Williams, London
Charlotte Williams, London GB
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20150126359 | PROCESS FOR PRODUCING NANOPARTICLES - This invention relates to a process for the preparation of surface-functionalised metal oxide, metal sulphide, metal selenide or metal telluride nanoparticles, a process for the preparation of a composite material comprising such nanoparticles, nanoparticles and a composite material produced thereby, the use of such nanoparticles in catalysis and a catalyst comprising such nanoparticles. | 05-07-2015 |
Charlotte K. Williams, London GB
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20110077380 | CARBOHYDRATE LACTONE POLYMERS - The present invention relates to a novel carbohydrate lactone, functionalized aliphatic polyesters and copolymers formed therefrom, and processes for the preparation thereof from renewable resources. | 03-31-2011 |
20110118435 | BIMETALLIC CATALYTIC COMPLEXES FOR THE COPOLYMERISATION OF CARBON DIOXIDE AND AN EPOXIDE - The present invention provides a novel catalyst of formula (I): wherein M is selected from Zn(H), Co(II), Mn(II), Mg(II), Fe(II), Cr(III)-X or Fe(III)-X, and the use thereof in polymerising carbon dioxide and an epoxide. | 05-19-2011 |
20140249279 | METHOD OF SYNTHESISING POLYCARBONATES IN THE PRESENCE OF A BIMETALLIC CATALYST AND A CHAIN TRANSFER AGENT - The invention provides a process for the synthesis of a polycarbonate, the process comprising the step of reacting carbon dioxide with at least one epoxide in the presence of a catalyst of formula (I) and a chain transfer agent. The invention also provides a polymerisation system for the copolymerisation of carbon dioxide and at least one epoxide comprising a catalyst of formula (I) and a chain transfer agent, polycarbonates produced by the inventive process, a block copolymer comprising a polycarbonate produced by the inventive process and a method of producing the same. The invention also relates to novel catalysts of formula (III). | 09-04-2014 |
20150051370 | NOVEL BIMETALLIC CATALYTIC COMPLEXES FOR THE POLYMERISATION OF CARBON DIOXIDE AND AN EPOXIDE - The present invention provides a novel catalyst of formula (I): wherein M is selected from Zn(H), Co(II), Mn(II), Mg(II), Fe(II), Cr(III)-X or Fe(III)-X, and the use thereof in polymerising carbon dioxide and an epoxide. | 02-19-2015 |
Charlotte Katherine Williams, London GB
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20160108181 | METHOD AND CATALYST SYSTEM FOR PREPARING POLYMERS AND BLOCK COPOLYMERS - The present invention provides methods for producing block copolymers, either by the sequential addition of monomers, or using a “one-pot” method. The invention also relates to novel methods for producing polyesters by ring opening lactides and/or lactones and by copolymerising anhydrides and epoxides. | 04-21-2016 |
Christopher Charles Williams, London GB
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20140201227 | CONTENT-IDENTIFICATION ENGINE BASED ON SOCIAL MEDIA - A system and method for tracking trending topics on social media (e.g., Twitter) associated with a particular event and identifying relevant images or videos that are associated with the trending topic. For example, the system may monitor Twitter feeds associated with a particular sports event and analyze content posted in those feeds. Comments about a particular play made during the sports event (e.g., a touchdown) are detected by the system in the monitored feed content and used to locate and retrieve photos or videos associated with that particular play for display on a website or other content portal. | 07-17-2014 |
Colin H. Williams, London GB
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20080293045 | Recombinase Polymerase Amplification - This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and portability relative to other amplification methods. Further disclosed are conditions to enable real-time monitoring of RPA reactions, methods to regulate RPA reactions using light and otherwise, methods to determine the nature of amplified species without a need for gel electrophoresis, methods to improve and optimize signal to noise ratios in RPA reactions, methods to optimize oligonucleotide primer function, methods to control carryover contamination, and methods to employ sequence-specific third ‘specificity’ probes. Further described are novel properties and approaches for use of probes monitored by light in dynamic recombination environments. | 11-27-2008 |
20090269813 | Methods For Multiplexing Recombinase Polymerase Amphlification - This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes. | 10-29-2009 |
20110059506 | Recombinase polymerase amplification - This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundreds of megabases in length. | 03-10-2011 |
20120015367 | Methods for Multiplexing Recombinase Polymerase Amplification - This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes. | 01-19-2012 |
20120082990 | Recombinase Polymerase Amplification - This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundres of megabases in length. | 04-05-2012 |
20140234846 | Recombinase Polymerase Amplification - This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundreds of megabases in length. | 08-21-2014 |
20140295436 | Methods for Multiplexing Recombinase Polymerase Amplification - This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes. | 10-02-2014 |
20160032374 | Recombinase Polymerase Amplification - This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed methods may allow amplification of DNA up to hundreds of megabases in length. | 02-04-2016 |
20160097090 | Methods for Multiplexing Recombinase Polymerase Amplification - This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes. | 04-07-2016 |
