Kingsbury, US
Ben Kingsbury, Davis, CA US
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20090025699 | DEVICE FOR THROWING AN OBJECT - A device for throwing an object is provide which includes a body having a first and second end, where the second end is connected to a pivot mechanism; and a swingable arm rotatable between a first position and a second position. The swingable arm has a first end connected to the pivot mechanism and a second end connected to an object holder. The pivot mechanism includes a pivot housing including at least one outwardly extending protrusion to stop rotation; and a base unit rotatably engaged with the pivot housing and capable of rotating the swingable arm relative to the base unit. | 01-29-2009 |
Brent A. Kingsbury, Beaverton, OR US
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20100114849 | Allocating Priorities to Prevent Deadlocks in a Storage System - One embodiment is a server in a cluster storage system. The server includes a Global Lock Manager (GLM) that receives requests for lock priorities for transactions from local lock manager (LLMs) in the cluster storage system. The GLM prevents deadlocks in the cluster storage system by issuing groups of priorities for transactions to the LLMs. | 05-06-2010 |
Brian Kingsbury, Cortlandt Manor, NY US
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20140032570 | Discriminative Learning Via Hierarchical Transformations - Techniques for discriminative learning via hierarchical transformations. A method includes obtaining a model of a first set of data, two or more data transformations, and a second set of data, evaluating the two or more data transformations to determine which data transformation will most effectively modify the second set of data to match the model, and selecting the data transformation that will most effectively modify the second set of data to match the model based on the evaluation. | 01-30-2014 |
20140032571 | Discriminative Learning Via Hierarchical Transformations - A system and an article of manufacture for discriminative learning via hierarchical transformations, which includes obtaining a model of a first set of data, two or more data transformations, and a second set of data, evaluating the two or more data transformations to determine which data transformation will most effectively modify the second set of data to match the model, and selecting the data transformation that will most effectively modify the second set of data to match the model based on the evaluation. | 01-30-2014 |
Brian Kingsbury, Davenport, IA US
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20110082710 | ELECTRONIC MEDICAL RECORD CREATION AND RETRIEVAL SYSTEM - An electronic medical record system enables organic growth of medical conditions or choices linked to predefined human body systems or an anatomical image. These choices are used as blue print launchers that form sentences/paragraphs as a user interacts with the choice lists. The choice lists can include a set of control variables that can be selected to create a medical history of a patient in the form of one or more visit notes. The medical history of the patient is formed by user selection of some of the control variables for insertion into fillable data entry locations in the sentences/paragraphs. The sentences/paragraphs are in the form of blue prints which are available generically to be populated with patient specific information to form customized blue prints for a particular patient. Multiple data perspectives in the electronic medical record system allows relatively easy and simultaneous collection of the complex medical data to produce medical visit notes or letters during a patient office visit. | 04-07-2011 |
Brian Kingsbury, Burlington, MA US
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20140164299 | HYBRID PRE-TRAINING OF DEEP BELIEF NETWORKS - Pretraining for a DBN initializes weights of the DBN (Deep Belief Network) using a hybrid pre-training methodology. Hybrid pre-training employs generative component that allows the hybrid PT method to have better performance in WER (Word Error Rate) compared to the discriminative PT method. Hybrid pre-training learns weights which are more closely linked to the final objective function, allowing for a much larger batch size compared to generative PT, which allows for improvements in speed; and a larger batch size allows for parallelization of the gradient computation, speeding up training further. | 06-12-2014 |
Brian D. Kingsbury, Watauga, TX US
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20090269019 | Connector Housing for a Communication Network - A connector housing for use with a communication network and management system thereof includes a housing having a plurality of berths each configured to receive an optical connector adapter unit. A housing electrical connector is associated with each berth and faces the front of the housing to engage an adapter unit electrical connector as the adapter unit is inserted into the berth. Guide elements guide and align the housing electrical connectors with the adapter unit connectors as the adapter units are inserted into the berth to allow blind mating of the housing electrical connectors and the adapter unit connectors. Electrical contacts from at least two housing electrical connectors are consolidated into a cable connector positioned adjacent the back of the housing. | 10-29-2009 |
