Wang, La Jolla
Cathy Wang, La Jolla, CA US
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20150352228 | METHODS AND COMPOSITIONS FOR ENHANCING TRANSDUCTION EFFICIENCY OF RETROVIRAL VECTORS - The present invention provides methods for enhancing transduction efficiency of a viral vector into a host cell such as a stem cell. The methods involve transducing the host cell with the vector in the presence of an inhibitor of mTOR complexes (e.g., rapamycin or analog compound thereof). Also provided in the invention are kits or pharmaceutical combinations for delivering a therapeutic agent into a target cell with enhanced targeting frequency and payload delivery. The kits or pharmaceutical combinations typically contain a viral vector encoding the therapeutic agent, and an inhibitor of mTOR complexes. | 12-10-2015 |
Cathy X. Wang, La Jolla, CA US
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20150352228 | METHODS AND COMPOSITIONS FOR ENHANCING TRANSDUCTION EFFICIENCY OF RETROVIRAL VECTORS - The present invention provides methods for enhancing transduction efficiency of a viral vector into a host cell such as a stem cell. The methods involve transducing the host cell with the vector in the presence of an inhibitor of mTOR complexes (e.g., rapamycin or analog compound thereof). Also provided in the invention are kits or pharmaceutical combinations for delivering a therapeutic agent into a target cell with enhanced targeting frequency and payload delivery. The kits or pharmaceutical combinations typically contain a viral vector encoding the therapeutic agent, and an inhibitor of mTOR complexes. | 12-10-2015 |
Jean Wang, La Jolla, CA US
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20150353590 | METHODS AND COMPOSITIONS FOR TREATMENT OF CYANIDE AND HYDROGEN SULFIDE TOXICITY - A composition and method for treating excess cyanide and hydrogen sulfide comprising administering a cobinamide. Further a method for determining extent of binding by an agent to an extracellular matrix. | 12-10-2015 |
Jiangyun Wang, La Jolla, CA US
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20080233611 | Orthogonal Translation Components for the in Vivo Incorporation of Unnatural Amino Acids - The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as | 09-25-2008 |
20090209000 | Genetically Programmed Expression of Proteins - The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as | 08-20-2009 |
Jianing Wang, La Jolla, CA US
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20110244027 | 2'-Fluoro-6'-Methylene Carbocyclic Nucleosides and Methods of Treating Viral Infections - The present invention relates to 2′-Fluoro-6′-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of viral infections and secondary disease states and conditions thereof, especially including Hepatitis B virus (HBV) and secondary disease states and conditions thereof (cirrhosis and liver cancer), Heptatitis C virus (HCV), Herpes Simplex virus I and II (HSV-1 and HSV-2), cytomegalovirus (CMV), Varicella-Zoster Virus (VZV) and Epstein Barr virus (EBV) and secondary cancers which occur thereof (lymphoma, nasopharyngeal cancer, including drug resistant (especially including lamivudine and/or adefovir resistant) and other mutant forms of these viruses. | 10-06-2011 |
Jiwu Wang, La Jolla, CA US
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20110214192 | PHOTOCONVERTIBLE FLUORESCENT PROTEINS - The present disclosure provides an isolated nucleic acid sequence encoding a monomeric photoconvertible fluorescent protein, and fragments and derivatives thereof. Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell comprising the vector, and use of the vector in a method for expressing the nucleic acid sequence. The present disclosure further provides an isolated nucleic acid, or mimetic or complement thereof, that hybridizes under stringent conditions to the nucleic acid sequence. Additionally, the present provides a monomeric photoconvertible fluorescent protein encoded by the nucleic acid sequence, as well as derivatives, fragments, and homologues thereof. Also provided is an antibody that specifically binds to the photoconvertible fluorescent protein. | 09-01-2011 |
20120093737 | LIGHT-ABSORBING COMPOSITIONS AND METHODS OF USE - The present disclosure relates to methods and compositions comprising naturally occurring light absorbing molecules for preventing damages from light exposure. Specific embodiments of this disclosure include fluorescent proteins from | 04-19-2012 |
20120094279 | Use of enzymes for altering ratios of partially matched polynucleotides - The present disclosure relates to novel methods of discriminating and/or detecting mis-matched polynucleotide populations in a sample by determining the ratios of mismatched polynucleotide species after specific enzymatic digestion treatment. Aspects of this disclosure includes obtaining, enhancing and/or determining the amount of one DNA or RNA species versus another in a given sample following enzyme digestion treatment; determining the relative abundance of the species contained in the sample based on the changes in the relative ratios following enzymatic treatment. | 04-19-2012 |
20130302295 | FEEDER-FREE DERIVATION OF HUMAN-INDUCED PLURIPOTENT STEM CELLS WITH SYNTHETIC MESSENGER RNA - The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed. | 11-14-2013 |
