method includes providing a channel matrix corresponding to a channel in a MIMO communication system, preprocessing the channel matrix to form at least an upper triangular matrix, implementing a relaxed size reduction process, and implementing a basis update process. Implementing the relaxed size reduction process comprises choosing a first relaxed size reduction parameter for a first-off-diagonal element of the upper triangular matrix, choosing a second relaxed size reduction parameter, which is greater than the first relaxed size reduction parameter, for a second-off-diagonal element of the upper triangular matrix evaluating whether a first relaxed size reduction condition is satisfied for the first-off-diagonal element of the upper triangular matrix, and evaluating whether a second relaxed size reduction condition is satisfied for the second-off-diagonal element of the upper triangular matrix. | 06-21-2012 |
20120236968 | ENHANCED LATTICE REDUCTION SYSTEMS AND METHODS - An exemplary embodiment of the present invention provides a lattice reduction method comprising obtaining a preliminary estimate of a transformation matrix, generating a covariance matrix based on the preliminary estimate of the transformation matrix, reducing diagonal elements of the covariance matrix to generate a unimodular transformation matrix, and using the unimodular transformation matrix to obtain an estimate of an input. | 09-20-2012 |
20120263261 | INCREMENTAL LATTICE REDUCTION SYSTEMS AND METHODS - An exemplary embodiment of the present invention provides an incremental lattice reduction method comprising: receiving an input signal at a plurality of input terminals; evaluating a reliability assessment condition using a primary symbol vector estimate of at least a portion of the input signal; terminating the incremental lattice reduction method if the reliability assessment condition is satisfied; and if the reliability assessment condition is not satisfied, performing at least one iteration of a lattice reduction detection sub-method to obtain a secondary symbol vector estimate. | 10-18-2012 |
20130022155 | ENHANCED LATTICE REDUCTION SYSTEMS AND METHODS - An exemplary embodiment of the present invention provides a lattice reduction method comprising obtaining a preliminary estimate of a transformation matrix, generating a covariance matrix based on the preliminary estimate of the transformation matrix, reducing diagonal elements of the covariance matrix to generate a unimodular transformation matrix, and using the unimodular transformation matrix to obtain an estimate of an input. | 01-24-2013 |
Patent application number | Description | Published |
20110104344 | Heat-Stable Concentrated Milk Product - The invention provides a stable concentrated dairy liquid, such as concentrated milk, with improved flavor, color, and mouthfeel, and a method of production thereof. The method utilizes specific thermal treatments to produce the stable concentrated dairy liquid to which a stabilizer and mouthfeel enhancer are added. The resulting products have a sterilization value F | 05-05-2011 |
20110250327 | Intermediate Moisture Bar Using A Dairy-Based Binder - A chewy and intermediate moisture bar is provided that uses a dairy-based binder generally without the need to employ gums, humectants, and sugar syrups as a binder to achieve the moist and chewy texture. In one aspect, the bar includes a dry base uniformly blended with a dairy-based binder that uses high levels of dairy proteins as the main binding component. A method of forming the chewy and intermediate moisture bar is also provided that may use a lay or delay period to allow moisture equilibration or migration from the binder to the dry base. | 10-13-2011 |
20130022729 | Methods For Reducing Viscosity And Delaying Onset Of Cold Gelation Of High Solids Concentrated Milk Products - Methods are provided for treating high solids concentrated milk products to delay gelation of the concentrated milk products by minimizing the rate at which the viscosity of the concentrates increases during cold storage. By another approach, the methods described herein are effective to substantially reduce the viscosity of the concentrated milk products. The methods described herein advantageously increase the length of time the high solids milk concentrates remain fluid and pumpable during refrigerated shelf-life. The high solids concentrated milk products treated with the methods provided herein include about 33 to about 43 percent total solids. By one approach, the high solids concentrated milk products have a pH of about 4.6 to about 6.7, and include salt at about 0.25 to about 6 percent by weight of the concentrate. | 01-24-2013 |
20130064944 | Heat-Stable Concentrated Milk Product - The invention provides a stable concentrated dairy liquid, such as concentrated milk, with improved flavor, color, and mouthfeel, and a method of production thereof. The method utilizes specific thermal treatments to produce the stable concentrated dairy liquid to which a stabilizer and mouthfeel enhancer are added. The resulting products have a sterilization value F | 03-14-2013 |
20130202745 | Intermediate Moisture Bar Using A Dairy-Based Binder - A chewy and intermediate moisture bar is provided that uses a dairy-based binder generally without the need to employ gums, humectants, and sugar syrups as a binder to achieve the moist and chewy texture. In one aspect, the bar includes a dry base uniformly blended with a dairy-based binder that uses high levels of dairy proteins as the main binding component. A method of forming the chewy and intermediate moisture bar is also provided that may use a lay or delay period to allow moisture equilibration or migration from the binder to the dry base. | 08-08-2013 |
Patent application number | Description | Published |