20110097050 | Mounting Platforms for Integrally Supporting an Optical Splice Tray(s) and/or an Optical Splitter(s) in a Multi-Port Optical Connection Terminal and Related Methods - Multi-port optical connection terminals and mounting platforms and related methods designed to secure optical components inside an enclosure of the multi-port optical connection terminals are disclosed. In one embodiment, a multi-port optical connection terminal includes an enclosure comprising a base and a cover configured to attach to the base to define an interior cavity. A mounting platform defining a mounting surface for mounting at least one optical component comprised from the group consisting of at least one splice tray and at least one optical splitter to the at least one mounting surface is provided. A plurality of mounting tabs of the mounting platform are configured to extend into channels disposed in an interior wall of the base. In this manner, the mounting platform and any optical components secured thereto are secured inside the interior cavity, which may prevent damage to optical fibers and/or splices of the optical components. | 04-28-2011 |
20110268405 | STACKABLE SHELVES FOR A FIBER OPTIC HOUSING, AND RELATED COMPONENTS AND METHODS - Stackable shelves for a fiber optic housing and related components and methods are disclosed. In one embodiment, a stackable shelf for a fiber optic housing is provided. The stackable shelf comprises a mounting surface and one or more stacker assemblies stacked above the mounting surface, each configured to support fiber optic equipment in one or more height spaces. The one or more stacker assemblies are further configured to support one or more additional removable stacker assemblies each configured to support fiber optic equipment at one or more additional height spaces. In another embodiment, a removable stacker assembly configured to support fiber optic equipment in a stackable shelf is provided. Related methods are also disclosed. | 11-03-2011 |
20110268410 | REMOVABLE FIBER MANAGEMENT SECTIONS FOR FIBER OPTIC HOUSINGS, AND RELATED COMPONENTS AND METHODS - Removable fiber management sections for fiber optic housings, and related components and methods are disclosed. In one embodiment, a fiber optic system is provided. The fiber optic system comprises a fiber optic housing defining at least one interior chamber configured to support fiber optic equipment. The fiber optic system also comprises a removable front section connected to the fiber optic housing and defining at least one front section interior chamber coupled to the at least one interior chamber of the fiber optic housing. The removable front section is configured to support at least one fiber management device to manage one or more fibers connected to fiber optic equipment disposed in the enclosure. In another embodiment, a method of managing optical fiber in a fiber optic system is provided. | 11-03-2011 |
20110268411 | FIBER OPTIC HOUSINGS CONFIGURED FOR TOOL-LESS ASSEMBLY, AND RELATED COMPONENTS AND METHODS - Fiber optic housings configured for tool-less assembly, and related components and methods are disclosed. A fiber optic housing is provided having a top, a bottom, a right side, and a left side which removably attach to each other tool-lessly, and by other than external fastening means, thereby defining at least one interior chamber configured to support fiber optic equipment. The top, bottom, right side, and left side may be removably attached to each other by using a snap attachment integral to at least one of the bottom, the right side, and the left side. One or more mounting brackets and/or strain relief brackets may be attached to the fiber optic housing by other than external fastening means, which may be done by using a quick snap attachment integral to at least one of the sides of the fiber optic housing and the mounting brackets and/or strain relief brackets. | 11-03-2011 |
20110268413 | Rotatable Routing Guide and Assembly - A rotatable routing guide assembly for fiber optic cables routed in a fiber optic equipment shelf is disclosed. The assembly comprises a guide portion, an attachment feature and a keyed receiver. The guide portion has a bottom, a top, a deformable first wall, a deformable second wall and a third wall forming a plurality of segments, and is configured to receive fiber optic cables of different sizes by different ones of the plurality of segments. The attachment feature removably attaches the guide portion to the shelf. The attachment feature has a first tab forming a first notch with the guide portion, and a second tab forming a second notch with the guide portion. The keyed receiver is located in the shelf and has a lip extending partially around an interior edge. The lip is received in at least one of the first notch and the second notch and friction fit between at least one of the first tab and the second tab and the guide portion. | 11-03-2011 |
Brian Duane Kingsbury, Watauga, TX US
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20130004122 | MULTI-PORT OPTICAL CONNECTION TERMINAL ASSEMBLIES SUPPORTING OPTICAL SIGNAL SPLITTING, AND RELATED TERMINALS AND METHODS - Multi-port optical connection terminal assemblies, related terminals and methods are disclosed herein. In one embodiment, a multi-port optical connection terminal assembly may include an enclosure including an internal cavity, an input orifice, and optical connection nodes. The multi-port optical connection terminal assembly may also include an optical splitter comprising a body, an input optical fiber, and output optical fibers. At least a portion of the body of the optical splitter may be disposed outside the internal cavity of the enclosure. The input optical fiber of the optical splitter may be disposed outside the internal cavity of the enclosure, and the plurality of the output optical fibers of the optical splitter may be disposed inside the internal cavity. In this manner, the enclosure of the multi-port optical connection terminal assembly is not required to be sized to completely contain the optical splitter. | 01-03-2013 |
20130266282 | FIBER BODY HOLDER AND STRAIN RELIEF DEVICE - A fiber optic apparatus including a retainer assembly having at least one retainer configured to toollessly, releasably retain a fiber body and or one or more optical fibers is disclosed. An attachment feature may toollessly, removably attach the retainer assembly to a mounting surface. The at least one retainer is configured to releasably retain the fiber body via mounting bosses on the fiber body. A stacking feature may be configured to removably attach a second retainer assembly to the retainer assembly. The at least one retainer may be configured to releasably retain the one or more optical fibers to strain relief the one of more optical fibers. The mounting surface may be fiber optic equipment. The fiber optic equipment may be a shelf mounted to a chassis in a fiber optic equipment rack. | 10-10-2013 |
