Patent application number | Description | Published |
20080226741 | Cross-linked Polymer Particles - Biodegradable cross-linked particles, as well as related compositions and methods, are disclosed. | 09-18-2008 |
20080311173 | IMPLANTABLE OR INSERTABLE MEDICAL DEVICES FOR CONTROLLED DELIVERY OF A THERAPEUTIC AGENT - The present invention is directed to novel implantable or insertable medical devices that provide release of a therapeutic agent. According to a first aspect of the present invention, a therapeutic-agent-releasing medical device is provided, which comprises: (a) an implantable or insertable medical device; (b) a release layer disposed over at least a portion of the implantable or insertable medical device, and (c) a therapeutic agent. The release layer regulates the rate of release of the therapeutic agent from the medical device upon implantation or insertion of the device into a patient. The release layer comprises (i) a first polymer comprising one or more polymer chains that form one or more polymer phase domains when the first polymer is in a pure solid-state form; and (ii) a second polymer comprising two or more polymer chains that form two or more phase domains when the second polymer is in a pure solid-state form. The first and second polymers are preferably selected such that at least one polymer chain in the second polymer is compatible with at least one polymer chain in the first polymer. The present invention is also directed to methods of forming the above implantable or insertable medical devices, methods of administering a therapeutic agent to a patient using such devices, and methods of modulating the release of therapeutic agents from implantable or insertable medical devices. | 12-18-2008 |
20090053276 | INJECTABLE HYDROGEL COMPOSITIONS - In accordance with one aspect of the invention, injectable compositions are provided, which contain temperature-sensitive hydrogel particles. The hydrogel particles may be provided in dry form, or they may be provided in hydrated form in an aqueous fluid. The temperature-sensitive hydrogel particles may have an upper critical solution temperature (UCST) below normal body temperature, they may have a lower critical solution temperature (LCST) above normal body temperature, or they may have a LCST that changes from below normal body temperature to above normal body temperature after injection into a subject. | 02-26-2009 |
20090053281 | EMBOLIZATION - Articles and methods that include a particle having a maximum dimension of at most 5,000 microns, and an embolic coil capable of binding to the particle, are disclosed. | 02-26-2009 |
20090053318 | Forming Embolic Particles - Methods of making polymer particles, as well as related particles, compositions, and methods are disclosed. | 02-26-2009 |
20090068279 | MICROSPHERES WITH SURFACE PROJECTIONS - Methods of making polymer particles, as well as related particles, compositions, and methods are disclosed. | 03-12-2009 |
20090092547 | Injectable Particles - According to an aspect of the invention, injectable polymeric particles are provided which contain branched poly(vinyl alcohol). Other aspects of the invention pertain to methods of making such particles. Still other aspects of the invention pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions. | 04-09-2009 |
20090092676 | CROSS-LINKED POLYMER PARTICLES - Cross-linked polymer particles, as well as related compositions and methods, are disclosed. | 04-09-2009 |
20090092677 | MULTI-COMPONENT PARTICLES FOR INJECTION AND PROCESSES FOR FORMING THE SAME - In accordance with one aspect of the invention, novel compositions containing injectable particles are provided in which the injectable particles contain at least two polymeric components that differ in composition from one another (e.g., because at least one polymeric component contains a polymer that is not present in another polymeric component). | 04-09-2009 |
20090117039 | CHARGED BIODEGRADABLE POLYMERS FOR MEDICAL APPLICATIONS - In accordance with one aspect of the invention, implantable medical devices are provided which include polymeric compositions that comprise at least one type of biodegradable ionic polymer. The at least one type of biodegradable ionic polymer comprises a biodegradable polymer core and one or more ionic end groups. | 05-07-2009 |
20090125051 | COMBINATION COIL AND LIQUID EMBOLIC FOR EMBOLIZATION - A system and method for treating a target site (e.g., vascular aneurysm), the system including an occlusive member (e.g., a coil) configured to be positioned within the target site, the occlusive member comprising a first reactant disposed thereon. The system further includes a second reactant that is introduced within the target site in close proximity to the occlusive member (e.g., using a same delivery device used to deliver the occlusive member to the target site), wherein a polymer filling may be formed by reacting the first reactant with the second reactant, the polymer filling helping to anchor the occlusive member within the target site. In one embodiment, the first reactant includes a prepolymer while the second reactant includes an activator. | 05-14-2009 |
20090138076 | MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS - The present invention is generally directed to medical devices, and more specifically to medical devices that are at least partially insertable or implantable into the body of a patient. The medical devices generally comprise (a) a therapeutic agent, more typically, a high-molecular-weight therapeutic agent, and (b) at least one polymeric layer, which typically acts to control the release of the therapeutic agent from the medical device. Also disclosed herein are methods of making such medical devices. | 05-28-2009 |
20090169471 | PARTICLES FOR INJECTION AND PROCESSES FOR FORMING THE SAME - According to an aspect of the invention, injectable particles are provided that include (a) porous polymeric particles that contain at least one type of particle-forming polymer and (b) a pore-filling composition that includes at least one therapeutic agent and at least one pore-filling polymer. The pore-filling composition at least partially fills the pores of the injectable porous polymeric particles. Other aspects of the invention pertain to methods of making such particles. | 07-02-2009 |
20090169627 | PARTICLES FOR INJECTION AND PROCESSES FOR FORMING THE SAME - In accordance with one aspect of the invention, injectable particles are provided which comprise (a) a first group of injectable particles comprising first polymeric particles loaded with a first therapeutic agent and (b) a second group of injectable particles comprising second polymeric particles loaded with a second therapeutic agent. The first and second polymeric particles may be the same or different, and the first and second therapeutic agents may be the same or different. Other aspects of the invention pertain to methods of making such particles, to kits that comprise such particles, and to methods of treatment that employ such injectable particles. | 07-02-2009 |
20090169639 | PARTICLES FOR INJECTION AND PROCESSES FOR FORMING THE SAME - In accordance with one aspect of the invention, injectable particles are provided which comprise (a) a vinyl formal polymer, (b) a glucosamine polymer, and (c) an ionically or covalently bound agent selected from therapeutic agents, cell surface binding agents, and combinations thereof. Other aspects of the invention pertain to methods of making and using such particles. | 07-02-2009 |
20090169641 | COMPRESSIBLE PARTICLES - Disclosed herein are methods that include providing a first particle having pores, the first particle having a first compression test value, and partially cross-linking the first particle to form a second particle having pores, the second particle having a second compression test value that is larger than the first compression test value by 25% or more, where a maximum dimension of the first particle is 5,000 microns or less, and a maximum dimension of the second particle is 5,000 microns or less. | 07-02-2009 |
20120083523 | MEDICAL DEVICES HAVING POLYMERIC REGIONS WITH COPOLYMERS CONTAINING HYDROCARBON AND HETEROATOM-CONTAINING MONOMERIC SPECIES - According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes the following: (a) one or more unsaturated hydrocarbon monomer species and (b) one or more heteroatom-containing monomer species. | 04-05-2012 |
20130224487 | CROSS-LINKED POLYMER PARTICLES - Biodegradable cross-linked particles, as well as related compositions and methods, are disclosed. | 08-29-2013 |