Patent application number | Description | Published |
20120193636 | Very high transmittance, back-illuminated, silicon-on-sapphire semiconductor wafer substrate for high quantum efficiency and high resolution, solid-state, imaging focal plane arrays - An advanced, very high transmittance, back-illuminated, silicon-on-sapphire wafer substrate design is presented for enabling high quantum efficiency and high resolution, silicon or silicon-germanium avalanche photodiode detector arrays. The wafer substrate incorporates a stacked antireflective bilayer between the sapphire and silicon layers, comprised of single crystal aluminum nitride (AlN) and non-stoichiometric, silicon rich, amorphous silicon nitride (a-SiN | 08-02-2012 |
20120299143 | Thin, very high transmittance, back-illuminated, silicon-on-saphire semiconductor substrates bonded to fused silica - A very high transmittance, back-illuminated, silicon-on-thin sapphire-on-fused silica wafer substrate design is presented for enabling high quantum efficiency and high resolution, silicon or silicon-germanium avalanche photodiode detector arrays with improved indirect optical crosstalk suppression. The wafer substrate incorporates a stacked antireflective bilayer between the sapphire and silicon, comprised of single crystal aluminum nitride (AlN) and non-stoichiometric, silicon rich, amorphous silicon nitride (a-SiN | 11-29-2012 |
20130012028 | High purity, environmentally clean method and apparatus, for high rate, liquid anisotropic etching of single crystal silicon or etching of polycrystalline silicon, using an overpressure of ammonia gas above aqueous ammonium hydroxide - A high purity, non-toxic, environmentally friendly method for anisotropically etching single crystal silicon and etching polysilicon, suitable for microelectronics, optoelectronics and microelectromechanical (MEMS) device fabrication, using high purity aqueous ammonium hydroxide (NH | 01-10-2013 |
20130115139 | Compact, safe and portable hydrogen generation apparatus for hydrogen on-demand applications - A compact, chemical-mechanical apparatus, having no electrical components, for storing and generating hydrogen safely, on-demand, at the time and point of use in small or large quantities using the environmentally clean chemical reaction between sodium metal and water to generate hydrogen (H | 05-09-2013 |
20130115860 | Linear, automated apparatus and method for clean, high purity, simultaneous lapping and polishing of optics, semiconductors and optoelectronic materials - A linear, automated apparatus and method for clean, cost-effective, simultaneous lapping and polishing of optics, semiconductors and optoelectronic materials is presented, constructed principally from corrosion resistant stainless steel or nickel, enabling utilization of high purity water based abrasive slurry. The circular stainless steel or nickel lapping plate of the apparatus supports a synthetic nylon or rayon pad, whereby material is abraded from the workpiece primarily through the reciprocal, back and forth, linear movement of the workpiece holder, diametrically across the circular lapping plate, with intermittent rotation in step increments of the workpiece holder and affixed workpiece, tracing arcs of 180 degrees, first in a clockwise and subsequently counterclockwise direction. Intermittent rotation of the circular lapping plate for the sole purpose of ensuring uniform wear on the circular nylon or rayon pad and lapping plate, eliminates the need for periodic, time consuming conditioning or reflattening of the lapping plate. | 05-09-2013 |
Patent application number | Description | Published |
20090163371 | Anchor-Assisted Fragment Selection and Directed Assembly - The invention provides methods for compound and lead generation and discovery. In particular, the present invention provides a method for generating compounds and for selecting compounds that bind to a target. The present invention provides a way by which anchors (e.g., weak binders) and anchor-scaffold conjugates can be evolved into new generations of compounds having improved target binding and other desired pharmaceutical properties through control of both synthetic input and selection criteria. | 06-25-2009 |
20100120750 | METHODS FOR INDUCING POLYPLOIDIZATION OF MEGAKARYOCYTES AND FOR TREATING BLOOD AND BONE MARROW DISEASES AND DISORDERS - Disclosed are methods for inducing polyploidization of megakaryocyte cells and for promoting differentiation of megakaryocyte cells into platelet-producing cells. The methods may be utilized for treating blood and bone marrow diseases and disorders in a subject in need thereof and for identifying agents for treating blood and bone marrow diseases and disorders. | 05-13-2010 |
20100159455 | RECEPTOR FAMILY PROFILING - The invention provides compositions and methods, e.g., assay technologies and their use in biodetection and diagnostics. More particularly, the invention provides compositions and methods based on nucleic acid-templated chemistry in biodetection and profiling of receptors (and their families) and proteins (and their families), and the use of same in diagnostics. | 06-24-2010 |
20130338092 | COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS - This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods and uses thereof for treating leukemia. | 12-19-2013 |
Patent application number | Description | Published |
20110076448 | Methods for Patterning Substrates Using Heterogeneous Stamps and Stencils and Methods of Making the Stamps and Stencils - The present invention is directed to heterogeneous stamp and stencil compositions, methods for patterning substrates using contact printing processes employing the heterogeneous stamps and stencils, and products formed by the contact printing processes. | 03-31-2011 |