Brian E.d. Kingsbury, Cortlandt Manor, NY US
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20140019388 | SYSTEM AND METHOD FOR LOW-RANK MATRIX FACTORIZATION FOR DEEP BELIEF NETWORK TRAINING WITH HIGH-DIMENSIONAL OUTPUT TARGETS - Systems and methods for reducing a number of training parameters in a deep belief network (DBN) are provided. A method for reducing a number of training parameters in a deep belief network (DBN) comprises determining a network architecture including a plurality of layers, using matrix factorization to represent a weight matrix of a final layer of the plurality of layers as a plurality of matrices, and training the DBN having the plurality of matrices. | 01-16-2014 |
20150161987 | SYSTEMS AND METHODS FOR ACCELERATING HESSIAN-FREE OPTIMIZATION FOR DEEP NEURAL NETWORKS BY IMPLICIT PRECONDITIONING AND SAMPLING - A method for training a deep neural network, comprises receiving and formatting speech data for the training, preconditioning a system of equations to be used for analyzing the speech data in connection with the training by using a non-fixed point quasi-Newton preconditioning scheme, and employing flexible Krylov subspace solvers in response to variations in the preconditioning scheme for different iterations of the training. | 06-11-2015 |
20150161995 | LEARNING FRONT-END SPEECH RECOGNITION PARAMETERS WITHIN NEURAL NETWORK TRAINING - Techniques for learning front-end speech recognition parameters as part of training a neural network classifier include obtaining an input speech signal, and applying front-end speech recognition parameters to extract features from the input speech signal. The extracted features may be fed through a neural network to obtain an output classification for the input speech signal, and an error measure may be computed for the output classification through comparison of the output classification with a known target classification. Back propagation may be applied to adjust one or more of the front-end parameters as one or more layers of the neural network, based on the error measure. | 06-11-2015 |
20150279358 | METHOD AND SYSTEM FOR EFFICIENT SPOKEN TERM DETECTION USING CONFUSION NETWORKS - Systems and methods for spoken term detection are provided. A method for spoken term detection, comprises receiving phone level out-of-vocabulary (OOV) keyword queries, converting the phone level OOV keyword queries to words, generating a confusion network (CN) based keyword searching (KWS) index, and using the CN based KWS index for both in-vocabulary (IV) keyword queries and the OOV keyword queries. | 10-01-2015 |
20150317990 | DEEP SCATTERING SPECTRUM IN ACOUSTIC MODELING FOR SPEECH RECOGNITION - Deep scattering spectral features are extracted from an acoustic input signal to generate a deep scattering spectral feature representation of the acoustic input signal. The deep scattering spectral feature representation is input to a speech recognition engine. The acoustic input signal is decoded based on at least a portion of the deep scattering spectral feature representation input to a speech recognition engine. | 11-05-2015 |
20160005398 | METHOD AND SYSTEM FOR EFFICIENT SPOKEN TERM DETECTION USING CONFUSION NETWORKS - Systems and methods for spoken term detection are provided. A method for spoken term detection, comprises receiving phone level out-of-vocabulary (OOV) keyword queries, converting the phone level OOV keyword queries to words, generating a confusion network (CN) based keyword searching (KWS) index, and using the CN based KWS index for both in-vocabulary (IV) keyword queries and the OOV keyword queries. | 01-07-2016 |
Brian E. D. Kingsbury, Yorktown Heights, NY US
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20150032449 | Method and Apparatus for Using Convolutional Neural Networks in Speech Recognition - Speech recognition techniques are employed in a variety of applications and services serving large numbers of users. As such, there is an increasing demand for speech recognition systems with enhanced performance. Specifically, enhanced performance in large vocabulary continuous speech recognition (LVCSR) systems is a market demand. Herein, convolutional neural networks are explored as an alternative speech recognition approach and different CNN architectures are tested. According to at least one example embodiment, a method and corresponding apparatus for performing speech recognition comprise employing a CNN with at least two convolutional layers and at least two fully-connected layers in speech recognition. Using the CNN a textual representation of input audio data may be provided based on output data by the CNN. | 01-29-2015 |
Brian E. D. Kingsbury, Cortlandt Manor, NY US
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20140067738 | Training Deep Neural Network Acoustic Models Using Distributed Hessian-Free Optimization - A method for training a neural network includes receiving labeled training data at a master node, generating, by the master node, partitioned training data from the labeled training data and a held-out set of the labeled training data, determining a plurality of gradients for the partitioned training data, wherein the determination of the gradients is distributed across a plurality of worker nodes, determining a plurality of curvature matrix-vector products over the plurality of samples of the partitioned training data, wherein the determination of the plurality of curvature matrix-vector products is distributed across the plurality of worker nodes, and determining, by the master node, a second-order optimization of the plurality of gradients and the plurality of curvature matrix-vector products, producing a trained neural network configured to perform a structured classification task using a sequence-discriminative criterion. | 03-06-2014 |
