Patent application number | Description | Published |
20080199916 | Multiplex targeted amplification using flap nuclease - Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed. In one aspect targets are circularized using a single circularization probe that is complementary to two regions in the target that flank a region to be amplified. The targets may hybridize to the circularization probe so that 5′ or 3′ flaps are generated and methods for removing flaps and circularizing the resulting product are disclosed. In another aspect targets are hybridized to dU probes so that 5′ and 3′ flaps are generated. The flaps are cleaved using 5′ or 3′ flap endonucleases or 3′ to 5′ exonucleases. The target sequences are then ligated to common primers, the dU probes digested and the ligated targets amplified. | 08-21-2008 |
20110124052 | Multiplex Targeted Amplification Using Flap Nuclease - Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed. In one aspect targets are circularized using a single circularization probe that is complementary to two regions in the target that flank a region to be amplified. The targets may hybridize to the circularization probe so that 5′ or 3′ flaps are generated and methods for removing flaps and circularizing the resulting product are disclosed. In another aspect targets are hybridized to dU probes so that 5′ and 3′ flaps are generated. The flaps are cleaved using 5′ or 3′ flap endonucleases or 3′ to 5′ exonucleases. The target sequences are then ligated to common primers, the dU probes digested and the ligated targets amplified. | 05-26-2011 |
20130065768 | RANDOM ARRAY SEQUENCING OF LOW-COMPLEXITY LIBRARIES - The invention is directed to a method of sequencing low-complexity amplicons randomly arrayed at high density on a surface. Methods of the invention include preparing amplicons for sequencing by a sets of primers that ensure initial signals front different amplicons on the surface will be evenly distributed among the different nucleotides being added in a sequencing by synthesis operation. | 03-14-2013 |
20130302801 | DETECTION AND QUANTIFICATION OF SAMPLE CONTAMINATION IN IMMUNE REPERTOIRE ANALYSIS - The invention is directed to methods for detecting and quantifying nucleic acid contamination in a tissue sample of an individual containing T cells and/or B cells, which is used for generating a sequence-based clonotype profile. In one aspect, the invention is implemented by measuring the presence and/or level of an endogenous or exogenous nucleic acid tag by which nucleic acid from an intended individual can be distinguished from that of unintended individuals. Endogenous tags include genetic identity markers, such as short tandem repeats, rare clonotypes or the like, and exogenous tags include sequence tags employed to determine clonotype sequences from sequence reads. | 11-14-2013 |
20140255929 | MOSAIC TAGS FOR LABELING TEMPLATES IN LARGE-SCALE AMPLIFICATIONS - The invention relates to methods of labeling nucleic acids, such as fragments of genomic DNA, with unique sequence it referred to herein as “mosaic tag,” prior to amplification and/or sequencing. Such sequence tags are useful for identifying amplification and sequencing errors. Mosaic tags minimize sequencing and amplification artifacts due to inappropriate annealing priming, hairpin formation, or the like, that may occur with completely random sequence tags of the prior art. In one aspect, mosaic tags are sequence tags that comprise alternating constant regions and variable regions, wherein each constant region has it position in the mosaic tag and comprises a predetermined sequence of nucleotides and each variable region has a position in the mosaic tag and comprises a predetermined number of randomly selected nucleotides. | 09-11-2014 |
20150152482 | Multiplex Targeted Amplification Using Flap Nuclease - Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed. In one aspect targets are circularized using a single circularization probe that is complementary to two regions in the target that flank a region to be amplified. The targets may hybridize to the circularization probe so that 5′ or 3′ flaps are generated and methods for removing flaps and circularizing the resulting product are disclosed. In another aspect targets are hybridized to dU probes so that 5′ and 3′ flaps are generated. The flaps are cleaved using 5′ or 3′ flap endonucleases or 3′ to 5′ exonucleases. The target sequences are then ligated to common primers, the dU probes digested and the ligated targets amplified. | 06-04-2015 |
20150259726 | Multiplex Targeted Amplification Using Flap Nuclease - Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed. In one aspect targets are circularized using a single circularization probe that is complementary to two regions in the target that flank a region to be amplified. The targets may hybridize to the circularization probe so that 5′ or 3′ flaps are generated and methods for removing flaps and circularizing the resulting product are disclosed. In another aspect targets are hybridized to dU probes so that 5′ and 3′ flaps are generated. The flaps are cleaved using 5′ or 3′ flap endonucleases or 3′ to 5′ exonucleases. The target sequences are then ligated to common primers, the dU probes digested and the ligated targets amplified. | 09-17-2015 |
20150259734 | LARGE-SCALE BIOMOLECULAR ANALYSIS WITH SSEQUENCE TAGS - The invention is directed to sequence-based profiling of populations of nucleic acids by multiplex amplification and attachment of one or more sequence tags to target nucleic acids anchor copies thereof followed by high-throughput sequencing of the amplification product. In some embodiments, the invention includes successive steps of primer extension, removal of unextended primers and addition of new primers either for amplification (for example by PRC) or for additional primer extension. Some embodiments of the invention are directed to minimal residual disease (MRD) analysis of patients being treated for cancer. Sequence tags incorporated into sequence reads provide an efficient means for determining clonotypes and at the same time provide a convenient means for detecting carry-over contamination from other samples of the same patient or from samples of a different patient which were tested in the same laboratory. | 09-17-2015 |
