Brown, MD
Adam Brown, Berwyn Heights, MD US
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20110014472 | PREPARATION OF SILICA STABILIZED BIOLOGICAL TEMPLATES FOR THE PRODUCTION OF METAL AND LAYERED NANOPARTICLES - The present invention relates to a system and method providing for increased silica growth on a bio-template, wherein the bio-template is pretreated with aniline to produce a uniform silica attractive surface and yielding a significant silica layers of at least 10 nm, and more preferably at least 20 nm in thickness, thereby providing for a high degree of stability to the bio-template. | 01-20-2011 |
Alicja T. Brown, Silver Spring, MD US
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20120201849 | VACCINE STABILIZER - Disclosed herein is a formulation capable of enhancing thermostability and shelf-life of a biological product, the formulation comprising: a tertiary amine N-oxide or a derivative thereof represented by the formulae: | 08-09-2012 |
Ami Shah Brown, Halethorpe, MD US
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20110200640 | MULTIVALENT ANTIHELMINTHIC VACCINE - A multivalent anthelmintic vaccine targets both hookworm and schistosomiasis. The vaccine includes, at a minimum, a recombinant third-stage larval hookworm antigen, a recombinant adult stage hookworm antigen, and a recombinant schistosome antigen. Preferably, the hookworm antigens are | 08-18-2011 |
Andrea M. Brown, Baltimore, MD US
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20150314625 | HIGH RESOLUTION LASER LABELING OF MICROSCOPIC GLASS SLIDES AND HISTOLOGICAL SECTIONS - The present invention is directed to a device and a laser, eye-safe method for laser marking slides for use in conjunction with a light microscope. The device is an attachment for a light microscope that allows the operator to make marks on preparations of biological tissues or other materials placed on a glass slide or between a glass slide and a cover slip. The marks can be used to indicate or highlight a microscopic structure or feature of interest. The marking on the slide is performed as the specimen is examined, without having to remove it from the microscope stage. In this way the invention has application in a biomedical or pathology laboratory for diagnostic, research, archival, and teaching or training purposes. | 11-05-2015 |
Andrew David Brown, Columbia, MD US
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20080245460 | RUNFLAT TIRE WITH SIDEWALL COMPONENT CONTAINING HIGH STRENGTH GLASS BUBBLES - A pneumatic runflat tire comprising a sidewall component comprising a rubber composition comprising at least one diene based elastomer and from about 1 to about 40 phr of glass bubbles having a crush strength of at least 10,000 psi as measured by ASTM D3102-78 in glycerol. | 10-09-2008 |
Anthony Brown, Hyattsville, MD US
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20090277896 | MULTI-FUNCTION LIQUID CONTAINER - A container is provided for heating or otherwise processing the contents of the container. For example, the container may be a kettle or kettle for heating fluids therein. The container may receive a command, desired characteristic or desired range for processing the contents of the container. The container may further include at least one sensor such as a temperature sensor or pressure sensor for determining a corresponding characteristic of the contents of the container. Based on at least one determined characteristic and/or the input command, the container may heat or otherwise process the contents therein. The results and/or current status of the contents may further be provided through a display. Also, based on the current status of the contents, the container may further process/heat the contents or discontinue processing/heating of the contents. | 11-12-2009 |
Arick Brown, Rockville, MD US
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20140309403 | NOVEL PROTEIN PURIFICATION METHODS - The invention provides methods of reducing fouling of ultrafiltration membranes in processes wherein virus particles are removed from aqueous solutions comprising virus particles and at least one protein by adding a surfactant or non-surfactant, non-ionic agent to the aqueous solution prior to filtration. The invention also provides methods to dissociate protein aggregates or to reduce the formation of protein aggregates by adding a surfactant or non-surfactant, non-ionic agent to the protein solution. | 10-16-2014 |
Ari D. Brown, Baltimore, MD US
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20130043394 | APPARATUS FOR ULTRASENSITIVE LONG-WAVE IMAGING CAMERAS - An apparatus for ultrasensitive long-wave imaging cameras is provided. In one embodiment, the apparatus includes a filter configured to allow high frequencies of interest to pass through the filter. The apparatus also includes an antenna that is configured to receive the high frequencies of interest. The apparatus further includes a plurality of bolometers that are configured to measure data regarding the high frequencies of interest. | 02-21-2013 |
Bruce Brian Brown, Severna Park, MD US
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20160001857 | Subsea Structure Cleaning Apparatus and Method - The invention relates to an apparatus and related method for cleaning vessel hulls and other subsea structures at sea. In an embodiment, a hull cleaning system comprises a housing defining an interior void; a multifunction bar; a propulsion system; a power system; a positioning system; a water pump operatively connected to the power system; a high flow manifold operatively in fluid communication with the water pump; a hull cleaner; and a suction device configured to selectively adhere the hull cleaning system to a hull. In a further embodiment, a remotely operated work class vehicle, which is typically able to be deployed from any platform outfitted to accept its launch, recovery and support equipment and which may further be innately unstable when not adhered to an underwater structure such as when flying through open water, comprises a frame; an inspection sensor; a hydraulically powered, high pressure water jet pump; a predetermined tooling set connected to the housing; and a propulsion system, which includes a suction device, configured to propel the remotely operated work class vehicle about a surface. | 01-07-2016 |
Bryan Brown, Silver Spring, MD US
