Patent application number | Description | Published |
20090221338 | PHYSICAL EXERCISE VIDEO GAME METHOD AND APPARATUS - Described herein is a game and game system including one or more user motion tracking devices. In some embodiments, a heart rate sensor is also used to monitor the user. | 09-03-2009 |
20090221372 | FOOTPAD-BASED GAME AND GAMING SYSTEM - Described herein are games and game systems including a text messaging phone keypad foot mat. The phone keypad foot mat typically includes regions similar to the buttons of an enlarged telephone keypad. A user can step on these input regions (“buttons” or “keys”) to type a text. Thus, a player “types” a text message by stepping or dancing on the keyboard foot mat similar to the way that a text message may be typed by hand on a telephone keypad (e.g., sending a text message from a cell phone). Various games can be played using the devices, systems and methods described herein. | 09-03-2009 |
20090221401 | RHYTHM ROPE - The improved jump ropes devices described herein generally include a source of rhythmic sound, a sensor for determining the motion of the jump rope, and a visual output (e.g., feedback) for indicating how well a user is moving or jumping in time to the rhythmic component of the sound. The device may also include a controller for receiving input from the source of rhythmic sound and the sensor, and controlling the visual output. Methods of using the devices are also described. | 09-03-2009 |
20110130247 | RHYTHM ROPE - The improved jump ropes devices described herein generally include a source of rhythmic sound, a sensor for determining the motion of the jump rope, and a visual output (e.g., feedback) for indicating how well a user is moving or jumping in time to the rhythmic component of the sound. The device may also include a controller for receiving input from the source of rhythmic sound and the sensor, and controlling the visual output. Methods of using the devices are also described. | 06-02-2011 |
Patent application number | Description | Published |
20080261817 | Methods for Analyzing Global Regulation of Coding and Non-Coding RNA Transcripts Involving Low Molecular Weight RNAs - In some embodiments of the invention, methods are provided to interrogate the transcriptional activity relating to RNAs of small molecular weight. The methods employ hybridization of a large number of oligonucleotide probes with nucleic acid derived from RNAs of small molecular weight. | 10-23-2008 |
20080287308 | SYSTEM, METHOD, AND COMPUTER SOFTWARE PRODUCT FOR GENOTYPE DETERMINATION USING PROBE ARRAY DATA - An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate. | 11-20-2008 |
20110160092 | Methods for Selecting a Collection of Single Nucleotide Polymorphisms - The invention relates to the selection of a collection of relevant single nucleotide polymorphisms across a genome to design a nucleic acid probe array. As such, the invention relates to diverse fields impacted by the nature of genetics, including biology, medicine, and medical diagnostics. | 06-30-2011 |
20110208500 | Methods and computer software for detecting splice variants - Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events. | 08-25-2011 |
20120173159 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR NUCLEIC ACID SEQUENCING - A method for nucleic acid sequencing includes receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces including one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space includes a sample nucleic acid; processing, for at least some of the defined spaces determined to include a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows. | 07-05-2012 |
20120185178 | Methods and Computer Software for Detecting Splice Variants - Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events. | 07-19-2012 |
20120221255 | System, Method, and Computer Software Product for Genotype Determination Using Probe Array Data - An embodiment of a method of analyzing data from processed images of biological probe arrays is described that comprises receiving a plurality of files comprising a plurality of intensity values associated with a probe on a biological probe array; normalizing the intensity values in each of the data files; determining an initial assignment for a plurality of genotypes using one or more of the intensity values from each file for each assignment; estimating a distribution of cluster centers using the plurality of initial assignments; combining the normalized intensity values with the cluster centers to determine a posterior estimate for each cluster center; and assigning a plurality of genotype calls using a distance of the one or more intensity values from the posterior estimate. | 08-30-2012 |
