Patent application number | Description | Published |
20130073170 | SYSTEM AND METHOD FOR SIMULATING A GAS TURBINE COMPRESSOR - A method for simulating a compressor of a gas turbine is disclosed. The method may generally include determining a predicted pressure ratio and a predicted mass flow of the compressor based on a model of the gas turbine, monitoring an actual pressure ratio and an actual mass flow of the compressor, determining difference values between at least one of the predicted pressure ratio and the actual pressure ratio and the predicted mass flow and the actual mass flow, modifying the difference values using an error correction system to generate a compressor flow modifier and using the compressor flow modifier to adjust the predicted pressure ratio and the predicted mass flow. | 03-21-2013 |
20140018973 | SYSTEMS AND METHODS FOR LIQUID FUEL MODELING - A system includes a model-based control unit configured to receive a lower heating value for a liquid fuel having a composition. The processor is configured to determine a specific gravity, a hydrocarbon ratio, or both, for the liquid fuel based, at least in part, on the lower heating value of the liquid fuel. The processor is configured to compare the hydrocarbon ratio, the specific gravity, and/or the lower heating value of the liquid fuel to a collection of hydrocarbon ratios, specific gravities, and/or lower heating values for a plurality of mixtures of methane and ethylene. The processor is configured to identify a mixture of methane and ethylene from the collection that best matches the hydrocarbon ratio, the specific gravity, and/or the lower heating value of the liquid fuel and configured to use the identified mixture of methane and ethylene as a model for the composition of the liquid fuel. | 01-16-2014 |
Patent application number | Description | Published |
20090214382 | Methods of sterilizing biological mixtures using alpha-keto acids - Methods are disclosed for sterilizing biological materials to reduce the level of one or more biological contaminants or pathogens therein, such as viruses, bacterial (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multicellular parasites, and/or prions or similar agents responsible. These methods involve the use of alpha-keto acids in methods of sterilizing biological materials with irradiation. | 08-27-2009 |
20110039302 | Method of Producing Factor VIII Proteins by Recombinant Methods - Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the cell under conditions for producing commercially viable Factor VIII protein. Also provided are nucleic acid molecules which encode a Factor VIII protein operably linked to a Chinese hamster elongation factor 1-α (CHEF1) promoter, which may be used in the methods provided herein. | 02-17-2011 |
Patent application number | Description | Published |
20090202039 | Methods for Sterilizing Biological Materials Containing Non-Aqueous Solvents - Methods are disclosed for sterilizing biological materials to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, | 08-13-2009 |
20090221492 | EXPRESSION OF ACTIVE HUMAN FACTOR IX IN MAMMARY TISSUE OF TRANSGENIC ANIMALS - Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention. Transgenic animals of the present invention are produced by introducing into developing embryos DNA that encodes Factor IX, such that the foreign DNA is stably incorporated in the DNA of germ line cells of the mature animal. Particularly efficient expression was accomplished using a chimeric construct comprising a mammary gland specific promoter, Factor IX cDNA that lacked the complete or any portion of the 5′-untranslated and 3′-untranslated region, which is substituted with a 5-′ and 3′-end of the mouse whey acidic protein gene. In vitro cell cultures of cells explanted from the transgenic mammal of the invention and methods of producing Factor IX from such said culture and methods of treating hemophilia B are also described. | 09-03-2009 |
20110091353 | Methods for Sterilizing Tissue - Methods are disclosed for sterilizing tissue to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria, (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, prions or similar agents responsible, alone or in combination, for TSEs and/or single or multicellular parasites. The methods involve sterilizing one or more tissues with irradiation. | 04-21-2011 |
20120276079 | METHOD OF PRODUCING RECOMBINANT VITAMIN K DEPENDENT PROTEINS - Methods for producing cell lines with high levels of biologically active recombinant vitamin K dependent proteins are described. The transfected cell lines do not include heterologous genes for processing enzymes and are not subject to selection pressure such as methotrexate resistance. Cell lines producing Factor VII/VIIa and Factor IX are described. These cell lines can be used for isolation of Factor VII/VIIa and/or Factor IX for treatment of Hemophilia. | 11-01-2012 |
20130266982 | METHOD OF PRODUCING BIOLOGICALLY ACTIVE VITAMIN K DEPENDENT PROTEINS BY RECOMBINANT METHODS - The invention relates to commercially viable methods for producing biologically active vitamin K dependent proteins, particularly Factor IX. Factor IX is produced at a level of at least about 15 mg/L and is at least 25% biologically active. The method relies upon co-expression of one or more of paired basic amino acid converting enzyme (PACE), vitamin K dependent epoxide reductase (VKOR) and vitamin K dependent γ-glutamyl carboxylase (VKGC) at a preferred ratio so that the vitamin K dependent protein is efficiently produced and processed by a recombinant cell. | 10-10-2013 |