David G. Williams, London GB
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20110002926 | HEPATITIS C VIRUS ANTIBODIES - This invention relates to humanized antibodies and fragments thereof which bind to hepatitis C virus E2 protein and methods of their use. | 01-06-2011 |
20120027722 | HEPATITIS C VIRUS COMBINATION THERAPY - The present invention relates to methods and compositions for the treatment or prevention of hepatitis C virus comprising the administration of a combination of anti-hepatitis C virus antibodies and a-interferon. | 02-02-2012 |
Dominic Christopher Courtenay Williams, London GB
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20100229127 | SYSTEM AND METHOD FOR NAVIGATING POSTS IN A DISCUSSION - A method for navigating posts in a discussion including parent posts and child posts, a child post being in reply to a parent post, wherein a further reply can be made to a child post and wherein multiple child posts can be made in reply to respective parent or child posts, the method including receiving posts and storing posts; arranging posts in a discussion linearly one below another; providing a parent navigator which, when actuated, causes a copy of a parent post to be inserted adjacent its child post. Some embodiment comprise providing a child navigator which, when actuated, causes a copy of a parent post to be inserted adjacent its child post. Various other methods and apparatus are also provided. | 09-09-2010 |
Edward T. Williams, London GB
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20150226169 | FUEL PUMP ARRANGEMENTS - A fuel pump arrangement for a fuel injection system is described. The fuel pump arrangement comprises one or more cam-driven pump units, and the or each pump unit comprises a pumping chamber and a pumping element for pressurising fuel in the pumping chamber. The or each pumping element is driven by a respective cam of the fuel pump arrangement to undergo at least one pumping stroke per revolution of the cam. The fuel pump arrangement is configured such that the fuel volume displaced in a first pumping stroke is greater than the fuel volume displaced in a second pumping stroke. In this way, the efficiency of operation of the fuel pump arrangement can be improved. | 08-13-2015 |
Gareth Williams, London GB
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20120077863 | GUANIDINO-SUBSTITUTED BI-AND POLYPHENYLS AS SMALL MOLECULE CARRIERS - A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein —X | 03-29-2012 |
20140349931 | DETECTION AND TREATMENT OF BREAST CANCER - The present invention describes methods for determining the risk that a breast precursor lesion will progress to invasive breast cancer and/or the risk of recurrent non-invasive disease in a patient, comprising detecting the presence and/or level of PAPPA and/or PAPPA functional activity in a breast tissue sample obtained from the patient, wherein if PAPPA is not present, or is present at a reduced amount compared to a control, there is the risk of progression to invasive cancer and/or the risk or recurrent disease. | 11-27-2014 |
Gregory Williams, London CA
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20120132581 | FILTER FOR REMOVING SEDIMENT FROM WATER - A system for removing sediment from water is disclosed. The exemplary embodiments described herein disclose a system comprising a filter chamber, having a deck positioned inside to divide it into an upper chamber and a lower chamber. The deck may have a plurality of holes to hold filtration elements and also may have a ridge or a skirt or both. An inlet line may be tangentially connected to the filter chamber and introduce influent liquid into the filter chamber below the deck and outside of the skirt. | 05-31-2012 |
20140299553 | FILTER FOR REMOVING SEDIMENT FROM WATER - A system for removing sediment from water is disclosed. The exemplary embodiments described herein disclose a system comprising a filter chamber, having a deck positioned inside to divide it into an upper chamber and a lower chamber. The deck may have a plurality of holes to hold filtration elements and also may have a ridge or a skirt or both. The filtration elements may be filter cartridges with multiple elongated filter elements that extend down into the lower chamber. | 10-09-2014 |
Gregory Richard Williams, London CA
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20090020466 | Separator Tank - A separator tank for separating and trapping contaminants in rainwater and runoff is disclosed. According to one embodiment of the present invention, the separator tank comprises a container having a bottom wall, side wall, and top wall defining an internal chamber; an insert located inside of the internal chamber, the insert comprising a weir defining an intake area between the weir and the side wall; and a round-edged orifice positioned within the intake area; an inlet conduit for introducing an influent liquid into the intake area; wherein the weir is positioned such that the weir induces the influent liquid to flow in a swirling motion within the intake area. According to another embodiment of the present invention an insert for a separator tank is disclosed. The insert includes a weir defining an intake area for receiving an influent liquid; and a round-edged orifice positioned within the intake area. | 01-22-2009 |
20090045128 | Filter For Removing Sediment From Water - A system for removing sediment from water is disclosed. The exemplary embodiments described herein disclose a system comprising a filter chamber, having a deck positioned inside to divide it into an upper chamber and a lower chamber. The deck may have a plurality of holes to hold filtration elements and also may have a ridge or a skirt or both. An inlet line may be tangentially connected to the filter chamber and introduce influent liquid into the filter chamber below the deck and outside of the skirt. | 02-19-2009 |
