Patent application number | Description | Published |
20090215983 | Compounds and methods for inhibiting hepatitis C virus replication - The inventors have discovered that an ATPase-deficient dominant-negative mutant NS3 protein of hepatitis C virus inhibits activity of the wild-type NS3 protein and inhibits replication of hepatitis C virus (HCV). The solved crystal structure of a multi-enzyme NS3 complex on a DNA substrate is also provided. The inventors have tested a peptide matching the sequence of a portion of NS3 that interacts with another NS3 molecule for inhibiting HCV replication. The peptide inhibits HCV replication. Accordingly, the invention provides a method of inhibiting HCV replication in cells infected with HCV involving transforming the cells with a vector expressing a dominant-negative mutant NS3 gene. The invention also provides a method of inhibiting HCV replication in cells infected with HCV involving administering to the cells a dominant-negative mutant NS3 protein. The invention also provides peptides and agents that inhibit HCV replication and methods of identifying agents that inhibit HCV replication. | 08-27-2009 |
20100129341 | FUSION PROTEINS OF COLLAGEN-BINDING DOMAIN AND PARATHYROID HORMONE - Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented. | 05-27-2010 |
20130337017 | FUSION PROTEINS OF COLLAGEN-BINDING DOMAIN AND PARATHYROID HORMONE - Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented. | 12-19-2013 |
20140377215 | DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN - Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided. | 12-25-2014 |
20150038423 | DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN - Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided. | 02-05-2015 |
20150284701 | FUSION PROTEINS OF COLLAGEN-BINDING DOMAIN AND PARATHYROID HORMONE - Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented. | 10-08-2015 |
Patent application number | Description | Published |
20120319520 | DC MOTOR - A dc motor includes a stator having multiple field magnet poles, and an armature having an armature core, armature coils, and a commutator, and brushes brought into contact with the commutator. The armature coils include concentrated winding coil units wound on respective teeth, and connecting wire units that electrically connect each of the concentrated winding coil units together. A segment group of the commutator includes a first segment and a second segment placed adjacently to each other, to which the concentrated winding coil units are connected, the segment group also includes a third segment disposed next to the adjacent placement, and only the connecting wire unit is connected to the third segment. The connecting wire units include connecting wire units that pass through slots and connect each of the concentrated winding coil units together. | 12-20-2012 |
20140346916 | COMMUTATOR MOTOR AND METHOD OF CONNECTING WINDINGS OF THE SAME - A commutator motor is configured such that an armature includes an armature core having teeth and slots, an armature coil, and a commutator having segments. The armature coil includes coil units in which windings are wound on the teeth, and jumper wire units for interconnecting between the coil units. Segment group includes first and second segments to which the coil units are connected, and a third segment to which only the jumper wire unit is connected. The first and second segments are disposed adjacent to each other, and the third segment is disposed next to the adjacent arrangement. The configuration includes the jumper wire unit that is wired from the third segment such that each of one part of the wire unit running to one side and the other part of the wire unit running to the other side is wired to pass through the same slot to interconnect between the coil units. | 11-27-2014 |
20150275962 | MOTOR - A motor which includes: inner ring having upper end surface, outer ring, and balls between inner ring and outer ring. Pressurizing spring, into which rotary shaft is inserted, is located between core and bearing, and provides bias forces in the axial direction of rotary shaft. Outer ring is pressed to fit into bearing holding part. Inner ring is fitted onto rotary shaft with gap therebetween. Upper end surface of inner ring is in contact with pressurizing spring. Pressurizing spring applies the bias forces of different strengths onto a surface in which upper end surface contacts with pressurizing spring, along a circumferential direction with the axial direction as a center. | 10-01-2015 |
Patent application number | Description | Published |
20120063826 | CLEANING BLADE, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE USING SAME - A cleaning blade for cleaning a moving surface of an object by contacting an edge thereof with the moving surface is provided. The cleaning blade includes a strip-shaped elastic main body, in which a leading end portion thereof including the edge is impregnated with an ultraviolet-crosslinked resin; and a cover layer, which is located on a surface of a portion of the crosslinked resin-impregnated portion including the edge as an outermost layer and which has higher hardness than the strip-shaped elastic main body. | 03-15-2012 |
