Wolf, MA
Beni Wolf, Lexington, MA US
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20140363451 | Anti-FOLR1 Immunoconjugate Dosing Regimens - Methods of administering immunoconjugates that bind to FOLR1 are provided. The methods comprise administering an anti-FOLR1 immunoconjugate to a person in need thereof, for example, a cancer patient, at a therapeutically effective dosing regimen that results in minimal adverse effects. | 12-11-2014 |
Beni B. Wolf, Lexington, MA US
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20140099332 | DIAGNOSTIC ASSAYS AND KITS FOR DETECTION OF FOLATE RECEPTOR 1 - The invention generally relates to antibodies that bind to human folate receptor 1 and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided. | 04-10-2014 |
Dana E. Wolf, Newton, MA US
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20090048971 | Payment Card with Dynamic Account Number - A payment card comprises a processor, a trigger source coupled to the processor, and a display for outputting at least a portion of a dynamic account number under control of the processor responsive to the trigger source. The dynamic account number is determined based at least in part on a seed stored in the payment card and an output of the trigger source. In an illustrative embodiment, the dynamic account number is generated utilizing a time-based or event-based one-time password algorithm. For example, in a time-based embodiment, the trigger source may comprise a time of day clock, with the dynamic account number being determined based at least in part on the seed and a current value of the time of day clock. In an event-based embodiment, the trigger source may comprise an event counter, with the dynamic account number being determined based at least in part on the seed and a current value of the event counter. | 02-19-2009 |
Dana Elizabeth Wolf, Boston, MA US
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20140351939 | SYSTEMS AND METHODS FOR DETERMINING AN OBJECTIVE SECURITY ASSESSMENT FOR A NETWORK OF ASSETS - A security assessment tool can determine computer assets in a network and provide an overall security score for the network. The overall security score can represent an objective measure of the security of the network that considers potential security threats to the computer assets, counter measures deployed in the network to address the potential security threats, and the effectiveness of the counter measures. Based on the overall security assessment, the security assessment tool can provide recommendations for improving the security of the network. | 11-27-2014 |
20140351940 | SYSTEMS AND METHODS FOR ASSESSING SECURITY FOR A NETWORK OF ASSETS AND PROVIDING RECOMMENDATIONS - A security assessment tool can determine computer assets in a network and provide an overall security score for the network. The overall security score can represent an objective measure of the security of the network that considers potential security threats to the computer assets, counter measures deployed in the network to address the potential security threats, and the effectiveness of the counter measures. Based on the overall security assessment, the security assessment tool can provide recommendations for improving the security of the network. | 11-27-2014 |
Daniel A. Wolf, Cambridge, MA US
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20140171491 | INTRANASAL DELIVERY OF AAV ENCODING THERAPEUTIC ENZYMES TO THE CENTRAL NERVOUS SYSTEM FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES - The invention provides a method to prevent, inhibit or treat one or more neurological symptoms associated with a lysosomal storage disease in a mammal in need thereof, which includes intranasally administering to the mammal a composition comprising an effective amount of a lysosomal storage enzyme or a recombinant adeno-associated virus vector comprising an open reading frame encoding a lysosomal storage enzyme. Also provided are compositions and devices useful in the methods. | 06-19-2014 |
David E. Wolf, Sudbury, MA US
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20120184831 | SYSTEMS, DEVICES AND METHODS FOR MONITORING HEMODYNAMICS - Systems, devices and methods for monitoring hemodynamics are described. The systems and methods generally involve directing light toward an area of the body and detecting the resulting scattered light. The scattered light is detected and an electrical signal representative of the scattered light intensity is generated from the detected light. The electrical signal is analyzed by measuring temporal fluctuations of such signals to monitor pathological states over time including hemorrhagic shock, hypoxia, and tissue graft vascularization. Such monitoring can have significant benefits to patients. | 07-19-2012 |
20140323879 | SYSTEMS, DEVICES AND METHODS FOR MONITORING HEMODYNAMICS - Systems, devices and methods for monitoring hemodynamics are described. The systems and methods generally involve directing light toward an area of the body and detecting the resulting scattered light. The scattered light is detected and an electrical signal representative of the scattered light intensity is generated from the detected light. The electrical signal is analyzed by measuring temporal fluctuations of such signals to monitor pathological states over time including hemorrhagic shock, hypoxia, and tissue graft vascularization. Such monitoring can have significant benefits to patients. | 10-30-2014 |
Eric A. Wolf, Norwood, MA US
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20140257729 | TIME SYNCHRONIZED REDUNDANT SENSORS - A redundant sensor includes at least two sensing elements. The redundant sensor includes methods and apparatus for time-stamping and combining data from the sensing elements. A method of use and additional embodiments are disclosed. | 09-11-2014 |