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20120046863 | ORBIT COVARIANCE, ESTIMATION AND ANALYSIS TOOL - Improved orbit/covariance estimation and analysis (OCEAN) system and method are presented utilizing ground station observations collected from satellites passing overhead to estimate the positions, velocities, and other parameters of multiple satellites using weighted least squares (WLS) batch and/or Kalman filter smoothing (KFS) estimation algorithms to estimate each parameter, with or without a priori knowledge of the errors involved with each observed parameter. | 02-23-2012 |
Christopher M. Brown, Gaithersburg, MD US
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20150323153 | OPTICAL TRANSFORMER, PROCESS FOR MAKING AND USE OF SAME - An optical transformer includes: an optomechanical member configured: to receive incident light; and to produce primary light from the incident light including an initial propagation that includes a nonlinear scan; and a lens configured: to receive the primary light from the optomechanical member; to linearize the nonlinear scan; and to produce secondary light including a final propagation that comprises a linear scan, such that the optical transformer is configured to transform the nonlinear scan of the primary light to the linear scan of the secondary light. A process for optically transforming a nonlinear scan includes receiving an incident light by an optical transformer that includes an optomechanical member and a lens; producing a primary light from the incident light that includes an initial propagation having a nonlinear scan; communicating the primary light from to the lens; and producing a secondary light to optically transform the nonlinear scan, the secondary light including a final propagation that comprises a linear scan, based on optically linearizing the initial propagation. | 11-12-2015 |
Christopher Y. Brown, Olney, MD US
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20100217299 | SURGICAL REMOVAL OF INTERNAL TISSUE - Methods and devices are provided for macerating and removing tissue. In general, a maceration device is provided that can be distally advanced into a body in a minimally invasive surgical procedure and positioned proximate to tissue desirable for removal from the body. The maceration device can include an elongate shaft having a cutting element positioned on the shaft's side (i.e., not located on a distal tip of the elongate shaft). The cutting element can rotate to macerate tissue. When being introduced to the body, an elongate axis of the elongate shaft and a longitudinal axis of the cutting element can be substantially parallel to each other. When the cutting element rotates, the elongate axis of the elongate shaft and longitudinal axis of the cutting element can not be parallel during at least a portion of the cutting element's rotation. | 08-26-2010 |
20130197306 | Cable-Driven Morphable Manipulator - A device includes first and second sheets of first and second elastic materials, respectively, and a control wire. The first sheet has a first thickness and a first length and is shaped to have a first cross-section having a first inner periphery and a first outer periphery. The second sheet has a second thickness and a second length and is shaped to have a second cross-section having a second inner periphery and a second outer periphery. One of the first sheet and the second sheet has a spacing disposed in along one of the first length and the second length, respectively. The first outer periphery is less than or equal to the second inner periphery. The second sheet surrounds the first sheet. The control wire has an end constrained to one of the first sheet the first material and the second sheet. The control wire is disposed within the spacing. | 08-01-2013 |
David M. Brown, Baltimore, MD US
Patent application number | Description | Published |
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20150314625 | HIGH RESOLUTION LASER LABELING OF MICROSCOPIC GLASS SLIDES AND HISTOLOGICAL SECTIONS - The present invention is directed to a device and a laser, eye-safe method for laser marking slides for use in conjunction with a light microscope. The device is an attachment for a light microscope that allows the operator to make marks on preparations of biological tissues or other materials placed on a glass slide or between a glass slide and a cover slip. The marks can be used to indicate or highlight a microscopic structure or feature of interest. The marking on the slide is performed as the specimen is examined, without having to remove it from the microscope stage. In this way the invention has application in a biomedical or pathology laboratory for diagnostic, research, archival, and teaching or training purposes. | 11-05-2015 |
David M. Brown, Ellicott City, MD US
Patent application number | Description | Published |
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20130048884 | AGILE IR SCENE PROJECTOR - An infrared (IR) scene projector device includes a light emitter and a thermal emitter. The light emitter is configured to selectably provide visible light. The thermal emitter includes a vertically aligned carbon nanotube (VACN) array. The VACN array includes a plurality of carbon nanotubes disposed proximate to a thermally conductive substrate, such that a longitudinal axis of the carbon nanotubes extends substantially perpendicular to a surface of the substrate. The thermal emitter absorbs the visible light from the light emitter and converts the visible light from the light emitter into IR radiation. | 02-28-2013 |
20140086267 | High Energy Fiber Laser Modulator - A laser device includes a seed laser, a polarizer, a pseudorandom bit sequence (PRBS) pattern generator, and a phase modulator. The polarizer may be optically coupled to receive an output of the seed laser and may generate a polarization filtered output. The PRBS pattern generator may be configured to generate a PRBS pattern. The phase modulator may be configured to apply a PRBS modulation scheme to the polarization filtered output based on the PRBS pattern. The PRBS pattern may be generated to have a length above a first threshold for avoiding an occurrence of backward propagation being in phase with forward propagation in an active fiber receiving an output of the phase modulator when the pattern repeats and below a second threshold for phase mismatch in the active fiber. | 03-27-2014 |
