Rao, MA
Anjana Rao, Cambridge, MA US
Patent application number | Description | Published |
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20090178146 | Regulators of NFAT - Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein. Methods of identifying an agent that modulates intracellular calcium, methods to screen for an agent that modulates NFAT regulator function, methods to diagnose unexplained immunodeficiency in a subject, and methods for identifying an agent for treating or preventing a disease or disorder associated with a NFAT regulator protein or calcium signaling are also disclosed. | 07-09-2009 |
20090186422 | SPECIFIC INHIBITORS OF NFAT ACTIVATION BY CALCINEURIN AND THEIR USE IN TREATING IMMUNE-RELATED DISEASES - Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided. | 07-23-2009 |
20100135910 | Modulation of Anergy and Methods for Isolating Anergy-Modulating Compounds - The present invention provides methods for identifying compounds capable of modulating anergy by inhibiting the production or activity of anergy associated E3 ubiquitin ligases or by altering the interaction between a ligase and its substrate. | 06-03-2010 |
20100323371 | STROMAL INTERACTING MOLECULE KNOCKOUT MOUSE AND USES THEREOF - This invention relates to knockout mice for the Ca | 12-23-2010 |
20110212100 | METHODS FOR MODULATING DEVELOPMENT AND EXPANSION OF IL-17 EXPRESSING CELLS - This invention provides methods and compositions for modulating the development and/or expansion of Th17 cells for use, for example, in the treatment of autoimmune diseases, persistent inflammatory diseases, infectious diseases and other Th17 related and/or IL-17 related diseases. | 09-01-2011 |
20110236894 | SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS - The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation. | 09-29-2011 |
20110269174 | REGULATORS OF NFAT - Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a recombinant cell comprising at least one NFAT regulator protein or fragment or derivative thereof, assessing the effect of the test agent on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, and identifying the test agent that has an effect on an activity, interaction, expression, or binding to the NFAT regulator protein or fragment or derivative thereof, whereby the identified test agent is characterized as an agent that modulates an NFAT regulator protein. Methods of identifying an agent that modulates intracellular calcium, methods to screen for an agent that modulates NFAT regulator function, methods to diagnose unexplained immunodeficiency in a subject, and methods for identifying an agent for treating or preventing a disease or disorder associated with a NFAT regulator protein or calcium signaling are also disclosed. | 11-03-2011 |
20120264231 | ASSAY FOR ORAI CALCIUM CHANNEL REGULATORS - The methods and systems described herein are based, in part, on the discovery that STIM modulates calcium release from store-operated channels through a direct interaction with the ORAI channel. Based on this discovery, methods and systems are described herein for identifying an agent that modulates calcium flux through the ORAI channel and/or regulates intracellular calcium via the ORAI channel. The methods and systems can also be used to detect an interaction between STIM and a functional ORAI channel. | 10-18-2012 |
20120272343 | STROMAL INTERACTING MOLECULE KNOCKOUT MOUSE AND USES THEREOF - This invention relates to knockout mice for the Ca | 10-25-2012 |
20130158101 | REGULATORS OF NFAT AND/OR STORE-OPERATED CALCIUM ENTRY - Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca | 06-20-2013 |
20140093542 | REGULATORS OF NFAT AND/OR STORE-OPERATED CALCIUM ENTRY - Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca | 04-03-2014 |
Anoop Rao, Cambridge, MA US
Patent application number | Description | Published |
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20100000862 | Integrated Blood Glucose Measurement Device - A portable combination for measuring a glucose concentration value in a sample has a portable glucose meter (GM) having a test strip port for receiving a disposable electrochemical test strip, means for calculating a glucose concentration value in a sample applied to a test strip received in the test strip port, and optionally a rechargeable GM battery. Next the combination has a portable rechargeable supplemental battery pack (SBP). The combination also has a web enabled portable device (WEPD) having a rechargeable WEPD battery and a wireless connection to the internet. The GM, the SBP, and the WEPD are electrically coupled to allow power transfer between the GM, the SBP, and the WEPD. The GM and the WEPD are communicatively coupled to allow for data transfer between the GM and the WEPD. The GM and SBP are detachable from and reattachable to the WEPD to form the portable combination. Lastly the combination has means for managing battery operations of the combination. These means are effective to cause the GM to draw operating power first from the SBP, second from the WEPD battery, and third from the GM battery, if the GM battery is present. | 01-07-2010 |
20100249965 | Integrated Blood Glucose Measurement Device - The present invention provides a method of transferring data between a diagnostic measurement device and a portable consumer electronic device (CED). The method includes a step of communicatively coupling the diagnostic measurement device and the CED through an audio port located on the CED. The method also includes the step of transferring data from the diagnostic measurement device to the CED through the audio port of the consumer electronic device. | 09-30-2010 |
