Patent application number | Description | Published |
20080227693 | Cyclic Peptide Isolation by Spray Drying - Methods for isolation of a synthetic cyclic peptide by spray drying, including spray drying at elevated temperatures, products made by the methods, and synthetic cyclic peptides preparations with defined characteristics, including an essentially amorphous acid addition salt of Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH in the form of a fine powder with a particle diameter of about 2 to about 20 microns. | 09-18-2008 |
20130058930 | SUBCUTANEOUS NEEDLE ASSISTED JET INJECTION ADMINISTRATION OF METHOTREXATE - The present application is directed, at least in part, to a method of treating an autoimmune disorder in a subject in need of treatment. In one exemplary embodiment, the method comprises introducing into the subcutaneous tissue of the subject, from a needle assisted jet injection device, a composition comprising methotrexate in a dose ranging from about 5 mg to about 50 mg, wherein the pharmacokinetic profile of said methotrexate, obtained following administration of the methotrexate by the needle assisted jet injection device, is substantially the same as the pharmacokinetic profile of the same dose of methotrexate when administered by an intramuscular injection or a subcutaneous injection. The present invention provides benefits and improvements, including an improved clinical utility, improved therapeutic efficacy, over conventional methods of administering methotrexate. | 03-07-2013 |
20130303985 | NEEDLE ASSISTED JET INJECTION ADMINISTRATION OF TESTOSTERONE COMPOSITIONS - The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device. | 11-14-2013 |
20140107568 | METHOD OF DETERMINING AN INJECTED DOSE BASED ON A KNOWN ORAL DOSE - The present disclosure relates to methods of determining dosages of compositions used in injection devices, in view of known oral doses of the same compositions. | 04-17-2014 |
Patent application number | Description | Published |
20080226693 | Apparatus and Method for Making a Polymeric Structure - The apparatus and method for preparing a polymeric structure from which a number of medical devices may be constructed is described. The structures are preferably formed from bioabsorbable materials using low temperature fabrication processes, whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. The method includes preparing a solution of at least one bioabsorbable polymer and a solvent. The solution is then deposited onto a stage and converted into a structure. The solvent is evaporated from the structure. The dried solution forms a structure that is removed from the stage and further dried before being stored in an inert environment. Thereafter, a medical device such as a stent may be constructed from the structure. | 09-18-2008 |
20090024202 | CEA SYSTEM AND METHOD FOR DELIVERING A SELF-EXPANDING STENT - Self-expanding stent delivery systems and methods having an introducer that receives a delivery catheter. The delivery catheter includes an outer body, an inner body and a stent loaded onto a stent bed within the inner body. The outer body receives the inner body with the stent loaded on the stent bed thereof. The outer body helps constrain the stent in its undeployed state in the stent bed until the stent is deployed by retraction of the outer body of the delivery catheter when the stent is identified as positioned across an intended treatment site. At least one anchoring mechanism provided on the inner body helps maintain the undeployed loaded stent appropriately in the stent bed during deployment. The at least one anchoring mechanism can include radiopaque material to increase fluoroscopic visualization of the stent during deployment, and the self-expanding stent can be a bio-absorbable material including drugs or other bio-active agents incorporated therein or provided thereon. The at least one anchoring mechanism can instead comprise a set of at least two bumpers between which the stent is loaded until deployed by retraction of the outer body of the delivery catheter when the stent has been appropriately positioned across an intended treatment site. After deployment of the stent at the intended treatment site, removal of the inner body and outer body of the delivery catheter and of the introducer occurs. Reliable and accurate emplacement of the stent across an intended treatment site is rendered more likely as a result. | 01-22-2009 |
20090026650 | METHOD OF FORMING A BIOABSORBABLE DRUG DELIVERY DEVICES - A bioabsorbable drug delivery device and various methods of making the same. The devices are preferably formed from bioabsorbable materials using low temperature fabrication processes, whereby drugs or other bio-active agents are incorporated into or onto the device and degradation of the drugs or other agents during processing is minimized. Radiopaque markers may also be incorporated into, or onto, the devices. The devices may be generally tubular helical stents comprised of a solid ladder or an open lattice configuration, or a hybrid combination thereof. The tubular helical stents are generally formed from precursor fibers, films or tubes. The solid ladder configuration provides increased radiopacity and increased radial strength, whereas the open lattice configuration provides better endothelialization and fluid flow through the stent. The drug or other agent delivery capacity of the devices may provide local or regionalized drug or other agent delivery, or a combination thereof, with more consistent concentrations of drugs or other agents delivered from the device to the treatment site along the entire length of the device. | 01-29-2009 |
20090148492 | METHOD OF MAKING A VASCULAR CLOSURE DEVICE - A method of making a biocompatible, implantable medical device, including a vascular closure device is disclosed. The method includes forming a biocompatible polymer into at least one fiber and randomly orienting the at least one fiber into a fibrous structure having at least one interstitial spaces. Polymeric materials may be utilized to fabricate any of these devices. The polymeric materials may include additives such as drugs or other bioactive agents as well as antibacterial agents. In such instances, at least one agent, in therapeutic dosage, is incorporated into at least one of the fibrous structure and the at least one fiber. | 06-11-2009 |
20090171388 | VASCULAR CLOSURE DEVICE - A biocompatible material may be configured into any number of implantable medical devices including a vascular closure device. The vascular closure device includes a fibrous structure formed from at least one randomly oriented fiber, the randomly oriented fiber comprising at least one polymer, and at least one agent, in therapeutic dosage, incorporated into at least one of the fibrous structure and the at least one randomly oriented fiber. | 07-02-2009 |
20090318955 | VASCULAR CLOSURE DEVICE - The present invention provides a porous structure that works very effectively to seal a puncture site with optimum porosity, absorbent capacity and perfect anatomical fit. The plug density and other fiber properties/geometry (total denier; number of filaments; etc) have provided an efficient structure that allows instantaneous absorption of blood during deployment. The final size of the plug with absorbed fluids provides an anatomical fit and seals the puncture site within few minutes after deployment. | 12-24-2009 |
20100280600 | DUAL DRUG STENT - Implantable medical devices may be utilized to locally delivery one or more drugs or therapeutic agents to treat a wide variety of conditions, including the treatment of the biological organism's reaction to the introduction of the implantable medical device. These therapeutic agents may be released under controlled and directional conditions so that the one or more therapeutic agents reach the correct target area, for example, the surrounding tissue and/or the bloodstream. | 11-04-2010 |
20140336700 | VASCULAR CLOSURE DEVICE - A biocompatible material may be configured into any number of implantable medical devices including a vascular closure device. The vascular closure device includes a fibrous structure formed from at least one randomly oriented fiber, the randomly oriented fiber comprising at least one polymer, and at least one agent, in therapeutic dosage, incorporated into at least one of the fibrous structure and the at least one randomly oriented fiber. | 11-13-2014 |