Jennifer Williams, London GB
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20120251446 | Peptide Conjugates Comprising Polyhistidine Sequence and Free Cysteine and Their Uses in Imaging - Bioconjugates for use in imaging are disclosed include a linker sequence fused to a polypeptide capable of binding a target in a biological system. The linker sequence is designed so that it is capable of being radiolabelled, e.g. with a complex comprising a radionuclide, via a free cysteine residue and the polyhistidine sequence in the label that are both capable of simultaneously binding to a complex comprising the radionuclide. These interactions can improve significantly the rate and efficiency of radiolabelling compared to either protein with the His-tag or the free cysteine alone. Optionally, the free cysteine residue provides a site which can be covalently bonded to a moiety such as a second label, in a site-specific manner. | 10-04-2012 |
Julian David Williams, London GB
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20140295140 | Friction Surface - According to the present invention there is provided a polymer friction surface subject to sliding contact with footware worn by a user wherein said friction surface is embossed and said footware having hard, gloss interface with said friction surface. | 10-02-2014 |
Juliet Williams, London GB
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20110183962 | SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS - The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors. | 07-28-2011 |
20140200217 | SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS - The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors. | 07-17-2014 |
Mark Henstridge Williams, London GB
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20140201258 | SYSTEM AND METHOD OF BROWSING OFFLINE AND QUERIED CONTENT - Embodiments of systems and methods for browsing offline and queried content are presented herein. Specifically, embodiments may receive a request for content from a mobile application. Embodiments may also determine whether the requested content is in a cache associated with the mobile application. If it is determined that the content is not in the cache, embodiments may deliver the requested content to the mobile application. | 07-17-2014 |
Matthew Williams, London GB
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20140254772 | UNUSUAL EVENT DETECTION IN A TELECOMMUNICATIONS NETWORK - Measures for detecting unusual communication session events in a telecommunications network. A Markov model for events occurring in communication sessions conducted in the network is maintained. The maintaining includes assigning a probability of occurrence metric to a plurality of event sequences in the conducted communication sessions. In response to a given sequence of communication session events being assigned a probability of occurrence metric which exceeds a predetermined threshold, an unusual communication session event alert in association with the given sequence is triggered. | 09-11-2014 |
20140323127 | PROCESSING DATA - Measures for processing data in a telecommunications network. At a cache, a subscriber configuration data request requesting subscriber configuration data for a subscriber device is received from a network node in a cluster of network nodes. In response to receipt of the subscriber configuration data request, it is determined that a shared cache store does not contain subscriber configuration data for the subscriber device. In response to the determination, subscriber configuration data for the subscriber device is retrieved from a subscriber configuration network node. The subscriber configuration data for the subscriber device retrieved from the subscriber configuration network node is transmitted to the network node. | 10-30-2014 |
Matthew John Williams, London GB
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20130340151 | BICYCLE HELMET WITH VENT - A bicycle helmet can include at least one ventilation opening and an exhaust port such that airflow enters the helmet through the ventilation opening and exits through the exhaust port, providing ventilation for a user. The orientation and location of the ventilation openings can reduce the aerodynamic drag of the helmet by delaying flow separation from the surface of the helmet and prevent airflow stagnation around the user's shoulders and neck. | 12-26-2013 |
Nigel Emlyn Williams, London GB
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20080231848 | Frictional Pivots for Gravitational Alignment - A frictional pivot | 09-25-2008 |
20110010953 | Frictional Pivots for Gravitational Alignment - A frictional pivot | 01-20-2011 |
Norman Stanley Williams, London GB
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20120061447 | Method And Apparatus For Forming Stoma Trephines And Anastomoses - The present invention relates to a stapler apparatus, comprising a stapler having a proximal end, a distal end and a longitudinal axis, the stapler further comprising a trigger, an anvil docking pin aligned substantially parallel with the longitudinal axis of the stapler, and a stapling means, the anvil docking pin and stapling means being at the distal end of the stapler, and a detachable anvil, comprising an anvil head and an anvil shaft, wherein the anvil shaft is adapted to receive the anvil docking pin and operation of the trigger causes the stapling means to be actuated, characterised in that the length of the anvil shaft is at least 4 cm. The present invention also relates to a method of forming an anastomosis between two surfaces using the stapler apparatus of the invention and a method of forming a stoma trephine in a subject using the stapler apparatus of the invention. The present invention further relates to the use of the stapler apparatus or anvil for a stapler apparatus in such methods and a kit of parts comprising the stapler apparatus of the invention and additional components. | 03-15-2012 |