Balaji M. Rao, Cambridge, MA US
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20100036097 | Mutant Interleukin-2 (IL-2) Polypeptides - The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα. | 02-11-2010 |
Basrur Rama Rao, Lexington, MA US
Patent application number | Description | Published |
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20130241783 | Ultra-High Frequency (UHF)-Global Positioning System (GPS) Integrated Antenna System for a Handset - Embodiments provide an integrated antenna system that enables dual-use operation (e.g., communications and navigation). In an embodiment, the integrated antenna system includes a sleeve monopole antenna system and stacked shorted annular ring (SAR) patch antenna system, which are compactly integrated to fit on a military handset or a smart phone. In an embodiment, the integrated antenna system enables communication in the 225-450 MHz Ultra-High Frequency (UHF) band and reception of various Global Navigation Satellite System (GNSS) bands. | 09-19-2013 |
20140022139 | Conformal Electro-Textile Antenna and Electronic Band Gap Ground Plane for Suppression of Back Radiation From GPS Antennas Mounted on Aircraft - An antenna system having reduced back radiation is disclosed. The antenna system includes an antenna and ground plane. The antenna includes electro-textiles and is configured to operate in at least the frequency range between 1.1-1.6 GHz. The ground plane includes electro-textiles and is configured to operate as a frequency selective surface with electronic band gap characteristics to suppress edge and curved surface diffraction effects. In this system, the antenna and ground plane are configured to be located on a curved surface and to radiate with a directional radiation pattern having attenuated back lobes. | 01-23-2014 |
Chang Rao, Cambridge, MA US
Patent application number | Description | Published |
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20100168082 | Heterobicyclic Carboxamides as inhibitors for kinases - The invention relates to novel organic compounds of formula (I) | 07-01-2010 |
20110092505 | ORGANIC COMPOUNDS - The present invention provides novel organic compounds of Formula I: methods of use, and pharmaceutical compositions thereof. | 04-21-2011 |
20120245187 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES - The invention relates to novel organic compounds of formula (I) | 09-27-2012 |
20130005750 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES - The invention relates to novel organic compounds of formula (I) | 01-03-2013 |
20130005751 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES - The invention relates to novel organic compounds of formula (I) | 01-03-2013 |
20130005753 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES - The invention relates to novel organic compounds of formula (I) | 01-03-2013 |
20130012529 | HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES - The invention relates to novel organic compounds of formula (I) | 01-10-2013 |
Chang Rao, Waltham, MA US
Patent application number | Description | Published |
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20100168123 | AKT PROTEIN KINASE INHIBITORS - The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: | 07-01-2010 |
20130184253 | TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS - The present invention provides a compound of formula I: | 07-18-2013 |
20140349995 | TETRAHYDROPYRIDO-PYRIDINE AND TETRAHYDROPYRIDO-PYRIMIDINE COMPOUNDS AND USE THEREOF AS C5A RECEPTOR MODULATORS - The present invention provides a compound of formula I: | 11-27-2014 |
Doreen Rao, Watertown, MA US
Patent application number | Description | Published |
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20110064774 | BULKING AGENT - The invention relates to bulking agents and apparatus and methods for using the disclosed bulking agents. The bulking agents can be used to treat such conditions as urinary and fecal incontinence, gastro-esophageal reflux, aneurismal blockages, and cosmetic deformities. The invention also relates to an injection method that reduces the injection pressure required to place the bulking agents. | 03-17-2011 |
Doreen Rao, Sudbury, MA US
Patent application number | Description | Published |
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20090240101 | DISSOLVABLE PROTECTIVE TREATMENT FOR AN IMPLANTABLE SUPPORTIVE SLING - The invention provides, in one embodiment, a sling assembly including an implantable supportive sling and a biocompatible dissolvable protective treatment on at least a portion of the sling. | 09-24-2009 |
20110184226 | DISSOLVABLE PROTECTIVE TREATMENT FOR AN IMPLANTABLE SUPPORTIVE SLING - The invention provides, in one embodiment, a sling assembly including an implantable supportive sling and a biocompatible dissolvable protective treatment on at least a portion of the sling. | 07-28-2011 |
20110263927 | MEDICAL SLINGS - A sling in accordance with the invention includes a synthetic material and a non-synthetic material positioned adjacent thereto. The non-synthetic material may be wrapped around or may be attached to the synthetic material. Additionally, the non-synthetic material may include slits. Methods for making such slings are also described. | 10-27-2011 |
20110263932 | PELVIC FLOOR REPAIR IMPLANTS AND METHODS - The invention generally relates to surgically implantable supportive slings. More specifically, in various embodiments, the invention is directed to sling assemblies for pelvic floor repair that utilize one or more materials, attached without a mechanical fixation device, and related methods of use and fabrication. | 10-27-2011 |