20160112124 | Free Space Optical Communication - An optical communications beacon receiver including a camera for capturing a plurality of beacon images. The plurality of beacon images includes a beacon signal transmitted from a beacon transmitter. The beacon receiver also including processing circuitry configured for determining the state of the beacon signal for each of the plurality of beacon images based on the known pattern, at least one beacon image of the plurality of beacon images includes a beacon on state and at least one beacon image of the plurality of beacon images includes a beacon off state, comparing the at least one beacon image including the beacon on state to the at least one beacon image including the beacon off state, and determining a beacon location based on the comparison of the at least one beacon image including the beacon on state to the at least one beacon image including the beacon off state. | 04-21-2016 |
Donald Brown, Baltimore, MD US
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20160090034 | Illuminated Emergency Warning Device - An illuminated emergency warning device for warning drivers to merge into the next lane due to a disabled vehicle. The emergency warning device includes a rectangular housing having a front wall and a rear wall. A first light assembly is disposed on the front wall of the housing and a second light assembly is disposed on the rear wall of the housing, wherein each light assembly is arranged in an arrow shape thereon. The arrow shape indicates to other drivers which direction to proceed in order to avoid the disabled vehicle. The present invention further comprises a flexible support secured to the housing and a mount, wherein the mount allows the device to be removably attached to the exterior of a vehicle. The emergency warning device further includes a power source and a control each electrically connected to the light assemblies for powering and controlling the device. | 03-31-2016 |
Emmet Brown, Dickerson, MD US
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20110245089 | LABORATORY CENTRAL CONTROL UNIT METHOD AND SYSTEM - The present disclosure provides a method for coordinating data between a plurality of sample processing systems comprising: providing, using a central control unit, data to a pre-analytical sample processing system identifying a sample undergoing pre-analytical processing, receiving data, at the central control unit, indicating the transfer of the sample to an analytical system, providing, from the central control unit (CCU), data associated with the sample to the analytical system, and receiving a result associated with the sample from the analytical system | 10-06-2011 |
Emmett Brown, Dickerson, MD US
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20110159578 | Multiple-input Analytical System - The present disclosure provides an automated sample processing system that can receive samples in different first and second formats and process both sample formats. The disclosure also provides a human papillomavirus testing apparatus. The apparatus has a first input to receive first test specimens in the form of pre-processed cervical samples, and a second input to receive unprocessed cervical samples. A first subsystem prepares second test specimens from the unprocessed cervical samples, and a second subsystem selectively processes and tests first specimens, second test specimens, or first and second test specimens to determine the presence of one or more human papillomavirus indicators. | 06-30-2011 |
Eric W. Brown, Taneytown, MD US
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20140322168 | PAENIBACILLUS ALVEI STRAIN TS-15 AND ITS USE IN CONTROLLING PATHOGENIC ORGANISMS ON CROPS - The present invention provides a newly isolated bacterial strain of | 10-30-2014 |
Garry L. Brown, Baltimore, MD US
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20100096906 | Rim cover - The Rim Cover is a specially designed protective shield, specifically intended to protect valuable tire rims from the variety of chemicals typically used when detailing tires. The present invention can be manufactured of coated paperboard or heavy duty plastic material, or of any other suitable material. The Rim Cover can be produced in a variety of sizes appropriate for use with the various size rims available on the market and are a circular, convex unit. | 04-22-2010 |
Jennifer B. Brown, Berlin, MD US
Patent application number | Description | Published |
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20120016715 | OPTIMIZING IT INFRASTRUCTURE CONFIGURATION - A computer implemented method optimizes a configuration of an information technology (IT) infrastructure. A processor establishes a technology rule set, which defines technology weights of an IT infrastructure by mapping capabilities of IT infrastructure components to IT infrastructure attributes needed to execute a specific workload. A candidate IT infrastructure for executing the specific workload is then configured. The processor then receives responses, provided by a customer, to an attribute questionnaire. Each question in the attribute questionnaire is mapped to an IT infrastructure attribute of the candidate IT infrastructure, and the responses define a customer's level of agreement/disagreement with the technology weights. In response to the processor determining that the candidate IT infrastructure fails to meet the customer's expectations, the candidate IT infrastructure is reconfigured until the customer's expectations are met. | 01-19-2012 |
20130246123 | OPTIMIZING IT INFRASTRUCTURE CONFIGURATION - A computer implemented method optimizes a configuration of an information technology (IT) infrastructure. A processor establishes a technology rule set, which defines technology weights of an IT infrastructure by mapping capabilities of IT infrastructure components to IT infrastructure attributes needed to execute a specific workload. A candidate IT infrastructure for executing the specific workload is then configured. The processor then receives responses, provided by a customer, to an attribute questionnaire. Each question in the attribute questionnaire is mapped to an IT infrastructure attribute of the candidate IT infrastructure, and the responses define a customer's level of agreement/disagreement with the technology weights. In response to the processor determining that the candidate IT infrastructure fails to meet the customer's expectations, the candidate IT infrastructure is reconfigured until the customer's expectations are met. | 09-19-2013 |
John Christopher Brown, Hanover, MD US
Patent application number | Description | Published |
