Patent application number | Description | Published |
20100075996 | PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS - Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds. | 03-25-2010 |
20120122901 | PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS - Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds. | 05-17-2012 |
20150148357 | PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS - Described herein is pyrrolo{2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds. | 05-28-2015 |
20150374701 | PYRROLO[2,3-D]PYRIMIDINE COMPOUNDS - Described herein is pyrrolo {2,3-d}pyrimidine compounds, their use as Janus Kinase (JAK) inhibitors, pharmaceutical compositions containing this compounds, and methods for the preparation of these compounds. | 12-31-2015 |
Patent application number | Description | Published |
20150047441 | SAMPLE CARRIER FOR DRIED BIOLOGICAL SAMPLES - Described is a biological sample carrier based on a rigid hydrophilic object fabricated from a non-absorbing inert porous material. A biological fluid sample applied to the surface of the object is absorbed into the pores and constituents of the biological fluid sample remain in the pores after drying. Unlike a disc punched from a conventional dried blood spot (DBS) card, the object is easily handled. In contrast to DBS cards containing glass fiber structures that interact with basic analytes and other DBS card having adsorbing fibers that tend to separate blood constituents as the sample spreads through the fibers, the biological sample carrier is substantially inert to drug analytes. | 02-19-2015 |
20150266019 | APPARATUS AND METHOD FOR ANALYTE EXTRACTION - Described is a matrix spot processing device comprising a tubular apparatus. An absorbent media is located either separate from, or attached to, the tubular apparatus. A sample is spotted on the absorbent media. A reservoir is in the tubular apparatus. A first region of the reservoir is constructed and arranged to have an extraction solvent. A second region of the reservoir, which may or may not be the same as the first region, is constructed and arranged to receive an extract generated from an interaction between the extraction solvent and the spotted sample at the absorbent media. | 09-24-2015 |
20150285714 | INTEGRAL SAMPLE IDENTIFICATION THROUGHOUT A WORKFLOW PROCESS - Provided are devices and methods for sample collection and processing. A tubular body has a chamber closed at a first end by a thin penetrable barrier and open at a second end opposite the first end. The tubular body further includes a partition that divides the chamber into two adjacent compartments, wherein a first compartment of the two adjacent compartments has the partition facing opposite the open end of the chamber and a second compartment of the two adjacent compartments has the partition facing opposite the closed end of the chamber. The partition has one or more holes to allow passage of fluid from the first compartment into the second compartment. A tracking identification may be permanently affixed to the first end of the tubular body. | 10-08-2015 |
Patent application number | Description | Published |
20100163645 | POPPET CHECK VALVE FOR AIR-ASSISTED SPRAY GUN - An air-assisted sprayer comprises a platform, a fluid cup, an air reservoir, a spray cap, a pressure line, a fluid reservoir and a poppet valve. The fluid cup is connected to the platform to hold a volume of fluid. The air reservoir extends through the platform and is configured to receive pressurized air. The spray cap is connected to the platform to receive pressurized air from the air reservoir. The pressure line connects the air reservoir with the fluid cup to pressurize the volume of fluid. The fluid reservoir extends from the fluid cup to the platform to provide pressurized fluid to the spray cap. The poppet valve is in fluid communication with the pressure line between the volume of fluid and the air reservoir to prevent fluid from entering the air reservoir. | 07-01-2010 |
20100163648 | INTEGRATED FLOW CONTROL ASSEMBLY FOR AIR-ASSISTED SPRAY GUN - An air-assisted sprayer comprises a platform, an air reservoir, a fluid reservoir, a spray cap and a dual flow valve. The air reservoir extends through the platform and is configured to receive a source of pressurized air. The fluid reservoir extends through the platform to intersect the air reservoir, and is configured to receive a source of pressurized fluid. The spray cap is configured to receive pressurized air from the air reservoir and pressurized fluid from the fluid reservoir to discharge a stream of atomized fluid from the platform. The dual flow valve is positioned within the platform to intersect the air reservoir and the fluid reservoir to simultaneously vary volumetric flow rates of the pressurized air and the pressurized fluid over a range. | 07-01-2010 |