20130190720 | BULKING AGENTS - The invention relates to bulking agents and apparatus and methods for using the disclosed bulking agents. The bulking agents can be used to treat such conditions as urinary and fecal incontinence, gastro-esophageal reflux, aneurismal blockages, and cosmetic deformities. The invention also relates to an injection method that reduces the injection pressure required to place the bulking agents. | 07-25-2013 |
20130204078 | POROUS SURGICAL FILMS - According to an aspect of the present invention, surgical films for soft tissue repair are provided. The surgical films comprise at least one sheet of a non-filamentous material within which pores are formed. Further aspects of the invention, among others, pertain to methods of using such surgical films and to kits containing such surgical films. | 08-08-2013 |
20140072636 | BULKING AGENTS - The invention relates to bulking agents and apparatus and methods for using the disclosed bulking agents. The bulking agents can be used to treat such conditions as urinary and fecal incontinence, gastro-esophageal reflux, ancurismal blockages, and cosmetic deformities. The invention also relates to an injection method that reduces the injection pressure required to place the bulking agents. | 03-13-2014 |
20140378747 | MEDICAL SLINGS - A sling in accordance with the invention includes a synthetic material and a non-synthetic material positioned adjacent thereto. The non-synthetic material may be wrapped around or may be attached to the synthetic material. Additionally, the non-synthetic material may include slits. Methods for making such slings are also described. | 12-25-2014 |
20150335452 | STENT DELIVERY SYSTEM - A stent delivery device having a locking mechanism. The device includes a handle assembly, an elongate inner member, and an elongate outer tubular member surrounding the elongate inner member. The handle assembly includes a handle attached to one of the inner member and the outer tubular member, and an actuator attached to the other of the inner member and the outer tubular member. Actuation of the actuator relative to the handle between a first position and a second position causes axial movement of the outer tubular member relative to the inner member. The locking mechanism has a locked position in which the actuator is prevented from moving from the first position to the second position and an unlocked position in which the actuator is permitted to move from the first position to the second position. | 11-26-2015 |
Doreen S. Rao, Sudbury, MA US
Patent application number | Description | Published |
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20160038179 | REUSABLE DELIVERY DEVICES - According to an aspect, a medical device may include a needle member, and a handle coupled to the needle member. The handle may define a track portion. The medical device may also include a pusher member having a sheath disposed around a portion of the needle member, and an extension member being movably coupled to the track portion of the handle such that the pusher member is configured to move from a first position to a second position during a surgical procedure. The pusher member may be removable from the handle. The sheath may define a slot, and the pusher member may be removable from the needle member through the slot. | 02-11-2016 |
D.v.g.l.n Rao, Lexington, MA US
Patent application number | Description | Published |
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20130070251 | Systems and Methods of Dual-Plane Digital Holographic Microscopy - An embodiment of the disclosed DHM system includes a light source configured to emit coherent optical waves, a first optical Fourier element configured to Fourier transform the optical waves from the object area, wherein the Fourier transform occurs at a Fourier plane and the optical waves from the object area includes directly transmitted waves and diffracted waves, a phase modulator at the Fourier plane configured to introduce a phase delay between the directly transmitted waves and the diffracted waves, a second optical Fourier element configured to receive the directly transmitted waves and the diffracted waves from the phase modulator and to inversely Fourier transform the directly transmitted waves and the diffracted waves to provide interfered optical waves, and at least one imaging device configured to record the interfered optical waves at two image planes to generate a first interferogram and a second interferogram. | 03-21-2013 |
D. V. Gopal L.n. Rao, Lexington, MA US
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20100245694 | Systems and Methods of All-Optical Fourier Phase Contrast Imaging Using Dye Doped Liquid Crystals - An assembly for converting a microscope into a phase contrast microscope includes a first optical Fourier element that Fourier transforms light from a coherent light source, a cell in the Fourier plane arranged to receive light from the first optical Fourier element, a second optical Fourier element arranged to receive light from the cell and inversely Fourier transform the received light to provide an image, an image sensor that detects the image and generates an electronic representation of the image, and an adaptor capable of coupling the first and second Fourier elements, the cell, and the image sensor to the microscope such that the first Fourier element Fourier transforms light collected by the microscope objective. The cell includes liquid crystal molecules having a phase transition temperature, wherein at temperatures exceeding the phase transition temperature, light transmitting through the liquid crystal molecules obtains a different phase than light transmitting through the liquid crystal molecules at temperatures below the phase transition temperature. | 09-30-2010 |
