Sinden
Aaron David Sinden, Valleyford, WA US
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20110198050 | Casting composite ingot with metal temperature compensation - An exemplary embodiment of the invention provides a method of direct chill casting a composite metal ingot. The method involves sequentially casting two or more metal layers to form a composite ingot by supplying streams of molten metal to two or more casting chambers within a casting mold of a direct chill casting apparatus. Inlet temperatures of one or more of the streams of molten metal are monitored at a position adjacent to an inlet of a casting chamber fed with the stream, and the inlet temperatures are compared with a predetermined set temperature for the stream to determine if there is any difference. A casting variable that affects molten metal temperatures entering or within the casting chambers (e.g. casting speed) is then adjusted by an amount based on the difference of the compared temperatures to eliminate adverse casting effects caused by the difference of the inlet temperature and the set temperature. Preferably an adjustment is selected that causes the monitored temperature to approach the set temperature. Another exemplary embodiment provides equipment for operation of the method. | 08-18-2011 |
20120241118 | REDUCTION OF BUTT CURL BY PULSED WATER FLOW IN DC CASTING - The invention provides a method of reducing butt curl during DC casting of a metal ingot. The ingot is cast in at least two stages, including an initial casting stage and then a steady-state casting stage carried out at higher casting speed. The emerging ingot is cooled by directing a liquid coolant onto its outer surface. During the first casting stage, the liquid coolant is directed in the form of at least two streams, including a constant first stream in the form of a series of first jets, and an intermittent second stream in the form of a series of second jets. The first and second jets impact the outer surface at locations spaced from each other peripherally and/or longitudinally of the ingot. Both the first and second streams experience film boiling when they contact the ingot. The invention includes apparatus for the method. | 09-27-2012 |
David Sinden, Valleyford, WA US
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20120160442 | Elimination of Shrinkage Cavity in Cast Ingots - An exemplary embodiment provides a method of eliminating a shrinkage cavity in a metal ingot cast by direct chill casting. The method involves casting an upright ingot having an upper surface at an intended height. Upon completion of the casting, the lower tip of the spout is maintained below the molten metal near the center of the upper surface. The metal flow through the spout is terminated and a partial shrinkage cavity is allowed to form as metal of the ingot shrinks and contracts. Before the partial cavity exposes the lower tip of the spout, the cavity is preferably over-filled with molten metal, while avoiding spillage of molten metal, and then the flow of metal through the spout is terminated. These steps are repeated until no further contraction of the metal causes any part of the upper surface to contract below the intended ingot height. | 06-28-2012 |
20140262119 | INTERMITTENT MOLTEN METAL DELIVERY - Automated processes that dynamically control rate of delivery of molten metal to a mold during a casting process. Such automated processes can use dynamic metal level variation, control pin pulses and/or oscillation during the mold fill and transient portion of the cast. It has been found that such pulses keep metal flowing in a manner that addresses problems, particularly at the beginning of an ingot cast, associated with metal meniscus contracting and pulling away from the mold on the short faces and corners. | 09-18-2014 |
20150224573 | INTERMITTENT MOLTEN METAL DELIVERY - Automated processes that dynamically control rate of delivery of molten metal to a mold during a casting process. Such automated processes can use dynamic metal level variation, control pin pulses and/or oscillation during the mold fill and transient portion of the cast. It has been found that such pulses keep metal flowing in a manner that addresses problems, particularly at the beginning of an ingot cast, associated with metal meniscus contracting and pulling away from the mold on the short faces and corners. | 08-13-2015 |
John Sinden, Surrey GB
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20090238799 | Conditionally-Immortalised Pancreatic Cells - Conditionally immortalized pancreatic cells are produced which remain immortal in the presence of 4-hydroxytamoxifen (4-OHT) but express normal pancreatic cell markers when 4-OHT is not present. The cells therefore permit cell lines to be constructed to produce cells useful for transplantation or in screening assays. | 09-24-2009 |
20120076854 | CELLULAR COMPOSITIONS FOR USE IN THERAPY - The present invention provides a therapeutic composition comprising: | 03-29-2012 |
20120093786 | TREATMENT OF LIMB ISCHEMIA - The present invention uses neural stem cells in the manufacture of a medicament for the treatment of a patient suffering peripheral arterial disease. The invention is particularly suited for treating limb ischemia or Buerger's disease. | 04-19-2012 |
20130045189 | METHODS OF TREATING STROKE THROUGH ADMINISTRATION OF CTX0E03 CELLS - The subject invention pertains to methods to enhance the therapeutic effects of cellular or drug treatment in various diseases and disorders. More particularly, the present invention provides methods of treating disorders by administering CTX0E03 cells to the patient, intravenously or intraarterially. The treatment is useful for neurodegenerative diseases, such as stroke. The CTX0E03 cells may be cryopreserved and/or passaged before administration into the patient. Administration of the CTX0E03 cells into stroke rat models was at or within 48 hours after stroke. Testing of the rat models through elevated body swing test to measure of neurobehavioral status at the time of transplant and repeated triphenyltetrazolium chloride (TTC) staining as a measure of infarct volume showed short term survival that provided significant protection from the stroke. | 02-21-2013 |
