Patent application number | Description | Published |
20140242662 | Manipulation of Cells on a Droplet Actuator - A method of growing cells on a droplet actuator is provided. The method may include providing a droplet actuator including a cell culture droplet including a cell culture medium and one or more cells; and maintaining the droplet at a temperature suitable for causing the cells to grow in the cell culture medium on the droplet actuator. Related methods, droplet actuators, and systems are also provided. | 08-28-2014 |
20150027889 | DROPLET ACTUATOR AND METHOD - The invention provides droplet actuators and droplet actuator cassettes including reagent storage capabilities, as well as methods of making and using the droplet actuators and cassettes. The invention also provides continuous flow channel elements and techniques for using electrodes to manipulate droplets in flowing streams. The invention also discloses methods of separating compounds on a droplet actuator. Various other aspects of the invention are also disclosed. | 01-29-2015 |
20150038344 | Method of Preparing a Nucleic Acid Library - A method of preparing a nucleic acid library in droplets in contact with oil, including: (a) blunt-ending nucleic acid fragments in a droplet in the oil to yield blunt-ended nucleic acid fragments; (b) phosphorylating the blunt-ended nucleic acid fragments in a droplet in the oil to yield phosphorylated nucleic acid fragments; coupling A-tails to the phosphorylated nucleic acid fragments in a droplet in the oil to yield A-tailed nucleic acid fragments; and (d) coupling nucleic acid adapters to the A-tailed nucleic acid fragments in a droplet in the oil to yield the nucleic acid library comprising adapter-ligated nucleic acid fragments. | 02-05-2015 |
20150065360 | Systems for and Methods of Hybrid Pyrosequencing - The systems and methods of the invention provide a guided approach to pyrosequencing (i.e., hybrid pyrosequencing). A de novo nucleic acid sequence may compared to a library of possible results and the next nucleotide to be dispensed is selected based on the comparison of the de novo sequence and the library of possible results. In another example, at least the first nucleotide to be dispensed is selected based on a query of a database(s) of non-sequence parameters (e.g., incidence of infection, diagnostic symptoms, sample source) and subsequent dispensations determined based on a comparison of the de novo sequence and the library of possible results (e.g., candidate sequences). The systems and methods of the invention may be performed using a droplet actuator. | 03-05-2015 |
20150111237 | BIOTINIDASE ASSAYS - The invention relates to methods for enzymatic detection of biotinidase activity. In certain aspects, the invention provides methods for bench-based enzymatic detection of biotinidase activity. In other aspects, the invention provides methods for bench-based enzymatic detection in droplets in oil. The droplet-based methods may be performed in an automated manner using digital microfluidics technology on a droplet actuator device. The enzymatic assays for biotinidase activity may be used for newborn testing for biotinidase deficiency, and may be combined with other droplet-based enzymatic assays in a panel of tests for newborn testing. | 04-23-2015 |
20150184219 | Enzyme Assays on a Droplet Actuator - The invention is directed to droplet actuator devices and assay methods. The invention includes assay methods of conducting an assay comprising combining a sample with an umbelliferyl derivative, wherein the sample potentially comprises an enzyme capable of cleaving the umbelliferyl derivative and where the umbelliferyl derivative comprises an umbelliferyl core modified with one or more modifying moieties. | 07-02-2015 |
20150197799 | POLYNUCLEOTIDE MODIFICATION ON SOLID SUPPORT - The present disclosure relates to the field of molecular biology and more specifically to methods for capturing and amplifying target polynucleotides on a solid surface. | 07-16-2015 |
20150267242 | ACYL-COA DEHYDROGENASE ASSAYS - A method for conducting medium-chain acyl-CoA dehydrogenase (MCAD) and very-long-chain acyl-CoA dehydrogenase (VCAD) enzymatic activity assays is provided. The method may include, but is not limited to, preparing a sample; preparing an enzyme-specific substrate/reagent mixture; mixing an aliquot of the prepared sample with an aliquot of the enzyme-specific substrate/reagent mixture; reading absorbance in the range of about 600 nm; incubating the prepared sample and enzyme-specific substrate/reagent mixture; and reading absorbance in the range of about 600 nm at various time intervals. | 09-24-2015 |
