Sokoloff
Alexander V. Sokoloff, Madison, WI US
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20090113562 | Novel T7 Phage Peptide Display System and Uses Thereof - A bacteriophage T7 display vector for expressing and displaying an exogenous peptide, wherein the display vector comprises a polynucleotide encoding a bacteriophage T7 tail fiber protein p17 in which a hepatocyte-targeting determinant sequence is inactivated, and wherein a cloning site is contained in a coding sequence for the tail fiber protein p17 or in a coding sequence for a capsid protein p10B. Also provided are a host cell containing the display vector as described above, a bacteriophage T7 particle comprising at least one copy of a p17 protein which comprises an exogenous peptide displayed thereon, or at least one copy of a p10 protein with an exogenous peptide displayed thereon, wherein a hepatocyte-targeting determinant sequence on the bacteriophage T7 tail fiber protein p17 is inactivated. The present invention further provides a viral lysate containing assembled bacteriophage T7 particle described above, and a method for determining if a candidate peptide is a liver-targeting peptide, or for screening for liver targeting peptides. | 04-30-2009 |
Alex V. Sokoloff, Madison, WI US
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20100004180 | Agents for the Detection and Modulation of B-Cells and Antibodies - The present invention relates to the identification and use of peptide and peptide analogs that represent epitopes for naturally-occurring antibodies (Nabs). These epitopes may be used to monitor the degree of autoimmunity in an organism, as well as to modulate the activity of B-cells producing Nabs. | 01-07-2010 |
Constantine Sokoloff, New York, NY US
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20090234759 | Auction-Based Security Valuation - Disclosed are computer-implemented techniques for valuing non-marketable financial instrument such as employee stock options. The techniques include determining a market price of a derivate security that represents exposure to the non-marketable financial instrument by receiving bids or offers at a pre-determined time prior to the start of an auction and determining price information in a computer prior to a scheduled auction close. The determined price information is disseminated to auction participants, and the techniques includes closing the auction and executing on a computer orders and bids for the security at the determined price. | 09-17-2009 |
20100100500 | Calculation of a Price of a Security Based on Volatility Detection - Amongst other things, a computer implemented method for releasing a security for trading in a trading venue includes determining volatility in prices of quotations for a security before the security is released for trading; comparing the determined volatility to a volatility threshold; calculating an adjusted price of the quotations based on the output of the determined volatility in the prices; sending a message to release the security for trading, with the security having the adjusted price that is based on the outcome of comparing | 04-22-2010 |
20150228021 | CALCULATING ADJUSTED TRANSACTION MATCHING PARAMETER OF A DATA ITEM BASED ON A DETERMINED VARIABILITY OF A TRANSACTION MATCHING PARAMETER FOR THE DATA ITEM - A computer-implemented method and apparatus for releasing a data item having an identifier for transaction processing in a data transaction processing system in which data items are transacted by a hardware matching processor that matches electronic data transaction request messages for the same one of the data items based on multiple transaction matching parameters from client computers over a data communication bus. A restriction on the hardware matching processor from processing electronic data transaction request messages for the data item is detected. A hardware data processor determines a variability in one of the transaction matching parameters for the data item. The determined variability is compared to a variability threshold established for the data item, and an adjusted one transaction matching parameter of the data item is calculated based on the determined variability. The hardware matching processor is permitted to process received electronic data transaction request messages for the data item that comply with the adjusted one transaction matching parameter. | 08-13-2015 |
Constantine Sokoloff, Jersey City, NJ US
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20150261614 | Systems and Methods for Data Synchronization and Failover Management - A Data Synchronization and Failover Management (DSFM) system monitors simultaneous execution of non-identical instances of a software application and may label as a particular result of the software application the earliest output corresponding to that result produced by one of the instances. The DSFM may label one of the instances as a primary instance and the other instances as secondary instances and, if the primary instance fails, may re-label one of the secondary instances that computed all of the operations associated with the last result produced prior to the failure of the primary instance, as a new primary instance. | 09-17-2015 |
