Patent application number | Description | Published |
20090144863 | Expression Enhancing Intron Sequences - The invention relates to methods for the identification and use of introns with gene expression enhancing properties. The teaching of this invention enables the identification of introns causing intron-mediated enhancement (IME) of gene expression. The invention furthermore relates to recombinant expression construct and vectors comprising said IME-introns operably linked with a promoter sequence and a nucleic acid sequence. The present invention also relates to transgenic plants and plant cells transformed with these recombinant expression constructs or vectors, to cultures, parts or propagation material derived there from, and to the use of same for the preparation of foodstuffs, animal feeds, seed, pharmaceuticals or fine chemicals, to improve plant biomass, yield, or provide desirable phenotypes. | 06-04-2009 |
20140237683 | EXPRESSION ENHANCING INTRON SEQUENCES - The invention relates to methods for the identification and use of introns with gene expression enhancing properties. The teaching of this invention enables the identification of introns causing intron-mediated enhancement (IME) of gene expression. The invention furthermore relates to recombinant expression construct and vectors comprising said IME-introns operably linked with a promoter sequence and a nucleic acid sequence. The present invention also relates to transgenic plants and plant cells transformed with these recombinant expression constructs or vectors, to cultures, parts or propagation material derived there from, and to the use of same for the preparation of foodstuffs, animal feeds, seed, pharmaceuticals or fine chemicals, to improve plant biomass, yield, or provide desirable phenotypes. | 08-21-2014 |
20150033409 | EXPRESSION CASSETTES FOR REGULATION OF EXPRESSION IN MONOCOTYLEDONOUS PLANTS - The present invention relates to expression cassettes comprising at least one transcription regulating nucleotide sequence obtainable from the group of genes of monocotyledonous plants consisting of caffeoyl-CoA-O-methyltransferase genes, C8,7-sterol isomerase genes, hydroxyproline-rich glycoprotein (HRGP) genes, lactate dehydrogenase genes, and chloroplast protein 12 like genes. More preferably the transcription regulating sequences are obtainable from | 01-29-2015 |
Patent application number | Description | Published |
20090041717 | HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR - A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with K | 02-12-2009 |
20110014208 | Method of Treating Osteoarthritis with an Antibody to NGF - Methods are disclosed for treating osteoarthritis in a human subject in need thereof, comprising administering to the subject a therapeutically effective amount of an anti-human NGF antibody, or antigen-binding fragment thereof, wherein at least one symptom associated with osteoarthritis is prevented, ameliorated or improved. | 01-20-2011 |
20110059095 | HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN PROTEASE-ACTIVATED RECEPTOR-2 - The present invention provides antibodies that bind to protease-activated receptor-2 (PAR-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human PAR-2. The antibodies of the invention are useful, inter alia, for the treatment of diseases and disorders associated with one or more PAR-2 biological activities, including the treatment of pain conditions, inflammatory conditions and gastrointestinal conditions. | 03-10-2011 |
20110256587 | HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR - A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with K | 10-20-2011 |
20120093824 | METHODS FOR TREATING PRURITUS BY ADMINISTERING AN ANTIBODY THAT SPECIFICALLY BINDS HUMAN PAR2 - The present invention provides methods for treating pruritus by blocking human protease activated receptor-2 (PAR2) activity. The methods of the invention can be used to treat pruritus associated with atopic dermatitis, psoriasis, burn scarring, hypertrophic scarring, keloids, renal failure or hepatic failure. The methods of the invention include administering an antibody or antigen-binding fragment thereof that specifically binds human PAR2. | 04-19-2012 |
20120164688 | HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR - A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with K | 06-28-2012 |
20130028892 | METHOD OF TREATING OSTEOARTHRITIS WITH AN ANTIBODY TO NGF - Methods are disclosed for treating osteoarthritis in a human subject in need thereof, comprising administering to the subject a therapeutically effective amount of an anti-human NGF antibody, or antigen-binding fragment thereof, wherein at least one symptom associated with osteoarthritis is prevented, ameliorated or improved. | 01-31-2013 |
20130195878 | ANTI-ASIC1 ANTIBODIES AND USES THEREOF - The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders. | 08-01-2013 |
20140056907 | ANTI-ASIC1 ANTIBODIES AND USES THEREOF - The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. According to certain embodiments, the antibodies of the invention are selective for ASIC1 and do not bind other acid-sensing ion channels in the absence of ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders. | 02-27-2014 |
