Patent application number | Description | Published |
20100297758 | ARTIFICIAL PEPTIDE AND USE THEREOF - The present invention provides a method of transporting a peptide motif of interest into a nucleus of a eukaryotic cell from outside the cell, including: synthesizing a peptide chain having an amino acid sequence constituting the peptide motif of interest at an N-terminal end or a C-terminal end of a cell membrane-permeable nucleolar localization signal sequence defined by the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO: 1); adding the synthesized peptide to a culture medium which includes the eukaryotic cell or a tissue containing the eukaryotic cell; and culturing the eukaryotic cell to which the synthesized peptide is added, or the tissue containing the cell. | 11-25-2010 |
20120035112 | NEURONAL DIFFERENTIATION-INDUCING PEPTIDE AND USE THEREOF - A neuronal differentiation inducer provided by the present invention contains an artificially synthesized peptide which includes an amino acid sequence constituting a signal peptide in amyloid precursor protein (APP), or a partial sequence of the amino acid sequence constituting this signal peptide. | 02-09-2012 |
20120122210 | CARRIER PEPTIDE FRAGMENT AND USE THEREOF - A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample. | 05-17-2012 |
20120122225 | CARRIER PEPTIDE FRAGMENT AND USE THEREOF - The method for transferring a foreign substance provided by the present invention includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence WRRQARFK (SEQ ID NO. 1) or any amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample. | 05-17-2012 |
20120149053 | CARRIER PEPTIDE FRAGMENT AND USE THEREOF - A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including any amino acid sequence selected from SEQ ID Nos. 1, 2, 3, 4, 5, and 6, or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence of the selected sequence identification number, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample. | 06-14-2012 |
20120208752 | CELL PROLIFERATION-PROMOTING PEPTIDE AND USE THEREOF - A cell proliferation promoter includes, as an active ingredient, an artificially synthesized peptide that includes (A) an amino acid sequence constituting a membrane-permeable peptide and (B) an amino acid sequence selected from SEQ ID NOs: 19 to 103 or an amino acid sequence formed by substituting, deleting and/or adding one or several amino acid residues in the selected amino acid sequence. | 08-16-2012 |
20130005034 | ARTIFICIAL PEPTIDE AND USE THEREOF - Disclosed is a method for transforming human or non-human mammalian stem cells by introducing a desired peptide motif into the stem cells. The stem cell transformation method disclosed herein uses a synthesized peptide having an amino acid sequence which constitutes the desired peptide motif on the N-terminal end or C-terminal end of a cell membrane-permeable nucleolar localization signal sequence defined by the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO:1). | 01-03-2013 |
20130079273 | CELL GROWTH-PROMOTING PEPTIDE AND USE THEREOF - The pharmaceutical composition includes at least one pharmaceutically acceptable carrier, and an active ingredient including an artificially synthesized peptide includes: (A) an amino acid sequence constituting a cell-penetrating peptide and (B) an amino acid sequence constituting the signal peptide in amyloid precursor protein (APP) or an N-terminal partial amino acid sequence or C-terminal partial amino acid sequence from the amino acid sequence constituting that signal peptide. | 03-28-2013 |
20130323776 | CARRIER PEPTIDE FRAGMENT AND USE THEREOF - A method for transferring a foreign substance includes: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including any amino acid sequence selected from SEQ ID NOS: 1-6, or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence of the selected sequence identification number, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample. | 12-05-2013 |
20140051647 | SYNTHETIC PEPTIDE THAT INDUCES EXPRESSION OF TNF RECEPTOR 2 AND USE THEREOF - This invention provides a TNFR2 expression-inducing composition including as an active ingredient a peptide having TNFR2 expression-inducing activity, and a method for producing cells that express TNFR2 selectively by use of the composition. The cell production method provided by this invention includes: culturing at least one species of cells capable of expressing TNF receptor 2, and supplying the cells with a synthetic peptide consisting of a nuclear localization signal sequence (NLS) or a nucleolar localization signal sequence (NoLS) to enhance TNFR2 expression in the cells. | 02-20-2014 |
20140178990 | CELL PROLIFERATION-PROMOTING PEPTIDE AND USE THEREOF - A method for manufacturing at least one kind of eukaryotic cells or a biosynthetic substance derived from the eukaryotic cells by proliferating the cells, which includes preparing an artificially synthesized peptide for promoting proliferation of the at least one kind of eukaryotic cells, incubating the eukaryotic cells in a culture medium, and adding the synthesized peptide at least once to the culture medium during the incubation process. The synthesized peptide includes an amino acid sequence selected from SEQ ID NOS: 1 to 18, and an amino acid sequence selected from SEQ ID NOS: 19 to 97. | 06-26-2014 |