20140341868 | TREATMENT OF LIMB ISCHEMIA - The present invention uses neural stem cells in the manufacture of a medicament for the treatment of a patient suffering peripheral arterial disease. The invention is particularly suited for treating limb ischemia or Buerger's disease. | 11-20-2014 |
John Sinden, Guildford, Surrey GB
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20150366897 | STEM CELL MICROPARTICLES AND miRNA - This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production, in particular neural stem cell microparticles and their use in therapy. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601). Identified miRNAs include hsa-miR-1246, hsa-miR-4492, hsa-miR-4488 and hsa-miR-4532. | 12-24-2015 |
John Sinden, Guildford GB
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20130171177 | Therapeutic Use of Neural Stem Cells - The present invention provides an isolated cell obtainable from the CTX0E03 neural stem cell line for use in the treatment of a disorder associated with elevated levels of pro-inflammatory cytokines, wherein the disorder is selected from unipolar and bipolar depression, schizophrenia, obsessive compulsive disorder, autism and autistic syndrome disorders. | 07-04-2013 |
20150079046 | STEM CELL MICROPARTICLES - This invention relates to stem cell microparticles, their use and production, in particular neural stem cell microparticles and their use in therapy. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601). | 03-19-2015 |
Joseph D. Sinden, Walla Walla, WA US
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20100147979 | POWER-ASSISTED DOCKING STATION FOR MOBILE IRRIGATION APPARATUS - A mobile irrigation apparatus includes a frame assembly supporting at least one sprinkler and adapted for movement in a first direction along a path in a field to be irrigated; a docking station suspended from the frame assembly and adapted to engage and open one or more supply valves in a hydrant located in or adjacent the path for movement in a second direction substantially transverse to the first direction, and at least one power actuator arranged to move the docking station in the second direction in response to at least one sensor to thereby facilitate lateral alignment of the docking station with the hydrant. | 06-17-2010 |
Joseph Daniel Sinden, Walla Walla, WA US
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20100288846 | CONTINUOUS-FEED LINEAR IRRIGATOR WITH SEPARATE OR INTEGRATED DOCKING DEVICES AND RELATED METHOD - A linear irrigation system includes a linear irrigator movable in a first direction along a path of travel and including plural towers supporting a truss assembly extending laterally in a direction substantially perpendicular to the path of travel. The truss assembly carries a plurality of sprinklers connected to a water supply pipe. A plurality of hydrants are spaced along the water supply pipe, each hydrant having a valve, and a pair of laterally adjacent trolleys are mounted on an elongated frame for movement in two opposite directions, each trolley having a docking station and hydrant valve actuator, the docking stations resiliently suspended from said trolleys for movement in at least three mutually perpendicular directions and adapted to engage and disengage, successively, the plurality of hydrants on the supply pipe extending below and between the pair of trolleys. The trolleys and docking stations may be carried on a mobile cart or incorporated into the linear irrigator | 11-18-2010 |
Kenneth Walter Sinden, Essex GB
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20080227988 | Crystallisation and Purification of Glycopyrronium Bromide - A method for the production of crystalline glycopyrronium bromide, comprises the reaction of glycopyrronium base with methyl bromide in a solvent, in which the solvent is selected such that the diastereoisomeric ratio of the product favours the R, S and S, R diastereoisomers over the R, R, and S, S diastereoisomers, and separating the desired diastereoisomers by one or more controlled crystallisation steps. This method gives a product having a particle size of narrow distribution. | 09-18-2008 |
Richard Sinden, Worcestershire GB
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20140134224 | STABLE COMPOSITION OF HOCI, A PROCESS FOR ITS PRODUCTION AND USES THEREOF - A stable antimicrobial aqueous hypochlorous acid solution that retains its activity for at least three months and can be provided with high levels of hypochlorous acid (more than 500 ppm), the aqueous hypochlorous acid composition having low chloride concentrations (maximum chloride levels of 1:3 chloride to hydrochlorous acid) and a pH between 3.5 and 7.0 to stabilise the composition without the need for additional stabilisers. A solid composition is also provided for producing the stable solution. | 05-15-2014 |
Robert Sinden, Berks GB
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20080241075 | Parasite Vaccine - The present invention includes compositions and methods for the development and use of a vaccine that includes one or more FusM antigens in a carrier adapted to trigger a FusM-specific immune response in the human blood stream. | 10-02-2008 |
Robert E. Sinden, Berks GB
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20110091526 | Parasite Vaccine - Compositions and methods for the development and use of a vaccine that includes one or more FusM antigens in a carrier adapted to trigger a FusM-specific immune response in the human blood stream are disclosed herein. | 04-21-2011 |