20140038267 | NOVEL MONOMERIC YELLOW-GREEN FLUORESCENT PROTEIN FROM CEPHALOCHORDATE - The present disclosure provides isolated nucleic acid sequences encoding a monomeric green/yellow fluorescent proteins, and fragments and derivatives thereof. Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell comprising the vector, and use of the vector in a method for expressing the nucleic acid sequence. The present invention further provides an isolated nucleic acid, or mimetic or complement thereof, that hybridizes under stringent conditions to the nucleic acid sequence. Additionally, the present invention provides a monomeric green/yellow fluorescent protein encoded by the nucleic acid sequence, as well as derivatives, fragments, and homologues thereof. Also provided is an antibody that specifically binds to the green/yellow fluorescent protein. | 02-06-2014 |
20140349401 | FEEDER-FREE DERIVATION OF HUMAN-INDUCED PLURIPOTENT STEM CELLS WITH SYNTHETIC MESSENGER RNA - The present disclosure relates generally to novel methods and compositions for using engineered reprogramming factor(s) for the creation of induced pluripotent stem cells (iPSCs) through a kinetically controlled process. Specifically, this disclosure relates to establishing combinations of reprogramming factors, including fusions between conventional reprogramming factors with transactivation domains, optimized for reprogramming various types of cells. More specifically, the exemplary methods disclosed herein can be used for creating induced pluripotent stem cells from various mammalian cell types, including human fibroblasts. Exemplary methods of feeder-free derivation of human induced pluripotent stem cells using synthetic messenger RNA are also disclosed. | 11-27-2014 |
Lele Wang, La Jolla, CA US
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20150055736 | METHOD AND APPARATUS FOR DECODING RECEIVED SEQUENCE - A method and apparatus for embodying an algorithm that can simultaneously restore a present codeword and an interference codeword with low complexity so as to obtain high throughput in a wide interference signal power level are provided. By simultaneously restoring a desired codeword and an interference codeword by considering an interference signal upon decoding, high throughput performance can be obtained regardless of a power level of the interference signal. | 02-26-2015 |
Lingquan Wang, La Jolla, CA US
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20090072270 | Low voltage transistors - The invention provides a transistor having a substrate, a structure supported by the substrate including a source, drain, gate, and channel, wherein the source and the channel are made of different materials, and a tunnel junction formed between the source and the channel, whereby the tunnel junction is configured for injecting carriers from the source to the channel. | 03-19-2009 |
Shaoxuan Wang, La Jolla, CA US
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20130307847 | RENDERING AND ENCODING ADAPTATION TO ADDRESS COMPUTATION AND NETWORK - A method for graphics rendering adaptation by a server that includes a graphics rendering engine that generates graphic video data and provides the video data via a communication resource to a client. The method includes monitoring one or both of communication and computation constraint conditions associated with the graphics rendering engine and the communication resource. At least one rendering parameter used by the graphics rendering engine is set based upon a level of communication constraint or computation constraint. Monitoring and setting are repeated to adapt rendering based upon changes in one or both of communication and computation constraints. In preferred embodiments, encoding adaptation also responds to bit rate constraints and rendering is optimized based upon a given bit rate. Rendering parameters and their effect on communication and computation costs have been determined and optimized. A preferred application is for a gaming processor miming on a cloud based or data center server that services mobile clients over a wireless network for graphics intensive applications, such as massively multi-player online role playing games, or augmented reality. | 11-21-2013 |
Siming Wang, La Jolla, CA US
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20150207060 | MAGNETIC AND ELECTRICAL CONTROL OF ENGINEERED MATERIALS - Methods, systems, and devices are disclosed for controlling the magnetic and electrical properties of materials. In one aspect, a multi-layer structure includes a first layer comprising a ferromagnetic or ferrimagnetic material, and a second layer positioned within the multi-layer structure such that a first surface of the first layer is in direct physical contact with a second surface of the second layer. The second layer includes a material that undergoes structural phase transitions and metal-insulator transitions upon experiencing a change in temperature. One or both of the first and second layers are structured to allow a structural phase change associated with the second layer cause a change magnetic properties of the first layer. | 07-23-2015 |
Tiejun Wang, La Jolla, CA US
