Patent application number | Description | Published |
20080199540 | Orally-administrable compositions comprising stable amorphous calcium carbonate - The present invention provides orally-administrable compositions comprising stable amorphous calcium carbonate (ACC). The compositions are preferably prepared as solid dosage forms such as tablets, capsules and powders. The present invention further provides methods for supplementing oral calcium intake in subjects and as well as methods for treating osteoporosis, osteomalacia and related diseases. | 08-21-2008 |
20100012581 | DENITRIFICATION TREATMENT SYSTEM AND METHOD - A two-stage treatment process, for the treatment of nitrate rich water, particularly aquaculture pond water, wherein in the first stage a degassing chamber is used for removing dissolved oxygen from a stream of water flowing out of the aquaculture system, and in the second stage the stream of water obtained from said degassing chamber is flown into a denitrifying biofilter comprising a biofilter media which functions as a biological growth media and as a carbon source, wherein said denitrifying biofilter is capable of biologically reducing both nitrate and nitrite compounds into nitrogen gas. | 01-21-2010 |
20100098774 | COMPOSITION COMPRISING CRUSTACEAN GASTROLITH COMPONENTS AND ITS USE - Provided is a formulation containing amorphous or microcrystalline calcium carbonate finely interspersed with organic matter in a ratio of 10 parts of the carbonate per 1 to 3 parts of the organic matter, wherein the organic matter consists of chitin and polypeptide. The formulation is efficient in treating various pathological conditions, including proliferative diseases, neurological disorders, and musculoskeletal disorders. | 04-22-2010 |
20100221362 | STABLE AMORPHOUS CALCIUM CARBONATE COMPRISING SYNTHETIC PHOSPHORYLATED PEPTIDES - Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations. | 09-02-2010 |
20100310677 | STABLE AMORPHOUS CALCIUM CARBONATE COMPRISING PHOSPHORYLATED AMINO ACIDS - Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated amino acid which stabilizes the amorphous form of said calcium carbonate. The compositions are useful in pharmaceutical and nutraceutical formulations. | 12-09-2010 |
20110010784 | INSULIN-LIKE GENE OF PRAWNS AND USES THEREOF - Nucleic acid molecules encoding an insulin-like factor of the androgenic gland of the freshwater prawn | 01-13-2011 |
20120073508 | INSULIN-LIKE GENE IN PRAWNS AND USES THEREOF - The present invention relates to a nucleic acid molecule encoding an insulin-like factor of the androgenic gland of the freshwater prawn | 03-29-2012 |
20130122117 | COMPOSITION COMPRISING CRUSTACEAN GASTROLITH COMPONENTS AND ITS USE - Provided is a formulation containing amorphous or microcrystalline calcium carbonate finely interspersed with organic matter in a ratio of 10 parts of the carbonate per 1 to 3 parts of the organic matter, wherein the organic matter consists of chitin and polypeptide. The formulation is efficient in treating various pathological conditions, including proliferative diseases, neurological disorders, and musculoskeletal disorders. | 05-16-2013 |
20150056306 | AMORPHOUS CALCIUM CARBONATE FOR THE TREATMENT OF CALCIUM MALABSORPTION AND METABOLIC BONE DISORDERS - Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor. | 02-26-2015 |
Patent application number | Description | Published |
20110052572 | REGULATORS OF MMP-9 AND USES THEROF - A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed. | 03-03-2011 |
20120003236 | ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS - A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor. | 01-05-2012 |
20130030158 | ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS - An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12. | 01-31-2013 |
20130039922 | ANTIBODIES THAT INHIBIT METALLOPROTEINS - The present application relates to antibodies which recognize [2 (2-aminoethylcarbomoyl)-ethoxymethyl]-tris-[2-N-(3-imidazol-1-yl-propyl))-ethoxymethyl]methane, a hapten molecule which closely mimics the local structure and conformation of the reactive zinc site in matrix metalloproteinases. An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed. | 02-14-2013 |
20130209491 | METHODS OF GENERATING ANTIBODIES TO METALLOENZYMES - A method of generating an antibody which inhibits a metalloenzyme is disclosed. The method comprises immunizing a subject with:
| 08-15-2013 |
20130224225 | ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS - An antibody comprising an antigen recognition region which comprises CDR amino acid sequences set forth in SEQ ID NO: 7, 8, 9, 10, 11 and 12. | 08-29-2013 |
20130280247 | REGULATORS OF MMP-9 AND USES THEREOF - A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed. | 10-24-2013 |
20140141014 | ANTIBODIES THAT INHIBIT METALLOPROTEINS - An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed. | 05-22-2014 |
20140370031 | ANTIBODIES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME USEFUL FOR INHIBITING ACTIVITY OF METALLOPROTEINS - A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor. | 12-18-2014 |
20150132281 | VARIANTS OF TACE PRO-DOMAIN AS TNF-A INHIBITOR AND THEIR MEDICAL USE - A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a pro-domain of TNF-alpha converting enzyme (TACE), said polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification at a site selected from the group consisting of R | 05-14-2015 |
