Patent application number | Description | Published |
20100009363 | RBP4 In Insulin sensitivity/resistance, diabetes, and obesity - Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity. | 01-14-2010 |
20120295950 | RBP4 IN INSULIN SENSITIVITY/RESISTANCE, DIABETES, AND OBESITY - Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity. | 11-22-2012 |
20130243790 | Methods Of Treating Obesity By Inhibiting Nicotinamide N-Methyl Transferase (NNMT) - The present invention, in various embodiments, relates to methods of inhibiting NNMT production or activity in a cell, and methods of treating or preventing obesity or a related metabolic condition in a subject in need thereof, comprising administering a nicotinamide N-methyltransferase (NNMT) antagonist. The invention further provides methods of identifying NNMT antagonists useful for treating obesity and related metabolic disorders. | 09-19-2013 |
20140044737 | RBP4 IN INSULIN SENSITIVITY/RESISTANCE, DIABETES, AND OBESITY - Methods for screening molecules that modulate the activity of Retinol Binding Protein 4 (RBP4) and their use in treatment of insulin resistance are described. Also described are methods of diagnosing insulin resistance and related conditions by detecting modulation of RBP4 activity. | 02-13-2014 |
20150126438 | Novel ChREBP Isoforms and Methods Using the Same - The invention provides diagnostic and prognostic methods and methods of evaluating treatment protocols for disorders such as obesity, diabetes, metabolic syndrome, cancer and vascular disease by detecting the levels of a novel isoform of ChREBP, termed ChREBP β. The invention also provides nucleic acids, proteins, reporter constructs based on ChREBP β and methods of identifying one or more agents that modulate the expression of a ChREBP β target gene. | 05-07-2015 |
20150133551 | Lipids That Increase Insulin Sensitivity And Methods Of Using The Same - The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders—including diabetes-related disorders, Metabolic Syndrome, polycyctic ovarian syndrome, cancer, and inflammatory disorders using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects. | 05-14-2015 |
Patent application number | Description | Published |
20090164259 | METHOD AND SYSTEM FOR BIASING SUGGESTED ROOMS AND/OR RESOURCE SEARCH RESULTS BASED ON USER BEHAVIOR RELATED TO RESCHEDULING AND/OR CANCELLING EXISTING RESERVATIONS - A system for biasing suggested room and/or resource search results based on user behavior related to rescheduling and/or canceling existing resource reservations. The system uses historical data, statistical analysis, and heuristics to generate suggestions as to which users may be willing and/or able to give up their existing resource reservations for a particular time slot. By monitoring which users reschedule and/or cancel existing reservations, and how often they do so, the system is able to provide a user in need of a previously reserved room/resource with a prioritized list indicating which other users with existing resource reservations during the desired time slot are relatively more likely to cancel their reservations, and/or to transfer their reservations to the scheduling user. | 06-25-2009 |
20100250682 | UTILIZING E-MAIL RESPONSE TIME STATISTICS FOR MORE EFFICIENT AND EFFECTIVE USER COMMUNICATION - A method of increasing email correspondence responsiveness may include detecting a first set of email messages transmitted by a first correspondent to a second correspondent, creating a tracking record based on the responsiveness of the second correspondent to each email message of the first set of email messages, performing a first statistical analysis of the tracking record, generating a set of responsiveness metrics based on the first statistical analysis, detecting new outgoing email messages addressed to the second correspondent, and providing a user-configurable email message format for each detected outgoing message, the user-configurable email message format. According to the example embodiment, the user-configurable email message format is configured to increase effective email response time from the second correspondent and the user-configurable email message format is based on the set of responsiveness metrics. | 09-30-2010 |
20110317523 | MERGING CALENDAR ENTRIES - A method, operable on a processing device, for merging calendar entries may include receiving a plurality of calendar entries each associated with entry identification data. The method may also include comparing by the processing device at least a portion of the entry identification data associated with each of the calendar entries. The method may additionally include merging, by the processing device, the calendar entries based at least in part on comparing of at least the portion of the entry identification data associated with each of the at least two calendar entries. The method may further include comparing at least one time attribute associated with each of the calendar entries and comparing at least one textual attribute associated with each of the calendar entries and basing merging the calendar entries additionally on comparing the time attributes and the textual attributes. | 12-29-2011 |
20140344369 | ELECTRONIC MAIL READ RECEIPT PROCESSING - Processing electronic mail includes receiving an electronic mail having a read receipt request and determining, using a processor, that the electronic mail includes a read receipt distribution list. The read receipt distribution list specifies at least one sender-defined user including a subset of at least one recipient of the electronic mail. Using the processor, a read receipt is sent to the sender of the electronic mail and to each user specified on the read receipt distribution list responsive to detecting an opening of the electronic mail by at least one recipient of the electronic mail. | 11-20-2014 |