20130060482 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MAKING BASE CALLS IN NUCLEIC ACID SEQUENCING - A method for nucleic acid sequencing includes receiving a plurality of observed or measured signals indicative of a parameter observed or measured for a plurality of defined spaces; determining, for at least some of the defined spaces, whether the defined space comprises one or more sample nucleic acids; processing, for at least some of the defined spaces, the observed or measured signal to improve a quality of the observed or measured signal; generating, for at least some of the defined spaces, a set of candidate sequences of bases for the defined space using one or more metrics adapted to associate a score or penalty to the candidate sequences of bases; and selecting the candidate sequence leading to a highest score or a lowest penalty as corresponding to the correct sequence for the one or more sample nucleic acids in the defined space. | 03-07-2013 |
20130090860 | METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MAKING BASE CALLS IN NUCLEIC ACID SEQUENCING - A method for nucleic acid sequencing includes: receiving a signal comprising measurements of a parameter measured in response to a plurality of nucleotide flows flowed in a space comprising a sample nucleic acid; normalizing the signal to obtain a normalized signal; adaptively normalizing the normalized signal to obtain an adaptively normalized signal; and predicting a sequence of base calls corresponding to the sample nucleic acid using the adaptively normalized signal. | 04-11-2013 |
20130231870 | METHODS AND COMPUTER PROGRAM PRODUCTS FOR COMPRESSION OF SEQUENCING DATA - A compression method includes measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises at least one region associated with expected measured values and at least one region associated with unpredictable measured values; applying a first compression process to the waveform, the first compression process including an averaging of one or more frames in one or more portions of the waveform; and applying a second compression process to the waveform, the second compression process including a truncating of data corresponding to a portion of the waveform that is not related to a nucleotide incorporation component of the waveform. | 09-05-2013 |
20130288902 | SYSTEMS AND METHODS FOR PAIRED END SEQUENCING - Systems and methods for analyzing overlapping sequence information can obtain first and second overlapping sequence information for a polynucleotide, align the first and second sequence information, determine a degree of agreement between the first and second sequence information for a location along the polynucleotide, and determine a base call and a quality value for the location. | 10-31-2013 |
20140051584 | Methods and Apparatuses for Estimating Parameters in a Predictive Model for Use in Sequencing-by-Synthesis - A method of estimating a parameter related to sequencing of a sample nucleic acid template includes: receiving signal data relating to nucleotide incorporation events resulting from a series of flows of nucleotides onto an array of wells including (i) a first well containing the sample nucleic acid template and (ii) a plurality of other sample-containing wells; determining sequence information for the sample nucleic acid template using signal data from the first well; and constructing a phase-state model for a set of nucleotide flows that contributed at least in part to the sequence information, wherein the model includes a signal correction parameter that is determined using signal data from the plurality of other sample-containing wells. | 02-20-2014 |
20140093881 | Methods and Computer Program Products for Compression of Sequencing Data - A compression method includes: measuring a waveform associated with a chemical event occurring on a sensor array, wherein the waveform comprises a plurality of measured values and the chemical event is indicative of a number of nucleotide incorporations in a genetic sequencing reaction; applying a first compression process to the waveform, the first compression process including a truncating of data corresponding to a portion of the waveform that is not related to nucleotide incorporations in the genetic sequencing reaction; and applying a second compression process to the waveform, the second compression process including a data substitution process that replaces at least a portion of the waveform with a plurality of coefficients representative of the portion of the waveform. | 04-03-2014 |
Patent application number | Description | Published |
20090054903 | BONE FIXATION IMPLANT SYSTEM AND METHOD - A bone-fastening system includes an implant with a threaded screw, a distal nut with a threaded bore, and a proximal washer which may also be threaded. An instrument for implanting the implant includes a handle and a barrel terminating in a holder for the washer. A c-shaped bridge assembly has a first end connected to the barrel and a second end including a holder for the nut in axial alignment with the washer. A manually operated control on the instrument, coupled to an elongated element in the barrel, causes the washer to move toward the nut, thereby applying compressive pressure to bone portions to be fastened together. A drive mechanism disposed within the barrel has a distal end with a holder for the screw and a proximal end that is turned by a user, thereby advancing the screw through the washer to the nut to fasten the bone portions under compression. The manually operated control is preferably a trigger that is squeezed toward the handle by a user. A separate control, also preferably in the form of a trigger, is used to release pressure on the elongated element in the barrel, enabling the implant to be easily removed from the implant once in position. | 02-26-2009 |