20130189012 | CLEANING BLADE, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE USING THE CLEANING BLADE - A cleaning blade including a strip-shaped elastic blade having at least one obtuse-angled edge on a tip portion thereof, and a cover layer, which is located on a surface of the tip portion of the elastic blade including the obtuse-angled edge and which is harder than the elastic blade. The obtuse-angled edge having the cover layer thereon is contacted with a moving surface of a member to be cleaned to remove a powdery material from the moving surface of the member. | 07-25-2013 |
20130243484 | IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - An image forming apparatus including an image bearing member having a surface layer A having a surface hardness of 200 N/mm | 09-19-2013 |
20130243506 | IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - An image forming apparatus including at least a photoreceptor; and a cleaning blade formed of a strip-shaped elastic blade to contact an edge line to the surface of the photoreceptor, wherein the photoreceptor includes a surface layer comprising a particulate material, and the edge line of the cleaning blade includes a substrate of the elastic blade; a mixed layer having a thickness not less than 1.0 μm, formed of the substrate and at least one of an acrylic resin and a methacrylic resin, located at the surface of the substrate; and a surface layer having a thickness not less than 0.1 μm, formed of at least one of an acrylic resin and a methacrylic resin, located on the surface of the substrate. | 09-19-2013 |
20130243507 | CLEANING BLADE, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - A cleaning blade, including a strip-shaped elastic blade to contact the surface of a member to be cleaned, traveling on an edge line of the elastic blade, to remove a powder from the surface thereof, wherein the edge line of the elastic blade is impregnated with an ultraviolet curable resin including a fluorinated acrylic monomer, a surface layer harder than the elastic blade is formed on each of an under surface thereof, having the edge line as one line of the under surface and facing the member, and an apical surface thereof, having the edge line as one line of the apical surface and being parallel to a direction of the thickness thereof, and the apical surface is impregnated with the ultraviolet curable resin at a depth of from 50 to 150 μm and the under surface is impregnated therewith at a depth of from 20 to 100 μm. | 09-19-2013 |
20130251401 | IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - An image forming apparatus, including a photoreceptor; a charger; an irradiator; an image developer; a transferer; a fixer; and a cleaning blade formed of a strip-shaped elastic blade, removing a powder from the surface of the photoreceptor passing an edge line of the blade while contacting thereto, wherein the photoreceptor includes a crosslinked resin surface layer formed of at least one of an acrylic resin and a methacrylic resin, and the cleaning blade includes a contact point with the photoreceptor, including a substrate; a mixed layer formed of at least one of an acrylic resin and a methacrylic resin, located at the surface of the substrate; and a surface layer formed of at least one of an acrylic resin and a methacrylic resin, located on the surface of the substrate. | 09-26-2013 |
20140064810 | IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - An image forming apparatus includes an electrophotographic photoreceptor; and a cleaning blade. The electrophotographic photoreceptor includes an outermost layer having a ten-point average roughness Rz of from 0.5 to 2.4 μm and an average interval between concavities and convexities Sm of from 30 to 300 μm, and the cleaning blade includes a reed-shaped elastic blade having a contact point to the electrophotographic photoreceptor. The contact point includes a substrate; a mixed layer overlying the substrate, including a material forming the substrate and at least one of an acrylic resin and a methacrylic resin and having a thickness not less than 1.0 μm; and a surface layer overlying the mixed layer, including at least one of an acrylic resin and a methacrylic resin and having a thickness not less than 0.1 μm. | 03-06-2014 |
20140178103 | IMAGE FORMING APPARATUS, PROCESS CARTRIDGE, AND IMAGE FORMING METHOD - An image forming apparatus, including: an image bearing member; a charging unit; an exposure unit; a developing unit; a transfer unit; a fixing unit; and a cleaning unit including a cleaning blade, wherein the charging unit includes a charging roller that is brought into contact with the image bearing member for charging, the charging roller abutting the image bearing member at a pressing force of 10 mN/cm to 1,000 mN/cm, wherein the cleaning blade includes an elastic member that abuts the surface of the image bearing member to remove a residue attached to the surface of the image bearing member, and wherein an abutment part of the elastic member, which abuts the surface of the image bearing member, includes a cured product of an ultraviolet curable composition containing a (meth)acrylate compound having an alicyclic structure having 6 or more carbon atoms in a molecule. | 06-26-2014 |