20150158953 | REGULATORS OF MMP-9 AND USES THEREOF - A method of regulating an activity of metalloproteinase 9 (MMP-9) is disclosed. The method comprises contacting the MMP-9 with an agent which specifically interacts with an OG domain of the MMP-9. Molecules capable of specifically interacting with the OG domain, methods of identifying same, pharmaceutical compositions comprising same and uses thereof are also disclosed. | 06-11-2015 |
Patent application number | Description | Published |
20100333237 | METHOD FOR PROTECTING PLANTS FROM STRESS AND SENESCENCE - The present invention relates to regulation of ureide levels for optimal plant survival during nutrient remobilization such as occurs during normal growth, dark stress and senescence. Plants can be genetically engineered or selected using a suitable gene marker to have enhanced ureide accumulation. The present invention further provides methods of protecting plants, or extending the shelf life of fresh plant produce by application of exogenous ureides. | 12-30-2010 |
20110265224 | CONTROL OF SO2 METABOLISM IN PLANTS AND ITS APPLICATIONS - SO-transgenic plants overexpressing or lacking SO activity, having modified tolerance or susceptibility to toxicity of sulfite-producing substances, methods for their production and the use thereof for bioremediation of pollutants, as sentinel plants, for enhancing post-harvest quality of plants, plant tissues and plant products and for therapeutic applications. | 10-27-2011 |
20150181884 | METHOD FOR PROTECTING PLANTS FROM STRESS AND SENESCENCE - The present invention relates to regulation of ureide levels for optimal plant survival during nutrient remobilization such as occurs during normal growth, dark stress and senescence. Plants can be genetically engineered or selected using a suitable gene marker to have enhanced ureide accumulation. The present invention further provides methods of protecting plants, or extending the shelf life of fresh plant produce by application of exogenous ureides. | 07-02-2015 |
Patent application number | Description | Published |
20090240764 | NETWORK STORAGE SYSTEM FOR A DOWNLOAD INTENSIVE ENVIRONMENT - A network storage system for a download intensive environment is provided. The network storage comprises at least a data storage server (DSS) that includes an interface enabling connection of the DSS to a network at a location that enables at least a view of network transactions performed by a plurality of clients; a storage unit; and a system adapted to monitor the network transactions occurring on the network and identification of the network transactions as belonging to a registered client of the DSS, and storing in the storage the transactions with an identification corresponding to the registered client. | 09-24-2009 |
20140222772 | STORAGE SYSTEM AND METHODS FOR TIME CONTINUUM DATA RETRIEVAL - A method and system for storage of a data block for time continuum back-in-time data retrieval. The method comprises receiving a data block from a user node; updating an index stored in a memory respective of a time that the data block was received, wherein the time is a past time for retrieval of the data block; generating a hash number respective of contents of the data block; updating the index with the generated hash number; checking for existence of the generated hash number in a database; upon determination that the generated hash number does not exist in the database saving the data block in a storage device; increasing monotonously a transaction number respective of the generated hash number; and updating the index with the transaction number. | 08-07-2014 |
20150149786 | NETWORK STORAGE SYSTEM FOR A DOWNLOAD INTENSIVE ENVIRONMENT - A network storage system for a download intensive environment is provided. The network storage comprises at least a data storage server (DSS) that includes an interface enabling connection of the DSS to a network at a location that enables at least a view of network transactions performed by a plurality of clients; a storage unit; and a system adapted to monitor the network transactions occurring on the network and identification of the network transactions as belonging to a registered client of the DSS, and storing in the storage the transactions with an identification corresponding to the registered client. | 05-28-2015 |
20150186450 | TECHNIQUES FOR ENSURING CONSISTENCY OF DATA UPDATES TRANSACTIONS IN A DISTRIBUTED STORAGE SYSTEM - A method and system for ensuring consistency in data updates transactions in a distributed storage system (DSS) are provided. The method includes receiving an aggregated transaction request comprising monotonous transaction requests, wherein each monotonous transaction request is initiated by at least one computing node of a plurality of computing of nodes in the DSS, wherein the root computing node and the plurality of computing nodes are arranged in a tree structure; generating a range of transaction indexes based on the aggregated transaction request; and passing the generated range of transaction indexes along the plurality of computing nodes according to their respective level in the tree structure hierarchy, wherein each of the plurality of computing nodes initiating the monotonous transaction request is allocated with a unique portion of the aggregated transaction indexes, thereby ensuring time-order access to at least one storage device in the DSS. | 07-02-2015 |