Mcguigan
Alison Mcguigan, Toronto CA
Patent application number | Description | Published |
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20100316690 | Modular assembly of tissue engineered constructs - Scaleable, vascularised tissue constructs that are composed of a multiplicity of cell containing, discrete and separable modules, methods of fabricating same and uses thereof. The tissue construct is a tissue substitute used in tissue transplantation or substitution or for the purpose of in vitro mimic of normal tissue. | 12-16-2010 |
20120171258 | Modular Assembly of Tissue Engineered Constructs - Scaleable, vascularised tissue constructs that are composed of a multiplicity of cell containing, discrete and separable modules, methods of fabricating same and uses thereof. The tissue construct is a tissue substitute used in tissue transplantation or substitution or for the purpose of in vitro mimic of normal tissue. | 07-05-2012 |
Brian Mcguigan, Doune GB
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20130309778 | ASSAY DEVICE AND READER - The present invention relates to a microfluidic based assay system, comprising a disposable assay cartridge and associated reading device, as well as the individual components themselves. The present invention also relates to methods of conducting assays, using the cartridge and device of the invention, as well as kits for conducting assays. | 11-21-2013 |
20140017709 | MICROFLUIDICS BASED ASSAY DEVICE - A subtractive corrective assay device and methodology, whereby ail required binding and label detection reagents are initially located within the detection zone. Application of a magnetic field is used to selectively remove bound label from the detection zone by means of paramagnetic particles. The relationship between measured label concentration before and after the application of a magnetic field within the detection zone is used to accurately measure analyte concentration within the sample. | 01-16-2014 |
Brian Mcguigan, London GB
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20100242971 | RESTRAINT - A restraint harness for a child is described. The restraint harness comprises an upper torso restraint, a lower torso restraint and at least one attachment device for attaching the upper and lower torso restraints to a stretcher or other device. In use, the upper torso restraint and the lower torso restraint restrain independently of each other. | 09-30-2010 |
20110295912 | DATA STORAGE AND TRANSFER - A method and apparatus for storing data regarding parameter values by making a series of measurements of parameter values at times separated by predetermined time intervals, processing the series of measurements of parameter values made at predetermined time intervals to identify events at different times, generating a further series of measurements of parameter values at each of said different times, and storing each of said further series of measurements of parameter values in association with said respective different time. | 12-01-2011 |
Chris Mcguigan, Cardiff GB
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20140140955 | SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS - This invention is directed to novel compounds of formula (I) having the structure (I) wherein U, V, W, Z, R | 05-22-2014 |
20140286903 | Substituted Purine Nucleosides, Phosphoramidate and Phosphordiamidate Derivatives for Treatment if Viral Infections - This invention is directed to compounds of Formula (I) having the structure that are useful in the treatment of viral infections in mammals, particularly in humans, mediated, at least in part, by a virus in the Flaviviridae family of viruses. | 09-25-2014 |
Christopher Mcguigan, Peterson Super Ely GB
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20150291650 | Process for Preparing Nucleoside Prodrugs - Provided is a process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral center of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Cu, Fe, La and Yb. | 10-15-2015 |
Christopher Mcguigan, Whitchurch GB
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20130012468 | CHEMICAL COMPOUNDS - 3-(2′,3′-dideoxy-ribo-β-L-furanosyl)[2,3-d]pyrimidin-2(3H)-one derivatives comprising 6-substitutents on the base moiety are shown to have anti-viral properties, particularly with respect to vaccinia and measles. The compounds have unnatural L ribose stereochemistry. | 01-10-2013 |
Christopher Mcguigan, Cardiff GB
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20090215715 | Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer - Phosphoramidate derivatives of nucleoside compounds such as cladribine, isocladribine, fludaribine and clofarabine have enhanced therapeutic potency in | 08-27-2009 |
20100222295 | Anti-Viral Pyrimidine Nucleoside Derivatives - A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH | 09-02-2010 |
20110015147 | ANTI-VIRAL PYRIMIDINE NUCLEOSIDE ANALOGUES - A compound of formula (I) wherein Ar can be one six-membered or two fused six-membered aromatic rings; R | 01-20-2011 |
20110124592 | NUCLEOSIDE ARYL PHOSPHORAMIDATES AND THEIR USE AS ANTI-VIRAL AGENTS FOR THE TREATMENT OF HEPATITUS C VIRUS - Phosphoramidate derivatives of nucleoside compounds of formula I derived from bases such as adenine and guanine have enhanced therapeutic potency, in particular, enhanced potency with respect to the prophylaxis or treatment of a viral infection such as hepatitis C virus. The glycoside moiety of the nucleoside compound is suitably substituted at the β-2′ position with methyl and the phosphoramidate group, suitably comprises 1-naphthyl linked by —O— to the P atom. | 05-26-2011 |
20110184003 | COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRAL INFECTION - The invention relates to compounds and methods for treating or preventing a viral infection, by administering a monophosphorylated prodrug of acyclovir or monophosphorylated derivative of an acyclovir prodrug to a subject suffering from or susceptible (to a viral infection, such as HIV infection. | 07-28-2011 |
20130096079 | Anti-Viral Pyrimidine Nucleoside Derivatives - A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH | 04-18-2013 |
20130252918 | PHOSPHORAMIDITE DERIVATIVES OF GEMCITABINE FOR USE IN THE TREATMENT CANCER - Phosphorodiamidate derivatives of e.g. gemcitabine are provided for use in treating cancer. In one embodiment, the two amidate motifs each comprises NR′R″ where R′ is H and R″ is CR | 09-26-2013 |