20140205338 | CLEANING BLADE, AND IMAGE FORMING APPARATUS USING SAME AND PROCESS CARTRIDGE - Provided is a cleaning blade formed of an elastic blade and configured to abut on the surface of a cleaning target member, which allows a leading end edge portion of the elastic blade to move on the surface thereof, to remove powder from the surface of the cleaning target member. A blade surface of the elastic blade, which has the leading end edge portion of the elastic blade on one side thereof and faces the surface of the cleaning target member, has a Martens hardness of 1.2 N/mm | 07-24-2014 |
20140356042 | IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - An image forming apparatus includes an image carrier, a charging mechanism to charge a surface of the image carrier, an electrostatic latent image forming mechanism to form an electrostatic latent image on the surface of the image carrier, a developing mechanism to develop the electrostatic latent image formed on the surface of the image carrier into a toner image, a transfer mechanism to transfer the toner image on the surface of the image carrier to a transfer body, and a cleaning mechanism including a cleaning blade to clean a transfer residue toner adhering to the surface of the image carrier by contacting the surface of the image carrier. The cleaning blade includes a strip shaped elastic blade and a surface layer formed on an opposing surface of the strip shaped elastic blade opposite the surface of the image carrier. | 12-04-2014 |
20150023707 | CLEANING BLADE, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE - A cleaning blade includes an elastic member configured to come into contact with a surface of a member to be cleaned and remove residual matter adhering to the surface of the member to be cleaned. The elastic member satisfies the following requirements a and b: a. The elastic member has a contact portion configured to come into contact with the surface of the member to be cleaned and the contact portion includes a modified layer that contains a cured product of an ultraviolet curable composition containing a (meth)acrylate compound; and b. A value obtained by normalizing a peak area ratio S | 01-22-2015 |
20150117896 | CLEANING BLADE AND IMAGE FORMING APPARATUS INCLUDING SAME - A cleaning blade for an image forming apparatus includes a base and a contact portion disposed on the base that contacts and cleans a surface of an intermediate transfer belt. A Martens hardness of the contact portion of the cleaning blade is at least 2 [N/mm | 04-30-2015 |
20150139711 | CLEANING BLADE, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE - Provided is a cleaning blade including an elastic member configured to abut on a surface of a cleaning target member and remove residual material deposited thereon, wherein elastic member satisfies requirements a to c below,
| 05-21-2015 |
20150212479 | CLEANING BLADE, METHOD FOR PREPARING THE CLEANING BLADE, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE USING THE CLEANING BLADE - A cleaning blade is provided. The cleaning blade includes a strip-shaped elastic blade. At least the tip edge portion of the elastic blade, which is to be contacted with the surface of a moving object to remove a powdery material from the surface of the moving object, includes an ultraviolet crosslinked resin, which includes an acrylate or methacrylate unit including a fluorine-containing group, and another acrylate or methacrylate unit having a tricyclodecane or adamantane skeleton, from the surface of the tip edge portion to a depth of not less than 5 μm. | 07-30-2015 |
20150253722 | CLEANING BLADE, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - A cleaning blade cleaning the surface of an object includes a rigid holder; and a strip-shaped elastic body fixed on the holder, including a tip ridgeline contacting the surface of the object. The elastic body has a length (L) projecting from the holder not less than 4 mm, a Martens hardness of from 1.0 to 10.0 N/mm | 09-10-2015 |
20150261171 | CLEANING BLADE, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE USING THE CLEANING BLADE - A cleaning blade includes a supporting member, and a tabular elastic member. One end portion of the elastic member is fixed to the supporting member, and the other end portion is a free end portion whose tip edge is to be contacted with a member to be cleaned while rubbing the surface to remove a residual material therefrom. The tip portion of the free end portion of the elastic member ranging in length from 0 to 500 μm from the tip surface thereof includes at least a cured material of a curable compound and an elastic material of the elastic member. The elastic member satisfies the relationship, 0.05(%)≦[(t | 09-17-2015 |
20160004206 | CLEANING BLADE, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - A cleaning blade cleaning the surface of an object includes a rigid holder; and a strip-shaped elastic body fixed on the holder, including a tip ridgeline to contact the surface of the object. The cleaning blade includes a part having a Martens hardness of from 0.9 to 5.0 N/mm | 01-07-2016 |
20160004207 | CLEANING BLADE, IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE - A cleaning blade cleaning the surface of an object includes a rigid holder; and a strip-shaped elastic body fixed on the holder, having a tip ridgeline to contact the surface of the object. The elastic body has a Martens hardness M1 in the range of from 0.9 to 10.0 N/mm | 01-07-2016 |