Patent application number | Description | Published |
20090081765 | CELL ELECTROPHYSIOLOGICAL SENSOR AND METHOD FOR MANUFACTURING THE SAME - In a cell electrophysiological sensor having a thin plate with a through hole, a support plate with a through hole and a container plate with a through hole stuck to an upper portion of this support plate, the support plate and the container plate are stuck to each other through fusion with a portion of the outer shape of a first electrode in a ring shape intervening in a portion of the interface. In this configuration, a cell electrophysiological sensor which allows for measurement with high precision can be attained, and a manufacturing method which is excellent in terms of mass production can be provided. | 03-26-2009 |
20090152110 | Chip For Cell Electrophysiological Sensor, Cell Electrophysiological Sensor Using The Same, and Manufacturing Method of Chip for Cell Electrophysiological Sensor - A chip for a cell electrophysiological sensor has a substrate. The substrate has a through-hole formed from the upside to the downside, and the opening of the through-hole is formed in a curved surface curved from the upside and downside of the substrate toward the inner side of the through-hole. In this configuration, the electrolyte solution (first electrolyte solution and second electrolyte solution) flows more smoothly, and the sample cell can be sucked accurately, and the trapping rate of the sample cells is improved. | 06-18-2009 |
20090281410 | DEVICE FOR CELLULAR ELECTROPHYSIOLOGY SENSOR, CELLULAR ELECTROPHYSIOLOGY SENSOR USING THE DEVICE, AND METHOD FOR MANUFACTURING THE CELLULAR ELECTROPHYSIOLOGY SENSOR DEVICE - A leakage current on a side surface of a sensor chip of a cell electrophysiological sensor is reduced. In order to do so, a sensor chip having a continuity hole and a chip holding part covering the side surface of the sensor chip are provided. The sensor chip includes silicon as a main component, and the chip holding part is made of glass. The chip holding part is adhesively bonded to the side surface of the sensor chip by glass welding. Thus, in the cell electrophysiological sensor device of the present invention, the airtightness between the side surface of the sensor chip and the chip holding part is improved, so that a leakage current can be reduced. | 11-12-2009 |
20100019756 | DEVICE FOR MEASURING CELLULAR POTENTIAL, SUBSTRATE USED FOR THE SAME AND METHOD OF MANUFACTURING SUBSTRATE FOR DEVICE FOR MEASURING CELLULAR POTENTIAL - A device for measuring cellular potential includes a substrate, a first electrode tank, a first electrode, a second electrode tank and a second electrode. The first electrode tank and the second electrode tank are disposed on the upper side and lower side of the substrate, respectively. The first electrode is disposed inside the first electrode tank and the second electrode is disposed inside the second electrode tank. The substrate includes a single crystal plate having a diamond structure with (100) plane orientation or (110) plane orientation. The substrate has a first surface provided with a depression and a second surface facing this first surface. From the depression to the second surface, a through-hole is formed. The depression has an inner wall extending from the opening of the through-hole to the outer periphery, curving and being connected to the first surface. | 01-28-2010 |
20100270148 | CELL ELECTROPHYSIOLOGICAL SENSOR - A cell electrophysiological sensor is provided with: a well having a wall formed by at least one curved face, with opening sections being formed on the two ends thereof; a frame substrate having a through hole and an electrode; a cell electrophysiological sensor chip that is provided with a thin plate having a second through hole; and a void substrate, and in this structure, the frame substrate has a thickness greater than the thickness of the cell electrophysiological sensor chip and the opening diameter of the third opening section is made larger than the opening diameter of the fourth opening section. | 10-28-2010 |
Patent application number | Description | Published |
20090239033 | DIAPHRAGM AND DEVICE FOR MEASURING CELLULAR POTENTIAL USING THE SAME, MANUFACTURING METHOD OF THE DIAPHRAGM - A diaphragm is formed by etching a substrate. This substrate has a first surface provided with a depression by isotropic dry etching, and a second surface opposite the first surface. Furthermore, a through-hole is formed from the depression to the second surface by anisotropic dry etching. The depression and the through-hole are formed by using one resist mask. The depression has a hemispherical shape or a semi-elliptical spherical shape. | 09-24-2009 |
20100126922 | COMPONENT SEPARATION DEVICE - A component separating device includes a flow channel, an acoustic wave generator for generating an acoustic wave in the flow channel, a first inlet channel for introducing a fist solution containing solid particles into the flow channel, a second inlet channel for introducing a second solution, and outlet channels for discharging a solution from the flow channel. A density grade generator is provided at the first inlet channel for forming a density grade of the solid particles. This component separating device extracts the solid particles into a high-purity solution at a high collecting rate. | 05-27-2010 |
20100170790 | BIOSENSOR - A sensor includes a diaphragm having a through-hole ( | 07-08-2010 |