20140278390 | CLASSIFIER-BASED SYSTEM COMBINATION FOR SPOKEN TERM DETECTION - Systems and methods for processing a query include determining a plurality of sets of match candidates for a query using a processor, each of the plurality of sets of match candidates being independently determined from a plurality of diverse word lattice generation components of different type. The plurality of sets of match candidates is merged by generating a first score for each match candidate to provide a merged set of match candidates. A second score is computed for each match candidate of the merged set based upon features of that match candidate. The first score and the second score are combined to provide a final set of match candidates as matches to the query. | 09-18-2014 |
Brian Edward Doorenbos Kingsbury, Cortlandt Manor, NY US
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20090248394 | MACHINE TRANSLATION IN CONTINUOUS SPACE - A system and method for training a statistical machine translation model and decoding or translating using the same is disclosed. A source word versus target word co-occurrence matrix is created to define word pairs. Dimensionality of the matrix may be reduced. Word pairs are mapped as vectors into continuous space where the word pairs are vectors of continuous real numbers and not discrete entities in the continuous space. A machine translation parametric model is trained using an acoustic model training method based on word pair vectors in the continuous space. | 10-01-2009 |
Celia Kingsbury, Cream Ridge, NJ US
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20080214580 | 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION - The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II: | 09-04-2008 |
20080287468 | PURINE AND IMIDAZOPYRIDINE DERIVATIVES FOR IMMUNOSUPPRESSION - The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas: | 11-20-2008 |
20090069289 | 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION - The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II: | 03-12-2009 |
20110046131 | PURINES AS PKC-THETA INHIBITORS - A chemical genus of purines, which are useful as PKCθ inhibitors, is disclosed. The genus is represented by the formula (I); A representative example is: (II) | 02-24-2011 |
20110218189 | PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS - The present invention relates to a pyrrolo[2,3-d]pyrimidin-2-yl-amine derivative according to formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising one or more of said pyrrolo[2,3-d]pyrimidine-2-ylamine derivatives and to their use in therapy, for instance in the treatment of PKCθ mediated disorders. | 09-08-2011 |
Christina H. Kingsbury, Hendersonville, TN US
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20130239612 | MODULAR DECORATIVE LOCKET - A locket is provided including a cap and a base. The cap includes a cylindrical wall portion; a top portion combining with the cylindrical portion to define an internal cap aperture, the internal aperture having internal threads defined therein; and a decorative element protruding from the top portion in a direction opposite of the cylindrical wall portion. The base includes a bottom and a cylindrical wall, the cylindrical wall defining an internal base aperture. The base further including outwardly protruding threads operable to selectively engage threads of the cap such that rotational motion of the cap or base causes engagement and disengagement of the cap and the base. The base further including a track including upper and lower annular elements, the track sized and shaped to receive at least a portion of a coupler therein. | 09-19-2013 |
Christina Heatherly Kingsbury, Hendersonville, TN US
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20110185542 | Device and Method for Adjusting Fabric - An apparatus used in adjusting a garment or a piece of fabric and a method for implementing the same. The apparatus includes a bottom piece of fabric attached to a top piece of fabric and a piece of elastic sized to fit between the top and bottom pieces of fabric. The top piece of fabric includes two openings, one toward each end, through which the elastic piece fits. The elastic piece includes a plurality apertures sized to be able to receive buttons, which buttons are attached to the top and bottom pieces of fabric and buttoned through a corresponding aperture in the elastic piece. | 08-04-2011 |
Colin William Kingsbury, Boston, MA US
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20160092822 | METHODS AND SYSTEMS FOR APPLYING A CONTINUOUS IMPROVEMENT PROCESS TO TALENT - A computer-implemented method includes assessing each of a plurality of workers, using an assessment test evaluating a plurality of performance characteristics. The method includes correlating each assessment with actual performance by each of the plurality of workers. The method includes identifying at least one highly-correlated leading indicator of performance. The method includes modifying a hiring process to incorporate the identified at least one highly-correlated leading indicator of performance. The method includes providing to a candidate for hire, an assessment test including at least one question aimed at determining whether the candidate for hire possesses the identified at least one highly-correlated leading indicator of performance. The method includes evaluating whether the candidate for hire demonstrates the identified at least one highly-correlated leading indicator of performance. The method includes determining whether to hire the candidate based on the evaluation. | 03-31-2016 |
Gillian Kingsbury, Roslindale, MA US
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20080213778 | Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses - The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 09-04-2008 |