Patent application number | Description | Published |
20110145206 | ATOMIC DELETION OF DATABASE DATA CATEGORIES - A device maintains, in a database, a plurality of data items, each data item of the plurality of data items being associated with a respective category. The device associates, in the database, a first counter value with each data item, the first counter value indicating a number of times the respective category has been deleted from the database at a time when the data item was stored in the database. The device associates, in the database or another database, a second counter value with the respective category, the second counter value indicating a current value for a number of times the respective category has been deleted from the database. The device selectively deletes, from the database, one or more data items of the plurality of data items from the database based on the first counter values and the second counter value. | 06-16-2011 |
20110145209 | ATOMIC DELETION OF DATABASE DATA CATEGORIES - A device may maintain, in a database, a plurality of data items, each data item of the plurality of data items being associated with a respective category and supplemental information relating to deletion of the data item. The device may associate a group of counters with at least one of the categories and receive a deletion request corresponding to one of the group of categories, the deletion request including the supplemental information. The device may identify a counter associated with the category corresponding to the deletion request based on the supplemental information. The device may then increment the identified counters and selectively delete the data items based on values of the counters. | 06-16-2011 |
20120144471 | UPDATING STORED PASSWORDS - A device may include an authentication server and a server. The authentication server may receive a first form of a password from a client in accordance with an authentication protocol, and authenticate the client based on a comparison of the first form to a value derived from a second form of the password stored in a password database. The comparison fails when the first form is not comparable to a value derived from the second form. The server may establish a secure connection to the client, receive a plain-text password from the client over the secure connection, authenticate the client by comparing a value derived from the plain-text password with a value derived from the second form, and update the password database with a third form of the password that permits the authentication server to successfully authenticate the client when the authentication server receives the first form. | 06-07-2012 |
20120239685 | ATOMIC DELETION OF DATABASE DATA CATEGORIES - A device maintains, in a database, a plurality of data items, each data item of the plurality of data items being associated with a respective category. The device associates, in the database, a first counter value with each data item, the first counter value indicating a number of times the respective category has been deleted from the database at a time when the data item was stored in the database. The device associates, in the database or another database, a second counter value with the respective category, the second counter value indicating a current value for a number of times the respective category has been deleted from the database. The device selectively deletes, from the database, one or more data items of the plurality of data items from the database based on the first counter values and the second counter value. | 09-20-2012 |
20150195273 | UPDATING STORED PASSWORDS - A device may include an authentication server and a server. The authentication server may receive a first form of a password from a client device in accordance with an authentication protocol, and authenticate the client device based on a comparison of the first form to a value derived from a second form of the password stored in a password database, where the comparison fails when the first form is not comparable to a value derived from the second form. The server may establish a secure connection to the client, receive a plain-text password from the client device over the secure connection, authenticate the client device by comparing a value derived from the plain-text password with a value derived from the second form, and update the password database with a third form of the password that permits the authentication server to successfully authenticate the client device when the authentication server receives the first form. | 07-09-2015 |
Patent application number | Description | Published |
20090142335 | Methods of diagnosis and treatment of metabolic disorders - The invention features diagnostic methods for metabolic disorders (e.g., diabetes and obesity), methods for screening for compounds useful in the treatment of metabolic disorders, and methods for treatment of metabolic disorders that involve sirtuin2. | 06-04-2009 |
20090220973 | OBESITY AND BODY FAT DISTRIBUTION - Described are methods for predicting and diagnosing genetically-based obesity and body fat distribution, and for identifying compounds for the treatment and prevention of obesity. | 09-03-2009 |