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20120088432 | DEER CALL - A deer call includes a cylindrical mouthpiece in which a reed assembly is mounted for oscillatory movement creating a sound replicating that of a deer and a sound attenuating tube secured to the mouthpiece. The mouthpiece is composed of a rigid tubular member and an elastic skin secured about the tubular member. The rigid tubular member includes a central cut-out section exposing the elastic skin to an interior of the mouthpiece thereby defining the elastic skin resonance control surface, wherein the elastic skin in the area of the elastic skin resonance control surface includes a sound control aperture allowing the user to control air pressure within the mouthpiece and thereby control amplitude of sound generated by the deer call. | 04-12-2012 |
Jolie Brown, Bethesda, MD US
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20090184125 | Waste Container - A waste container includes a top chamber, a base chamber, upper and lower lids, and a drive mechanism mechanically coupling the lower lid with the upper lid. The top chamber has a first opening for receiving waste, and the base chamber has a second opening for receiving waste from the top chamber. The upper lid is disposed on the top chamber and moves between a closed position covering the first opening and an open position exposing the first opening. The lower lid is disposed on the base chamber and moves between a closed position covering the second opening and an open position exposing the second opening. The drive mechanism is actuated so as to move the lower lid to the open position when the upper lid moves to the closed position from the open position. The lower lid returns to the closed position when the upper lid is in the closed position. | 07-23-2009 |
Jonathan Miles Brown, Silver Spring, MD US
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20110309831 | SIDE CHAIN DEUTERATED AMINO ACIDS AND METHODS OF USE - Protein structural determination using NMR techniques is improved through use of proteins in which one or more amino acids in the peptidic sequence are isotopically enriched in the sidechain with | 12-22-2011 |
Kevin Edward Brown, Kensington, MD US
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20100136514 | INFECTIOUS CLONE OF HUMAN PARVOVIRUS B19 AND METHODS - The invention relates to infectious clones of parvovirus B19, methods of cloning infectious B19 clones, and methods of cloning viral genomes that have secondary DNA structures that are unstable in bacterial cells. A B19 infectious clone and methods of producing B19 infectious clones are useful for producing infectious virus. Infectious virus is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B19 infections. | 06-03-2010 |
Kimberly Ann Brown, Laurel, MD US
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20120144247 | SYSTEM, APPARATUS AND METHOD FOR PROVIDING TRAINING THROUGH INCORPORATION OF METAPHORICAL EXPRESSIONS - A system, apparatus and method for providing training through incorporation of metaphorical expressions are provided. A method includes receiving selected user preferences via a computer. The method also includes displaying a story board based on the selected user preferences, where the display shows text and images and the computer simultaneously plays vocals. Further, the method includes prompting the user to perform a task. Where the user successfully completes the task, the method includes taking the user to a next task. If the user does not successfully complete the task, the method includes repeating the story board and prompting the user to attempt the task again until the task is successfully completed. | 06-07-2012 |
Lanika A. Brown, Gaithersburg, MD US
Patent application number | Description | Published |
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20080274535 | Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids - A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate-metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. | 11-06-2008 |
20080286759 | Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids - A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. | 11-20-2008 |
20100035298 | Hepatocyte Bioreactor System For Long Term Culture of Functional Hepatocyte Spheroids - A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function for periods on the order of months. The cultures may be used to produce hepatocyte products, evaluate metabolism of an agent, propagate Hepatitis C virus and test agents as inhibitors of this virus. Thus, the culture system disclosed herein makes long term functional cultivation of human hepatocytes feasible. | 02-11-2010 |
Lawrence G. Brown, Towson, MD US
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20090059364 | SYSTEMS AND METHODS FOR ELECTRONIC AND VIRTUAL OCULAR DEVICES - An ocular device is be used to magnify virtual and real scenes in a binocular or monocular configuration. A plurality of lenses is positioned as though each of the lenses is tangent to a surface of a first sphere having a center that is located substantially at a center of rotation of an eye of a user. A plurality of displays is positioned as though each of the displays is tangent to a surface of a second sphere having a radius larger than the first sphere's radius and having a center that is located at a center of rotation of the eye. Each of the displays corresponds to at least one of the lenses, and is imaged by the corresponding lens. A processor displays an image to the user using the plurality of displays. An input device allows the user to adjust a magnification of the image. | 03-05-2009 |
20090243965 | LIGHTWEIGHT HEAD MOUNTED DISPLAY WITH MULTIPLE ADJUSTMENTS - A head mounted display assembly including a frame comprising a base ( | 10-01-2009 |
20110241976 | SYSTEMS AND METHODS FOR PERSONAL VIEWING DEVICES - Images are overlaid using a personal viewing device, such as a head mounted display. The personal viewing device includes a mount, an electronic display, a lens, and an electronic circuit. The electronic display, lens, and electronic circuit are physically attached to the mount. The electronic display and lens are positioned by the mount so that an eye views the electronic display through the lens. The electronic circuit overlays a first image with a second image to produce an overlaid image. The electronic circuit then displays the overlaid image on the electronic display. The electronic circuit can include an image generating device. The image generating device can generate the first image and/or the second image. The image generating device can be a video player or a processor. The personal viewing device can further include a wireless transceiver attached to the mount. | 10-06-2011 |