20110065124 | Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses - The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 03-17-2011 |
Gillian Kingsbury, Wayland, MA US
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20120270219 | NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES - The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 10-25-2012 |
20140072968 | Novel Genes Encoding Proteins Having Prognostic, Diagnostic, Preventive, Therapeutic, and Other Uses - The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. | 03-13-2014 |
Gillian A. Kingsbury, Wayland, MA US
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20090304703 | Compositions and methods for the diagnosis and treatment of immune disorders - The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders. | 12-10-2009 |
20100076178 | Dual Variable Domain Immumoglobulins and Uses Thereof - The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease. | 03-25-2010 |
20100260668 | Dual Variable Domain Immunoglobulins and Uses Thereof - The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease. | 10-14-2010 |
20110263827 | Dual Variable Domain Immunnoglobulins and Uses Thereof - The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease. | 10-27-2011 |
20120148573 | COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF IMMUNE DISORDERS - The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. In particular, the invention describes a gene known in the art, alternatively, as ST2, T1 and Fit-1, and referred to herein as the 103 gene. The 103 gene is disclosed herein to be differentially expressed in TH2 cells and not in TH1 cells. Further, the 103 gene product is demonstrated herein to be an important modulator of TH2 and TH2-like immune response both in vitro and in vivo. Thus, the 103 gene, its gene products and antibodies that specifically bind thereto can be used diagnostically or as targets for therapeutic intervention in the treatment of a variety of immune disorders. | 06-14-2012 |
20150017168 | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF - The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease. | 01-15-2015 |
20150104452 | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF - The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease. | 04-16-2015 |
Gillian Ann Kingsbury, Wayland, MA US
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20110223176 | BASIGIN BINDING PROTEINS - Isolated binding proteins, e.g., antibodies, which bind to Basigin (BSG), e.g., human BSG2, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies. | 09-15-2011 |
Jason Kingsbury, Brookline, MA US
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20100292486 | RECYCLABLE METATHESIS CATALYSTS - Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are disclosed, including a Ru complex bearing a 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene and styrenyl ether ligand. The heterocyclic ligand significantly enhances the catalytic activity, and the styrenyl ether allows for the easy recovery of the Ru complex. Derivatized catalysts capable of being immobilized on substrate surfaces are also disclosed. The present catalysts can be used to catalyze ring-closing metathesis (RCM), ring-opening (ROM) and cross metatheses (CM) reactions, and promote the efficient formation of various trisubstituted olefins at ambient temperature in high yield. | 11-18-2010 |
Jim Kingsbury, San Francisco, CA US
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20150106232 | DURATION AND ACCESS BASED SELLING OF PRODUCTS - Disclosed are methods, systems, paradigms and structures for duration and access based selling of products. Hypervertical is a concept of offering products for sale through specific channels for specific time periods. An online selling entity creates an online sales event offering products for sale. The online sales event is valid for a predefined duration. While the online sales event is active, access to the products are provided exclusively through the online sales event. However, upon expiry of the online sales event, which causes the online sales event to be deleted and access to the products be revoked, the access to the products is provided through third-party applications, such as search results of a search engine, social networking sites, other third-party websites. The third-party applications present the products as, for example, advertisements, accessing which the user can navigate to the online selling entity to view or purchase the products. | 04-16-2015 |
Jonathan Kingsbury, Apple Valley, MN US
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20160045943 | CIP WASH COMPARISON AND SIMULATION - One embodiment includes a method for simulating an operational effect of one or more changes in a CIP process. The method includes providing a graphical user interface configured to receive inputs from a user, receiving at least one proposed adjustment to one CIP phase of the CIP process, and generating a simulated CIP process based on a first set of CIP data and the at least one proposed adjustment to generate simulated CIP data based on the simulated CIP process. The simulated CIP data is displayed on the display. The simulated CIP data includes at least one of the amount or the total cost of each consumable used to generate the simulated CIP data. A total cost of the simulated CIP process is calculated, where the total cost of the simulated CIP process incorporates the proposed adjustment. | 02-18-2016 |