20150155705 | CIRCUIT DESIGNS FOR INDUCED TRANSIENT IMMUNITY - A circuit for protecting a voltage supply to a sensor from a transient event is provided. The circuit includes at least one buffer capacitor configured to provide output during the transient event, the output substantially equivalent to output of a regulated supply during normal operation of the sensor. A method of fabrication and a sensor are disclosed. | 06-04-2015 |
Fyodor Wolf, Belmont, MA US
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20120102164 | DEPLOYMENT OF LOCATION BASED APPLICATIONS WITH CROWDSOURCED STRUCTURED POINTS OF INPUT FOR DATA ENTRY - A method for managing location based applications providing crowdsourced structured points of input for data entry includes deploying deployable applications to a mobile computing device. Each deployable application includes a location based application component and a corresponding point of input defining structured data to be provided through a user interface control for a portion of a display for the application component. The method also includes selecting a subset of the deployable applications for display in the mobile computing device and activating one of the deployable applications in the subset for display in the mobile computing device to receive data input. Further, the method includes receiving data input for a point of input corresponding to a location based application component of the activated one of the deployable applications. Finally, the method includes storing geographic coordinates and the data input in connection with a portion of a display, such as a map display, for a corresponding application component of the activated one of the deployable applications. | 04-26-2012 |
20120102165 | CROWDSOURCING LOCATION BASED APPLICATIONS AND STRUCTURED DATA FOR LOCATION BASED APPLICATIONS - Embodiments of the present invention provide a method, system and computer program product for deploying a location based applications providing crowdsourced structured points of input for data entry. In an embodiment of the invention, a method for deploying a location based application providing crowdsourced structured points of input for data entry includes the selection of a location based application component, such as a map, for inclusion in a deployable application and the definition of a point of input for the location based application component. In this regard, the point of input can include at least one user interface control accepting data input of structured data. Finally the deployable application can be uploaded to a deployable application repository over a computer communications network for deployment to requesting mobile devices over the computer communications network. | 04-26-2012 |
Gerald L. Wolf, Westborough, MA US
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20090004113 | Macrophage-Enhanced MRI (MEMRI) - Methods for assessing stage of cancer in a subject are provided, comprising administering a macrophage imaging agent to the subject, making a magnetic resonance image of regions of the subject's body at cancer risk, and using the image to assess macrophage density and displacement associated with any primary cancer or metastatic cancer in the subject, such density and displacement being indicative of neoplasia. The macrophage imaging agent may be an ultrasmall superparamagnetic iron oxide particle and in particular embodiments, the macrophage imaging agent has a blood half-life sufficient to permit microphage trapping throughout the regions at cancer risk. Additional embodiments provide methods for assessing efficacy of an anticancer treatment in a subject, methods for determining frequency of follow-up MEMRI evaluation in a subject, methods for determining metastatic potential of cancer foci in a subject, and methods for determining prognosis of cancer in a subject. Methods for directing site of biopsy in a subject by performing a whole body MEMRI evaluation of the subject to identify macrophage density at a tumor site of interest and assessing the macrophage density to identify the site of biopsy in the subject, macrophage density being an indicator of tumor growth are also provided, in addition to methods for providing individualized cancer treatment to a subject in need thereof using whole body MEMRI evaluation. | 01-01-2009 |
Gerald L. Wolf, Newton, MA US
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20120003160 | Macrophage-Enhanced MRI (MEMRI) in a Single Imaging Session - Methods for performing macrophage-enhanced MRI, utilizing a macrophage imaging agent, in a single imaging session are provided. The macrophage imaging agent may be an ultrasmall superparamagnetic iron oxide particle. One embodiment includes administering a macrophage imaging agent to the subject during an administration session then allowing a passage of time sufficient for accumulation of the agent in macrophages of the subject. Subsequently, in a single imaging session, a macrophage-enhanced magnetic resonance image is acquired to target macrophages and a different magnetic resonance image is acquired to target physiological phenomenon other than macrophages. Additional embodiments provide methods wherein the acquisition of a different magnetic resonance image is achieved by vascular-enhanced MRI protocols or perfusion-enhanced MRI protocols, or combinations thereof. Further embodiments provide methods for utilizing acquired images in assessment of treatment of disease. | 01-05-2012 |