Mark W. Brown, Myersville, MD US
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20080262739 | Submersible Portable In-situ Automated Water Quality Biomonitoring Apparatus and Method - A submersible biomonitoring system for monitoring water quality in situ includes a submersible chamber constructed of a di-electric material and sized to allow suitable signals from one or more aquatic organisms to be received by eliminating cross-talk between cells while allowing ambient conditions to be maintained inside the chamber. The aquatic organism exhibits ventilatory behavior and body movement sensitive to water quality which manifest as electrical signals picked up by electrodes and communicated to a pre-amplifier that conditions the signals for communication to a land-based amplifier and/or controller that is used to interpret the signals to determine when the water to which the organism is exposed has caused physiological stress to the organism. | 10-23-2008 |
Mark W. Brown, Meyersville, MD US
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20130042332 | Device and method for inducing brain injury in animal test subjects - An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology. | 02-14-2013 |
20140343458 | Device and method for inducing brain injury in animal test subjects - An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology. | 11-20-2014 |
Martin J. Brown, Germantown, MD US
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20090263830 | VISUALIZATION AND QUANTITIATION OF CELLULAR CYTOTOXICITY USING CELL-PERMEABLE FLUOROGENIC PROTEASE SUBSTRATES AND CASPASE ACTIVITY INDICATOR MARKERS - This invention provides a non-radioactive assay to monitor and quantify the target-cell killing activities mediated by cytotoxic T lymphocytes (CTLs). This assay is predicated on the discovery that apoptosis pathway activation and, in particular, caspase activity, provides a measure of cytotoxic effector cell activity. In one embodiment, measurement of CTL-induced caspase activation in target cells is achieved through detection of the specific cleavage of fluorogenic caspase substrates. This assay reliably detects antigen-specific CTL killing of target cells, and provides a more sensitive, more informative and safer alternative to the standard | 10-22-2009 |
Michael A. Brown, Columbia, MD US
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20130099599 | Thermally Efficient Power Conversion Modules for Space Solar Power - A space solar power system that has sun-tracking curved reflectors, such as off-axis parabolic reflectors, a secondary reflector, and a power conversion module for converting the sunlight into microwave energy and transmit the energy to remote locations. The power conversion module can have a modular stepped conical shape, with additional radiator area configured in vertical sidewalls, horizontal radiator panels, or both. Hinged, fold-out units can house the microwave conversion electronics and the antenna for transmitting the microwave radiation to the remote ground station. | 04-25-2013 |
Michael C. Brown, North East, MD US
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20140286936 | ANTI-HUMAN CXCR4 ANTIBODIES - The present invention provides novel antibodies to human CXCR4 with high affinity to the target and the ability to act potently as antagonists. The antibodies disclosed herein bind to a diverse range of epitopes. | 09-25-2014 |
20140322236 | ANTI-HUMAN ADORA2A ANTIBODIES - The present invention provides novel antibodies to human ADORA2A. | 10-30-2014 |
Michael Craig Brown, North East, MD US
Patent application number | Description | Published |
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20120231474 | CONSTRUCTS THAT ALLOW FOR DETECTION AND QUANTITATION OF MEMBRANE PROTEINS - A construct is described that allows for detection and quantitation of membrane-bound polypeptides. | 09-13-2012 |
Michael Jay Brown, Baltimore, MD US
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20120325044 | FIRE CONTROL SWITCH FOR FIREARM - A fire control switch for a firearm includes a lever assembly mounted to a first end or to a second end of a shaft. The lever assembly includes a spring-loaded rotatable pawl moveable between a first position and a second position, wherein the lever assembly is mounted to the shaft when the pawl is in the first position and can be released from the shaft by moving the pawl from the first position to the second position. In other embodiments, a second lever assembly or cap may be mounted to the other end of the shaft. | 12-27-2012 |
Michael Stephen Brown, Pasadena, MD US
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20090251851 | TELECOM POWER DISTRIBUTION UNIT WITH INTEGRATED FILTERING AND TELECOM SHELF COOLING MECHANISMS - The present invention provides highly efficient system level EMI filtering in a dual feed Power Distribution Unit (PDU) using custom designed magnetic components that are uniquely designed to provide excellent performance under various load conditions. The PDU of the present invention includes filters for providing the necessary EMI filtering at all frequencies in the range between 200 Hz and 200 MHz under all load conditions including a single feed failure. Additionally, the present invention provides mechanisms for cooling EMI components using a combination of natural convection and conduction techniques at the board level to ensure no loss of EMI filtering performance. The present invention also includes blank panels made of formed Aluminum alloy sheet metal pieces or the like to direct air flow to components on printed wiring boards (PWB's) using air director plates. | 10-08-2009 |
Michael Stephen Brown, Pasedena, MD US
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20110176810 | SYSTEM AND METHOD FOR MULTI-RATE, HIGH-SENSITIVITY CLOCK AND DATA RECOVERY WITH ADJUSTABLE DECISION THRESHOLD, RF INPUT, AND OPTICAL-TO-ELECTRICAL CONVERSION - The present invention provides a system and method for multi-rate, high-sensitivity CDR, including a variable/adjustable decision threshold, RF input clock recovery, and OE conversion feature. The system includes an optical input connector, CDR circuit, decision threshold circuit, internal power supply, OE converter, external electrical output, and multiple clock outputs. The system is assembled in a single, stand-alone unit. The system includes an OC-192 data output, and OC-192 (9.953-10.709 GHz) and ¼ OC-48 (2.488-2.677 GHz) clock outputs. The decision threshold level is adjustable and optimized by a system user. The system is also used in combination with a digital communications analyzer. A recovered clock of the CDR circuit provides trigger for the DCA. The system includes an electrical input connector. Optionally, the system triggers directly from an RF electrical input in substitution of an optical input. The system is also used to convert an optical signal to an electrical signal, bypassing the CDR circuit. | 07-21-2011 |
