Sanjeev Kumar
Sanjeev Kumar Chandrayan, Bihar IN
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20080300843 | RECOMBINANT MESO-ACTIVE THERMOSTABLE PROTEINS AND PROCESSES OF DESIGN AND BIOSYNTHESIS THEREOF - The present invention deals with examination of the alterability of part, or whole, of the surfaces of beta sheet-based protein structures, focusing especially on enzymes. The alteration is done by supplanting/transplanting a part, or whole, of the surface of one protein onto the surface of a homologous protein of superimposable polypeptide backbone, by exploiting the structural features of beta sheets to alter only the regions of the surface involved in substrate/ligand binding and catalysis. The transplantation involves replacement of a selected set of non-contiguous residues constituting the surface regions desired to be altered in one enzyme/protein, by a set of non-contiguous residues located at analogous positions in the other enzyme/protein, in a manner that is likely to facilitate folding and function of the new protein formed by combining residues from both enzymes/proteins. The present invention also deals with using this surface engineering approach to selectively combine enzyme/protein characteristics from different domains of life that are not ordinarily combined by natural evolution, such as the creation of novel proteins that retains the bulk of the thermostable scaffold of a thermophile enzyme onto which the active surface of a mesophile homolog is transplanted, so as to create a thermo-stable protein with meso-active functional characteristics of pH and temperature of optimal function. | 12-04-2008 |
20150322418 | RECOMBINANT MESO-ACTIVE THERMO-STABLE PROTEIN AND PROCESSES OF DESIGN AND BIOSYNTHESIS THEREOF - The present invention deals with examination of the alterability of part, or whole, of the surfaces of beta sheet-based protein structures, focusing especially on enzymes. The alteration is done by supplanting/transplanting a part, or whole, of the surface of one protein onto the surface of a homologous protein of superimposable polypeptide backbone, by exploiting the structural features of beta sheets to alter only the regions of the surface involved in substrate/ligand binding and catalysis. The transplantation involves replacement of a selected set of non-contiguous residues constituting the surface regions desired to be altered in one enzyme/protein, by a set of non-contiguous residues located at analogous positions in the other enzyme/protein, in a manner that is likely to facilitate folding and function of the new protein formed by combining residues from both enzymes/proteins. The present invention also deals with using this surface engineering approach to selectively combine enzyme/protein characteristics from different domains of life that are not ordinarily combined by natural evolution, such as the creation of novel proteins that retains the bulk of the thermostable scaffold of a thermophile enzyme onto which the active surface of a mesophile homolog is transplanted, so as to create a thermo-stable protein with meso-active functional characteristics of pH and temperature of optimal function. | 11-12-2015 |
Sanjeev Kumar Chandriki, Bangalore IN
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20150159512 | METHOD AND SYSTEM FOR USE IN COOLING A JOINT FLANGE BOLT OF A ROTARY MACHINE - A method of cooling at least one joint flange bolt used with a rotary machine includes extracting a working fluid having a first temperature that is lower than an operating temperature at a first joint flange bolt hole. The method also includes diverting a first portion of the extracted working fluid into a first supply hole that is in flow communication with a first clearance gap defined between the first joint flange bolt hole and the joint flange bolt. The method further includes exhausting the first portion of extracted working fluid through a first exhaust hole in flow communication with the first clearance gap, such that the first portion of extracted working fluid flows around the exterior surface of the joint flange bolt. Additionally, the method includes routing the first portion of the extracted working fluid into a first conduit in flow communication with the first exhaust hole. | 06-11-2015 |
Sanjeev Kumar Gupta, Los Altos, CA US
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20150095341 | SYSTEM AND A METHOD FOR HIERARCHICAL DATA COLUMN STORAGE AND EFFICIENT QUERY PROCESSING - An embodiment provides intermediate data derived in the form of column stores which are in turn based on hierarchical data stores. This intermediate data represents a reduced subset of data matched appropriately to a query (or modified query) such that the amount of data handled in a query processing task on large data is greatly reduced. An embodiment may appropriately choose column data stores and/or modify queries in order leverage parallelization techniques such as map-reduce in order to query large data. The result is the ability to query large data stores in parallel while reducing the amount of data that must be handled. | 04-02-2015 |
Sanjeev Kumar Jain, New Delhi IN
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20150342489 | QRS COMPLEX IDENTIFICATION IN ELECTROCARDIOGRAM SIGNALS - The present subject matter relates to processing of Electrocardiogram (ECG) signals, and in particular, relates to identifying a QRS complex in an ECG signal. The method includes receiving, and filtering the ECG signal by passing through at least one of a first low-pass filter and a high-pass filter to obtain a filtered ECG signal. The filtered ECG signal is processed based on a moving average technique. Further, a search region is identified in the processed ECG signal, and a maximum amplitude peak is identified in a time interval of the filtered ECG signal that corresponds to a time span of the search region of the processed ECG signal. The maximum amplitude peak is an R peak of the QRS complex. Subsequently, a Q peak and an S peak of the QRS complex is identified based on the R peak. | 12-03-2015 |
Sanjeev Kumar Jain, Uttar Pradesh IN