20120097329 | Stencils for High-Throughput Micron-Scale Etching of Substrates and Processes of Making and Using the Same - The present invention is directed to stencils for high-throughput, high-resolution etching of substrates and processes of making and using the same. | 04-26-2012 |
20130153514 | Apparatus and Methods for Treating Fluids Using Ultraviolet Light - The present invention is directed to apparatuses and methods for treating fluids with ultraviolet light, including fluid streams, utilizing elliptical chambers. Suitably, water or other fluids can be disinfected using the chambers. Methods for optimizing irradiation of the fluid in the apparatuses are also provided. | 06-20-2013 |
20140370643 | FORMULATION FOR ACIDIC WET CHEMICAL ETCHING OF SILICON WAFERS - Acid etch compositions for etching multicrystalline silicon substrates are disclosed which may include hydrofluoric acid, an oxidizer, an acid diluent, and soluble silicon. The soluble silicon may be hexafluorosilicic acid or ammonium fluorosilicate. Silicon substrates patterned with organic resist may be used with the acid etch compositions for selective silicon patterning for solar cell applications. | 12-18-2014 |
20150037923 | METHODS TO SELECTIVELY TREAT PORTIONS OF A SURFACE USING A SELF-REGISTERING MASK - Processes increase light absorption into silicon wafers by selectively changing the reflective properties of the bottom portions of light trapping cavity features. Modification of light trapping features includes: deepening the bottom portion, increasing the curvature of the bottom portion, and roughening the bottom portion, all accomplished through etching. Modification may also be by the selective addition of material at the bottom of cavity features. Different types of features in the same wafers may be treated differently. Some may receive a treatment that improves light trapping while another is deliberately excluded from such treatment. Some may be deepened, some roughened, some both. No alignment is needed to achieve this selectively. The masking step achieves self-alignment to previously created light trapping features due to softening and deformation in place. | 02-05-2015 |
20150064265 | Vehicles for Controlled Delivery of Different Pharmaceutical Agents - A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution. | 03-05-2015 |
Patent application number | Description | Published |
20110022312 | Generating and Tracking Activity Patterns for Mobile Devices - Described are methods and apparatuses, including computer program products, for tracking patterns associated with mobile devices. The system includes a server computing device configured to receive location information from a mobile device associated with a user. The location information includes location information based on GPS information sent from the mobile device. One or more activity patterns associated with the user of the mobile device are generated by the server computing device. The generating includes tracking the location information over a period of time and determining one or more categories of repeated activity based on the tracking. | 01-27-2011 |
20110022540 | Location-Based Address Determination and Real Estate Valuation - Described are methods and apparatuses, including computer program products, for location-based address determination and real estate valuation. Current location information from a mobile device is received by a server computing device. The location information includes global positioning data associated with the mobile device and photographic data associated with one or more photos taken by the mobile device and associated with the location. A street address based on the location information is determined by the server computing device. The photographic data is processed in associated with the global positioning data, wherein the photographic data is used to determine the street address. Financial data associated with the street address is received. | 01-27-2011 |
20110023063 | Inserting Personalized Information into Digital Content - products, for inserting personalized information into digital content. A request for digital video content is received by a computing device. The request includes authentication data associated with a user of a client device. Personalized data to be inserted into the requested video content is generated by the computing device. The personalized data and the requested video content are combined by the computing device. The combining includes replacing one or more frames of the requested video content with the personalized data to generate personalized video content. | 01-27-2011 |
20120192221 | Inserting Personalized Information into Digital Content - Described are methods and apparatuses, including computer program products, for inserting personalized information into digital content. A digital media player receives a personalized video content stream comprising personalized data associated with a user that replaces one or more frames of requested video content. The player extracts the personalized data from the one or more replaced frames of the video content stream, and displays the personalized data and the video content stream to a user. | 07-26-2012 |
20130318249 | Communication Session Transfer Between Devices - Methods and apparatuses, including computer program products, are described for communication session transfer between a plurality of computing devices. A first computing device detects the presence of a second computing device in proximity to the first computing device, where the first computing device has established a first communication session with a remote computing device. The first computing device establishes a wireless connection to the second computing device. The first computing device receives, from the second computing device, information associated with the first communication session. The first computing device establishes a second communication session with the remote computing device using the received information, where the second communication session is established with the same state as the first communication session. | 11-28-2013 |