20140057866 | PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER - Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase. | 02-27-2014 |
20150072948 | ANTI-VIRAL PYRIMIDINE NUCLEOSIDE DERIVATIVES - A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH | 03-12-2015 |
20150183817 | PHOSPHORAMIDATE DERIVATIVES OF 5-FLUORO-2'-DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER - Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase. | 07-02-2015 |
Peter Mcguigan, Selborne GB
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20120060454 | CAM-TYPE LOCKING DEVICE FOR RETAINING STATIC FILTER PANELS IN A FILTER HOLDING FRAME - A filter holder assembly includes at least one frame having a peripheral wall and an inwardly directed peripheral edge substantially perpendicular to said peripheral wall and adapted to support a filter. At least one cam lock lever is secured to the peripheral wall at a first predetermined distance from the inwardly directed peripheral edge for compressing the filter in the frame and against said inwardly directed peripheral edge. The cam lock lever has a handle portion at one end thereof and a cam head provided with a cam foot at an opposite end thereof. The cam lock lever is rotatable to cause the cam foot to move between an open position and clamping position where the cam foot exerts a compressive force on the filter. | 03-15-2012 |
Peter Mcguigan, Hampshire GB
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20130014478 | Systems, Methods, and Apparatus for Providing FiltrationAANM Mann; RichardAACI HampshireAACO GBAAGP Mann; Richard Hampshire GBAANM Kulkarni; AbhijeetAACI HampshireAACO GBAAGP Kulkarni; Abhijeet Hampshire GBAANM McGuigan; PeterAACI HampshireAACO GBAAGP McGuigan; Peter Hampshire GB - Certain embodiments of the invention may include systems, methods, and apparatus for mounting filters. According to an example embodiment of the invention, a method is provided for mounting one or more filters in a housing with a tubesheet, an intermediate support, and a directional mount. The method can include providing a filter with a first filter section, manipulating the first filter section with respect to the intermediate support, and manipulating the first filter second end with respect to the intermediate support, where the first filter second end maintains its relative position with respect to the intermediate support, and the intermediate support is operable to engage with a second end of the directional mount. | 01-17-2013 |
20130014479 | Systems, Methods, and Apparatus for Providing FiltrationAANM Mann; RichardAACI HampshireAACO GBAAGP Mann; Richard Hampshire GBAANM Hiner; SteveAACI HampshireAACO GBAAGP Hiner; Steve Hampshire GBAANM Kulkarni; AbhijeetAACI HampshireAACO GBAAGP Kulkarni; Abhijeet Hampshire GBAANM McGuigan; PeterAACI HampshireAACO GBAAGP McGuigan; Peter Hampshire GB - Certain embodiments of the invention may include systems, methods, and apparatus for providing filtration. According to an example embodiment of the invention, a method is provided for mounting a filter including two or more filter sections in a housing. The method can include providing a first filter section configured for mounting to a tubesheet, the first filter section having a first filter first end and a first filter second end, wherein the first filter second end comprises one or more upper clamp devices; mounting the first filter section with the first filter first end adjacent to the tubesheet; providing a second filter section having a second filter first end comprising one or more lower clamp devices; and securing the second filter section to the first filter section, wherein the one or more lower clamp devices cooperate with the one or more upper clamp devices to secure the second filter section relative to the first filter section. | 01-17-2013 |
Peter Thomas Mcguigan, Selborne Alton GB
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20130097979 | FILTER CLAMPING SYSTEM - A spring loaded filter clamping frame includes a rear frame section which defines an interior space to secure a filter element. The rear frame section includes a projection extending toward the interior space and a rear latch mechanism. A front frame section defines an interior space and is slidably engaged with the rear frame section. An aperture in the front frame section interacts with the projection. A front latch mechanism with a latch mechanism biasing member interacts with the rear latch mechanism. A frame biasing member is located between the rear frame section and the front frame section. The frame biasing member applies a force urging the rear frame section and the front frame section apart, resulting in a filter clamping frame. In further examples, the frame biasing member is a coil spring and the latch mechanisms are hooks. | 04-25-2013 |
Peter Thomas Mcguigan, Selborne GB
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20120222359 | PRESSURE RELIEF DOOR WITH COUNTERWEIGHT MECHANISM - A counterweight mechanism that includes a radial arm with a weight and a series of elements interconnected between the door and the arm. The weight provides a closing force when in a first position and provides an opening force when in another position. The weight may be an over center weight and the closing force reduces when the weight moves toward an over center position. The counterweight mechanism may require manual resetting after the weight is in the second position. Door movement may be though an angle that is less than an angle of movement of the radial arm | 09-06-2012 |
20140144320 | CARTRIDGE FILTER DIMENSIONAL COMPENSATOR - A cartridge filter insert includes a body, an internal opening, and an exterior surface. The internal opening is configured to permit an airflow through the body. The exterior surface is configured to removably engage a surface of a cartridge filter having an outlet. The internal opening has an inside dimension smaller than an inside dimension of the outlet of the cartridge filter to effectively reduce the inside dimension of the outlet. An inlet filter house including the cartridge filter and the cartridge filter insert are also provided. Methods of filtering a fluid using the cartridge filter and the cartridge filter insert within the inlet filter house are also provided. | 05-29-2014 |