Milton Brown, Brookeville, MD US
Patent application number | Description | Published |
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20110281836 | Silent desensitizers of neuronal NACHR and methods of use thereof - One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. | 11-17-2011 |
20150044293 | RADIOPROTECTOR COMPOUNDS - Radioprotector compounds including 3,3′-diindolylmethane (DIM) analogs, are provided. Further provided are methods for their use in reducing or preventing radiation damage, killing a tumor cell and protecting a non-tumor cell, and treating cancer. | 02-12-2015 |
20150344440 | Compounds and Methods of Use Thereof for Treating Tumors - The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses methods for treating or preventing diseases and disorders associated with abnormal cell growth, for example, treating or preventing cancer or tumor growth, which methods include administering to a mammal in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound of the invention or a pharmaceutically acceptable salt thereof. | 12-03-2015 |
Milton I. Brown, Brookeville, MD US
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20110269733 | Silent Desensitizers of Neuronal nAChR and Methods of Use Thereof - One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. | 11-03-2011 |
Milton L. Brown, Brookeville, MD US
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20100130579 | CANCER THERAPY - The present invention relates to methods of inducing expression of an epigenetically silenced gene, RASSF1A, in cells, particularly human cells, such as cancer cells. It also relates to methods of treating an individual, prophylactically or therapeutically, for cancer in which RASSF1A is epigenetically silenced. | 05-27-2010 |
20100317739 | HISTONE DEACETYLASE INHIBITORS - Novel histone deacetylase inhibitors, including novel fluorescent histone deacetylase inhibitors, are described. Methods for making and using the same, e.g., to treat cancer, are provided. | 12-16-2010 |
20110152339 | FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION - The invention provides methods for the treatment of cancer in a subject comprising administering a dansyl-carbazole compound. | 06-23-2011 |
20110230442 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS - Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [ | 09-22-2011 |
20110269178 | FLUORESCENT CDK INHIBITORS FOR TREATMENT OF CANCER - Disclosed are molecules and their synthesis. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo. | 11-03-2011 |
20120128693 | CADHERIN-11 INHIBITORS AND METHODS OF USE THEREOF - Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis. | 05-24-2012 |
20120149663 | BORONIC ACID COMPOSITIONS AND METHODS RELATED TO CANCER - Disclosed are compounds and methods related to boronic acid derivatives of resveratrol. Certain of these derivatives have enhanced efficacy relative to resveratrol, function as irreversible modulators, and act at the GI/S phase of the cell cycle. | 06-14-2012 |
20120196896 | Treatment for Oxidative Stress and/or Hypertension - One aspect of the invention relates to compounds, compositions and methods for treating oxidative stress and/or hypertension. In certain embodiments, the invention relates to a mixture of tempol and an angiotensin receptor blocker (ARB) and the use of said mixture to treat oxidative stress and/or hypertension. In certain embodiments, the invention relates to a tempol/ARB adduct and the use of said adduct to treat oxidative stress and/or hypertension. | 08-02-2012 |
20140088148 | SMALL MOLECULE INHIBITORS OF XBP1 SPLICING - Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity. | 03-27-2014 |
20140135325 | NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING - The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell. | 05-15-2014 |
20140323461 | Phenyl-Substituted Nicotinic Ligands, and Methods of Use Thereof - Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety, Alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, Lewy Body Dementia, Attention Deficit Hyperactivity Disorder (ADHD), Parkinson's disease, Huntington's disease, Tourette's syndrome, amyotrophic lateral sclerosis, inflammation, stroke, spinal cord injury, dyskinesias, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, autism, mutism, trichotillomania, hypothermia, and disorders of sleep. | 10-30-2014 |
20140378428 | 2,5-Disubstituted-Pyridyl Nicotinic Ligands, and Methods of Use Thereof - Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia. | 12-25-2014 |
20150064168 | Cadherin-11 Inhibitors and Methods of Use Thereof - Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis. | 03-05-2015 |
20160031853 | 2-Halo-5-Alkynyl-Pyridyl Nicotinic Ligands - Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia. | 02-04-2016 |
Milton Lang Brown, Brooksville, MD US
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20130158063 | Compounds, Compositions and Methods Related to PPAR Antagonists - Disclosed are compounds, compositions and methods related PPAR antagonists. Certain compounds are effective at inhibiting PPARs. The compositions can be used to inhibit PPARs, treat cancer and treat metabolic disorders. | 06-20-2013 |
Milton Lang Brown, Brookville, MD US
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20100004179 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY - Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein. | 01-07-2010 |
20100167994 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY - Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein. | 07-01-2010 |
20150051260 | METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS - Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors. | 02-19-2015 |
20150329488 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY - Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein. | 11-19-2015 |
Richard G. Brown, Aberdeen, MD US
