Bayly, CA
Christopher Bayly, Quebec CA
Patent application number | Description | Published |
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20090253672 | Cathepsin Cysteine Protease Inhibitors - This invention relates to a novel class of compounds, represented by the formula (I) below, wherein the meanings of R1, R2, R3, R4, R5, R6, R7, X and Y are indicated therein, which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsms K L, S and B These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis, osteoarthritis and rheumatoid arthritis | 10-08-2009 |
Christopher Bayly, Beaconsfield CA
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20090148850 | Methods for identifying modulators of P2RY14 - Methods for identifying modulators of P2RY14 are described. The methods are particularly useful for identifying agents that are useful for treating metabolic syndrome. | 06-11-2009 |
20090176859 | Cathepsin cysteine protease inhibitors - The present invention relates to a novel class of compounds mainly, leucinamide-amino-carboxylate derivatives of formula (I) wherein Y is CR | 07-09-2009 |
20090176861 | Cathepsin cysteine protease inhibitors - The present invention relates to a novel class of compounds mainly, substituted leucinamide-carboxylate derivatives of formula (I) wherein X is O or NR | 07-09-2009 |
20100022477 | FUSED AROMATIC PTP-1B INHIBITORS - The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes. | 01-28-2010 |
20100063013 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS - The present invention relates to novel compounds of the formula (I), wherein R′-R7, X, Y, D and n are as defined in the specification. These compounds are cysteine protease inhibitors which include but are not limited to inhibitors of cathepsms K, L, S and B and are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. | 03-11-2010 |
20120178679 | FUSED AROMATIC PTP-IB INHIBITORS - The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes. | 07-12-2012 |
20130281365 | FUSED AROMATIC PTP-1B INHIBITORS - The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes. | 10-24-2013 |
20150045325 | FUSED AROMATIC PTP-1B INHIBITORS - The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown (Formula I) above and methods of treating or preventing PTP-1B mediated diseases, including diabetes. | 02-12-2015 |
Christopher I. Bayly, Beaconsfield CA
Patent application number | Description | Published |
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20090281103 | Renin Inhibitors - The present invention relates to novel renin inhibitors of the general Formula (I), and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds. These novel renin inhibitors are used in treating cardiovascular events and renal insufficiency. | 11-12-2009 |
20110230446 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS - This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. | 09-22-2011 |
20120046293 | RENIN INHIBITORS - The present invention relates to renin inhibitor compounds having the structure | 02-23-2012 |
20130035312 | CATHEPSIN CYSTEINE PROTEASE INHIBIORS - This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis. | 02-07-2013 |
Reid Bayly, Toronto CA
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20100126929 | MEMBRANE SUPPORTED BIOFILM APPARATUS AND PROCESS - A membrane supported biofilm apparatus has a plurality of hollow fiber gas permeable membranes in a tank containing water to be treated. The membranes have an outside diameter of about 200 microns or less and occupy between 0.5% and 4% of the tank volume. A biofilm supported on the membranes occupies between about 40% and 80% of the volume of water to be treated in a reactor. The membranes may be oriented generally vertically and a spreader may be located near the bottom of the apparatus to disperse the membranes. Wastewater treatment processes are described. A process to dentrify water or treat oxidized contaminants comprises introducing hydrogen into an inner volume of the membranes to grow autotrophic organisms in the biofilm near the membrane and heterotrophic organism near the water. Another process is operated at a biomass concentration of at least 10 g/L and up to about 40 g/L to maintain a biofilm having a surface area of over 1000 square metres per cubic metre of tank volume. A hybrid process has suspended biomass and a membrane supported biofilm. | 05-27-2010 |
20110049047 | GAS SPARGER FOR AN IMMERSED MEMBRANE - A gas sparger produces an intermittent flow of bubbles even if provided with a continuous gas flow. The sparger has a housing to collect a pocket of gas and a conduit to release some of the gas from the pocket when the pocket reaches a sufficient size. Optionally, a cover over an outlet from the conduit may break up or distribute the released gas. A large sparger for use with a commercial membrane module can comprise a plurality of smaller units. | 03-03-2011 |
20130161254 | MEMBRANE SUPPORTED BIOFILM APPARATUS AND PROCESS - A membrane supported biofilm apparatus has a plurality of hollow fiber gas permeable membranes in a tank containing water to be treated. A biofilm supported on the membranes occupies between about 40% and 80% of the volume of water to be treated in a reactor. Wastewater treatment processes are described. A process to denitrify water or treat oxidized contaminants comprises introducing hydrogen into an inner volume of the membranes to grow autotrophic organisms in the biofilm near the membrane and heterotrophic organism near the water. Another process is operated as a biomass concentration of at least 10 g/L and up to about 40 g/L to maintain a biofilm having a surface area of over 1000 square metres per cubic metre of tank volume. A hybrid process has suspended biomass and a membrane supported biofilm. | 06-27-2013 |