20120065665 | Forceps Comprising A Trocar Tip - The present invention relates to a forceps comprising an elongate body, a grip region at end of the elongate body, the grip region comprising a lever, a grasping assembly at the opposite end of the elongate body, the grasping assembly comprising a movable grasper and a trocar, and an actuating mechanism coupling the lever to the grasping assembly for effecting movement of the grasper relative to the elongate body. The present invention also relates to a kit of parts comprising a forceps of the invention and additional components. The invention further relates to a method of forming an anastomosis between two surfaces and a method of forming a stoma trephine in a subject using the kit of parts of the invention. The present invention also relates to the use of the forceps and the kit or parts of the invention in such methods. | 03-15-2012 |
Olatunde O. Williams, London GB
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20100222106 | BASE STATION ARRANGEMENT FOR A CELLULAR COMMUNICATION SYSTEM - A base station arrangement for a cellular communication system comprises a plurality of antennas ( | 09-02-2010 |
Peter Robert Williams, London GB
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20110160674 | VETERINARY SYRINGE FOR MULTIPLE INJECTIONS - A trigger operated syringe ( | 06-30-2011 |
Ralph Anthony David Williams, London GB
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20090074680 | STATHERIN PEPTIDE AND USE IN MEDICINE - A synthetic statherin peptide of general formula (I) X | 03-19-2009 |
Richard Owen Williams, London GB
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20090197957 | Methods and compositions for the treatment of pain - The present invention relates generally to the area of pain management and more particularly, to a method of analgesia and agents useful for same. More particularly, the present invention relates to a method of analgesia utilising a compound of formula (I). The method of the present invention is useful, inter alia, in the therapeutic or prophylactic treatment of pain, including acute pain, chronic non-malignant pain and chronic malignant pain. Also provided are compounds for use in the method of the invention. | 08-06-2009 |
20100041756 | METHOD OF MODULATING B CELL FUNCTIONING - The present invention relates generally to a method of modulating cellular functioning. More particularly, the present invention relates to a method of modulating B cell functioning, for example B cell proliferation, utilising an IDO-mediated tryptophan metabolite as herein defined (particular examples of such IDO-mediated tryptophan metabolites include 3-hydroxykynurenic acid, 3-hydroxyanthranilic acid, picolinic acid, quinolinic acid and tranilast). The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate B cell functioning such as antibody production, autoimmune conditions and B cell proliferation and neoplasias. In a related aspect, the present invention is directed to a method of therapeutically and/or prophylactically treating rheumatoid arthritis via the administration of the above-mentioned compounds. | 02-18-2010 |
Steven Williams, London GB
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20110025327 | METHOD FOR RADIOFREQUENCY MAPPING IN MAGNETIC RESONANCE IMAGING - A method of mapping a radio frequency magnetic field transmitted to a magnetic resonance imaging specimen. The method comprises the steps of: applying a first radio frequency pulse having a first excitation angle to the specimen and at a first time period after applying the first pulse applying one or more second radio frequency pulses each having a second excitation angle to the specimen, with a second time period between second pulses, to obtain a first data set defining a first sample of an image space; applying one or more third radio frequency pulses each having a third excitation angle to the specimen, with a third time period between third pulses, to obtain a second data set defining a second sample of the image space; applying one or more fourth radio frequency pulses each having a fourth excitation angle to the specimen, with a fourth time period between fourth pulses, to obtain a third data set defining a third sample of the image space; wherein the fourth excitation angle is different to the third excitation angle and/or the fourth time period is different to the third time period; calculating a magnetic field map data from at the three data sets; and outputting the magnetic field map data. | 02-03-2011 |
Timothy Peter Williams, London GB
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20130198204 | SYSTEM AND METHOD DETERMINING ONLINE SIGNIFICANCE OF CONTENT ITEMS AND TOPICS USING SOCIAL MEDIA - A set of content items is identified that is relevant to a topic. The communications provided with a plurality of social networking mediums are processed to identify individual communications that reference content items from the set. A score is determined for each of the one or more content items. The score of each of the one or more content items can be based at least in part on a number of instances in which that content item is referenced by the communications of the social networking mediums. A presentation can be provided that identifies a plurality of content items, as well as the score for each of the plurality of content items. | 08-01-2013 |