Ganesh Rao, Needham, MA US
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20120082156 | TIMESTAMP PREDICTOR FOR PACKETS OVER A SYNCHRONOUS PROTOCOL - A physical layer communication device (PHY) transmits and receives signal to and from a communication link using a synchronous protocol. The PHY communicates with a higher-layer device using a packet protocol. Timestamp values contained in timing-related messages in some packets are written or modified by the PHY. Delays incurred in transmitting and receiving the packets are predicted and used in setting the timestamp values. | 04-05-2012 |
Hemonth G. Rao, Bedford, MA US
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20110274429 | METHOD AND APPARATUS FOR PHASE SHIFT KEYED OPTICAL COMMUNICATIONS - A burst-mode differential phase shift keying (DPSK) communications system according to an embodiment of the present invention enables practical, power-efficient, multi-rate communications between an optical transmitter and receiver. An embodiment of the system utilizes a single interferometer in the receiver with a relative path delay that is matched to the DPSK symbol rate of the link. DPSK symbols are transmitted in bursts, and the data rate may be varied by changing the ratio of the burst-on time to the burst-off time. This approach offers a number of advantages over conventional DPSK implementations, including near-optimum photon efficiency over a wide range of data rates, simplified multi-rate transceiver implementation, and relaxed transmit laser line-width requirements at low data rates. | 11-10-2011 |
Kalipatnam Rao, Grafton, MA US
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20110215299 | SEMICONDUCTOR DEVICE INCLUDING A SUPERLATTICE AND DOPANT DIFFUSION RETARDING IMPLANTS AND RELATED METHODS - A semiconductor device may include a substrate and at least one MOSFET adjacent the substrate. The MOSFET may include a superlattice channel including a plurality of stacked groups of layers, a source and a drain adjacent the superlattice channel, and a gate adjacent the superlattice channel. Each group of layers of the superlattice channel may include a plurality of stacked base semiconductor monolayers defining a base semiconductor portion and at least one non-semiconductor monolayer constrained within a crystal lattice of adjacent base semiconductor portions. A first dopant may be in at least one region adjacent at least one of the source and drain, and a second dopant may also be in the at least one region. The second dopant may be different than the first dopant and reduce diffusion thereof. | 09-08-2011 |
Kalipatnam Vivek Rao, Grafton, MA US
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20080258134 | METHOD FOR MAKING A SEMICONDUCTOR DEVICE INCLUDING SHALLOW TRENCH ISOLATION (STI) REGIONS WITH MASKLESS SUPERLATTICE DEPOSITION FOLLOWING STI FORMATION AND RELATED STRUCTURES - A semiconductor device may include a semiconductor substrate having a surface, a shallow trench isolation (STI) region in the semiconductor substrate and extending above the surface thereof, and a superlattice layer adjacent the surface of the semiconductor substrate and comprising a plurality of stacked groups of layers. More particularly, each group of layers of the superlattice layer may include a plurality of stacked base semiconductor monolayers defining a base semiconductor portion, and at least one non-semiconductor monolayer constrained within a crystal lattice of adjacent base semiconductor portions. Moreover, at least some atoms from opposing base semiconductor portions may be chemically bound together with the chemical bonds traversing the at least one intervening non-semiconductor monolayer. The semiconductor device may further include a lateral spacer between the superlattice layer and the STI region and which may include a lower non-monocrystalline semiconductor superlattice portion and an upper dielectric portion. | 10-23-2008 |
20150214339 | TECHNIQUES FOR ION IMPLANTATION OF NARROW SEMICONDUCTOR STRUCTURES - A method to process a semiconductor device includes performing a first ion implant comprising first ions into a thin crystalline semiconductor structure, the first ion dose amorphizing a first region of the thin crystalline semiconductor structure; performing a second ion implant comprising dopant ions of a dopant species into at least the first region of the thin crystalline semiconductor structure; and performing at least one anneal of the semiconductor device after the first implant, wherein after the first and second implant and the at least one anneal, the thin crystalline semiconductor structure forms a mono-crystalline region without defects. | 07-30-2015 |
Meenakshi Rao, Jamaica Plain, MA US
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20130131144 | GDE Compositions and Methods - The present invention relates to compositions to treat glycerophosphodiester phosphodiesterase (GDE) related disorders. The invention also relates to methods treating GDE related disorders. The invention further relates to kits for treating GDE related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating GDE related disorders in a subject. | 05-23-2013 |
Milini A. Rao, Andover, MA US