20150314293 | Droplet Actuator Devices and Methods Employing Magnetic Beads - A method of providing a droplet in contact with a magnetically responsive bead and having a reduced quantity of a substance. The method generally includes the steps of (a) providing a droplet actuator comprising: (i) a substrate comprising electrodes arranged for conducting droplet operations on a surface; (ii) a starting droplet comprising: (1) one or more magnetically responsive beads; (2) a starting quantity of the substance; and (3) a starting volume; (b) magnetically immobilizing the one or more magnetically responsive beads at a location which is at a distance from a target droplet splitting zone; (c) conducting one or more droplet operations comprising droplet dividing operations selected to divide the combined droplet to yield a set of droplets comprising: (i) a droplet comprising substantially all of the one or more magnetically responsive beads and having a decreased quantity of the substance relative to the starting concentration; and (ii) a droplet substantially lacking the magnetically responsive beads. | 11-05-2015 |
20150353926 | POLYNUCLEOTIDE MODIFICATION ON SOLID SUPPORT - The present disclosure relates to the field of molecular biology and more specifically to methods for capturing and amplifying target polynucleotides on a solid surface. | 12-10-2015 |
Patent application number | Description | Published |
20140181016 | ASYNCHRONOUS REPLICATION CORRECTNESS VALIDATION - A method for backing up a client data set on a computer by generating a manifest of the client data set and storing the manifest on a remote server along with a server data set corresponding to the client data set; taking a snapshot of the server manifest and data set; and comparing the manifest to the remote server data set and synchronizing the client dataset if a difference is detected. | 06-26-2014 |
20140181034 | SYSTEMS AND METHODS FOR MINIMIZING NETWORK BANDWIDTH FOR REPLICATION/BACK UP - Systems and methods are disclosed for backing up a client data set on a computer by identifying changed files; generating a first sub-file signature for one or more segments of a changed file; subsequently generating a second sub-file signature for each file segment to detect insertions, removals, and rearrangements of data in the file; transmitting one more changed segment(s) in the file; and writing a manifest file reflecting the new target state. | 06-26-2014 |
20140181040 | CLIENT APPLICATION SOFTWARE FOR ON-LINE BACKUP AND DISASTER RECOVERY - Systems and methods communicate back-up data files to one or more data storage silos by at a customer computer, installing and running a client software; providing a system management platform coupled to the client software over the Internet; and receiving inputs from a user web portal to control operations of the client software and the system management platform to back up the customer computer. | 06-26-2014 |
20140181041 | DISTRIBUTED DATA STORE - Systems and methods are disclosed for backing up a computer with a distributed meta data store by splitting meta data from file data; storing the meta data for each file in a separate file; mapping the file data and meta data to an arbitrary file system; and reconstructing files for the arbitrary file system. | 06-26-2014 |
20140181579 | SYSTEMS AND METHODS FOR ON-LINE BACKUP AND DISASTER RECOVERY - A data recovery system includes a plurality of customer computers to be backed-up, each customer computer running a client software to communicate back-up data files; a system management platform coupled to the client software over the Internet, the system management platform receiving inputs from a web user portal to control operations of the client software and the system management platform to back up the customer computer; and two or more data storage silos, each including: a plurality of storage directors communicating with the client software; and a clustered data storage array. | 06-26-2014 |
20150309882 | SYSTEMS AND METHODS FOR MINIMIZING NETWORK BANDWIDTH FOR REPLICATION/BACK UP - Systems and methods are disclosed for backing up a client data set on a computer by identifying changed files; generating a first sub-file signature for one or more segments of a changed file; subsequently generating a second sub-file signature for each file segment to detect insertions, removals, and rearrangements of data in the file; transmitting one more changed segment(s) in the file; and writing a manifest file reflecting the new target state. | 10-29-2015 |
Patent application number | Description | Published |