Patent application number | Description | Published |
20090161738 | Transceiver system with reduced latency uncertainty - A transceiver system with reduced latency uncertainty is described. In one implementation, the transceiver system has a word aligner latency uncertainty of zero. In another implementation, the transceiver system has a receiver-to-transmitter transfer latency uncertainty of zero. In yet another implementation, the transceiver system has a word aligner latency uncertainty of zero and a receiver-to-transmitter transfer latency uncertainty of zero. In one specific implementation, the receiver-to-transmitter transfer latency uncertainty is eliminated by using the transmitter parallel clock as a feedback signal in the transmitter phase locked loop (PLL). In one implementation, this is achieved by optionally making the transmitter divider, which generates the transmitter parallel clock, part of the feedback path of the transmitter PLL. In one implementation, the word aligner latency uncertainty is eliminated by using a bit slipper to slip bits in such a way so that the total delay due to the word alignment and bit slipping is constant for all phases of the recovered clock. This allows for having a fixed and known latency between the receipt and transmission of bits for all phases of parallelization by the deserializer. In one specific implementation, the total delay due to the bit shifting by the word aligner and the bit slipping by the bit slipper is zero since the bit slipper slips bits so as to compensate for the bit shifting that was performed by the word aligner. | 06-25-2009 |
20120027026 | SCALABLE INTERCONNECT MODULES WITH FLEXIBLE CHANNEL BONDING - The present application discloses apparatus and methods for increasing channel utilization for a high-speed serial interface of an integrated circuit (IC). A new circuit architecture is disclosed which provides circuitry that may be programmed flexibly to support a multitude of different channel bonding schemes. In accordance with one aspect of the invention, the new architecture decouples the granularity of control-signal channel bonding from the granularity of data-aggregation channel bonding. This advantageously allows optimization of configurations for both types of channel bonding. In another aspect of the invention, the logical boundaries of bonded user channels are decoupled from the physical boundaries of the PCS modules. This decoupling advantageously eliminates a rigid constraint of previous architectures. | 02-02-2012 |
20140036931 | SCALABLE INTERCONNECT MODULES WITH FLEXIBLE CHANNEL BONDING - The present application discloses apparatus and methods for increasing channel utilization for a high-speed serial interface of an integrated circuit (IC). A new circuit architecture is disclosed which provides circuitry that may be programmed flexibly to support a multitude of different channel bonding schemes. In accordance with one aspect of the invention, the new architecture decouples the granularity of control-signal channel bonding from the granularity of data-aggregation channel bonding. This advantageously allows optimization of configurations for both types of channel bonding. In another aspect of the invention, the logical boundaries of bonded user channels are decoupled from the physical boundaries of the PCS modules. This decoupling advantageously eliminates a rigid constraint of previous architectures. | 02-06-2014 |
Patent application number | Description | Published |
20090048189 | TRICYCLIC-NUCLEOSIDE COMPOUNDS FOR TREATING VIRAL INFECTIONS - Disclosed are tricyclic nucleoside compounds of formula (I), and methods thereof for treating viral infections mediated at least in part by a Flaviviridae family virus. | 02-19-2009 |
20090062223 | AMINO TRICYCLIC-NUCLEOSIDE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE - Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses. | 03-05-2009 |
20090197856 | ANTIVIRAL COMPOUNDS - Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses. | 08-06-2009 |
20090253648 | Tricyclic-Nucleoside Compounds for Treating Viral Infections - Disclosed are compounds represented by formulae I, II, and III, and the compositions and methods thereof for treating viral infections caused by a Flaviviridae family virus. | 10-08-2009 |
20120183496 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE - The present invention provides, among other things, compounds represented by the general Formula I: | 07-19-2012 |
20120196833 | PHOSPHORUS CONTAINING QUINAZOLINE COMPOUNDS AND METHODS OF USE - Disclosed are novel quinazoline derivatives containing phosphorus substitutions and methods for the treatment of hyperproliferative diseases (e.g. cancer) using the compounds. These compounds are type I receptor protein kinase inhibitors useful in treating disorders related to abnormal protein kinase activities such as cancer and inflammation in mammals. Also disclosed are pharmaceutical compositions containing the compounds, methods for the preparation of the compounds and their pharmaceutically acceptable salts. | 08-02-2012 |
20140128417 | ALKYNE SUBSTITUTED QUINAZOLINE COMPOUND AND METHODS OF USE - The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer). | 05-08-2014 |
20140221314 | TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE - The invention provides for compositions comprising phosphorous containing tricyclic compounds, including phthalazin-1(2H)-one derivatives. The compounds are potent inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), particularly PARP-1 and potentially PARP-2. The also show good cellular activity in inhibiting poly(ADP-ribose) oligomer formation. The compounds may be useful as mono-therapy or in combination with other therapeutic agents in the treatment conditions where PARP is implicated, such as cancer, inflammatory diseases and ischemic conditions. Thus, also provided are methods for the treatment of a condition where PARP is implicated comprising administering to an effective amount of a compound of the invention to an individual in need thereof. | 08-07-2014 |