20160048779 | CIP WASH SUMMARY AND LIBRARY - One embodiment includes a method for monitoring a CIP process previously performed. The method includes accessing CIP process data stored in a CIP library. The CIP process data includes CIP phase data associated with a plurality of CIP phases in the CIP process previously performed, equipment data associated with objects used in the CIP process during one or more of the CIP phases, and consumable data associated with consumables consumed by corresponding equipment in the CIP process. In addition, the method includes displaying at least a portion of the CIP process data, and providing a graphical user interface. The graphical user interface is configured to: organize the CIP process data into at least one of (i) a plurality of CIP phases or (ii) consumable data, and sort equipment data according to one or more of the plurality of corresponding CIP phases or corresponding consumables. | 02-18-2016 |
Kevin M. Kingsbury, Bastrop, TX US
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20140173229 | Method and Apparatus for Automated Migration of Data Among Storage Centers - A method for controlling the storage of data among multiple regional storage centers coupled through a network in a global storage system is provided. The method includes steps of: defining at least one dataset comprising at least a subset of the data stored in the global storage system; defining at least one ruleset for determining where to store the dataset; obtaining information regarding a demand for the dataset through one or more data requesting entities operating in the global storage system; and determining, as a function of the ruleset, information regarding a location for storing the dataset among regional storage centers having available resources that reduces the total distance traversed by the dataset in serving at least a given one of the data requesting entities and/or reduces the latency of delivery of the dataset to the given one of the data requesting entities. | 06-19-2014 |
20140173232 | Method and Apparatus for Automated Migration of Data Among Storage Centers - A method for controlling the storage of data among multiple regional storage centers coupled through a network in a global storage system is provided. The method includes steps of: defining at least one dataset comprising at least a subset of the data stored in the global storage system; defining at least one ruleset for determining where to store the dataset; obtaining information regarding a demand for the dataset through one or more data requesting entities operating in the global storage system; and determining, as a function of the ruleset, information regarding a location for storing the dataset among regional storage centers having available resources that reduces the total distance traversed by the dataset in serving at least a given one of the data requesting entities and/or reduces the latency of delivery of the dataset to the given one of the data requesting entities. | 06-19-2014 |
Klint M. Kingsbury, Austin, TX US
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20090139100 | Multi-spot adjustable reflex bow sight - A bow sight that utilizes fiber optic wave guides as a basis for collecting ambient light and providing multiple sighting spots within the archer's field of view. The terminal ends of the fiber optic wave guides are positioned so as to have images thereof reflected on a moveable reflective plane (objective optic) within the bow sight. The multiple aiming spots thus reflected in the bow sight provide the archer with sighting spots for targets over a range of distances. Each of the individual fiber optic wave guides collects ambient light and terminates in a terminal block that may be varied in its position so as to individually adjust the reflected image of the aiming spot. Various mechanisms within the fiber optic terminal block for adjusting the position of the ambient light wave guide are also described. The bow sight provides the advantages of multispot ambient light fiber optic systems with the advantages of reflective (reflex) sighting systems. | 06-04-2009 |
20100064535 | Multi-Spot Adjustable Reflex Bow and Subsonic Weapon Sight - A bow sight that utilizes fiber optic wave guides as a basis for collecting ambient light and providing multiple sighting spots within the archer's field of view. The terminal ends of the fiber optic wave guides are positioned so as to have images thereof reflected on a moveable reflective plane (objective optic) within the bow sight. The multiple aiming spots thus reflected in the bow sight provide the archer with sighting spots for targets over a range of distances. A fixed angular reference indicator facilitates side to side (rotational) alignment. Each of the individual fiber optic wave guides collects ambient light and terminates in a terminal block that may be varied in its position so as to individually adjust the reflected image of the aiming spot. Various mechanisms within the fiber optic terminal block for adjusting the position of the ambient light wave guide are also described. The bow sight provides the advantages of multispot ambient light fiber optic systems with the advantages of reflective (reflex) sighting systems. | 03-18-2010 |
20110168151 | Bow Stabilizer with Integrated Adjustable Accessory Mounting Rails - A bow stabilizer/vibration dampener incorporating one or more attachment rails for mounting a variety of accessories to the stabilizer for use in conjunction with the bow or other target sighting device. The rails are adjustable side to side at their ends and are preferably of the picatinny or weaver rail configuration. Anywhere from one to four (or more) accessory rails may be positioned symmetrically or asymmetrically on the stabilizer. In addition, the invention anticipates application of the adjustable rail structures positioned in other locations on the bow. | 07-14-2011 |