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20150127497 | Search Based Content Inventory Comparison - The subject matter of this specification can be implemented in, among other things, a method that includes receiving a selection of content filters for content data that identifies products, packages, and repositories, and receiving a selection of environment filters. The method includes filtering the content data to identify content items in view of the content filters and the environment filters. The content items include one or more of the repositories, the products, or the packages. The method includes causing presentation of a list of the content items, which organizes the content items in view of release environments that are within the content items and repositories that are within the content items. The method includes receiving a selection of repository-environment combinations from the subset of the release environments and the subset of the repositories and causing presentation of a comparison of ones of the packages for each of the repository-environment combinations. | 05-07-2015 |
Naveen Gandham Rao, North Attleboro, MA US
Patent application number | Description | Published |
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20090310672 | Method and System for Rate Control in a Video Encoder - A method and system for a rate control block that adjusts the Quantization Parameter (QP) for a frame or macroblock based on the number of bits already used in encoding the frame or macroblock is disclosed. In an embodiment of the invention, the QP for a macroblock is adjusted dynamically against the QP for a frame as a function of the buffer occupancy. In another embodiment of the invention, a range of allowable QPs are defined based on the buffer occupancy. Embodiments of the invention are applicable to H.264 high-definition video conferencing. | 12-17-2009 |
Patricia Rao, Acton, MA US
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20090318357 | Molecules Preferentially Associated with Effector T Cells or Regulatory T Cells and Methods of Their Use - The present invention is based, at least in part, on the finding that certain molecules are preferentially associated with effector T cells or regulatory T cells. Accordingly, immune responses by one or the other subset of cells can be preferentially modulated. The invention pertains, e.g., to methods of modulating (e.g., up- or down-modulating), the balance between the activation of regulatory T cells and effector T cells leading to modulation of immune responses and to compositions useful in modulating those responses. The invention also pertains to methods useful in diagnosing, treating, or preventing conditions that would benefit from modulating effector T cell function relative to regulatory T cell function or from modulating regulatory T cell function relative to effector T cell function in a subject. The subject methods and compositions are especially useful in the diagnosis, treatment or prevention of conditions characterized by a too-vigorous effector T cell response to antigens associated with the condition, in the diagnosis, treatment or prevention of conditions characterized by a weak effector T cell response, in the diagnosis, treatment or prevention of conditions characterized by a too-vigorous regulatory T cell response, or in the diagnosis, treatment, or prevention of conditions characterized by a weak regulatory T cell response. | 12-24-2009 |
20110008330 | Compositions and methods of tolerizing a primate to an antigen - Inducing tolerance in a primate by use of a compound, or a combination of at least two compounds, that has certain characteristics when tested in vitro. The compound, alone or in combination, is preferably TRX1 antibody and the compound or combination is preferably used in accordance with a specified dosing regimen. | 01-13-2011 |
20150139986 | ILT3 BINDING MOLECULES AND USES THEREFOR - The present invention provides binding molecules that specifically bind to ILT3, e.g., human ILT3 (hILT3), on antigen presenting cells, such as for example, monocytes, macrophages and dendritic cells (DC), e.g., monocyte-derived dendritic cells (MDDC). The binding molecules of the invention are characterized by binding to hILT3 with high affinity and downmodulating immune responses in vitro, e.g., downmodulating alloimmune responses; the production of inflammatory cytokines by dendritic cells, e.g., monocyte-derived dendritic cells (MDDC); the upregulation of costimulatory molecules by DC, e.g., MDDC; and/or calcium flux in monocytes. In addition, the binding molecules upregulate the expression of inhibitory receptors on dendritic cells, e.g., immature dendritic cells. Surprisingly, these same binding molecules which downmodulate immune responses in vitro, are immunostimulatory in vivo. | 05-21-2015 |
Patricia E. Rao, Acton, MA US
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20130150440 | USE OF BIS [THIOHYDRAZIDE AMIDE] COMPOUNDS SUCH AS ELESCLOMOL FOR TREATING CANCERS - Improved cancer treatments with bis[thiohydrazide amide] compounds such as elesclomol, in particular for identifying patient populations that would benefit from such treatments. | 06-13-2013 |
Poornima Rao, Waltham, MA US
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20150174263 | COMPOSITIONS FOR TREATING CANCER AND METHODS FOR MAKING THE SAME - Described herein are compositions and methods relating to chemotherapeutic agent conjugates and the treatment of cancer. | 06-25-2015 |
Prasad Rao, Westborough, MA US