20080233551 | WIRELESS LEARNING SYSTEM - In one embodiment, the present invention provides a wireless learning system that includes a master control unit and a plurality of trigger units. Each trigger unit is able to wirelessly communicate with the master control unit and the other trigger units. Each trigger unit further includes at least one trigger switch and can provide an indication when that trigger unit is the first one of the trigger units to have its trigger switch actuated. | 09-25-2008 |
20090309307 | Toy dart assembly and method - Embodiments of the invention include a method for engaging a dart with a net. A dart is thrown toward a net. When the dart hits the net, the nose of the dart passes through an opening in the net for subsequently, lodging strands of the net in a recess situated behind the nose of the dart. Embodiments further include a recreational toy assembly having in combination a net and a dart. One or more strands of the net lodge in a recess behind the nose of the dart for coupling the dart to the net. The dart remains engaged to the net until the dart is removed from engagement with the net. For disengaging the dart from the net, the strand(s) is/are removed from the recess such that the nose of the dart may be passed out of opening in the net. The strands of the net provide the boundary or perimeter of the opening. | 12-17-2009 |
20100051777 | Collapsible Top Hanger Easel - A folding and collapsing easel that includes one or more retainer devices or attachments that can be coupled to the top of the display material. The easel includes a top portion and a bottom portion, each portion having three legs that are coupled together to form a stand. The top portion of the easel includes two elongated members that are pivotally coupled to two of the legs and further coupled to each other at adjacent ends, such that the elongated members may form a “V” shape when extended. The easel further includes one or more chart holding pins with retainer springs to secure display materials to the easel. | 03-04-2010 |
20130025045 | LAVATORY WASH STATION WITH INTEGRATED SINK AND SANITIZING HAND DRYER - A lavatory wash station includes a wash station housing, a sink basin connected to a front of the housing, wherein the sink basin has a rim, and a sanitizing hand dryer assembly having an air intake and an exit nozzle at the front of the housing. The air intake and the exit nozzle are connected by a dryer flow path and the exit nozzle is disposed at the front of the housing above the rim, where the exit nozzle provides air flow in a substantially downward vertical direction into the sink basin and the sanitizing hand dryer includes an ion generator that treats the air passing through the hand dryer. | 01-31-2013 |
20130031799 | SANITIZING HAND DRYER - A sanitizing hand dryer comprises a dryer housing having an inlet air channel and an outlet air channel. A blower draws air into the dryer housing through the inlet air channel, and directs the air out of the dryer housing through the outlet air channel A sanitizing system sanitizes the air within the inlet air channel and the air within the outlet air channel, wherein the sanitizing system within the inlet air channel includes at least one of a first air filter, a first ozone generator, a first sanitizing light source, a first photocatalytic oxidation system, a first ion generator, and a first electrostatic precipitator. The sanitizing system within the outlet air channel includes at least one of a second air filter, a second ozone generator, a second sanitizing light source, a second photocatalytic oxidation system, a second ion generator, and a second electrostatic precipitator. | 02-07-2013 |
20150361926 | INCREASED DIESEL ENGINE EFFICIENCY BY USING NITROUS OXIDE AS A FUEL ADDITIVE - A diesel engine fuel delivery system is equipped for addition of N | 12-17-2015 |
20150361930 | IMPROVED DIESEL ENGINE EFFICIENCY BY TIMING OF IGNITION AND COMBUSTION USING ULTRAVIOLET LIGHT - An exemplary embodiment of a UV light injector assembly is used to apply intense light that includes short wavelength UV to the interior of an engine cylinder near the desired time of fuel ignition. In an example embodiment, the light is produced by a short-arc xenon flash lamp. This flash lamp includes an integral reflector (e.g., a parabolic reflector) to collimate the majority of its light into parallel rays. The assembly includes a window for passing UV light into the cylinder. To direct the collimated rays of light from the flash lamp through the window a UV-transparent condensing lens is used to focus the light from the flash lamp onto the window. | 12-17-2015 |