20110204113 | Ball and Socket Belt Clip Bow Holder - A system for allowing an archer to temporarily position, place, and carry a bow when the bow is not specifically being drawn on a target. The system comprises two parts, a first part fixed on the bow and a second part positioned on the archer, typically in association with an article of clothing on the archer. The first part is a ball shaped component fixed to the bow. The user then wears a socket type clip, where the socket is sized to accommodate the ball by simply dropping the ball in for a quick attach and detach. A slot in the socket allows quick drop in ability, but is sized to secure to the bow as it swings in the socket during normal walking, hunting, climbing, or other shooting activities. The socket clip is preferably attached to the user's belt but may alternately be attached to the user's clothing, vehicle, or other stationary object for secure and tactical bow retention. | 08-25-2011 |
20140160475 | Light Gathering Adjustable Ballistic Reticule - A weapon sighting system for gathering ambient or generated light and projecting a fixed or adjustable ballistic reticule image for targeting. The system includes a partially reflective, zero parallax, optical lens assembly, an illuminating reticule projection component, and an adjustable bracket fixed to the weapon being sighted. The bracket supports the lens assembly at one end and the projection component at an opposing end. The projection component is aligned to project a light image onto the lens assembly to be reflected back into the target sightline. The projection component gathers ambient (or generated) light through polymer acrylic solid materials and/or fiber optics, and directs the light through a fixed or adjustable mask. The movement of the weapon effects a corresponding movement in the angle of reflection through the optics of the sighting system. An adjustable mask allows the projected image to change to accommodate near and distant targets. | 06-12-2014 |
20140165561 | Supercharger Turbocharger Bypass Back Draft Inlet Damper for Series Operation - A damper system for placement between a supercharger and a turbocharger. The damper is located in a plenum placed within the air path from the supercharger to the turbocharger. If the plenum is under positive pressure from the supercharger, the damper seals shut against the plenum, allowing the supercharger to build positive boost pressure to the turbocharger. The damper is designed to stay closed until the plenum experiences a slightly negative pressure. The damper then opens to expose the turbocharger inlet to atmospheric pressure. This allows the turbocharger to intake the airflow from the smaller supercharger, but also to intake additional airflow from the ambient air at atmospheric pressure. The damper allows an engine to take advantage of the low RPM and low load performance and efficiency of smaller superchargers and the performance and efficiency of larger turbochargers under higher load and higher exhaust mass flow rate. | 06-19-2014 |
20140216433 | BOW STABILIZER WITH INTEGRATED ADJUSTABLE ACCESSORY MOUNTING RAILS - A bow stabilizer incorporating one or more attachment rails for mounting a variety of accessories to the stabilizer for use in conjunction with the bow or other target sighting device. The stabilizer is rotationally adjustable about a center axis attachment post connecting the stabilizer to the bow. In addition to rotating the stabilizer for balance, the rails are individually adjustable side to side at their ends and are preferably of the picatinny or weaver rail configuration. Anywhere from one to four (or more) accessory rails may be positioned symmetrically or asymmetrically on the stabilizer. One or more counterbalance weights may be adjustably positioned on one or more of the rails to offset and balance the weight of attached accessories. | 08-07-2014 |
Klint Mclean Kingsbury, Austin, TX US
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20130092142 | Bilateral Adjustable Quiver with Releasable Bow Attachment - A quiver for holding arrows or bolts. The quiver may be releasably attached to a mounting rail on a bow, belt, or the like. The quiver includes a frame connecting two end structures, each end structure having arrow head pockets, arrow shaft clips, and a connector for attachment to the frame. At a midsection of the frame is a mounting block with an attachment mechanism for releasably securing the quiver to the mounting rail. The preferable mounting rail is of the Picatinny type. A first set of arrows (three in the preferred embodiment) may be positioned with arrow heads in the arrow head pockets of one end structure and arrow shafts in the arrow shaft clips of the second end structure. A second set of arrows is positioned in a similar manner but in the opposite direction between the end structures on the frame. | 04-18-2013 |
20130118019 | Bow Sight with Light Gathering Point Shaped Pins, Illuminated Yardage Indicia, and Individual Pin Micro-Adjustment - A bow sight with light gathering point shaped pins with illuminated yardage indicia. The point shaped pins are individually adjustable with both gross set point adjustments and micro set point adjustments. The sight pins are structured as plates stacked within a pin housing supported by an adjustment bracket connecting to a riser mount secured to the bow stock. The light gathering sight and structures provide brighter illumination while retaining a fine resolution point along with illuminated yardage indicators facing towards the archer. Each of the sight pins is grossly adjustable in a vertical orientation and finely adjustable through separate sets of adjustment bolts. The pin housing surrounds the sight pin tips to form a sight window through which the archer may aim the bow. Structures are provided on the external surface of the surrounding pin housing to support Picatinny Rails for accessory attachments. | 05-16-2013 |
