Patent application number | Description | Published |
20100112690 | INSERT DEVICE FOR MULTIWELL PLATE - An assembly comprises a multiwell test plate having a plurality of wells having an opening and a base surface, an insert plate having a plurality of inserts positioned to align with a corresponding one of the wells whereby the insert plate can be nested with the multiwell plate. Each of the inserts includes a supply port arranged for flow communication with a supply source, an exhaust port, a bottom portion having a plurality of channels extending between the supply port and the exhaust port, and a gas permeable membrane covering the bottom portion. Each of the inserts is sized to position the gas permeable membrane a desired distance from the base surface of the multiwell test plate when the multiwell test plate and the insert plate are coupled to one another. | 05-06-2010 |
20120077246 | Methods and Devices for Capturing Circulating Tumor Cells - A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The flow modification surface induces a rotational flow within the sample as it flows through the microfluidic device. | 03-29-2012 |
20130295551 | MICROFLUIDIC DEVICE AND METHOD FOR MODULATING A GAS ENVIRONMENT OF CELL CULTURES AND TISSUES - A microfluidic device having a perfusion chamber, the perfusion chamber having a base, a bath opening in the base, a supply inlet and an exhaust outlet. The device further includes a gas permeable membrane attached beneath the perfusion chamber, the gas permeable membrane having a first opening in registration with the supply inlet and a second opening in registration with the exhaust outlet. A substrate is attached to the gas permeable membrane, the substrate having at least one microchannel arranged for flow communication with the supply inlet and the exhaust outlet. In addition, a slide is attached to the substrate. As such, gas introduced through the supply inlet is communicated to the microchannel via the first opening, and the gas permeable membrane is positioned to be exposed to the gas to communicate the gas to the bath opening. | 11-07-2013 |
Patent application number | Description | Published |
20080220516 | Multi-well micropatterning by ablation - The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods. | 09-11-2008 |
20100170796 | In Vitro Microfluidic Model of Microcirculatory Diseases, and Methods of Use Thereof - One aspect of the invention relates to a microfluidic device which recreates important features of the human microcirculation on a microscope stage. In certain embodiments of the invention, the clinical scenario associated with ‘sickle cell crisis’ whereby blood vessels are occluded in various organs causing pain and tissue damage can be recreated. In certain embodiments, one can use a device of the invention to study the processes that lead to crisis, and screen therapies (such as small molecules) that might be used to prevent crisis. Further, certain embodiments of the invention allow one to study and screen therapies for a range of human blood disorders, such as hereditary spherocytosis, disorders of white blood cells, such as Waldenstrom's macroglobulinemia or leukocytosis, disorders of blood platelets and coagulation, such as hemophilia A and B, activated protein C resistance, and essential thrombocythemia. | 07-08-2010 |
20150065389 | MULTI-WELL MICROPATTERNING BY ABLATION - The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods. | 03-05-2015 |
Patent application number | Description | Published |
20120158209 | SYSTEM AND METHOD FOR DETERMINING A GROUND SPEED OF A MACHINE - The disclosure describes, in one aspect, a method for determining a machine ground speed. The method includes determining a first speed from a position determining system, determining a direction the machine is traveling at the first speed, determining a machine rate of inclination, and determining a compensated ground speed as a function of the first speed and the machine rate of inclination. | 06-21-2012 |
20130151086 | DETERMING A GROUND SPEED OF A MACHINE - The disclosure describes, in one aspect, a method for determining a machine ground speed. The method includes determining a machine speed from a position determining system, the machine speed includes a horizontal speed component and a vertical speed component, determining a direction the machine is moving at the machine speed, determining a machine inclination angle, determining a machine rate of inclination, and determining a compensated ground speed as a function of the horizontal speed component, the vertical speed component, the direction, the machine inclination angle, and the machine rate of inclination. | 06-13-2013 |
20130158817 | CONTROLLING A BOWL OF A SCRAPER - A method for controlling a bowl of a scraper is disclosed. The method includes receiving a signal from an input device, the signal is indicative of a mode of operation of the scraper, determining a cycle of operation of the scraper associated with the mode of operation, and controlling the bowl based in part on a sequence of parameter settings generated by a control system. The control system is configured to generate the sequence of parameter settings based in part on the cycle of operation of the scraper. | 06-20-2013 |
Patent application number | Description | Published |
20130340076 | CODE REPOSITORY INTRUSION DETECTION - The disclosed subject matter provides for code repository intrusion detection. A code developer profile can be generated based on characteristic features present in code composed by the developer. Characteristic features can be related to the coding propensities peculiar to individual developers and, over sufficient numbers of characteristic features, can be considered pseudo-signatures. A target code set is analyzed in view of one or more developer profiles to generate a validation score related to a likelihood of a particular developer composing a portion of the target code set. This can serve to confirm or refute a claim of authorship, or can serve to identify likely author candidates from a set of developers. Where the target code set authorship is determined to be sufficiently suspect, the code set can be subjected to further scrutiny to thwart intrusion into the code repository. | 12-19-2013 |
20140047275 | FLOW BASED FAULT TESTING - Flow based fault testing is provided. A logical constraint model or a state model (LS model) can be generated based on logic/state characteristics of a system under test (SUT). The LS model can be generated from logical constraint grammar statements. The logical constraint grammar can be parsed as part of a pre-test analysis to seek faults related to the logic or states of the model. The inputs and outputs related to the SUT can be employed to determine faults, including post-test analysis for faults. The disclosed subject matter can capture in an automated or semi-automated manner faults that can be missed in more conventional fuzz testing. Further, flow based fault testing can be employed alone, along with, or in combination with conventional fuzz testing. | 02-13-2014 |
20150026669 | METAPHOR BASED LANGUAGE FUZZING OF COMPUTER CODE - The disclosed subject matter provides for software testing using metaphor based language fuzzing. Metaphor based language fuzzing can decompose a code segment into a metaphor representing the code segment. The metaphor can be mutated based on determined logical perturbations to any element of the metaphor. The mutation of the metaphor can act as a surrogate for mutation of the code segment. The mutated metaphor can be analyzed to reveal performance differences in comparison to the code segment. These performance difference can be correlated to mutation of the metaphor such that a corresponding mutation of the code segment can be correlated by extrapolation. Moreover, mutators can be stored and reused on other metaphors. Furthermore, employing a metaphor as a root language surrogate can facilitate generating a reduced number of mutators as compared to directly mutating code segments in a plurality of computer languages. | 01-22-2015 |
Patent application number | Description | Published |
20130060187 | SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING WITH PULSED LIGHT - A method for controlling activation of Riboflavin applied to an eye includes applying the Riboflavin to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the Riboflavin with pulsed light illumination. The pulsed light illumination has an irradiance, dose, and an on/off duty cycle. The irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for Riboflavin cross-linking activity and to control photochemical efficiency. | 03-07-2013 |
20130245536 | SYSTEMS AND METHODS FOR CORNEAL CROSS-LINKING WITH PULSED LIGHT - A method for controlling activation of a cross-linking agent applied to an eye includes applying the cross-linking agent to a selected region of a cornea of the eye and initiating cross-linking activity in the selected region by activating the cross-linking agent with pulsed light illumination. The pulsed light illumination has a selectable wavelength, irradiance, dose, and on/off duty cycle. The wavelength, the irradiance, the dose, and the on/off duty cycle are adjusted in response to a determination of photochemical kinetic pathways for cross-linking activity and to control photochemical efficiency, depth of cross-linking, and density of cross-linking. | 09-19-2013 |