20160032873 | REDUCING FUEL CONSUMPTION OF SPARK IGNITION ENGINES - Atomic oxygen is provided for the purpose of promoting reliable ignition and smooth combustion in a spark ignition internal combustion engine is to disperse a low concentration of an atomic oxygen precursor, such as nitrous oxide (N2O), into the flammable mixture of air and gasoline vapor prior to the time of ignition. The introduction of N2O may take place in the intake manifold, in the stream of exhaust gas being returned as part of the EGR process, or directly into the combustion chamber (for example through a small orifice in the base of the spark plug or through a small nozzle located elsewhere in the cylinder head). Introduction of N2O directly into the combustion chamber may be continuous, or it may be pulsed so as to occur at the time of or shortly before, spark ignition. | 02-04-2016 |
Patent application number | Description | Published |
20110032727 | BACKLIGHT REFLECTORS HAVING A PRISMATIC STRUCTURE - A back reflector for a lightguide in a turning film backlight includes a prism film layer in direct contact with a reflective layer. The lightguide includes a light guiding region having a refractive index that is substantially spatially uniform. The reflective layer may be specular or diffuse and may include a multilayer polymeric film. | 02-10-2011 |
20120039084 | LIGHT ASSEMBLY - Light assembly ( | 02-16-2012 |
20120287432 | APPARATUS FOR MEASURING THE RETROREFLECTANCE OF MATERIALS - The present invention comprises various embodiments of a retroreflectometer capable of measuring the retroreflectance of a material. The retroreflectometer comprises an illumination path and a retroreflection path. The illumination path comprises focusing optics, a source aperture, a beamsplitter and a collimating lens. The retroreflection path comprises a focusing lens, a beamsplitter, a receiver aperture and a receiver. The source aperture shapes the transverse profile of the light to make it appropriate to the measurement. Focusing optics, such as a biconvex lens, may be placed between the light source and the source aperture. After the beam is reflected by the object under test, it enters the retroreflection path of the instrument. The focusing lens focuses the light through the beamsplitter and onto the receiver aperture. The receiver aperture may be the input slit for a spectrometer, or there may be optics, such as a lens or an optical fiber, that transfer the light from the aperture to the receiver. A photopically corrected detector, multiple detectors with filters or a spectrometer may be used in various embodiments of the present invention as the receiver. | 11-15-2012 |
20140022649 | PANORAMIC OPTICAL SYSTEMS - Panoramic optical systems are disclosed comprising an ellipsoidal mirror and a lens system that reduces astigmatism. The lens systems are capable of operating at fast speeds. Simple and highly manufacturable lens systems are provided for capturing and/or projecting high quality 360-degree panoramic scenes. | 01-23-2014 |
Patent application number | Description | Published |
20090120196 | APPARATUS AND METHOD FOR PRESSURE SENSING - An apparatus and method of pressure sensing. The system can include a sensing apparatus connectable with a supply conduit and a mounting plate. The apparatus can include a coupling device for receiving the supply conduit, a housing having first and second openings in fluid communication with each other where the first opening receives at least a portion of the coupling device, and a sensing device having an insertion portion and a sensing area. The insertion portion can be received in the second opening of the housing. A first connection between the housing and the mounting plate can be remote from the sensing area, and a second connection between the housing and the sensing device can be remote from the sensing area. | 05-14-2009 |
20090282925 | ASIC COMPENSATED PRESSURE SENSOR WITH SOLDERED SENSE DIE ATTACH - An ASIC compensated pressure sensor includes a sense die, an ASIC chip, and supporting elements. The sense die includes a metallized surface for attaching the sense die to a mounting surface. The resulting solder joint provides a hermetic seal that is resistant to a wide range of media associated with different environmental conditions. The mounting surface can contain the ASIC and electronics for compensation or can be attached to another mounting surface, which contains the ASIC and electronics. Either configuration can include collars of different styles for ease of assembly and in turn can be attached to a mating connector. The mounting surface can possess a closely matched coefficient of thermal expansion to the sense die in order to enhance electrical stability of the output signal over a wide temperature and pressure ranges. | 11-19-2009 |