20140130127 | Risk Adjusted, Multifactor Authentication - A computer-implemented method comprising: receiving, from a device used by a user, a request to access a resource hosted by a computer system; identifying, by the computer system, a level of risk associated with the user requesting access to the resource; adjusting, by the computer system an authentication standard for access to the resource, adjusting based on the identified level of risk; determining values for authentication factors used in authenticating the user's access to the resource; applying weights to the values for the authentication factors; and determining, based on a comparison of the weighted values to the adjusted authentication standard, whether the user is authorized to access the resource. | 05-08-2014 |
20140331293 | Risk Adjusted, Multifactor Authentication - A computer-implemented method comprising: receiving, from a device used by a user, a request to access a resource hosted by a computer system; identifying, by the computer system, a level of risk associated with the user requesting access to the resource; adjusting, by the computer system an authentication standard for access to the resource, adjusting based on the identified level of risk; determining values for authentication factors used in authenticating the user's access to the resource; applying weights to the values for the authentication factors; and determining, based on a comparison of the weighted values to the adjusted authentication standard, whether the user is authorized to access the resource. | 11-06-2014 |
20140379544 | METHODS AND SYSTEMS FOR EXPEDITED TRADING ACCOUNT FUNDING - A computer-implemented method is provided for opening an expedited account for a user. The method includes receiving a request from the user to make a trade associated with at least one financial instrument, in the absence of an account being opened for the user. The method includes determining a plurality of factors in response to the request, the plurality of factors including 1) a credit worthiness score of the user; 2) a source of capital identified by the user to cover the trade; and 3) a type of the at least one financial instrument associated with the trade. The method also includes opening the expedited account for the user with limited trading privileges, in which an amount of fund for trading is advanced to the user based on the plurality of factors. The method further includes allowing the user to make a trade up to the amount of fund advanced. | 12-25-2014 |
20150020185 | Communication Session Transfer Between Devices - Methods and apparatuses, including computer program products, are described for communication session transfer between a plurality of computing devices. A first computing device detects a presence of a second computing device in proximity to the first device, where the first device has established a first communication session with a remote computing device. The first device establishes a wireless connection to the second device. A first token is transmitted to the second device. A second token is received from the second device. The second token is authenticated via comparison to the first token. The first device transmits, to the second device, information indicating a state of the first communication session to enable the second device to establish a second communication session with the remote device, where the second communication session is established using the state of the first communication session. | 01-15-2015 |
20150296240 | INSERTING PERSONALIZED INFORMATION INTO DIGITAL CONTENT - Described are methods and apparatuses, including computer program products, for inserting personalized information into digital content. A digital media player receives a personalized video content stream comprising personalized data associated with a user that replaces one or more frames of requested video content. The player extracts the personalized data from the one or more replaced frames of the video content stream, and displays the personalized data and the video content stream to a user. | 10-15-2015 |
20150341682 | INSERTING PERSONALIZED INFORMATION INTO DIGITAL CONTENT - Described are methods and apparatuses, including computer program products, for personalizing video content. A server receives a request for a digital video stream from a client device and generates a first set of personalized frames to be inserted into the requested digital video stream. The server combines the first set of personalized frames and the requested digital video stream to generate a personalized video stream and transmits the personalized video stream to a downstream device. The downstream device generates a second set of personalized frames to be inserted into the personalized video stream and combines the second set of personalized frames and the personalized video stream to generate an updated personalized video stream for transmission to the client device. | 11-26-2015 |
20160057139 | COMMUNICATION SESSION TRANSFER BETWEEN DEVICES - Methods and apparatuses, including computer program products, are described for communication session transfer between a plurality of computing devices. A first computing device detects a presence of a second computing device in proximity to the first device, where the first device has established a first session with a remote computing device, and obtains first user authentication data. The first device establishes a wireless connection to the second device. A first token is transmitted to the second device. A second token and second user authentication data are received from the second device. The tokens and the user authentication data is authenticated. The first device transmits, to the second device, information indicating a state of the first communication session to enable the second device to establish a second communication session with the remote device, where the second communication session is established using the state of the first communication session. | 02-25-2016 |
