Patent application number | Description | Published |
20110159519 | OPTICAL BIOSENSORS - Provided are biosensors, compositions comprising biosensors, and methods of using biosensors in living cells and organisms. The biosensors are able to be selectively targeted to certain regions or structures within a cell. The biosensors may provide a signal when the biosensor is targeted and/or in response to a property of the cell or organism such as membrane potential, ion concentration or enzyme activity. | 06-30-2011 |
20120058494 | Quenched Dendrimeric Dyes for Florescence Detection - The present invention presents designs for high extinction quenched “dyedrons” that can be activated by conversion of a single acceptor/quencher in the molecular assembly to a fluorescent state. The quencher is activated by noncovalent binding to a unique complementary expressible fluorogen activating peptide (FAP). In this way, the quencher serves as the homogeneous switch, receiving energy efficiently from each of the donor molecules of the dendronic antenna, and releasing it as fluorescence only when activated by binding. The sum of the extinction of the multiple dyes on the antenna will provide dramatic enhancements in the effective brightness of the probe in standard imaging systems. This approach provides a set of probes with exceptional brightness, specifically targeted to an expressed tag that activates the fluorescence of the dyedron. | 03-08-2012 |
20130244891 | TARGETED PROBES OF CELLULAR PHYSIOLOGY - Biosensor comprising an activatable acceptor fluorogen linked via a linker to a donor which transfers energy to the fluorogen on detecting an analyte wherein the fluorogen component reacts and a 100 fold increase in intensity results when the fluorogen interacts non-covalently with an activator e.g. fluorogen activator peptide. | 09-19-2013 |
20140193830 | OPTICAL BIOSENSORS - Provided are biosensors, compositions comprising biosensors, and methods of using biosensors in living cells and organisms. The biosensors are able to be selectively targeted to certain regions or structures within a cell. The biosensors may provide a signal when the biosensor is targeted and/or in response to a property of the cell or organism such as membrane potential, ion concentration or enzyme activity. | 07-10-2014 |
Patent application number | Description | Published |
20100320335 | Air hose support clip to prevent lateral loading - Apparatus for suspending a device such as the end of a depending air brake hose from a railcar. A flexible strap of a synthetic resin such as moldable polyurethane is suspended from the railcar body, for example, by attachment to an apertured fitting on the railcar coupler. Elongated resilient wire clips are provided to attach the free end of the air hose. The wire clips are generally configured with a latching end including interlocking end portions for connection to the strap through a selected attachment aperture, a pair of flexibly resilient, elongated manually compressible elongated arms extending away from the latching end portions and a return portion joining the arms. The clip is further provided with a retainer operative when the arms are interlocked for maintaining the attachment aperture fitting within the confines of the return portion and out of position in which loading of the clip is exerted laterally of the clip arms. In a preferred embodiment, the clip is provided with a bend in its first arm operative to promote optimum point-loading of the clip, and this embodiment of the clip is particularly useful with a chain suspension strap. | 12-23-2010 |
20110198449 | Air Hose Support Clip to Prevent Lateral Loading - Apparatus for suspending a device such as the end of a depending air brake hose from a railcar. A flexible strap of a synthetic resin such as moldable polyurethane is suspended from the railcar body, for example, by attachment to an apertured fitting on the railcar coupler. Elongated resilient wire clips are provided to attach the free end of the air hose. The wire clips are generally configured with a latching end including interlocking end portions for connection to the strap through a selected attachment aperture, a pair of flexibly resilient, elongated manually compressible elongated arms extending away from the latching end portions and a return portion joining the arms. The clip is further provided with a retainer operative when the arms are interlocked for maintaining the attachment aperture fitting within the confines of the return portion and out of position in which loading of the clip is exerted laterally of the clip arms. In a preferred embodiment, the clip is provided with a bend in its first arm operative to promote optimum point-loading of the clip, and this embodiment of the clip is particularly useful with a chain suspension strap. | 08-18-2011 |
20120234202 | Malleable resilient pedestal wear plate - A wear plate for use with a railway truck, the wear plate being configured for installation on a downwardly facing surface of a pedestal opening of a side frame of a railway truck. The wear plate includes a base and a pair of side walls extending upwardly from opposite sides of the base with inwardly disposed locking features designed to engage the pedestal when the wear plate is installed, the locking features in a preferred embodiment being configured as resilient projections that engage, clamp or drag lock onto opposite sides of the pedestal with the base of the wear plate protecting the downwardly facing pedestal surface. The wear plate may be constructed from malleable or ductile metals or plastics. | 09-20-2012 |