20130336897 | THERANOSIS OF MACROPHAGE-ASSOCIATED DISEASES WITH ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (USPIO) - Macrophages sequester and aggregate ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) in their lysosomes. The amount of USPIO loading of macrophages depends upon the route and dose of administration, and the pharmacokinetics of accumulation and removal. Both fixed macrophages and activated macrophages associated with inflammatory diseases and cancer phagocytize USPIOs, and the loaded macrophages can serve to identify the extent of a macrophage-dependent disease as well as to direct treatment options. Furthermore, the absorption of energy from incident electromagnetic waves by the aggregated nanoparticles can be used for conformal thermotherapy. The USPIOs can further be used to carry drugs to the same activated macrophages. The co-administered drugs can be bound to the USPIO by condition-dependent releasing links that are responsive to local pH or heating. | 12-19-2013 |
20140249413 | THERANOSIS OF MACROPHAGE-ASSOCIATED DISEASES WITH ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES (USPIO) - Macrophages sequester and aggregate ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) in their lysosomes. The amount of USPIO loading of macrophages depends upon the route and dose of administration, and the pharmacokinetics of accumulation and removal. Both fixed macrophages and activated macrophages associated with inflammatory diseases and cancer phagocytize USPIOs, and the loaded macrophages can serve to identify the extent of a macrophage-dependent disease as well as to direct treatment options. Furthermore, the absorption of energy from incident electromagnetic waves by the aggregated nanoparticles can be used for conformal thermotherapy. The USPIOs can further be used to carry drugs to the same activated macrophages. The co-administered drugs can be bound to the USPIO by condition-dependent releasing links that are responsive to local pH or heating. | 09-04-2014 |
20150297757 | MACROPHAGE-ENHANCED MRI (MEMRI) IN A SINGLE IMAGING SESSION - Methods for performing macrophage-enhanced MRI, utilizing a macrophage imaging agent, in a single imaging session are provided. The macrophage imaging agent may be an ultrasmall superparamagnetic iron oxide particle. One embodiment includes administering a macrophage imaging agent to the subject during an administration session then allowing a passage of time sufficient for accumulation of the agent in macrophages of the subject. Subsequently, in a single imaging session, a macrophage-enhanced magnetic resonance image is acquired to target macrophages and a different magnetic resonance image is acquired to target physiological phenomenon other than macrophages. Additional embodiments provide methods wherein the acquisition of a different magnetic resonance image is achieved by vascular-enhanced MRI protocols or perfusion-enhanced MRI protocols, or combinations thereof. Further embodiments provide methods for utilizing acquired images in assessment of treatment of disease. | 10-22-2015 |
Gerald Lee Wolf, Newton, MA US
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20130224073 | Device for detection of magnetic nanoparticle aggregation or disaggregation - A device that uses radiofrequency detection of the aggregation or disaggregation of magnetic nanoparticles without using nuclear magnetic resonance methods is described. The signals from one or more magnetic nanoparticle species in separate sample wells are compared to ascertain that aggregation or disaggregation has occurred. Depending on the specific reagents used, the detected aggregation or disaggregation event can be interpreted as an indicator of the presence of a molecule or microorganism of interest in a liquid sample. | 08-29-2013 |
Jay B. Wolf, Framingham, MA US
Len Alan Wolf, Salem, MA US
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20150308915 | FUEL LEAK DETECTION SYSTEM FOR USE IN A TURBINE ENCLOSURE - A fuel leak detection system for use in a turbine enclosure is provided. The system includes a ventilation duct extending through an interior cavity of the turbine enclosure such that an extended portion of the ventilation duct is positioned within a bottom portion of the turbine enclosure. The ventilation duct includes a plurality of openings configured to allow air from within the turbine enclosure to be drawn into the ventilation duct through the plurality of openings. The system also includes a sensor system coupled in flow communication with the air drawn into the ventilation duct, the sensor system configured to detect fuel in the air. | 10-29-2015 |
Mary-Anne G. Wolf, North Billerica, MA US
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20110035244 | Project Management System for Integrated Project Schedules - A simulation system and technique for simulating a project is described. The simulation system includes a work detail database having stored therein a plurality of attributes for the project, and a schedule generator coupled to receive information from the work detail database and having a push processor and a pull processor coupled thereto. The push and pull processors utilize different techniques/methodologies to establish dates and activities in a schedule produced by the schedule generator. | 02-10-2011 |
Oren Wolf, Bedford, MA US