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20150085566 | INPUT TRIGGER INDEPENDENT LOW LEAKAGE MEMORY CIRCUIT - Wordline-driver biasing and column-based source-biasing circuitry facilitate reduced current leakage, for example, in SoC device SRAM circuits in a manner that is independent of the read/write/standby operating mode, and without an external trigger. Wordline-driver-biasing circuitry turns off (i.e., decouples from system power) wordline-drivers that are connected to unselected wordlines during read/write operations using one of a decoder-enable signal, which is generated in response to row address values, or based on the activation of a self-timing internal clock, which is generated by the memory circuit when it is activated (i.e., switched from standby to read/write mode). Alternatively, or in addition, source-biasing circuitry applies a relatively high source-biasing voltage to the source terminals of memory cells in unselected columns during read/write operations based on column address values (i.e., a low source voltage is applied only to the selected column being written to or read from). | 03-26-2015 |
Sanjeev Kumar Kaushalya, Mumbai IN
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20090086204 | Fluorescence Correlation Microscopy with Real-Time Alignment Readout - This invention relates to a confocal fluorescence correlation microscope with real-time alignment read out. With this instrument it is possible to do confocal imaging together with the particle size determination at a chosen location in the specimen. In particular, this invention relates to a detector module with a fixed aperture and detection electronics that can be conveniently connected to an existing confocal or multiphoton microscope, near the base of the objective lens of the microscope. This detector splits a part of the signal and uses it to generate a spot on the confocal image. This shows the spot where an FCS measurement can be carried out, and the same signal can then be used to perform a fluorescence correlation measurement after parking the excitation beam of the confocal to that spot. No alignment step is necessary for obtaining the measurement. | 04-02-2009 |
Sanjeev Kumar Mahto, Haifa IL
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20150031070 | OPTICALLY SENSITIVE CELL NETWORK - A neural network is disclosed. The neural network comprises a plurality of optogenetically modified neural cells being three-dimensionally distributed in a hydrogel medium and being disconnected from any solid support having a shear modulus above 1 GPa. | 01-29-2015 |
Sanjeev Kumar Mendirata, Ahmedabad IN
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20130289276 | PROCESS FOR PREPARING AN INTERMEDIATE OF SITAGLIPTIN VIA ENZYMATIC CONVERSION - The invention provides a process for preparing 3-hydroxy-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one (Formula I), into its racemic (R/S) form or any of its optically active (S) or (R) forms or enantiomeric excess mixture of any of the forms comprising: | 10-31-2013 |
Sanjeev Kumar Mendiratta, Ahmedabad, Gujarat IN
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20160115195 | PURIFICATION PROCESS FOR MONOCLONAL ANTIBODIES - The present invention provides an improved method for the purification of monoclonal antibody from cell culture. Process of purification of the desired monoclonal antibody comprises affinity, hydrophobic interaction and optionally ion exchange column chromatography. It provides more than 99% purity of the desired monoclonal antibody. | 04-28-2016 |
Sanjeev Kumar Mendiratta, Ahmedabad IN
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20130330808 | NOVEL PROCESS FOR THE PURIFICATION OF TISSUE PLASMINOGEN ACTIVATOR - The present invention provides process of purification of tissue plasminogen activator (tPA) from a crude mixture or a partially purified mixture containing tPA protein and impurities by using hydrophobic interaction column chromatography, optionally in combination with ion exchange column chromatography. | 12-12-2013 |
20150071936 | PHARMACEUTICAL FORMULATIONS OF TNF-ALPHA ANTIBODIES - The present invention provides certain improved formulations of proteins. Specifically, the present invention provides use of certain excipients that are useful for stabilization of antibody preparations. Additionally, the novel formulations of the present invention prevents the formation of aggregates or fragments or modifications of protein in solution. | 03-12-2015 |
Sanjeev Kumar Mendiratta, Gujarat IN
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20090215121 | Process for Preparing High Levels of Interferon Beta - The present invention relates to a novel process for the production of interferon-beta in improved yields by fermentation. | 08-27-2009 |
20090305354 | PROCESS FOR PREPARING HUMAN G-CSF - The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase. | 12-10-2009 |
20130244280 | EXPRESSION VECTOR FOR HIGH LEVEL EXPRESSION OF RECOMBINANT PROTEINS - The present invention provides an expression vector for the production of proteins and peptides comprising a promoter operably linked to gene of interest, TPL and VA genes I and II, matrix attachment regions (MARs)/SARs, and antibiotic marker. The vector is transfected in suitable host cell. | 09-19-2013 |
20140147896 | ENZYME FOR THE PRODUCTION OF OPTICALLY PURE 3-QUINUCLIDINOL - The present invention provides a process for production of optically pure quinuclidinol of formula-(I) by reduction of quinuclidinone of formula-(II) in presence of suitable oxidoreductase enzyme derived from | 05-29-2014 |
Sanjeev Kumar Mendirette, Gujarat IN
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20120142891 | FUSION PROTEIN SYSTEMS SUITABLE FOR HIGH EXPRESSION OF PEPTIDES - The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide. | 06-07-2012 |
Sanjeev Kumar Shangary, Ann Arbor, MI US
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20110112052 | SPIRO-OXINDOLE MDM2 ANTAGONISTS - Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases. | 05-12-2011 |
Sanjeev Kumar Upadhayay, Irvine, CA US
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20150072940 | Treatment of Obesity and Obesity-Related Disorders by Pharmalogical Targeting of Kv 1.3 Potassium Channels - Activation of brown adipose tissue, treatment of obesity and/or treatment of obesity-related disorders in human or non-human animal subjects by administering to the subject a potassium channel inhibiting agent. The potassium channel inhibiting agent may comprise ShK toxin or a modified ShK toxin. Examples of modified ShK toxins include ShK-186. | 03-12-2015 |