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20100057887 | SYSTEM AND METHOD FOR PROVIDING LOCALLY APPLICABLE INTERNET CONTENT WITH SECURE ACTION REQUESTS AND ITEM CONDITION ALERTS - Optimized delivery of locally applicable Internet content to users. A cache of locally applicable Internet content is maintained in a local content server, based upon a monitoring of locations of users requesting Internet content. Requests for Internet content are received from user equipment through a wireless network base station, and served from the local content server, which is logically proximate to the wireless network base station. The caching of locally applicable Internet content may be maintained on a layered basis. Secure action request receipt and corresponding performance, and item condition alerts are also described. | 03-04-2010 |
20110211113 | Method and apparatus for multimedia communications with different user terminals - Multimedia communications with cross-layer optimization in multimedia communications with different user terminals. Various optimization for the delivery of multimedia content across different channels are provided concurrently to a plurality of user terminals. | 09-01-2011 |
20120009944 | System and method for providing locally applicable internet content with secure action requests and item condition alerts - Optimized delivery of locally applicable Internet content to users. A cache of locally applicable Internet content is maintained in a local content server, based upon a monitoring of locations of users requesting Internet content. Requests for Internet content are received from user equipment through a wireless network base station, and served from the local content server, which is logically proximate to the wireless network base station. The caching of locally applicable Internet content may be maintained on a layered basis. Secure action request receipt and corresponding performance, and item condition alerts are also described. | 01-12-2012 |
20120240171 | METHOD AND APPARATUS FOR MULTIMEDIA COMMUNICATIONS WITH DIFFERENT USER TERMINALS - Multimedia communications in multimedia communications with different user terminals. Various optimization for the delivery of multimedia content across different channels are provided concurrently to a plurality of user terminals. | 09-20-2012 |
20150072711 | SYSTEM AND METHOD FOR PROVIDING LOCALLY APPLICABLE INTERNET CONTENT WITH SECURE ACTION REQUESTS AND ITEM CONDITION ALERTS - Optimized delivery of locally applicable Internet content to users. A cache of locally applicable Internet content is maintained in a local content server, based upon a monitoring of locations of users requesting Internet content. Requests for Internet content are received from user equipment through a wireless network base station, and served from the local content server, which is logically proximate to the wireless network base station. The caching of locally applicable Internet content may be maintained on a layered basis. Secure action request receipt and corresponding performance, and item condition alerts are also described. | 03-12-2015 |
20150319486 | METHOD AND APPARATUS FOR CROSS-LAYER OPTIMIZATION IN MULTIMEDIA COMMUNICATIONS WITH DIFFERENT USER TERMINALS - Multimedia communications with cross-layer optimization in multimedia communications with different user terminals. Various optimization for the delivery of multimedia content across different channels are provided concurrently to a plurality of user terminals. | 11-05-2015 |
Tiejun Ronald Wang, La Jolla, CA US
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20110149148 | Methods, systems and apparatus for displaying the multimedia information from wireless communication networks - Video signals for a mobile terminal are converted to accommodate reproduction by an alternative display terminal. The video signal is processed to provide a converted video signal appropriate for an alternative display terminal that is separate from the mobile terminal. This converted video signal is then provided for the alternative display terminal to accommodate the corresponding video display on a screen provided by the alternative (e.g., external) display terminal. | 06-23-2011 |
20120088546 | METHODS, SYSTEMS AND APPARATUS FOR DISPLAYING THE MULTIMEDIA INFORMATION FROM WIRELESS COMMUNICATION NETWORKS - Video signals for a mobile terminal are converted to accommodate reproduction by an alternative display terminal. The video signal is processed to provide a converted video signal appropriate for an alternative display terminal that is separate from the mobile terminal. This converted video signal is then provided for the alternative display terminal to accommodate the corresponding video display on a screen provided by the alternative (e.g., external) display terminal. | 04-12-2012 |
Wei Wang, La Jolla, CA US
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20130116146 | Peptide Microarray and Method of Use - A peptide microarray comprising a plurality of predicted unique binding peptides being selected by computational prediction of interaction with a protein of interest or a domain thereof. The selected unique binding peptides are pre-synthesized and then printed and/or immobilized onto a solid support surface via N-terminus with a linker. Methods of using the invention peptide microarray for quantitative determination of protein-peptide interaction, epitope mapping, and drug screening are also provided. | 05-09-2013 |