20140335613 | CELL GROWTH-PROMOTING PEPTIDE AND USE THEREOF - The pharmaceutical composition provided by the present invention comprises at least one pharmaceutically acceptable carrier, and an active ingredient including an artificially synthesized peptide comprises: (A) an amino acid sequence constituting a cell-penetrating peptide and (B) an amino acid sequence constituting the signal peptide in amyloid precursor protein (APP) or an N-terminal partial amino acid sequence or C-terminal partial amino acid sequence from the amino acid sequence constituting that signal peptide. | 11-13-2014 |
20140363889 | METHOD FOR PRODUCING MULTIPOLAR CELL - This invention provides a multipolar cell including three or more centrosomes dispersed therein and a multipolar spindle formed so as to extend from the three or more respective centrosomes. The multipolar cell production method provided by the present invention supplies cultured eukaryotic cells with a synthetic peptide as a multipolarity-inducing peptide, with the synthetic peptide having an amino acid sequence selected from SEQ ID NO: 1 to SEQ ID NO: 10 or an amino acid sequence formed by substituting, deleting and/or adding one, two or three amino acid residues in/from/to the selected amino acid sequence. As the eukaryotic cells, cultured tumor cells are used. | 12-11-2014 |
20150018286 | ANTITUMOR PEPTIDE AND USE THEREOF - This invention provides an antitumor peptide and an antitumor composition that includes the peptide for suppressing proliferation of at least one species of tumor cells. The antitumor composition provided by this invention includes an antitumor peptide capable of inducing formation of multipolar spindles in at least one species of tumor cells, and at least one species of pharmaceutically acceptable carrier, wherein the antitumor peptide is a synthetic peptide having an amino acid sequence selected from SEQ ID NOs: 1 to 22 or an amino acid sequence formed by substituting, deleting and/or adding one, two or three amino acid residues in/from/to the selected amino acid sequence. | 01-15-2015 |
Patent application number | Description | Published |
20080240926 | Cobalt-Free Ni-Base Superalloy - There is provided a Co-free Ni-base superalloy having a composition containing 1.0 to 10.0 wt % of Cr, 0.1 to 3.5 wt % of Mo, 7.5 to 10.0 wt % of W, 4.0 to 8.0 wt % of Al, 12.0 wt % or less of at least one species of Ta, Nb and Ti, 0 to 2.0 wt % of Hf, 0.1 to 5.0 wt % of Re and the remainder comprised of Ni and unavoidable impurities. The Co-free Ni-base superalloy exhibits high composition stability over a long period of time and is excellent in creep properties at high temperature, and also suitable as a turbine blade or turbine vane of atomic power generation in which maintenance for radioactive contamination and so forth are easy. | 10-02-2008 |
20090196760 | Nickel-Base Superalloy Excellent in the Oxidation Resistance - A nickel-base superalloy having excellent oxidation resistance is provided. It is useful as high-temperature members such as turbine blades and turbine vanes for jet engines or gas turbines. The nickel-base superalloy has a composition containing Co: 0.1 to 15% by weight, Cr: 0.1 to 10% by weight, Mo: 0.1 to 4.5% by weight, W: 0.1 to 15% by weight, Al: 2 to 8% by weight, Ta+Nb+Ti: 0 to 16% by weight, Hf: 0 to 5% by weight, Re: 0.1 to 16% by weight, Ru: 0.1 to 16% by weight, Si: 0.2 to 5% by weight and a balance made of Ni and unavoidable impurities. | 08-06-2009 |
20090317288 | Ni-Base Superalloy and Method for Producing the Same - A Ni-base superalloy having a chemical composition comprising Al: 4.5-7.0 wt %, Ta+Nb+Ti: 0.1-4.0 wt %, with Ta being less than 4.0 wt %, Mo: 1.0-8.0 wt %, W: 0.0-10.0 wt %, Re: 2.0-8.0 wt %, Hf: 0.0-1.0 wt %, Cr: 2.0-10.0 wt %, Co: 0.0-15.0 wt %, Ru: 0.0-5.0 wt %, and the balance being Ni and unavoidable impurities, and a method for producing the same are disclosed. The Ni-base superalloy has excellent creep property at high temperature and is suitable for use as a member at high temperature under high stress. | 12-24-2009 |
20100226779 | Ni-Base Superalloy, Method for Producing the Same, and Turbine Blade or Turbine Vane Components - A Ni-base superalloy having a chemical composition comprising Cr: 3.0-5.0 wt %, Co: 5.0-10.0 wt %, Mo: 0.5-3.0 wt %, W: 8.0-10.0 wt %, Ta: 5.0-8.0 wt %, Nb: 3.0 wt % or less, Al: 4.5-6.0 wt %, Ti: 0.1-2.0 wt %, Re: more than 3.0-4.0 wt %, Ru: 0.2-4.0 wt %, Hf: 0.01-0.2 wt %, and the balance being Ni and unavoidable impurities, a method for producing the same, and turbine blade or turbine vane components are disclosed. The Ni-base superalloy has high creep strength and textural stability under high temperature environment, and is excellent in applicability to turbine blade or turbine vane components of large-sized gas turbines. | 09-09-2010 |
20120133089 | HEAT TREATMENT FURNACE - A heating section | 05-31-2012 |