20100100052 | DIFFERENTIAL FORCE SENSOR - A differential force sensor method and apparatus for automatically monitoring manual injections through an intravenous line. The differential force sensor includes two piezoresistive sense die that are packaged in close proximity utilizing a number of packaging processes. The two piezoresistive sense die can be utilized to measure forces exerted on a diaphragm on either side of an orifice. The piezoresistive sense die can be packaged in close proximity to make intimate contact with the diaphragms on either side of the orifice. The differential force sensor further includes two plungers that make intimate contact with the diaphragm and transfer the force into the piezo-resistive sense dies. Additionally, one or more ASICs and microcontrollers can be utilized to provide thermal calibration and differential calculation. | 04-22-2010 |
20110000313 | DIFFERENTIAL FORCE SENSOR - A differential force sensor method and apparatus for automatically monitoring manual injections through an intravenous line. The differential force sensor includes two piezoresistive sense die that are packaged in close proximity utilizing a number of packaging processes. The two piezoresistive sense die can be utilized to measure forces exerted on a diaphragm on either side of an orifice. The piezoresistive sense die can be packaged in close proximity to make intimate contact with the diaphragms on either side of the orifice. The differential force sensor further includes two plungers that make intimate contact with the diaphragm and transfer the force into the piezo-resistive sense dies. Additionally, one or more ASICs and microcontrollers can be utilized to provide thermal calibration and differential calculation. | 01-06-2011 |
20110000318 | FORCE SENSOR APPARATUS - A force sensor apparatus and method of forming the same. The apparatus includes a force sense element that can be attached to a substrate. An actuator disposed in a hole formed within the cap is operably coupled to the force sense element for transferring force to the sense element in response to receiving a force from an external source. The force sense element is configured to sense the external force and generate an output signal representing the force. Preferably, one or more bond pads, associated with the force sense element and the substrate, can be electrically connected via wire bonding. A cover associated with an integrated flexible membrane can be mounted on the substrate in order to protect internal components associated with the force sensor apparatus from an external environment. | 01-06-2011 |
20130031976 | CABLE HARNESS FOR A SENSOR - The present disclosure relates to sensors including pressure sensors, humidity sensors, flow sensors, etc. In some cases, a cable harness assembly for connection with a sensor assembly may include a cable cover having a first end and a second end, a cable extending through an opening in the first end of the of the cable cover, and a crimp ring configured to engage the cable at a position within the cable cover, such that the attached crimp ring may not fit through the opening. The second end of the cable cover may be configured to connect to a housing of an electrical connector. Further, the cable may have wires that may be configured to electrically connect to electrical terminals of the electrical connector. In some instances, the electrical connector may be electrically connected to a sensor. | 02-07-2013 |
20130031984 | INTERCHANGEABLE PRESSURE SENSOR ASSEMBLY AND METHODS OF ASSEMBLY - The present disclosure relates to sensors including pressure sensors, humidity sensors, flow sensors, etc. In some cases, a sensor unit subassembly for installation in or use with a pressure sensor housing may include at least one pressure sensor signal output terminal supported by a printed circuit board, a pressure input port, and a pressure sense element secured relative to one or more printed circuit boards. The printed circuit board(s) may include circuitry configured to format pressure output signals provided by the pressure sense element into a particularly chosen output format, and may provide the formatted pressure output signal(s) to an attached electrical connector of the pressure sensor housing. In some cases, the sensor unit subassemblies can be mixed with a multitude of different electrical connectors and/or with a multitude of different port connections to from a wide array of pressure sensor assemblies. | 02-07-2013 |