20140179903 | High Affinity Human Antibodies to Human Protease-Activated Receptor 2 - The present invention provides antibodies that bind to protease-activated receptor-2 (PAR-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human PAR-2. The antibodies of the invention are useful, inter alia, for the treatment of diseases and disorders associated with one or more PAR-2 biological activities, including the treatment of pain conditions, inflammatory conditions and gastrointestinal conditions. | 06-26-2014 |
20140220023 | METHOD OF TREATING OSTEOARTHRITIS WITH AN ANTIBODY TO NGF - Methods are disclosed for treating osteoarthritis in a human subject in need thereof, comprising administering to the subject a therapeutically effective amount of an anti-human NGF antibody, or antigen-binding fragment thereof, wherein at least one symptom associated with osteoarthritis is prevented, ameliorated or improved. | 08-07-2014 |
Patent application number | Description | Published |
20090202717 | Anti-Fouling Coatings for Combustion System Components Exposed to Slag, Ash and/or Char - A coating for use in combustion systems includes a plurality of refractory metal particles in a ceramic, glass or metal matrix disposed on surfaces of the system that are prone to slag, ash, and/or char buildup during operation of the combustion system. The coating is effective to prevent any substantial interaction with the slag, ash, and/or char. | 08-13-2009 |
20090246500 | COMPONENT IN A COMBUSTION SYSTEM, AND PROCESS FOR PREVENTING SLAG, ASH, AND CHAR BUILDUP - Disclosed herein is a component in a combustion system comprising a composite, the composite comprising silicon carbide; and a refractory metal silicide comprising a phase selected from Rm | 10-01-2009 |
20100327537 | HERMETIC SEALING ASSEMBLY AND ELECTRICAL DEVICE INCLUDING THE SAME - Disclosed herein is a system including a motor comprising a rotor, a stator and a sealing assembly having at least one joint and a monolithic ceramic separator. Each joint of the sealing assembly is a chemical bond joint, and the monolithic ceramic separator is disposed in a gap between the rotor and the stator of the motor such that the sealing assembly hermetically isolates the rotor and the stator. | 12-30-2010 |
20110221456 | SENSOR SYSTEM AND METHODS FOR ENVIRONMENTAL SENSING - A sensor system, and an associated method for detecting harsh environmental conditions, is provided. The sensor system includes at least one sensor having an electrical sensing element. The electrical sensing element is based on certain classes of composite materials: (a) silicon carbide (SiC); (Mo,W) | 09-15-2011 |
20110240715 | WELDING PROCESS AND CORROSION-RESISTANT FILLER ALLOY AND CONSUMABLES THEREFOR - A nickel-based alloy and welding processes and consumables that use the alloy as a weld filler metal to fabricate, weld overlay, and repair components, including components of nuclear power plant reactors that contact the hot coolant water of the reactor. The nickel-based alloy consists of, by weight, 26 to about 30% chromium, 2 to about 4% iron, 2 to about 4% manganese, 2 to about 3% niobium, 1 to about 3% molybdenum, not more than 0.6% titanium, not more than 0.03% carbon, not more than 0.05% nitrogen, not more than 0.6% aluminum, not more than 0.5% silicon, not more than 0.01% copper, not more than 0.02% phosphorus, not more than 0.01% sulfur, with the balance nickel and incidental impurities. | 10-06-2011 |
Patent application number | Description | Published |
20100284656 | Short profile optical connector - A connector that enables fiber optic cables to terminate at equipment in cabinets having little space available for cable routing, without over bending. The construction includes a connector housing, and a yoke including a collar joined to a rear end of the housing. A tubular cable bend limiter is fixed at one end to the collar and the limiter directs a cable containing one or more bend insensitive fibers through a bend of, e.g., 90 degrees, between the collar and the opposite end of the limiter with a fiber bend radius of less than one inch (25.4 mm). If the limiter creates a fiber bend radius of 0.300 inch (7.62 mm), the distance between the front of the connector and the cable after bending may be as little as 1.26 inches (32 mm), allowing the cable and connector to be routed and terminated in limited space without impairing performance. | 11-11-2010 |
20130020015 | Apparatus and Methods for Routing an Optical Fiber or Cable Inside a Building or Living Unit - Apparatus and methods for routing an optical fiber over a desired span on a structural surface at a given premises are provided. When the optical fiber is unwound from a spool, the optical fiber attaches to the structural surface by an adhesive material. The adhesive material can be applied along the desired span, or portion thereof, before, during, or after the optical fiber is routed over the desired span. | 01-24-2013 |