20150261625 | TECHNIQUES FOR MESSAGE RETRANSMISSION MECHANISM - Embodiments of the Message Retransmission Mechanism Apparatuses, Methods and Systems (“MRM”) transform application requests for message journals via MRM components into expedited access to segmented message streams. In one implementation, the MRM may obtain message journal of messages written by applications during system operations and divide up the message obtained from the complete message journal into message segments. In some implementations, the MRM may provide recovering applications access to said message segments for expedited message consumption. | 09-17-2015 |
Daniel Sokoloff, Jupiter, FL US
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20090297251 | Surgical skin marker with disposable sterilized tip - A surgical skin marker has a handle body and a removably attached marking tip that is provided in a protective sterilized bag. After a single use, the marking tip can be removed and discarded. A new marking tip can be attached for a subsequent surgical procedure or treatment. Such a marker can help maintain a sterile surgical environment while minimizing waste and costs. | 12-03-2009 |
Martin Sokoloff, New York, NY US
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20150073313 | Devices and method utilizing ultra-low frequency non-vibratory tactile stimuli for regulation of physiological processes - The present devices and methods are configured to utilize ultra-low frequency non-vibratory tactile stimuli for the regulation of physiological processes. In one embodiment, an apparatus configured to generate and apply mechanical stimuli to skin of a user for regulating a physiological process includes a housing having a first surface for placement against the skin and an electro-mechanical actuator disposed within the housing and configured to generate and apply the mechanical stimuli to the skin. The mechanical stimuli comprise ultra-low frequency stimuli that have a frequency between about 2 Hz (two stimuli per second) to about 0.1 Hz (one stimulus every 10 seconds). The mechanical stimuli have sufficient energy so as to engage skin sensory receptors that are configured to convey signals to the nervous system where the stimuli are at least one of consciously perceived and subliminally perceived. | 03-12-2015 |
Pierre Sokoloff, Le Plessis Bouchard FR
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20090124630 | 3, 4-DIHYDRO-2-NAPHTHAMIDE DERIVATIVES AS SELECTIVE DOPAMINE D3 LIGANDS - The invention relates to 3,4-dihydro-2-naphthamide derivatives of formula (I), pharmaceutical compositions containing them and their therapeutic applications as partial agonists or antagonists of the dopamine D3 receptor for the treatment of neuropsychological disorders. | 05-14-2009 |
Pierre Sokoloff, Belleserre FR
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20090209551 | ESSENTIAL TREMOR DIAGNOSTIC AND TREATMENT - The invention relates to an in vitro method for diagnosing essential tremor wherein a mutation of dopamine D3 receptor gene or protein is sought. The invention further relates to the use of a ligand having anti-dopamine D3 receptor activity for treatment of essential tremor. | 08-20-2009 |
20090325984 | USE OF 1,7-DIMETHYLXANTHINE FOR THE MANUFACTURE OF A NON-ANXIOGENIC PSYCHOANALEPTIC DRUG FOR THE TREATMENT OF A NEUROPSYCHIATRIC DISORDER - The present invention relates to the use of paraxanthine for the manufacture of a non-anxiogenic psychoanaleptic drug for the treatment of a neuropsychiatric disorder. | 12-31-2009 |
20100029682 | NOVEL CHROMENE AND THIOCHROMENE CARBOXAMIDE DERIVATIVES, METHODS FOR PREPARING SAME AND THERAPEUTIC APPLICATIONS OF SAME - The present invention relates to novel chromene or thiochromene carboxamide derivatives, the preparation of same, pharmaceutical compositions of same and the use of same as dopamine D3 ligands as a medicament for central nervous system disorders. | 02-04-2010 |
20120157463 | CHROMONE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS - The present invention relates to chromone derivatives, their preparation, their pharmaceutical compositions and their application as D3 dopaminergic ligands as a medicament for disorders of the central nervous system. | 06-21-2012 |
20140179794 | LEVOMILNACIPRAN-BASED DRUG FOR FUNCTIONAL RECOVERY AFTER ACUTE NEUROLOGICAL EVENTS - The present invention concerns the use of levomilnacipran as medicinal product in functional recovery after a cerebrovascular accident or traumatic brain injury. The pharmaceutical compositions containing levomilnacipran are exclusively those not containing dextromilnacipran to a proportion of more than 5% by weight of the levomilnacipran/dextromilnacipran mixture, to avoid compromising functional recovery due to the alpha1-blocking property of dextromilnacipran. | 06-26-2014 |
20150190394 | DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE FOR TREATING PAIN - The present invention relates to a compound of following formula (I): or a pharmaceutically acceptable salt or solvate of same, a tautomer of same, or a stereoisomer or mixture of stereoisomers of same in any proportions, such as a mixture of enantiomers, notably a racemic mixture; for use in the treatment of pain. | 07-09-2015 |