20140221406 | QUINAZOLINE-7-ETHER COMPOUNDS AND METHODS OF USE - The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination. | 08-07-2014 |
20140322165 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE - The present invention provides, among other things, compounds represented by the general Formula I: | 10-30-2014 |
20150182514 | INHIBITORS OF HEPATITIS C VIRUS POLYMERASE - The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R | 07-02-2015 |
Patent application number | Description | Published |
20100290769 | OPTICAL IMAGE STABILIZATION IN A DIGITAL STILL CAMERA OR HANDSET - An optical image stabilization system for a camera module is disclosed. The stabilization system comprises a voice coil motor (VCM), at least one digital gyroscope for receiving signals from the VCM, and an angular velocity sensor for receiving signals from the digital gyroscope and outputting an angular position error signal. The stabilization system further comprises signal processing logic for receiving the error signal, and comparing the error signal to a reference signal and providing a stabilized image based upon that comparison, wherein the hard-coded logic, digital gyroscope and rate and position sensor resides on the same chip. | 11-18-2010 |
20120147495 | METHOD AND APPARATUS FOR REDUCING REPEATABLE RUNOUT IN STORAGE SYSTEMS - A storage system includes a first buffer configured to store a first repeatable runout profile (RRP) for a sector of a rotating storage medium. A second buffer is configured to store a second RRP for the sector. A controller: controls a servo of the rotating storage medium based on the first RRP during a first revolution of the rotating storage medium; and learns the second RRP (i) while operating in a track-following mode, and (ii) during the first revolution. The controller ceases learning of the second RRP when one of (i) the controller is operating in a seek mode and (ii) the rotating storage medium is in an off-track state. Subsequent to the first revolution of the rotating storage medium and based on whether the learning of the second RRP was stopped during the first revolution, the controller replaces the first RRP with the second RRP in the first buffer. | 06-14-2012 |
20120200497 | HIGH FIDELITY REMOTE CONTOLLER DEVICE FOR DIGITAL LIVING ROOM - Described herein is an intelligent remote controlling device. The device can include a six-axis motion sensor to accurately track three dimensional hand motions. For example, the sensors can include a three-axis accelerometer and a three-axis gyroscope. The remote control device can also include a processing unit integrated with the motion sensors in a single module. The processing unit can convert data regarding the hand motion to data regarding a cursor motion for a cursor that will be displayed on a screen of an electronic device. The processing unit can be integrated with the motion sensors in a single module. The processing unit can include at least two modes of functionality corresponding to different types of hand motion: a one to one mode where the cursor directly tracks the hand motion and a non-linear mode that filters data from the motion sensors to eliminate hand jitter. | 08-09-2012 |
20130197845 | N-USE AUTOMATIC CALIBRATION METHODOLOGY FOR SENSORS IN MOBILE DEVICES - A method, system and computer readable medium for calibrating an accelerometer in a portable device is disclosed. The method, system and computer readable medium comprises receiving data from the accelerometer, and providing accelerometer samples from the data based upon one or more selection rules that adaptively selects data that satisfy certain criteria. The method system and computer readable medium also includes fitting the accelerometer samples to a mathematical mode. The method system and computer readable medium further includes providing a bias of the accelerometer based upon a center of the mathematical model. | 08-01-2013 |
20130271372 | HIGH FIDELITY REMOTE CONTOLLER DEVICE FOR DIGITAL LIVING ROOM - Described herein is an intelligent remote controlling device (e.g. a mobile phone). The device can include a six-axis motion sensor to accurately track three dimensional hand motions. For example, the sensors can include a three-axis accelerometer and a three-axis gyroscope. The remote control device can also include a processing unit integrated with the motion sensors in a single module. The processing unit can convert data regarding the hand motion to data regarding a cursor motion for a cursor that will be displayed on a screen of an electronic device. The processing unit can be integrated with the motion sensors in a single module (e.g. an integrated circuit chip (IC)). The processing unit can include at least two modes of functionality corresponding to different types of hand motion: a one to one mode where the cursor directly tracks the hand motion and a non-linear mode that filters data from the motion sensors to eliminate hand jitter. | 10-17-2013 |
20140278183 | HEADING CONFIDENCE INTERVAL ESTIMATION - An inertial measurement system is disclosed. The inertial measurement system has an accelerometer processing unit that generates a calibrated accelerometer data. The inertial measurement system further includes a magnetometer processing unit generates a calibrated magnetometer data, and a gyroscope processing unit generates a calibrated gyroscope data. Using the calibrated accelerometer data, the calibrated magnetometer data, and the calibrated gyroscope data, the inertial measurement system generates a heading angle error indicative of the accuracy of the heading angle error. | 09-18-2014 |