20100150885 | METHODS AND COMPOSITIONS FOR INDUCING BROWN ADIPOGENESIS - Methods and compositions for treating obesity and related disorders. The methods include the use of stem cells treated with BMP-2, -4, -5, -6 and/or -7. | 06-17-2010 |
20110117049 | Methods and Compositions for Modulating Adipocyte Function - Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7. | 05-19-2011 |
20120135927 | BONE MORPHOGENETIC PROTEINS FOR THE TREATMENT OF INSULIN RESISTANCE - The present disclosure relates to compositions and methods for treating insulin resistance and/or obesity in a cell and/or a subject. | 05-31-2012 |
20120208750 | USE OF PROTEIN KINASE C DELTA (PKCD) INHIBITORS TO TREAT DIABETES, OBESITY, AND HEPATIC STEATOSIS - Described are methods of improving insulin sensitivity, and treating fatty liver disease (including non-alcoholic steatohepatitis (NASH)), by administering specific inhibitors of PKC delta. | 08-16-2012 |
20120251457 | METHODS AND COMPOSITIONS FOR MODULATING ADIPOCYTE FUNCTION - Methods and compositions for treating obesity and related disorders. The methods include the use of BMP-2, -4, -6 and -7. | 10-04-2012 |
20140107026 | BONE MORPHOGENETIC PROTEINS FOR THE TREATMENT OF INSULIN RESISTANCE - The present disclosure relates to compositions and methods for treating insulin resistance and/or obesity in a cell and/or a subject | 04-17-2014 |
20140194353 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NERVOUS DISORDERS ASSOCIATED WITH DIABETES - Compositions and methods for treating neural dysfunction. A exemplary method comprises administering to a subject having a neuropathy, e.g., a cognitive dysfunction or Alzheimer's, a therapeutically effective amount of an insulin or insulin analog, wherein the insulin or insulin analog crosses the BBB and/or a compound that increases SREBP-2 expression or activity in the CNS of the subject. | 07-10-2014 |
20140296325 | METHODS AND COMPOSITIONS FOR INDUCING BROWN ADIPOGENESIS - Methods and compositions for treating obesity and related disorders. The methods include the use of stem cells treated with BMP-2, -4, -5, -6 and/or -7. | 10-02-2014 |
20140364363 | GLYPICAN-4 BASED COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING INSULIN RESISTANCE - Provided herein are methods for increasing insulin sensitivity in a subject. A method may comprise administering to a subject in need of increased insulin sensitivity a therapeutically effective amount of a glypican-4 agent. Also provided herein are methods for determining whether a subject is or is likely to become insulin resistant. A method may comprise determining the level of glypican-4 in a subject, wherein an elevated level of glypican-4 indicates that a subject is or is likely to become insulin resistant. | 12-11-2014 |
20150147292 | NOVEL SURFACE MARKERS FOR ADIPOSE TISSUE - The present invention is based in part on the discovery of brown and white fat cell specific surface markers. It has been found that the small amino acid transporter Slca10/Asc1 is a specific surface marker for white adipocytes and that the ligand-gated ion channel P2X5 and the small amino acid transporter Slc36a2 are specific surface markers for brown adipocytes. Having identified these specific white and brown cell surface markers, the present invention provides compositions and methods suitable for the targeting of any number of agents to a white or brown adipose tissue and the identification and isolation of white or brown adipocytes for any number of uses including therapeutic, screening and diagnostic purposes. | 05-28-2015 |
Patent application number | Description | Published |
20100067972 | GRILL CLEANING UTENSIL - A cleaning utensil is disclosed having a housing comprised of a cleaning portion and a handle portion. The housing has a reservoir and a pump. The reservoir is adapted to contain a fluid. The cleaning portion has a scrubbing surface and an orifice, and the handle portion has an actuator. The pump communicates with the reservoir, the orifice, and the actuator; whereby actuation of the actuator causes the fluid to be drawn from the reservoir and exhausted from the orifice by the pump. The orifice is arranged and adapted to cause the fluid to be exhausted forwardly from the cleaning portion. A bristled scrubbing element is removably affixable to the cleaning portion and has a scrubbing surface extending up first and second opposite side surfaces of the cleaning portion and across a bottom surface of the cleaning portion from the first side to the second side. | 03-18-2010 |
20100294138 | VERSATILE COOKING DEVICE - Disclosed are accessories for use on the cooking grate of a barbeque grill or such, which are adapted to enable the effective grilling of such food items as fish, pizza, small items, and delicate items, alone of in combination, and which overcome drawbacks of grilling such food items while allowing the food items to receive the flavor benefits of grilling. | 11-25-2010 |
20110223296 | SANDWICH COOKING ACCESSORY - Disclosed is a sandwich cooking accessory having a plurality of pockets in which may be assembled a sandwich or into which may be placed a raw (not yet cooked) sandwich. The accessory also includes a panel engagable to the pockets to contain the assembled sandwiches during handling and cooking. The panel cooperates with the pockets to slightly, but not excessively, compress the sandwiches. The pockets and panel are perforated to enable heat to the sandwiches during cooking. The panel include a plurality of shield to protect certain portions of the sandwiches from excessive toasting during cooking. | 09-15-2011 |