20130042785 | Lightweight rerailer - A rerailer device for rerailing a railway vehicle onto a track, the device including a body with a ramp adapted to support a wheel of a railway vehicle thereon, a sloped face provided on said body and being configured with a slope that declines in a preferred direction toward the track on which the railway vehicle wheel is to be rerailed, and support means for supporting said sloped surface and railway vehicle wheels thereon, where the support configuration, material or combinations of configurations and materials facilitate lightweight construction. | 02-21-2013 |
20140046002 | CROSS-LINKED THERMOPLASTIC CO-POLYESTER ELASTOMER, METHOD OF MAKING SAME, AND ARTICLES COMPOSED THEREOF - A process for forming a cross-linked thermoplastic elastomer is disclosed herein. The cross-linked thermoplastic elastomer is a thermoplastic cross-linked copolyester and is preferably formed by heating a first mixture containing a thermoplastic elastomeric base material, a monomeric diisocyanate comprising between 1 to 10% of the total weight of the first mixture, and a second mixture of a first diamine and a second diamine comprising between 1 to 10% of the total weight of a total reaction product. The heated first mixture, which is flowable, is injected into at least one injection molding device, with the second mixture injected at predetermined intervals to create a homogeneous reaction product. The reaction product may be injected into a mold to produce articles. | 02-13-2014 |
20140076193 | LIGHTWEIGHT RERAILER - A rerailer device for rerailing a railway vehicle onto a track, the device including a body with a ramp adapted to support a wheel of a railway vehicle thereon, a sloped face provided on said body and being configured with a slope that declines in a preferred direction toward the track on which the railway vehicle wheel is to be rerailed, and support means for supporting said sloped surface and railway vehicle wheels thereon, where the support configuration, material or combinations of configurations and materials facilitate lightweight construction. | 03-20-2014 |
20140217052 | COUPLER KNUCKLE - An improved coupler knuckle with an improved interior configuration for handling forces imparted on the knuckle and transferring said imparted forces through the knuckle and improving handling of linear force loads and their transmission the interior having a force handling structure that includes spaced apart layers and cavities, with a cavity extending between the nose section and the tail section of the coupler knuckle. | 08-07-2014 |
20140217662 | POLYMER SPRING - A polymer spring has a hollow tubular polymer body, wherein the first end portion of the body, the second end portion of the body, and the mid-portion of the body together substantially maintain an annular cylindrical column structure throughout the length of the body from the first end portion of the body to the second end portion of the body, such that the mid-portion of the body has a substantial portion that is in direct alignment with the first end portion of the body and the second end portion of the body when the spring is compressed to eliminate or reduce the chances of the spring failing caused by the spring folding or buckling and to reduce material fatigue in the polymer spring associated with folding or buckling. | 08-07-2014 |
20140360965 | LIGHTWEIGHT YOKE FOR RAILWAY COUPLING - Lightweight yokes are provided. According to some embodiments, the basic overall appearance of the yoke may be maintained, but the actual material of which it is constructed is changed. According to other embodiments, the yoke is provided with an improved lightweight construction, and, yet other embodiments the yoke may be provided with an improved construction and formed from a preferred material. Yokes may be constructed from cast austempered ductile iron; whereas cast iron has a density, 0.26 lbs/in̂3, which is approximately 8% less than steel, 0.283 lbs/in̂3, thereby allowing for a reduction in weight over steel. A suitable austempering process is used to produce the austempered metal yoke. Yokes have improved configurations which may require less metal to produce the yoke. Both, the lightweight material and improvements in configuration of the yoke structure may combine to provide a lighter weight yoke. | 12-11-2014 |
20150217789 | LIGHTWEIGHT RERAILER - A rerailer device for rerailing a railway vehicle onto a track, the device including a body with a ramp adapted to support a wheel of a railway vehicle thereon, a sloped face provided on said body and being configured with a slope that declines in a preferred direction toward the track on which the railway vehicle wheel is to be rerailed, and support means for supporting said sloped surface and railway vehicle wheels thereon, where the support configuration, material or combinations of configurations and materials facilitate lightweight construction. | 08-06-2015 |
Patent application number | Description | Published |
20080255115 | THIAZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS - Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives. | 10-16-2008 |
20080300239 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS - Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives. | 12-04-2008 |
20090018131 | QUINAZOLINE DERIVATIVES AS P13 KINASE INHIBITORS - Invented is a method of inhibiting the activity/function of PI3 kinases using quinazoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinazoline derivatives. | 01-15-2009 |
20090306074 | THIAZOLIDINEDIONE DERIVATIVES AS P13 KINASE INHIBITORS - Invented is a method of inhibiting the activity/function of PI3 kinases using thiazolidinedione derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of thiazolidinedione derivatives. | 12-10-2009 |
20100179144 | QUINAZOLINE DERIVATIVES AS P13 KINASE INHIBITORS - Invented is a method of inhibiting the activity/function of PI3 kinases using quinazoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinazoline derivatives. | 07-15-2010 |