20100203621 | BIOSENSOR - A biosensor has the following elements: a diaphragm having a through-hole; a frame supporting the diaphragm and having a cavity; and pillars formed on the side of inner wall surface of the frame and on the surface of the diaphragm. This structure can suppress the occurrence of bubbles in the vicinity of the through-hole, and easily remove the remaining bubbles. Thus the measuring reliability of the biosensor can be improved. | 08-12-2010 |
20100219488 | SILICON STRUCTURE, METHOD FOR MANUFACTURING THE SAME, AND SENSOR CHIP - A silicon structure of the present invention is provided with a silicon substrate ( | 09-02-2010 |
20110111984 | SEQUENCER - A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon; and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion. | 05-12-2011 |
20110120864 | CELLULAR ELECTROPHYSIOLOGY SENSOR CHIP AND CELLULAR ELECTROPHYSIOLOGY SENSOR USING THE CHIP, AND METHOD OF MANUFACTURING CELLULAR ELECTROPHYSIOLOGY SENSOR CHIP - A cellular electrophysiology sensor is adapted to measure an electrical change of a test cell. A chip for the sensor includes a diaphragm, and a thermally-oxidized film mainly containing silicon dioxide on the diaphragm. The diaphragm includes a silicon layer and a silicon dioxide layer on an upper surface of the silicon layer. A through-hole passing through the silicon layer and the silicon dioxide layer is formed. The through-hole has an opening which opens at the silicon dioxide layer and is adapted to capture the test cell. The thermally-oxidized film is provided on an inner wall surface of the through-hole, and unified with the silicon dioxide layer at the opening of the through-hole. This cellular electrophysiology sensor chip can stably capture the test cell and provides a gigaseal stably even if test cells have different properties, | 05-26-2011 |
20110126590 | PROCESS FOR PRODUCING CELL ELECTROPHYSIOLOGICAL SENSOR AND APPARATUS FOR PRODUCING THE CELL ELECTROPHYSIOLOGICAL SENSOR - A process including holding sensor chip; holding glass tube surrounding the outer periphery of the side surface of sensor chip; applying a wind pressure to the side surface of glass tube from the outside of glass tube and melting glass tube to be glass-welded to the side surface of sensor chip. Thereby, the outer periphery of sensor chip can be surrounded by a highly hydrophilic glass tube. Thus, a cell electrophysiological sensor with high measurement accuracy can be produced. | 06-02-2011 |
20110232794 | FLOW CHANNEL STRUCTURE AND METHOD OF MANUFACTURING SAME - A flow channel structure includes a substrate having a flow channel formed therein, and plural fibrous bristles extending from the inner wall of the flow channel. The flow channel is configured to allow a solution to flow through the flow channel. The inner wall of the flow channel is made of silicon. The flow channel is configured to allow a solution to flow through the flow channel. This flow channel structure can homogenize the solution inside the flow channel. | 09-29-2011 |
20120325657 | SENSOR DEVICE - A sensor device includes a substrate and a sensor chip held on the substrate. The substrate includes a flow channel. The sensor chip includes a plate. The plate includes a first surface and a second surface opposite to the first surface. A plurality of through holes each penetrates through the first surface and the second surface. A direction of a line segment connecting centers of any two adjacent through holes among the plurality of through holes is neither parallel nor perpendicular to the center line of the flow channel. | 12-27-2012 |
20130008786 | SENSOR CHIP AND STORAGE METHOD THEREOF - A sensor chip is a sensor device for measuring a property of a substance by adsorbing the substance on a surface of the sensor chip. The sensor chip includes a diaphragm having a first surface, a second surface, and at least one through hole penetrating from the first surface to the second surface. At least a part of the first surface, the second surface, and an inner wall surface of the through hole is covered with a noncrystalline solid layer including SiOX as a main component, in which substance X is an element having higher electronegativity than that of silicon. | 01-10-2013 |
20130040094 | FIBROUS PROJECTIONS STRUCTURE - A silicon structure of the present invention is provided with a silicon substrate ( | 02-14-2013 |
20130102099 | METHOD OF MANUFACTURING CELLULAR ELECTROPHYSIOLOGY SENSOR CHIP - A cellular electrophysiology sensor is adapted to measure an electrical change of a test cell. A chip for the sensor includes a diaphragm, and a thermally-oxidized film mainly containing silicon dioxide on the diaphragm. The diaphragm includes a silicon layer and a silicon dioxide layer on an upper surface of the silicon layer. A through-hole passing through the silicon layer and the silicon dioxide layer is formed. The through-hole has an opening which opens at the silicon dioxide layer and is adapted to capture the test cell. The thermally-oxidized film is provided on an inner wall surface of the through-hole, and unified with the silicon dioxide layer at the opening of the through-hole. This cellular electrophysiology sensor chip can stably capture the test cell and provides a gigaseal stably even if test cells have different properties. | 04-25-2013 |
20130288350 | SENSOR - A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon, and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion. | 10-31-2013 |