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20110143644 | AIR REMOVAL UNIT - An air removal unit configured for removing exhaust air from an equipment rack or enclosure includes multiple fans to achieve a high airflow capacity while defining a compact and portable structure. The unit removably installs along an exhaust side of an equipment rack or enclosure to provide capabilities for managing the thermal output of equipment, such as servers, CPUs, communications, internetworking and other types of equipment. The unit includes one or more upper fan modules and one or more lower fan modules positioned below the upper fan modules. The upper and the lower fan modules are arranged in a stacked configuration along the depth of the unit with the lower fan modules positioned in an offset orientation relative to the upper fan modules. The stacked configuration and the offset orientation of the fan modules help to incorporate multiple fans with the unit while maintaining the compact and portable design. The unit is further configured to serve as a door of an equipment rack or enclosure to thereby provide access to the unit and the rack or enclosure during operation. The unit can be incorporated with a ventilation system or a cooling air system associated with an equipment room or data center. | 06-16-2011 |
Prashanth Rao, Wilmington, MA US
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20150078167 | Systems and Methods for Providing LTE-Based Backhaul - Systems and methods are disclosed for enabling a mesh network node to switch from a base station role to a user equipment role relative to a second mesh network node, and vice versa. By switching roles in this manner, the mesh network node may be able to benefit from increased uplink or downlink speed in the new role. This role reversal technique is particularly useful when using wireless protocols such as LTE that are asymmetric and allow differing throughput on uplink and downlink connections. Methods for determining whether to perform role reversal are disclosed, and methods for using role reversal in mesh networks comprising greater than two nodes are also disclosed. | 03-19-2015 |
20150094114 | Adjusting Transmit Power Across a Network - Systems and methods are disclosed for adjusting transmit power in a wireless network. In one embodiment, a method is disclosed that includes identifying a selected base station with a first coverage area for adjustment of transmit power; identifying a plurality of neighboring base stations with coverage areas nearby the first coverage area; retrieving a plurality of signal strength measurements from a plurality of mobile devices within the coverage areas of the plurality of neighboring base stations; determining, based on the plurality of measurements, an effect on the plurality of mobile devices within the coverage areas of the plurality of neighboring base stations; and sending an instruction for adjustment of transmit power to the selected base station. | 04-02-2015 |
20150098385 | Multicast and Broadcast Services Over a Mesh Network - A system is disclosed for providing multicast services to mobile devices, comprising a first network node providing a radio access network to a mobile device; a second network node coupled to the first network node and providing backhaul routing for the first network node; a controller node, coupled to both the first and the second network node and to a multicast packet gateway, wherein the controller node provides a virtualized interface of a single network node to the multicast packet gateway, thereby virtualizing the first and second network nodes to the multicast packet gateway such that the multicast packet gateway may be enabled to send a multicast data stream to the first and the second network nodes via the controller node. | 04-09-2015 |
20150257051 | Federated X2 Gateway - A gateway for X2 interface communication is provided, including: an X2 internal interface for communicating with, and coupled to, a plurality of radio access networks (RANs); and an X2 external interface for communicating with, and coupled to, a destination outside of the plurality of RANs, the X2 external interface further including a single X2 endpoint for the plurality of radio access networks, such that the X2 external interface provides a single interface for an external macro cell or core network to interact with the plurality of radio access networks. The gateway may further include a handover module for maintaining X2 signaling associations and transactions for incoming and outbound handovers, including X2 to S1 and S1 to X2 translation. | 09-10-2015 |
Prashanth Rao, Lowell, MA US
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20090163238 | Adjusting Wireless Signal Transmission Power - A home base station receives signal to interference and noise ratio data from at least one access terminal, determines whether a transmission power of the home base station should be adjusted based on the received signal to interference and noise ratio data, and then adaptively adjusts the transmission power of the home base station based on the received signal to interference and noise ratio data. | 06-25-2009 |
Rajesh R. Rao, Norwood, MA US
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20150322460 | COMPOSITIONS AND METHODS FOR REGULATING THERMOGENESIS AND MUSCLE INFLAMMATION USING METRNL AND METRN - The invention provides compositions and methods for regulating thermogenesis and muscle inflammation through modulation of Metrnl and/or Metrn activity and/or expression. Also provided are methods for preventing or treating metabolic disorders and muscle inflammation disorders in a subject through modulation of Metrnl and/or Metrn activity and/or expression. Further provided are methods for identifying compounds that are capable of treating metabolic disorders and muscle inflammation disorders by modulating Metrnl and/or Metrn activity and/or expression. | 11-12-2015 |
Ramdas Rao, Brighton, MA US