20150060568 | PAINT CAN ADAPTER FOR HANDHELD SPRAY DEVICE - An adapter allows direct connection of a handheld spray device to paint cans of varying dimensions. The adapter includes a cage for holding the paint can, a cap that connects the cage to the handheld spray device, and a gasket that seals the open upper end of the paint can to the cap. The adapter may also include a suction tube extension that is connectable between the pump inlet and the suction tube of the spray device. A can spacer insert is positionable in the cage to elevate paint cans of varying heights so that the upper ring of the paint can engages the gasket. | 03-05-2015 |
20160074895 | PAINT CAN ADAPTER FOR HANDHELD SPRAY DEVICE - An adapter ( | 03-17-2016 |
Patent application number | Description | Published |
20090197945 | Method for Generating Reference Controls for Pharmacogenomic Testing - Reference controls for use with pharmacogenomic testing, and methods for their identification, preparation, and use, are disclosed. The reference controls can confirm that pharmacogenomic testing correctly identifies individuals that do or do not have the mutation of interest, in both clinical trial and patient treatment settings. The reference controls can be selected to include one or more mutations to be identified, and prescreened to confirm that they bind to one or more of the primers used in the pharmacogenomic testing. The reference controls are human genomic DNA that includes certain identified polymorphisms (mutations) of interest, ideally derived from individuals, pre-selected and optionally properly consented, which have one or more of the polymorphism(s) of interest. The reference controls can be prepared by targeted pre-screening of human patients, by examining the genotype or genetic profile of the patients, isolating cells with the desired mutation, optionally immortalizing the cells, and obtaining DNA from the cells. The prescreening of prospective donors can be targeted based on any of a number of factors, such as genes of interest, mutations within the genes of interest, and membership in a specific ethnic or disease state population. The genomic DNA can be pre-screened for its ability to be detected, using a standard pharmacogenomic test, as including a specific mutation. Examples of mutations of interest include those present in a Phase I or Phase II metabolic enzyme such as CYP2D6, CYP2C19, CYP2C9, CYP2C8, and CYP3A5, CYP3A4, CYP2A6, CYP2B6, UGT1A1, DPD, ERCC1, MDR1, ADH2, NAT1 and NAT2 or any other metabolic or disease gene. | 08-06-2009 |
20100137426 | METHOD FOR GENERATING REFERENCE CONTROLS FOR PHARMACOGENOMIC TESTING - Reference controls for use with pharmacogenomic testing, and methods for their identification, preparation, and use, are disclosed. The reference controls can confirm that pharmacogenomic testing correctly identifies individuals that do or do not have the mutation of interest, in both clinical trial and patient treatment settings. The reference controls can be selected to include one or more mutations to be identified, and prescreened to confirm that they bind to one or more of the primers used in the pharmacogenomic testing. The reference controls are human genomic DNA that includes certain identified polymorphisms (mutations) of interest, ideally derived from individuals, pre-selected and optionally properly consented, which have one or more of the polymorphism(s) of interest. The reference controls can be prepared by targeted pre-screening of human patients, by examining the genotype or genetic profile of the patients, isolating cells with the desired mutation, optionally immortalizing the cells, and obtaining DNA from the cells. The prescreening of prospective donors can be targeted based on any of a number of factors, such as genes of interest, mutations within the genes of interest, and membership in a specific ethnic or disease state population. The genomic DNA can be pre-screened for its ability to be detected, using a standard pharmacogenomic test, as including a specific mutation. Examples of mutations of interest include those present in a Phase I or Phase II metabolic enzyme such as CYP2D6, CYP2C19, CYP2C9, CYP2C8, and CYP3A5, CYP3A4, CYP2A6, CYP2B6, UGT1A1, DPD, ERCC1, MDR1, ADH2, NAT1 and NAT2 or any other metabolic or disease gene. | 06-03-2010 |