20120165321 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS - Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives. | 06-28-2012 |
20130237535 | FATTY ACID SYNTHASE INHIBITORS - This invention relates to the use of spirocyclic piperidine derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of spirocyclic piperidines in the treatment of cancer. | 09-12-2013 |
20140100234 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS - Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives. | 04-10-2014 |
20140296224 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS - Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives. | 10-02-2014 |
Patent application number | Description | Published |
20080197542 | Apparatus and method for manufacturing and inspecting blow-molded plastic containers - A method and apparatus for manufacturing and inspecting plastic containers. The apparatus may comprise a blow-molder comprising a plurality of molds and spindles for forming a plastic container from a preform. The apparatus may also comprise an inspection device, located in the blow-molder, for inspecting the plastic container after formation by the blow-molder. The inspection device may comprise (i) two or more light energy sources for directing light energy from an exterior of the plastic container toward the plastic container after formation of the plastic container by the blow-molder, and (ii) two or more light energy sensors, each light energy sensor operatively associated with one of the light energy sources, wherein each light energy sensor is for sensing a portion of the light energy that passes through of the plastic container and generating a signal from the sensed portion of the light energy that passes through the plastic container that is related to the light energy absorbed by the plastic container. The apparatus may also comprise a transfer arm in the blow molder for transporting the plastic container along the transport path through the inspection device. The apparatus may also comprise a microprocessor in communication with the inspection device for (i) determining a container attribute of the plastic container based on the signals related to the light energy absorbed by the plastic container; and (ii) determining the mold involved in formation of the plastic container based on at least one signal received by the microprocessor. | 08-21-2008 |
20090278286 | IN-LINE INSPECTION SYSTEM FOR VERTICALLY PROFILING PLASTIC CONTAINERS USING MULTIPLE WAVELENGTH DISCRETE SPECTRAL LIGHT SOURCES - Systems and methods for in-line inspection of plastic blow molded containers. The inspection system may comprise a plurality of emitter assemblies arranged in a vertical array. Each emitter assembly may cyclically emit light energy in at least two different narrow wavelength bands at a container as the container passes through an inspection area. The system may also comprise a plurality of broadband photodetectors arranged in a vertical array, each photodetector facing at least one of the emitter assemblies with the inspection area therebetween such that the photodetectors are capable of sensing light energy that passes through the container when it is in the inspection area. The system may also comprise a processor in communication with the photodetectors for determining a characteristic of the container based on signals from the photodetectors. | 11-12-2009 |
20120018925 | INSPECTION SYSTEMS AND METHODS FOR BLOW-MOLDED CONTAINERS - Systems and methods for in-line inspection of plastic blow molded containers. The inspection system may comprise a plurality of emitter assemblies arranged in a vertical array. Each emitter assembly may cyclically emit light energy in at least two different narrow wavelength bands at a container as the container passes through an inspection area. The system may also comprise a plurality of broadband photodetectors arranged in a vertical array, each photodetector facing at least one of the emitter assemblies with the inspection area therebetween such that the photodetectors are capable of sensing light energy that passes through the container when it is in the inspection area. The system may also comprise a processor in communication with the photodetectors for determining a characteristic of the container based on signals from the photodetectors. | 01-26-2012 |
20120130677 | INSPECTION SYSTEM FOR PLASTIC CONTAINERS - Various embodiments are directed to systems and methods for generating section weights for blow-molded containers on-line. An inspection device may take a plurality of measurements of one or more container characteristics across a profile of a container while the container is on-line. A programmable processor may be programmed to receive the plurality of measurements and derive a material distribution of the container based on the plurality of measurements. The programmable processor may additionally be programmed to derive a relationship between the measured material distribution and section weights of a plurality of sections of the container and apply the relationship to determine section weights for the plurality of sections of the container. | 05-24-2012 |
20130268237 | CONTAINER THICKNESS MEASURING SYSTEMS AND METHODS - Various embodiments are directed to systems and methods for measuring a thickness of a container. For example, a control device may receive data indicating a surface topology of the container and based on the surface topology of the container, instruct a multi-axis positioning system to position a sensor relative to a first point of the container such that: a distance from the sensor to a surface at the first point is about equal to a predetermined distance; and the sensor direction is about normal to the surface at the first point. Data indicating the thickness at the first point may be received from the sensor. | 10-10-2013 |