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20110227797 | GRID NODE - There is provided a grid node having an outer shell, an inner shell that forms a space therebetween, and a multiprotocol antenna array positioned in the space. The multiprotocol antenna array has a supporting matrix; a first number of antennae that receive different RF frequencies, and the gird node can be changed to any one of the frequencies without removal of the grid node from its physical site. | 09-22-2011 |
Ram Das S. Rao, Brighton, MA US
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20130206944 | BRACKET - A bracket is provided that includes a plurality of apertures for mounting the bracket to a variety surfaces and connecting equipment selected by a user. The bracket may include an adjustable supporting arm and a connection box for providing a secure area for input and output devices to the equipment. The bracket may have a configuration that facilitates its mounting on a telephone or utility pole. | 08-15-2013 |
Ramdas Sitaram Rao, Brighton, MA US
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20130219279 | AGGREGATING NODES FOR EFFICIENT NETWORK MANAGEMENT SYSTEM VISUALIZATION AND OPERATIONS - There is provided a method that includes (a) accessing a data structure that (i) represents a plurality of nodes in an electrical power grid, and (ii) contains data indicative of an event reported by a node in the plurality of nodes, and (b) presenting, on a user interface, an element that represents the plurality of nodes, in aggregate, and indicates an existence of the event. There is also provided a system that performs the method, and a storage medium that contains instructions that cause a processor to execute the method. | 08-22-2013 |
20140129813 | PRODUCT HAVING A STORAGE DEVICE THAT HOLDS CONFIGURING INFORMATION - There is provided a product that includes (i) a component, (ii) a storage device that holds a configuration code that indicates that the component is installed in the product, (iii) a processor, and (iv) a memory that contains instructions that are readable by the processor and that control the processor to (a) read the configuration code from the storage device, (b) determine from the configuration code that the component is installed in the product, thus yielding a determination, and (c) execute an operation in response to the determination. | 05-08-2014 |
20150128254 | OFFLINE AUTHENTICATION WITH EMBEDDED AUTHORIZATION ATTRIBUTES - There is provided a method that includes (a) including in a dataset, data indicative of a time, (b) executing a hash function on the dataset to yield a hash value, and (c) employing the hash value as a password for a user to access a device. There is also provided a method that includes (a) including in a dataset, data indicative of a time, (b) executing a hash function on the dataset to yield a hash value, (c) determining that the hash value matches a password from a user, and (d) granting to the user, access to a device. There are also provided systems that perform the methods and storage devices that contain instructions for causing processors to perform the methods. | 05-07-2015 |
Reeta Prusty Rao, Newton, MA US
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20110033442 | TARGETS, INCLUDING YAP1, FOR ANTIFUNGAL DRUG DISCOVERY AND THERAPY - The present invention is based on the discovery of a two organism model system that can be used to identify virulence factors. The system is also useful in the process of drug delivery. More specifically, we have established valid fungal infection in | 02-10-2011 |
20140041064 | COMPOSITIONS AND METHODS FOR IDENTIFYING VIRULENCE FACTORS AND ANTI-FUNGAL AGENTS - The present invention is based on the discovery of a two- or three-organism model system that can be used to identify virulence factors involved in fungal infection and to screen for agents that attenuate the activity of those factors. The system includes a model eukaryote, the nematode, | 02-06-2014 |
Reeta Prusty Rao, Shrewsbury, MA US
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20140142107 | ANTIFUNGAL AGENTS AND USES THEREOF - Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial agents. | 05-22-2014 |
Sambasiva Rao, Franklin, MA US
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20110110950 | Therapeutic regimens for BAFF antagonists - Therapeutic regimens for administration of BAFF antagonists for treatment of immunologic and related disorders are described. Regimens involve a short-term BAFF antagonist administration course followed by an extended no-treatment period prior the round of administration. | 05-12-2011 |
20130230538 | METHOD OF TREATING A PATIENT HAVING AN AUTOIMMUNE DISORDER BY ADMINISTERING BAFFR POLYPEPTIDE - Therapeutic regimens for administration of BAFF antagonists for treatment of immunologic and related disorders are described. Regimens involve a short-term BAFF antagonist administration course followed by an extended no-treatment period prior the round of administration. | 09-05-2013 |
20150098953 | METHODS OF TREATING A PATIENT HAVING AN AUTOIMMUNE DISORDER BY ADMINISTERING A BAFF ANTAGONIST - Therapeutic regimens for administration of BAFF antagonists for treatment of immunologic and related disorder are described. Regimens involve a short-term BAFF antagonist administration course followed by an extended no-treatment period prior the round or administration. | 04-09-2015 |
Satyaprakash Rao, Marlborough, MA US