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20100093584 | Cleansing Formulations Comprising Non-Cellulosic Polysaccharide With Mixed Cationic Substituents - The present invention is related to the use of a non-cellulosic cationically modified polysaccharide in cleaning compositions and more particularly to a surfactant based cleansing composition comprising, a surfactant, a non-cellulosic cationically modified polysaccharide and a solvent for use in personal care composition, household care composition or an institutional care composition. | 04-15-2010 |
Rork S. Brown, Lexington, MD US
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20090307000 | METHOD AND SYSTEM FOR GLOBALLY MONITORING AIRCRAFT COMPONENTS - A method for monitoring information of at least one unemployed aircraft components includes monitoring information relating to each of the unemployed aircraft components, transmitting the information from each location of each the unemployed aircraft components to a remotely located central control, and collecting the information in a computer-readable medium associated with the central control to thereby provide remote access of the information. | 12-10-2009 |
Rosa Brown, Upper Marlboro, MD US
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20090235433 | Disposable Sock with Liquid Impermeable Inner Sole - This invention relates generally to a disposable sock with an inner liquid impermeable layer on the portion that covers the sole of the foot, and a breathable outer layer that encases the liquid impermeable layer and encases the remaining portion of the foot. The characteristics of the present invention increase circulation in the foot, aid in the absorption of a multitude of compounds, including lotions, ointments, or therapeutics to the foot, while minimizing bacterial growth, are cost efficient, lightweight and easy to use. | 09-24-2009 |
20100122783 | Window Covering For Energy Conservation - The present invention is an environmentally conscious window covering that will reduce the demand for electricity and appeal to the market for green building products used in construction and remodeling projects. The present invention is generally comprised of three layers, an outer eco-friendly (or “green) fabric layer that faces the interior of a building, an inner layer that may comprise polyethylene (PET) film layer that is aluminized and reflects 99% of ultraviolet rays, and an inner sheer layer that faces the window. The three layers are not adhered by synthetic or toxic adhesives. The present invention may also be equipped with an opening in the outer layer in the upper portion that can receive a rod for installation in the window space. | 05-20-2010 |
Sean Brown, Curtis Bay, MD US
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20110009107 | Systems, Methods, And Devices For Policy-Based Control and Monitoring of Use of Mobile Devices By Vehicle Operators - Systems, methods, and devices for controlling and limiting use of functions, such as calling, texting, chatting, emailing, Internet surfing, and similar applications, on a mobile device when the mobile device is in a moving vehicle, includes use of an on-board computer installed within the vehicle, a transmitter in electronic communication with the on-board computer that periodically transmits speed data of the vehicle to a receiver installed on the mobile device, wherein the mobile device includes suitable software and a rules-based policy that define and control when and which functions of the mobile device are disabled or interrupted by the software when the vehicle is in motion above a minimum threshold speed. Policies are set by default but may be customized for particular individuals, devices, or circumstances. Policies may also be customized for particular groups or subgroups of employees or contractors for company or legal compliance to reduce distracted driving. | 01-13-2011 |
20130316737 | Systems, Methods, and Devices for Policy-Based Control and Monitoring of Use of Mobile Devices by Vehicle Operators - Systems, methods, and devices for controlling and limiting use of functions, such as calling, texting, chatting, emailing, Internet surfing, and similar applications, on a mobile device when the mobile device is in a moving vehicle, includes use of an on-board computer installed within the vehicle, a transmitter in electronic communication with the on-board computer that periodically transmits speed data of the vehicle to a receiver installed on the mobile device, wherein the mobile device includes suitable software and a rules-based policy that define and control when and which functions of the mobile device are disabled or interrupted by the software when the vehicle is in motion above a minimum threshold speed. Policies are set by default but may be customized for particular individuals, devices, or circumstances. Policies may also be customized for particular groups or subgroups of employees or contractors for company or legal compliance to reduce distracted driving. | 11-28-2013 |
Steve A. Brown, Timonium, MD US
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20100094351 | OCCIPITAL PLATE FOR CERVICAL FIXATION - An adjustable occipital plate includes a central body portion having a plurality of arms extending therefrom in a generally Y-shaped configuration. Two of the arms include elongate slots for slidably receiving retaining members therein. Each retaining member includes a U-shaped channel for receiving a spine rod and a set screw. The central body portion and one arm include openings for receiving bone screws therein. Each of the arms may be angled with respect to the central body portion. | 04-15-2010 |
20120271360 | OCCIPITAL PLATE FOR CERVICAL FIXATION - An adjustable occipital plate includes a central body portion having a plurality of arms extending therefrom in a generally Y-shaped configuration. Two of the arms include elongate slots for slidably receiving retaining members therein. Each retaining member includes a U-shaped channel for receiving a spine rod and a set screw. The central body portion and one arm include openings for receiving bone screws therein. Each of the arms may be angled with respect to the central body portion. | 10-25-2012 |
Steven A. Brown, Timonium, MD US
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20110046675 | TRANSVERSE ROD CONNECTOR - A transverse rod connector includes an elongate member having first and second ends and first and second connection members. The first and second connection members are connected with first and second ends, respectively. The first and second connection members are configured for multidirectional positioning with respect to the elongate member. The first and second connection members are each dimensioned to be selectively and releasably secured to a bone anchor. The elongate member is longitudinally adjustable. | 02-24-2011 |