20130031985 | PRESSURE SENSOR ASSEMBLY - The present disclosure relates to sensors including pressure sensors, humidity sensors, flow sensors, etc. In some cases, a sensor assembly may include a pressure port connected to a sensor unit, an electrical connector connected to the sensor unit and an outer housing encompassing at least portions of the pressure port, sensor unit and electrical connector. In some instances, the sensor unit may include pressure signal output terminals electrically connected to electrical terminals of the electrical connector. | 02-07-2013 |
20130031986 | JOINT BETWEEN A PRESSURE SENSOR AND A PRESSURE PORT OF A SENSOR ASSEMBLY - The present disclosure relates to sensors including pressure sensors, humidity sensors, flow sensors, etc. In some illustrative cases, a sensor assembly may include a pressure port connected to a sensor unit, an electrical connector connected to the sensor unit and an outer housing encompassing at least portions of the pressure port, sensor unit and electrical connector. In one example, the sensor unit may include a carrier carrying a sense element, where the carrier may extend into a recess of the pressure port and may be secured to the pressure port at an internal side thereof through the use of an adhesive layer. | 02-07-2013 |
20130033830 | CONNECTOR ASSEMBLY FOR A SENSOR - The present disclosure relates to sensors including pressure sensors, humidity sensors, flow sensors, etc. In some cases, a connector assembly for a sensor assembly may include an electrical connector, a printed circuit board and a conductive outer housing. The electrical connector may include a mechanical connector and electrical terminals exposed at a first end and at a second end of the mechanical connector. The electrical connector, printed circuit board and conductive outer housing may all be electrically connected to one another. In some instances, a plurality of electrical connectors having different mechanically shaped second ends and similarly shaped first ends may be provided, from which one electrical connector may be chosen for use in the connector assembly. | 02-07-2013 |
20130033841 | PROTECTIVE COVER FOR PRESSURE SENSOR ASSEMBLIES - The present disclosure relates to sensors including pressure sensors, humidity sensors, flow sensors, etc. In some cases, a cover for use with a sensor assembly may include an electrically insulating body having perimeter features extending a majority of the way around perimeters of upper and lower printed circuit boards that the cover may vertically separate. In one example, the body of the cover may include support features that extend from a lower side of the cover and those support features may contact the lower printed circuit board in at least two locations. The support features of the cover may be separated by a gap and a sensor connected to the lower printed circuit board may be situated within the gap. | 02-07-2013 |
20130247689 | FORCE SENSOR - A force sensor may include a sense die mounted to a substrate and an actuating assembly for transmitting an external force to the sense die. The sense die may include a diaphragm, a boss extending from the diaphragm, and one or more sensing elements (e.g., piezoresistive elements positioned on the diaphragm). The actuation assembly may include a force receiving feature configured to receive an external force at a first end and transfer at least a portion of the received external force through a second end to the diaphragm via intimate contact with a bottom side of the boss. In some cases, the force sensor may also include signal conditioning circuitry. | 09-26-2013 |
20140144244 | INTERCHANGEABLE PRESSURE SENSOR ASSEMBLY AND METHODS OF ASSEMBLY - The present disclosure relates to sensors including pressure sensors, humidity sensors, flow sensors, etc. In some cases, a sensor unit subassembly for installation in or use with a pressure sensor housing may include at least one pressure sensor signal output terminal supported by a printed circuit board, a pressure input port, and a pressure sense element secured relative to one or more printed circuit boards. The printed circuit board(s) may include circuitry configured to format pressure output signals provided by the pressure sense element into a particularly chosen output format, and may provide the formatted pressure output signal(s) to an attached electrical connector of the pressure sensor housing. In some cases, the sensor unit subassemblies can be mixed with a multitude of different electrical connectors and/or with a multitude of different port connections to from a wide array of pressure sensor assemblies. | 05-29-2014 |