20120177568 | NOVEL MEDITOPES AND RELATED MEDITOPE-MONOCLONAL ANTIBODY DELIVERY SYSTEMS, SYNTHESIS AND THERAPEUTIC USES THEREOF - Meditope variants and methods for their use are provided herein. A meditope variant as described herein comprises a peptide having a sequence CQFDLSTRRLKC (SEQ ID NO:1) or CQYNLSSRALKC (SEQ ID NO:2) that has one or more modifications at of least one amino acid residue of the sequence. Multivalent meditope variant tethering entities are also provided. Such entities may include two or more meditopes coupled via a long linker, multivalent scaffold, biotin-streptavidin, or IgG Fc domain. Further, methods of treating, imaging or diagnosing a disease or condition are provided. Such methods may include administering a therapeutically effective amount of a pharmaceutical composition to a subject, the pharmaceutical compound comprising an antibody-meditope complex; a multivalent tethering agent in combination with a monoclonal antibody or functional fragment thereof; or a combination thereof. | 07-12-2012 |
20120301400 | MEDITOPES AND MEDITOPE-BINDING ANTIBODIES AND USES THEREOF - Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses. | 11-29-2012 |
20120302815 | MULTI-VALENT POLY-UBL CHAIN INHIBITORS AND METHODS OF USE - A composition used to develop a reagent for investigating Ubl-modifications in cellular functions and in the treatment of cancer is provided. The composition comprises gold nanoparticle (AuNP)-ligand conjugates that include at least two components: gold nanoparticles (AuNPs) and modified ubiquitin- or ubiquitin-like interacting motif (UIM or ULIM) mimetics. In one embodiment, the modified ULM mimetic is a modified SUMO interaction motif (SIM) mimetic. According to the embodiments described herein, the compound inhibits ubiquitin- or ubiquitin-like protein (Ubl)-mediated protein-protein interactions and sensitizes cells to ionizing radiation. The modified UIM and ULIM mimetics may be conjugated to the AuNP such that each AuNP is conjugated to a plurality of modified UIM or ULIM mimetics. The modified ULIM mimetics may be conjugated to the AuNP via a thiol group. | 11-29-2012 |
20150030535 | MEDITOPES AND MEDITOPE-BINDING ANTIBODIES AND USES THEREOF - Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses. | 01-29-2015 |
Patent application number | Description | Published |
20080241110 | Targeting of sall4 for the treatment and diagnosis of proliferative disorders associated with myelodysplastic syndrome (MDS) - The present invention discloses nucleic acids, proteins, and antibodies for SALL4 (including isoforms SALL4A, SALL4B, and SALL4C), a zinc finger transcriptional factor. Further, methods are disclosed which demonstrate that constitutive expression of SALL4 increases leukemogenic potential in cells of model animal systems. Moreover, constitutive expression of select isoforms (e.g., SALL4B) in transgenic mice demonstrate that these animals develop myelodysplastic syndrome (MDS)-like signs and symptoms, including subsequent acute myeloid leukemia (AML), which is transplantable. The disclosure also provides methods for identifying and purifying embryonic stem cells, adult stem cells, cancer stem cells, including leukemia stem cells, methods for identifying substances which bind to and/or modulate SALL4, methods for diagnosing MDS in a subject, and methods of treating a subject presenting MDS, AML and other forms of leukemia. | 10-02-2008 |
20080299077 | ISOLATION AND GROWTH OF STEM CELLS FROM HEMANGIOMAS - The present invention describes stem cells and progenitor cells derived from hemangiomas, including testing of angiogenic inhibitors using these cells. The invention as described is useful in providing a process to culture and propagate hemangioma stem cells and generate xenograft models to develop treatments for infantile hemangiomas and other types of vascular lesions. | 12-04-2008 |
20090191171 | Reprogramming of Differentiated Progenitor or Somatic Cells Using Homologous Recombination - The present invention provides methods and compositions for reprogramming somatic cells to a more primitive state, such as induced pluripotent stem cells, using homologous recombination. The induced pluripotent stem cells generated by the methods of the present invention are useful in a variety of therapeutic applications in the treatment and prevention of diseases and disorders. | 07-30-2009 |
20120030780 | TARGETING OF SALL4 FOR THE TREATMENT AND DIAGNOSIS OF PROLIFERATIVE DISORDERS ASSOCIATED WITH MYELODYSPLASTIC SYNDROME (MDS) - The present invention discloses nucleic acids, proteins, and antibodies for SALL4 (including isoforms SALL4A, SALL4B, and SALL4C), a zinc finger transcriptional factor. Further, methods are disclosed which demonstrate that constitutive expression of SALL4 increases leukemogenic potential in cells of model animal systems. Moreover, constitutive expression of select isoforms (e.g., SALL4B) in transgenic mice demonstrate that these animals develop myelodysplastic syndrome (MDS)-like signs and symptoms, including subsequent acute myeloid leukemia (AML), which is transplantable. The disclosure also provides methods for identifying and purifying embryonic stem cells, adult stem cells, cancer stem cells, including leukemia stem cells, methods for identifying substances which bind to and/or modulate SALL4, methods for diagnosing MDS in a subject, and methods of treating a subject presenting MDS. | 02-02-2012 |
20120117672 | ISOLATION AND GROWTH OF STEM CELLS FROM HEMANGIOMAS - The present invention describes stem cells and progenitor cells derived from hemangiomas, including testing of angiogenic inhibitors using these cells. The invention as described is useful in providing a process to culture and propagate hemangioma stem cells and generate xenograft models to develop treatments for infantile hemangiomas and other types of vascular lesions. | 05-10-2012 |