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20110022601 | BLOCK LEVEL TAGGING WITH FILE LEVEL INFORMATION - Embodiments for data tagging in a computing environment are provided. A write operation in an operating system (OS) file system level storage layer is intercepted. A set of signatures in a sub-chunk level is calculated. The set of signatures are aligned to the beginning of an OS file system-level object and stored in a memory location, such as a cache, along with file system information relating to the write operation and to the file system-level object that the data is written into. Following file system processing, and as the data is written into storage in blocks, the write operation is intercepted in the block level storage layer. A secondary set of signatures in a sub-block level is calculated using a common algorithm used to create the original set of signatures. The sets of signatures are compared against each other, and blocks of the data having matching signatures are tagged with the file system information stored in the memory location. | 01-27-2011 |
20110055293 | Data Repository Selection Within a Storage Environment - Described is a method, system, and computer program product for selecting a data repository within a computing environment. The data repository can exist on multiple target computing systems as a logical entity called a volume or a file system. When selecting at least one data repository, a data protection system of the computing environment analyzes the incoming data from a source computing system, in conjunction with information describing the data repositories. The data repository information, or repository characteristic information, can be stored on a repository volume table (RVT) of the data protection system. By determining a weighted selection score from the analysis of all the information available to the data protection system, the data protection system can intelligently select a data repository for storing data from the source computing system. Further, by tracking repository characteristic information on a continuous or periodic basis, the data protection system can enable emulated views of data that has been stored on the data repositories of the computing environment. | 03-03-2011 |
20110184916 | INCREMENTAL AND PRIORITIZED RESTORATION OF BLOCKS - A first computational platform generates a data structure that indicates a set of blocks, wherein the indicated set of blocks have to be rewritten to revert a logical storage structure stored in the first computational platform to a previous state. An Input/Output (I/O) request that corresponds to a read operation on a selected block of the logical storage structure is received. A determination is made from the data structure that the selected block has to be rewritten to revert the logical storage structure stored in the first computational platform to the previous state. The first computational platform receives the selected block from a second computational platform, in response to a request made by the first computational platform to the second computational platform for the selected block. | 07-28-2011 |
20110208930 | Providing Shared Access to Data Storage Resources Across Cluster Computing Environment Boundaries - Providing shared access to data storage resources in a cluster computing environment, including detecting when a computer node requests access to a data storage device in a manner that excludes a computing device from accessing the data storage device, where the computer node is configured to communicate with the data storage device along a first communications channel, and where the computing device is configured to communicate with the data storage device along a second communications channel that is exclusive of the first communications channel, and responsive to the detecting, causing the data storage device to allow the computer node and the computing device to share access to the data storage device. | 08-25-2011 |
Oren Wolf, Newton, MA US
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20120089572 | AUTOMATED AND SELF-ADJUSTING DATA PROTECTION DRIVEN BY BUSINESS AND DATA ACTIVITY EVENTS - Techniques for adjusting the frequency of data backups and initiating event-driven backups in a storage system are disclosed herein. In one embodiment, a self-adjusting backup frequency, known as a “Change Rate Objective,” is defined to conduct or delay backups for one or more volumes in the storage system on the basis of an associated policy value. The Change Rate Objective may be tied to one or more business or data activity events, such as the amount and type of data changes since a last backup. The storage system may also be tailored to conduct or delay full or incremental backups on the basis of a Change Rate Objective that measures whether a full or incremental or differential backup is more appropriate. Various data or system failures, or data or business events may also be used to adjust the retention periods of continuous data protection (CDP) data and delay a rollup of CDP data. | 04-12-2012 |
Oren Wolf, Waltham, MA US
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20130346374 | RESTORING OBJECTS IN A CLIENT-SERVER ENVIRONMENT - Provided are a computer program product, system, and method for restoring objects in a client-server environment. An entry is added to an index for each chunk identifier. Each index entry includes one of the chunk identifiers and a reference to the chunk of data in the target storage from which the chunk identifier was calculated. A request is transmitted to a server recovery agent to recover an object from the storage server. Chunk identifiers of chunks of data in the requested object to recover are received from the server recovery agent. A determination is made from the index of whether the received chunk identifiers for the requested object matches the chunk identifiers indicated in the index. A request is made of the chunks from the server recovery agent for the received chunk identifiers not matching chunk identifiers in the index entries. | 12-26-2013 |
Ralph Joseph Wolf, Lunenburg, MA US