20160003565 | Post Barrel Plenum Operated Gas Cycling System for Automatic Firearms - A gas buffer plenum positioned at the end of the barrel of an automatic firearm. A barrel side end cap connects the system to the barrel. A plenum tube holds one or more chamber walls and retains gas pressure within the enclosure. A target side end cap creates the final pressure chamber enclosure and is attached to the plenum tube to lock the system together. This gas buffer plenum allows a bullet to leave the barrel of the firearm before the bolt of the firearm starts to open. As the gas buffer plenum is filled with the exploding gas behind the bullet, the gas chambers build and maintain pressure that is then forced back through a hole in the plenum. The gas is forced down a gas tube or into a piston system. Depending on the configuration of the firearm, either the gas force, or the piston, strikes the bolt and cycles the firearm. The system may also be used to retrofit a gas operated firearm that uses a traditional gas block design. | 01-07-2016 |
Nathaniel J. Kingsbury, Davis, CA US
Patent application number | Description | Published |
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20120045818 | Plant-Based Production of Heterologous Proteins - Described herein are viral amplicon-based protein expression systems and methods useful for producing heterologous proteins, such as enzymes, by agroinfiltration. The methods involve producing an | 02-23-2012 |
20140106434 | APOPLAST WASH FLUID RECOVERY FOR IMPROVED RECOMBINANT ENDOGLUCANASE PRODUCTION IN TOBACCO LEAVES - The present disclosure relates to methods of increasing the production of an apoplast-targeted recombinant protein in a plant tissue and to methods of increasing the purity of an apoplast-targeted recombinant protein recovered from a plant tissue. | 04-17-2014 |
20150140644 | TREATMENT OF LEAF TISSUE FOR THE RECOVERY OF INTERSTITIAL RECOMBINANT PROTEINS BY THE APPLICATION OF CELL WALL DEGRADING ENZYMES - The present disclosure relates to methods of increasing the purity of an apoplast-targeted recombinant protein recovered from a plant tissue, and increasing the yield of recovery of an apoplast-targeted recombinant protein from a plant tissue. | 05-21-2015 |
Nicholas Scot Kingsbury, Huntington Station, NY US
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20100285283 | FASHION ACCESSORIES MADE FROM TRAFFIC CONE RUBBER - The present invention relates generally to fashion accessories designed and made from traffic cone rubber, more particularly related to Bracelets, Key Chains, Necklace Pendants, Earrings, Rings, Wallet, Belts, Zipper Pulls, Belly Button Piercing, Bookmarks, Bra, Door Hanger, Cell phone/Beeper/Pager Holder, Ipod Case, Cell Phone Charm, Wall Mask, Winter Hat/Beanie Hat, Baseball Cap, Tie, Hoodie, Satchel Bag, Sneaker, Decal Snaps, Money Clip, Magnet, Backpack, Watch Band, Relief Carving, Eyeglass Case, Headband, Coaster, Car Decoration, Ornament, Pet Products, Hair Clip, Change Purse, Purse, Pins/Buttons, Anklet, Lanyard, Nose Piercing, Charms, Button, and Cufflinks. | 11-11-2010 |
Ryan Scott Kingsbury, Durham, NC US
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20140255813 | ENERGY GENERATION AND STORAGE USING ELECTRO-SEPARATION METHODS AND DEVICES - Systems and methods for the storage of energy that can be easily converted to electrical power are disclosed. A concentration battery includes a stack of alternating cation and anion exchange membranes separated from one another by alternating first and second spaces; a first reservoir containing a concentrated ionic solution; a second reservoir containing a dilute ionic solution; multiple spaced first fluid pathways in fluid communication with the first reservoir and configured to flow concentrated ionic solution flows into the first spaces; and multiple spaced second fluid pathways in fluid communication with the second reservoir and configured to flow dilute ionic solution flows into the second spaces. The fluid pathways may be configured to flow the ionic solutions in a common first direction. Electrodes at either end of the device in fluid communication with the concentrated ionic solution permit electrical energy to be applied or extracted. A related method is included. | 09-11-2014 |
Ryan Wallace Kingsbury, Cambridge, MA US
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20160043800 | DESIGN OF A FREE-SPACE OPTICAL COMMUNICATION MODULE FOR SMALL SATELLITES - Communication bottlenecks, particularly in the downlink direction, are a common problem for many CubeSat developers. As described herein, a CubeSat module for a CubeSat comprises an optical transmitter to transmit data to a remote terminal, a receiver to acquire an optical beacon from a remote terminal, and a fine-pointing module operably and directly coupleable to a coarse-pointing module of the CubeSat. The fine-pointing module is configured to point the optical transmitter toward the remote terminal with an accuracy range that overlaps with an accuracy range of the coarse-pointing module of the CubeSat so as to establish a communications link between the CubeSat and the remote terminal over a low-Earth-orbit (LEO) distance. | 02-11-2016 |
Scot Douglas Kingsbury, Huntington Station, NY US
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20160030630 | ANTI-FUNGUS METHODS AND KIT FOR TREATMENT OF FUNGAL NAIL INFECTIONS - The present invention relates generally to methods and related kit to maximize the effectiveness of anti-fungus medicines including Vicks Vapor Rub and to mitigate the spread of infection to other toes or fingers and to other people. The kit consists of part of disposable nitrile glove or the like, anti-fungus medicine such as topical drug, and a tape. Barrier-inverting method and rolling-up method have been disclosed on how to apply the kit to the infected areas. | 02-04-2016 |
William Kingsbury, Wilmington, NC US
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20110319293 | SYNTHETIC PROTEASE SUBSTRATES, ASSAY METHODS USING SUCH SUBSTRATES AND KITS FOR PRACTICING THE ASSAY - Synthetic protease substrates and methods which facilitate the identification of substrates of a protease, particularly ubiquitin, ubiquitin-like, or proteasome protein are provided. | 12-29-2011 |
William D. Kingsbury, Wilmington, NC US
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20120114765 | ANTI-NEOPLASTIC COMPOUNDS, COMPOSITIONS AND METHODS - Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated. | 05-10-2012 |