20130151452 | Systems and Methods for Identifying Drug Targets Using Biological Networks - Certain embodiments of the invention may include systems and methods for identifying drug targets using biological networks. According to an example embodiment of the invention, a method is provided for predicting the effects of drug targets on treating a disease. The method can include constructing a structure of a Bayesian network based at least in part on knowledge of drug inhibiting effects on a disease; associating a set of parameters with the constructed Bayesian network; determining values of a joint probability distribution of the Bayesian network via an automatic procedure; deriving a mean Bayesian network with one or more averaged parameters based at least in part on the joint probability values; and calculating a quantitative prediction based at least in part on the mean Bayesian network. | 06-13-2013 |
20150254434 | Systems and Methods for Identifying Drug Targets Using Biological Networks - Certain embodiments of the invention may include systems and methods for identifying drug targets using biological networks. According to an example embodiment of the invention, a method is provided for predicting the effects of drug targets on treating a disease. The method can include constructing a structure of a Bayesian network based at least in part on knowledge of drug inhibiting effects on a disease; associating a set of parameters with the constructed Bayesian network; determining values of a joint probability distribution of the Bayesian network via an automatic procedure; deriving a mean Bayesian network with one or more averaged parameters based at least in part on the joint probability values; and calculating a quantitative prediction based at least in part on the mean Bayesian network. | 09-10-2015 |
Yibin Wang, La Jolla, CA US
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20090149412 | Method for Inhibition of Phospholamban Activity for the Treatment of Cardiac Disease and Heart Failure - The present invention provides a method for the treatment of heart failure through the use of small peptide complexes and recombinant proteins which function to enhance contractility in failing hearts and reduce blood pressure in individuals with hypertension by inhibiting the interaction between phospholamban and sacroplasmic reticulum Ca | 06-11-2009 |
Yibing (michelle) Wang, La Jolla, CA US
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20100002118 | DUAL SENSITIVITY IMAGE SENSOR - A system of taking images of different sensitivities at the same time uses both an image sensor, and an auxiliary part to the image sensor. The image sensor element can be a photogate, and the auxiliary part can be the floating diffusion associated with the photogate. Both the photogate and the floating diffusion accumulate charge. Both are sampled at different times. The floating diffusion provides a lower sensitivity amount of charge than the photogate itself. The system can have a photogate and floating diffusion in each pixel along with a select transistor, a reset transistor, and a follower transistor. All of this circuitry can be formed of CMOS for example. The system can also operate in a column/parallel mode, where each column of the photo sensor array can have a column signal processor which samples and holds the reset signal, the floating diffusion signal and the photogate signal. | 01-07-2010 |
Yingxiao Wang, La Jolla, CA US
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20090305309 | Methods and Compositions for Detecting Neoplastic Cells - Methods and compositions for identifying neoplastic cells in a biological sample are provided. | 12-10-2009 |
Yuliang Wang, La Jolla, CA US
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20090196788 | Methods For The Production Of Silver Nanowires - Embodiments of the present invention are directed to novel methods for the solution-based production of silver nanowires by adaptation of the polyol process. Some embodiments of the present invention can be practiced at lower temperature and/or at higher concentration than previously described methods. In some embodiments reactants are added in solid form rather than in solution. In some embodiments, an acid compound is added to the reaction. | 08-06-2009 |
20110023658 | Methods For The Production Of Silver Nanocubes - Embodiments of the present invention are directed to novel methods for the solution-based production of silver nanocubes. This method differs, inter alia, from the traditional polyol method in that reactants (such as AgNO | 02-03-2011 |
20110185853 | Methods For The Production Of Silver Nanowires - Embodiments of the present invention are directed to novel methods for the solution-based production of silver nanowires by adaptation of the polyol process. Some embodiments of the present invention can be practiced at lower temperature and/or at higher concentration than previously described methods. In some embodiments reactants are added in solid form rather than in solution. In some embodiments, an acid compound is added to the reaction. | 08-04-2011 |