20100331888 | SPINAL CORRECTION SYSTEM WITH MULTI-STAGE LOCKING MECHANISM - In a rod fixation system of the type used to treat various spinal conditions, the same fastener is used to lock both a polyaxial screw and a rod in position. A spinal correction device according to the invention, adapted for use with a rod and a polyaxial screw having a ball-shaped head and a threaded end, comprises a head-body and a cap. The head-body includes a lower internal cavity to receive the ball-shaped head of the screw, an upper bore to receive a fixation rod therethrough, and an upper end configured to receive the cap. The head-body and the cap are configured such that a first rotation of the cap locks the polyaxial screw in position, and a second rotation of the cap locks the rod in position. In the preferred embodiment, the head-body includes one or more gaps to facilitate flexion of the head-body as a rotational torque is placed on the cap. The gap or gaps may be horizontal, vertical or other angles relative to the axis of the entrapped rod. | 12-30-2010 |
20120035613 | BONE FIXATION IMPLANT SYSTEM AND METHOD - In one embodiment, a bone-fastening system includes a handle, a barrel assembly connected to the handle, and a bridge assembly connected to the barrel assembly. The bridge assembly may be configured to receive a first connector element and a second connector element in axial alignment with the first connector element so as to receive a fastening element between the first and second connector elements. The system may also include a control configured to, upon actuation, approximate the first connector element and the second connector element so as to apply compressive pressure to bone portions positioned between the first connector element and the second connector element. A drive mechanism configured to advance the fastening element through the bone portions and connect the first connector element with the second connector element to fasten the bone portions under compression may also be provided with the system. | 02-09-2012 |
20130338717 | MONOAXIAL AND POLYAXIAL PEDICLE SCREWS AND RELATED METHODS - Methods for installing bone anchors, such as pedicle screws or other surgical screws. In some implementations, the surgical screw may be coupled with a connection member, such as a tulip assembly, configured to couple the surgical screw with a stabilization member, such as a spinal fixation rod. The connection member may be initially coupled with the surgical screw in a polyaxial configuration, after which the connection member may be secured to the surgical screw in a monoaxial configuration. The stabilization member may then be coupled and secured with the connection member such that the stabilization member cannot move relative to the connection member. In some implementations, the stabilization member may be locked or secured to the connection member after the connection member has been secured to the surgical screw in a monoaxial configuration. | 12-19-2013 |
20140249587 | MEDICAL DEVICE LOCKING MECHANISMS AND RELATED METHODS AND SYSTEMS - Medical device locking mechanisms and related methods and systems. In some embodiments, the medical device may comprise an outer surface defining one or more fastener openings configured for receiving one or more fasteners. The one or more fasteners may comprise an upper surface configured to be engaged by a component of the locking system to prevent fastener backout. A plurality of petal structures may be configured to be selectively expanded or contracted to engage the head portion and retain the at least one fastener within the fastener opening to prevent the fastener from backing out of the fastener opening. A biasing member may selectively engage the plurality of petal structures to either expand or contract the plurality of petal structures to facilitate locking the fastener(s) in place within the device. | 09-04-2014 |
20140358184 | INTERLOCKING BIOMEDICAL IMPLANT FASTENER AND WASHER CONCEPTS - Biomedical implant fastener systems, such as bone screw systems and the like. In some embodiments, a fastener may comprise a first plurality of teeth, and a washer configured to be received on the fastener may comprise a second plurality of teeth configured to be engaged with the first plurality of teeth. The first plurality of teeth may be configured to engage with the second plurality of teeth such that so as to allow for selective rotation between the washer and the fastener in a first rotational direction and so as to prevent rotation between the washer and the fastener in a second rotational direction opposite from the first rotational direction when the fastener is engaged with the washer such that second plurality of teeth is engaged with the first plurality of teeth so as to prevent the fastener from backing out of the washer after engagement. | 12-04-2014 |