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20120143785 | Proxies for Actively Managed Funds - Among other things, receiving public information about an actively managed fund, selecting a group of financial assets, determining a group of weights corresponding to the group of financial assets thereby determining a weighted group of financial assets, the weights being determined based only on the public information, and publishing the contents of the weighted group of financial assets, wherein an expected valuation of the weighted group of financial assets is within a threshold percentage of an expected valuation of the actively managed fund. | 06-07-2012 |
Robert G. Wolf, Lincoln, MA US
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20160110447 | METHODS OF PROVIDING NETWORK GRAPHICAL REPRESENTATION OF DATABASE RECORDS - Methods of providing network graphical representation of database records. Selecting the database records according to descriptive criteria. Identifying attributes of the record class and associating network nodes to instances of the attributes from the database records. Connecting the network nodes with network links that designate network nodes having common instances of the attributes. | 04-21-2016 |
Stanley F. Wolf, Arlington, MA US
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20090156421 | ASSAYS AND METHODS FOR EVALUATING MULTIMERIC COMPLEXES - Assays, e.g., homogenous assays, and methods for identifying, quantifying and/or monitoring the formation and/or stability of a multimeric complex, e.g., a ternary complex are disclosed. The methods and assays of the invention can be used to identify and/or evaluate agents (e.g., proteins, peptides, antibody molecules, and small and large molecules) that interfere with and/or inhibit the formation of a multimeric complex (e.g., a ternary complex) or that disrupt a previously formed complex. | 06-18-2009 |
Stanley Francis Wolf, Arlington, MA US
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20080226645 | Methods and compositions for assessment and treatment of asthma - The present invention provides methods and compositions for the assessment and treatment of asthma and other inflammatory diseases, particularly those mediated by interleukin-13 (IL-13). The present invention also provides arrays comprising markers for asthma as well as IL-13 responsiveness. The markers of the present invention can be used in methods to diagnose a patient as having asthma or an IL-13-mediated condition, to evaluate the effectiveness of potential therapeutic agents, to identify or evaluate agents capable of modulating marker expression levels, and to select a treatment for a patient suffering from asthma or an IL-13-mediated condition. | 09-18-2008 |
Thomas L. Wolf, Winchester, MA US
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20090211260 | Multi-Spool Intercooled Recuperated Gas Turbine - A method and apparatus are disclosed for a gas turbine power plant with a variable area turbine nozzle and an integrated motor/alternator device for starting the gas turbine and power extraction after starting. | 08-27-2009 |
20100288571 | GAS TURBINE ENERGY STORAGE AND CONVERSION SYSTEM - The present invention combines the principles of a gas turbine engine with an electric transmission system. A method and apparatus are disclosed for utilizing metallic and ceramic elements to store heat energy derived from a regenerative braking system. The subject invention uses this regenerated electrical energy to provide additional energy storage over conventional electrical storage methods suitable for a gas turbine engine. The subject invention provides engine braking for a gas turbine engine as well as reducing fuel consumption. | 11-18-2010 |
20110240008 | Solar Receiver for Electric Power Conversion System - A solar receiver for conversion of solar radiation to thermal energy includes an enclosure defining a cavity and having an aperture for receiving an influx of concentrated solar radiation. A heat exchanger is received within the cavity for transferring heat out of the solar receiver. The heat exchanger comprises a plurality of heat exchange cells arranged in polygonal array within the cavity. Each heat exchange cell comprises an inlet, an outlet, and a heat exchange matrix interposed within a first volume defined between a first plate and a second plate spaced apart from the first plate. The inlet and outlet are in fluid communication with the first volume and the first plate, second plate, and heat exchange matrix are monolithically bonded as a unit. The first plate receives concentrated solar radiation and the heat exchange media defines a pathway for a fluid flowing from the inlet to the outlet between the first and second plates. The solar receiver further includes an inlet manifold in fluid communication with the inlet of each of the heat exchange cells and an outlet manifold in fluid communication with the outlet of the each of heat exchange cells. In a further aspect, a heat exchanger is provided. | 10-06-2011 |
20120000204 | MULTI-SPOOL INTERCOOLED RECUPERATED GAS TURBINE - A method and apparatus are disclosed for a multi-spool gas turbine power plant which utilizes motor/generator devices on two or more spools for starting the gas turbine and for power extraction after starting. Methods are disclosed for controlling engine responsiveness under changing load and/or ambient air conditions; providing a momentary power boost when required; providing some engine braking when needed; providing over-speed protection for the free power turbine when load is rapidly lowered or disconnected; charging an energy storage system; and restoring the compressors and/or turbines toward their operating lines when surge or choking limits are approached. | 01-05-2012 |