20140008280 | MEMBRANE SUPPORTED BIOFILM APPARATUS AND PROCESS - A membrane supported biofilm apparatus has a plurality of hollow fiber gas permeable membranes in a tank containing water to be treated. A biofilm supported on the membranes occupies between about 40% and 80% of the volume of water to be treated in a reactor. Wastewater treatment processes are described. A process to denitrify water or treat oxidized contaminants comprises introducing hydrogen into an inner volume of the membranes to grow autotrophic organisms in the biofilm near the membrane and heterotrophic organism near the water. Another process is operated as a biomass concentration of at least 10 g/L and up to about 40 g/L to maintain a biofilm having a surface area of over 1000 square metres per cubic metre of tank volume. A hybrid process has suspended biomass and a membrane supported biofilm. | 01-09-2014 |
Reid Bayly, Oakville CA
Patent application number | Description | Published |
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20120325742 | Gas Sparger for A Filtering Membrane - A gas sparger for a filtering membrane system produces an intermittent flow of bubbles even if provided with a relatively continuous gas flow. The sparger has a housing to collect a pocket of gas and a conduit to release some of the gas from the pocket when the pocket reaches a sufficient size. Optionally, a cover over an outlet from the conduit may break up or distribute the released gas. A large sparger for can comprise a plurality of smaller units or areas. The supply of gas to the sparger may vary in flow rate over larger periods of time in response to changes in conditions in the membrane system to change the time between consecutive bursts of bubbles. A gas supply pipe may have two or more outlets at different elevations in communication with each of two or more units or areas. The discharge of gas between two or more units or areas may be synchronized. One or more of a set of units or area may receive a supplied gas at a higher flow rate. | 12-27-2012 |
Reid Allyn Bayly, East York CA
Patent application number | Description | Published |
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20120091602 | INTEGRATED GAS SPARGER FOR AN IMMERSED MEMBRANE - A gas sparger produces an intermittent flow of bubbles even if provided with a continuous gas flow. The sparger has a housing to collect a pocket of gas and a conduit to release some of the gas from the pocket when the pocket reaches a sufficient size. The housing is integrated with the potting head of a module. The conduit passes through the potting head. | 04-19-2012 |
20120132579 | MEMBRANE FILTER ASSEMBLY AND PERMEATE CONNECTOR - The permeate collectors of a set of membrane filter elements are connected in line to form a vertical permeate collection pipe serving the set of elements. The connectors between adjacent elements are configured to allow a disconnected element to move perpendicular to the permeate collectors. When an element is disconnected, it may slide horizontally out of the frame. A connector has a spigot that spans between two sockets when connected. In a membrane assembly, each socket is associated with a permeate collector of a membrane filter element. To disconnect the sockets, the spigot is retracted further into one of the sockets until it is spaced apart from the other socket. With the spigot retracted, one membrane element may move relative to the other in a direction perpendicular to the direction of movement of the spigot. | 05-31-2012 |
Timothy K. Bayly, Warman CA
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20140020549 | Firearm Charging Handle - An improved charging handle for a firearm, specifically for automatic and semi-automatic rifles, where the charging handle is provided with operator engagement sides generally parallel to the long axis of the charging handle rod. In certain embodiments, the charging handle includes a latch mechanism comprising a non-pivoting pin for engagement with a detent on a firearm exterior surface and a biasing mechanism biasing the pin toward the elongate member, such that when the charging handle assembly is inserted fully into the firearm the pin engages the detent and is held in engagement by the biasing mechanism. In certain other embodiments the charging handle includes a latch mechanism that is rotationally secured to the handle portion and rotatable between a latched orientation and an unlatched orientation, and a biasing mechanism biasing the latch mechanism in the latched orientation and an interface member actuatable for moving the latch mechanism between the latched orientation and the unlatched orientation, wherein the interface member is at an angle to the elongate member when the latch mechanism is in the latched orientation, and the interface member is generally parallel to the elongate member when the latch mechanism is in the unlatched orientation. | 01-23-2014 |