20110097713 | Compositions and methods for pharmacogenomic screening of CYP2C9 and VKORC1 - Compositions and methods for determining an optimal dose of a medication for a subject are described that include determining the subject's genotype for the CYP2C9 and VKORC1 genes and determining the dose of the medication based on the genotype. Articles of manufacture also are provided that include polynucleotides for genotyping. | 04-28-2011 |
Patent application number | Description | Published |
20090031826 | High-Throughput Sample Preparation and Analysis for Differential Scanning Calorimetry - A high throughput workstation includes: a sample deposition and annealing robot, a pan/sample weighing robot, and a thermal analyzer equipped with autosampler and data analysis system. After deposition, the solvent can be removed and multiple samples annealed simultaneously in a controlled manner. The sample pans are weighed before and after the samples are prepared using a robotic weigher. The high throughput workstation facilitates analysis of thermal properties of samples obtained via parallel plate reaction (PPR) in substantially less time than corresponding manual techniques. | 02-05-2009 |
20090111944 | PSEUDO-BLOCK COPOLYMERS AND PROCESS EMPLOYING CHAIN SHUTTLING AGENT - A process for the polymerization of one or more addition polymerizable monomers to form a copolymer comprising multiple regions or segments of differentiated polymer composition or properties comprising contacting an addition polymerizable monomer or mixture of monomers under addition polymerization conditions with a composition comprising at least one olefin polymerization catalyst, a cocatalyst and a chain shuttling agent, said process being characterized by formation of at least some of the growing polymer chains under differentiated process conditions such that two or more blocks or segments formed within at least some of the resulting polymer are chemically or physically distinguishable. | 04-30-2009 |
20090215190 | APPARATUS AND METHOD FOR EXOTHERMIC AND ENDOTHERMIC REACTIONS - The present invention generally relates to an apparatus and method for running a plurality of essentially simultaneous exothermic reactions, endothermic reactions, or a combination thereof in sealed reactors and obtaining physico-chemical data, preferably temperature data, and, optionally, time data, for the reactions, wherein reaction mixtures in the sealed reactors are adiabatically thermally insulated from one another so that temperature in one sealed reactor does not materially affect temperature in any other, including an adjacent, sealed reactor. | 08-27-2009 |
20110118416 | Catalyst Composition Comprising Shuttling Agent for Ethylene Multi-Block Copolymer Formation - A composition for use in forming a multi-block copolymer, said copolymer containing therein two or more segments or blocks differing in chemical or physical properties, a polymerization process using the same, and the resulting polymers, wherein the composition comprises the admixture or reaction product resulting from combining:
| 05-19-2011 |
20110124818 | Catalyst Composition Comprising Shuttling Agent for Ethylene Multi-Block Copolymer Formation - A composition for use in forming a multi-block copolymer, said copolymer containing therein two or more segments or blocks differing in chemical or physical properties, a polymerization process using the same, and the resulting polymers, wherein the composition comprises the admixture or reaction product resulting from combining:
| 05-26-2011 |
20130030092 | Catalyst Composition Comprising Shuttling Agent for Ethylene Multi-Block Copolymer Formation - A composition for use in forming a multi-block copolymer, said copolymer containing therein two or more segments or blocks differing in chemical or physical properties, a polymerization process using the same, and the resulting polymers, wherein the composition comprises the admixture or reaction product resulting from combining:
| 01-31-2013 |
20140249286 | Catalyst Composition Comprising Shuttling Agent for Ethylene Multi-Block Copolymer Formation - A composition for use in forming a multi-block copolymer, said copolymer containing therein two or more segments or blocks differing in chemical or physical properties, a polymerization process using the same, and the resulting polymers, wherein the composition comprises the admixture or reaction product resulting from combining:
| 09-04-2014 |