Studnicka
Gary Studnicka, Berkeley, CA US
Patent application number | Description | Published |
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20110039722 | LIBRARIES, ARRAYS AND THEIR USES FOR TARGETED AFFINITY ENHANCEMENT - The present disclosure relates to methods and materials for enhancing the binding affinity of an antibody by means of generating a library or an array of targeted amino acid changes (e.g., mutations) at one or more positions in an antibody variable domain. The present disclosure relates to libraries or arrays and their uses for enhancing antibody affinity. The present disclosure relates to methods and materials for mutagenesis, including for the generation of novel or improved antibody variable domains and libraries or arrays of mutant antibody variable domains or nucleic acids encoding such mutant or modified variable domains. | 02-17-2011 |
20110118447 | METHODS AND MATERIALS FOR TARGETED AFFINITY ENHANCEMENT - The present disclosure relates to materials and methods for enhancing the binding affinity of antibodies by introducing a number of targeted amino acid changes in antibody variable domains. The present disclosure provides novel methods of flowcharted amino acid change cycles, of identifying residues as members of unique proximity groups and of determining the degree of conspicuousness of amino acid residues in antibody variable regions. The disclosed methods are useful for the selection of variable region amino acid residues that are candidates for change to produce antibody variable domains with enhanced affinity for their binding partners. | 05-19-2011 |
Gary Studnicka, Santa Monica, CA US
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20110319598 | METHODS AND MATERIALS FOR DETERMINING ISOELECTRIC POINT - The present disclosure relates to methods and materials for determining an isoelectric point for a protein including, for example, a binding molecule such as an antibody. The isoelectric points may be used in methods for the preparation of proteins. Such methods may comprise identifying amino acid residues that are exposed on the surface of the protein in a sequence of amino acid residues of the protein, assigning a pKa value to the surface exposed amino acid residues, and calculating the isoelectric point of the protein from the pKa values assigned to the surface exposed amino acid residues. The methods of the present disclosure may be used for selecting and utilizing a buffer for purification of a protein, preparing a protein formulation, purifying a protein and/or stabilizing a protein in solution. | 12-29-2011 |
Seth Carl Studnicka, Chillicothe, IL US
Patent application number | Description | Published |
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20090199794 | Crankcase ventilation system - A ventilation system for use with an internal combustion engine having a crankcase is disclosed. The ventilation system may have a breather housing connected to ventilate gases from the crankcase, and a filtration canister fluidly connected downstream of the breather housing. The filtration canister may have a filter housing, a filtering medium located within the filter housing to collect oil from the gases, and an oil collection container disposed within the filter housing and being configured to receive at least a portion of the filtering medium. The oil collection container may have a drain port in fluid communication with the crankcase. The filtration canister may also have at least one port configured to discharge the gases from the housing after the gases have passed through the filtering medium. | 08-13-2009 |
Zdenek Studnicka, Mississauga CA
Patent application number | Description | Published |
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20120042594 | BOARD COVER AND BOARD COVERING SYSTEM - A cover for a board is disclosed and comprises a sheet. The sheet has a pair of sides and a pair of ends. The sheet, in use, is disposed lengthwise upon said board. For and extending from each side of the sheet is provided a flange, the flange being either fixed at about 90 degrees to or pivotably attached to the sheet. The flanges, in use, extend in a common direction from the sheet, on opposite sides of said board. | 02-23-2012 |