Patent application number | Description | Published |
20140120083 | TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS - Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders. | 05-01-2014 |
20140377258 | Treatment Of Cancers Using PI3 Kinase Isoform Modulators - Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders. | 12-25-2014 |
20150283142 | TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS - Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders. | 10-08-2015 |
20150320754 | COMBINATION THERAPIES - Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor, or pharmaceutically acceptable form thereof, in combination with a second agent, or a pharmaceutically acceptable form thereof, wherein the second agent is chosen from one or more of 1) a CDK4/6 inhibitor, 2) an HDAC inhibitor, 3) a MEK inhibitor, 4) a mTOR inhibitor, 5) an AKT inhibitor, 6) a proteasome inhibitor, 7) an immunomodulator, 8) a glucocorticosteroid, 9) a BET inhibitor, 10) an epigenetic inhibitor, 11) a PI3K alpha inhibitor, 12) a topoisomerase inhibitor, or 13) an ERK inhibitor. Also provided herein are methods of treatment comprising administration of the compositions, and uses of the compositions, e.g., for treatment of cancer. | 11-12-2015 |
20150320755 | COMBINATION THERAPIES - Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor or a pharmaceutically acceptable form thereof, and a Bcl-2 inhibitor or a pharmaceutically acceptable form thereof. Also provided herein are methods for treating cancer comprising administration the compositions, and uses of the compositions, e.g., for the treatment of cancer. | 11-12-2015 |
Patent application number | Description | Published |
20130085780 | HEALTH CARE INFORMATION MANAGEMENT - A method, computer program product, and system is described. A patient condition associated with a patient record is identified based upon, at least in part, a first input associated with the patient record. A point-of-care prompt is provided based upon, at least in part, the patient condition and clinical authority information. A point-of-care input, associated with at least in part, one or more of education material, a condition assessment, co-morbidity information, a diagnosis protocol, a treatment protocol, medication information, clinical order information, visit order information, patient resource information, and care planning information, is received. Treatment information is provided based upon, at least in part, the point-of-care input and one or more of education material, a condition assessment, co-morbidity information, a diagnosis protocol, a treatment protocol, medication information, clinical order information, visit order information, patient resource information, and care planning information. | 04-04-2013 |
Patent application number | Description | Published |
20090187997 | Cre-lox based gene knockdown constructs and methods of use thereof - The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo. | 07-23-2009 |
20090217397 | Cre-lox based gene knockdown constructs and methods of use thereof - The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo. | 08-27-2009 |
20090217399 | Lentiviral Vectors That Provide Improved Expression And Reduced Variegation After Transgenesis - The present invention provides new lentiviral vectors that include an anti-repressor element (ARE) and, optionally, a scaffold attachment region (SAR). The lentiviral vectors provide expression of a heterologous nucleic acid in at least 50% of the cells of multiple cell types when used for lentiviral transgenesis. In certain embodiments of the invention the heterologous nucleic acid encodes an RNAi agent such as an shRNA. The invention further provides transgenic nonhuman animals generated using a lentiviral vector that includes an ARE and optional SAR. In addition, the invention provides a variety of methods for using the vectors including for achieving gene silencing in eukaryotic cells and transgenic animals, and methods of treating disease. The invention also provides animal models of human disease in which one or more genes is functionally silenced using a lentiviral vector of the invention. | 08-27-2009 |
20120214242 | CRE-LOX BASED GENE KNOCKDOWN CONSTRUCTS AND METHODS OF USE THEREOF - The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo. | 08-23-2012 |
20130024958 | LENTIVIRAL VECTORS THAT PROVIDE IMPROVED EXPRESSION AND REDUCED VARIEGATION AFTER TRANSGENESIS - The present invention provides new lentiviral vectors that include an anti-repressor element (ARE) and, optionally, a scaffold attachment region (SAR). The lentiviral vectors provide expression of a heterologous nucleic acid in at least 50% of the cells of multiple cell types when used for lentiviral transgenesis. In certain embodiments of the invention the heterologous nucleic acid encodes an RNAi agent such as an shRNA. The invention further provides transgenic nonhuman animals generated using a lentiviral vector that includes an ARE and optional SAR. In addition, the invention provides a variety of methods for using the vectors including for achieving gene silencing in eukaryotic cells and transgenic animals, and methods of treating disease. The invention also provides animal models of human disease in which one or more genes is functionally silenced using a lentiviral vector of the invention. | 01-24-2013 |