20150142057 | TRANSVERSE ROD CONNECTOR - A transverse rod connector includes an elongate member having first and second ends and first and second connection members. The first and second connection members are connected with first and second ends, respectively. The first and second connection members are configured for multidirectional positioning with respect to the elongate member. The first and second connection members are each dimensioned to be selectively and releasably secured to a bone anchor. | 05-21-2015 |
20150190179 | TRANSVERSE ROD CONNECTOR - A transverse rod connector includes an elongate member having first and second ends and first and second connection members. The first and second connection members are connected with first and second ends, respectively. The first and second connection members are configured for multidirectional positioning with respect to the elongate member. The first and second connection members are each dimensioned to be selectively and releasably secured to a bone anchor. | 07-09-2015 |
Steven W. Brown, Gaithersburg, MD US
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20130003064 | Dynamic Spectral Radiance Calibration Source - Systems and methods for measuring spectral distribution of an illumination source and providing desired output spectral radiance are described. The systems include a user defineable light source, an integrating sphere, and one or more light detectors. | 01-03-2013 |
Steven W. Brown, Washington Grove, MD US
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20090059210 | Simple matrix method for stray-light correction in imaging instruments - A simple matrix method and computer program product for stray-light correction in imaging instruments is provided. The stray-light correction method includes receiving raw signals from an imaging instrument and characterizing the imaging instrument for a set of point spread functions. For high resolution imaging instruments, the raw signals may be compressed to reduce the size of the correction matrix. Based on stray-light distribution functions derived from the point spread functions, a correction matrix is derived. This fast correction is performed by a matrix multiplication to the measured raw signals, and may reduce stray-light errors by more than one order of magnitude. Using the stray-light corrected instrument, significant reductions may be made in overall measurement uncertainties in radiometry, colorimetry, photometry and other applications. Because the PSFs may include other types of undesired responses, the stray-light correction also eliminates other types of errors, e.g., interreflection between a CCD and the detector window. | 03-05-2009 |
Tarajee Brown, Capitol Heights, MD US
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20090136282 | Disposable Body Wax Applicator System and Method - A single-use quantity of body wax is stored in elongated disposable dispensers. The dispensers are formed from hollow thermoplastic and are heated with a heater to melt the body wax. A dispenser tip is opened and the wax is squeezed out of the dispenser and spread over the desired area using a substantially flat surface of the elongated disposable dispenser. The dispenser is then disposed of after the single use. Additional dispensers can be of various sizes and are used for other body areas. A preferred heater holds multiple dispensers vertically in openings or holes and uses AC power to heat and melt the body wax for use. | 05-28-2009 |
20090189027 | Flexible Bottle Holder - A flexible bottle holder, such as for baby bottles, is made of child-safe plastic and attaches to support surfaces with a hand operated screw clamp. A flexible arm extends from the clamp and has a bottle support at the other end. The bottle support easily adjusts to various bottles and allows for quick and easy insertion and removal of bottles by an adult, but is resistant to easy removal by an infant and does not include any hardware that is dangerous to an infant. In one embodiment, the bottle support uses spring tabs to secure the bottle inside a plastic band. In another embodiment, an elastic fabric jacket secures the bottle to a bottle support cradle with a plurality of hook and loop fasteners. | 07-30-2009 |
Torrey Brown, Severna Park, MD US
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20090297561 | Method for vaccination of poultry by bacteriophage lysate bacterin - The invention provides methods of generating phage lysate bacterins, as well as phage lysate bacterin compositions. The invention further encompasses methods of vaccination comprising administering phage lysate bacterin to an animal in need thereof. The invention further encompasses methods of reducing infection or colonization of poultry or poultry eggs using phage bacterin lysates. | 12-03-2009 |
Torrey C. Brown, Severna Park, MD US
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20090053144 | REDUCTION IN BACTERIAL COLONIZATION BY ADMINISTERING BACTERIOPHAGE COMPOSITIONS - The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage. | 02-26-2009 |
20120148505 | Reduction In Bacterial Colonization By Administering Bacteriophage Compositions - The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage. | 06-14-2012 |
20130164374 | REDUCTION IN BACTERIAL COLONIZATION BY ADMINISTERING BACTERIOPHAGE COMPOSITIONS - The present invention provides a method for reducing the risk of bacterial infection or sepsis in a susceptible patient by treating the susceptible patient with a pharmaceutical composition containing bacteriophage of one or more strains which produce lytic infections in pathogenic bacteria. Preferably, treatment of the patient reduces the level of colonization with pathogenic bacteria susceptible to the bacteriophage by at least one log. In a typical embodiment, the susceptible patient is an immunocompromised patient selected from the group consisting of leukemia patients, lymphoma patients, carcinoma patients, sarcoma patients, allogeneic transplant patients, congenital or acquired immunodeficiency patients, cystic fibrosis patients, and AIDS patients. In a preferred mode, the patients treated by this method are colonized with the pathogenic bacteria subject to infection by said bacteriophage. | 06-27-2013 |