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20100229166 | SYSTEM AND METHOD FOR UPDATE OF FIRMWARE OF A STORAGE ARRAY CONTROLLER IN A STORAGE AREA NETWORK - A system and method for update of firmware of a storage array controller of a storage device in a storage area network. The I/O workload of the storage device is monitored to obtain workload information regarding I/O traffic of the storage device. The workload information is analyzed to identify patterns in the I/O traffic of the storage device. Based on one or more identified patterns in the I/O traffic, future I/O workload of the storage device is forecasted, and, according to the forecasted future I/O workload, at least one firmware update is scheduled. | 09-09-2010 |
20100293316 | Migration of Switch in a Storage Area Network - A method, system and computer program product for migrating at least one switch in a storage area network is disclosed. The migration is done by analysing the I/O traffic to identify patterns in the I/O traffic of the switch; forecasting future I/O workload of the switch based on one or more identified patterns in the I/O traffic, determining appropriate timing for migration based on the identified patterns and administrator inputs; processing the storage area network configuration data to identify the storage network physical and logical access paths to the or each selected switch to create a first connectivity map; generating a second connectivity map based on the first connectivity map and administrator inputs; and migrating the or each switch migration based on the second connectivity map and the appropriate timing. The migration may comprise routing the I/O traffic from the switch to be migrated to the alternate switches in the storage area network. The migration may further comprising transforming zones on the switch to be migrated and deploying the transformed zones to the new switch | 11-18-2010 |
Srinivasa Rao, Andover, MA US
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20140033242 | VIDEO SERVICE ASSURANCE SYSTEMS AND METHODS IN WIRELESS NETWORKS - A computer-implemented method, a video service assurance system, and a wireless network with video service assurance provide analytics associated with video services in a network, such as Long Term Evolution (LTE) wireless networks, and actionable recommendations to improve the video services. In particular, the computer-implemented method of video service assurance includes obtaining measurement data and statistics from at least one network element in a network related to a plurality of video streams thereon, performing data aggregation and analysis with the measurement data and statistics related to the video streams, and providing actionable recommendations for improvement of the video streams to the at least one network element based on the data aggregation and analysis. | 01-30-2014 |
Sudhir Rao, Somerville, MA US
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20110166028 | METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS - The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step. | 07-07-2011 |
20130178391 | METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS - The invention relates to the identification and use of gene expression profiles, or patterns, with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. It is to be understood and will be appreciated that the same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. Classifying may include stratifying the tumor (and thus stratifying a subject having the tumor), e.g., for a clinical trial. The methods may further comprise selecting a treatment based on the classifying step. The gene expression profiles may also aid in the early identification of patients who may be failing a therapeutic protocol with a gamma secretase inhibitor and thus provide the basis for early intervention. | 07-11-2013 |
Vakmiki Rao, Cambridge, MA US
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20140207475 | METHODS AND APPARATUS FOR ORDERS FOLLOW-UP - Methods and apparatus for using a practice management system to track patient compliance with orders issued to a patient by a medical provider. The method comprises determining whether the patient has filled the orders and sending, in response to determining that the patient has not filled the orders, a notification to the patient, wherein the notification includes information instructing the patient to access a user interface to retrieve information about the orders. The method further comprises receiving input via the user interface, wherein the input indicates a status related to filling the orders and updating the practice management system based on the input received via the user interface, wherein the updating is performed in response to receiving the input via the user interface. | 07-24-2014 |
Yeshwanth L. Rao, Burlington, MA US
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20090243584 | Fabrication of microstructures integrated with nanopillars along with their applications as electrodes in sensors - This invention presents microstructures enhanced with nanopillars. The invention also provides a novel way for manufacturing nanopillar-enhanced microstructures, using conventional microfabrication techniques. In some embodiments, the invention also provides methods of use for the nanopillar-enhanced microstructures. | 10-01-2009 |
Yeswanth L. Rao, Burlington, MA US
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20100066346 | Fabrication of microstructures integrated with nanopillars along with their applications as electrodes in sensors - This invention presents microstructures enhanced with nanopillars. The invention also provides ways for manufacturing nanopillar-enhanced microstructures. In some embodiments, the invention also provides methods of use for the nanopillar-enhanced microstructures. | 03-18-2010 |