Patent application number | Description | Published |
20100129360 | ANTIBODIES AGAINST HUMAN INTERLEUKIN-13 AND USES THEREFOR - This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders. | 05-27-2010 |
Patent application number | Description | Published |
20110313429 | METHOD AND APPARATUS FOR TISSUE GRAFTING AND COPYING - Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue. | 12-22-2011 |
20130190744 | METHODS AND DEVICES FOR SELECTIVE DISRUPTION OF VISCERAL FAT BY CONTROLLED COOLING - The present invention provides methods and apparatus for use in the selective disruption of visceral fat tissue by controlled cooling. | 07-25-2013 |
20150238214 | Method and Apparatus for Tissue Grafting and Copying - Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin. A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix. The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts. The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue. | 08-27-2015 |
Patent application number | Description | Published |
20090261907 | INTEGRATED CIRCUIT HAVING ON DIE STRUCTURE PROVIDING CAPACITANCE IN AMPLIFIER FEEDBACK PATH - An amplifier structure includes shield conductors that are provided spatially adjacent to elongated feedback signal lines that couple a feedback circuit to an amplifier input. The shield conductors are provided between the feedback signal lines and a ground plane, which interrupts a parasitic capacitance that otherwise would be established between the feedback signal line and ground. The shield conductors are electrically coupled to the amplifier's outputs which create a capacitance between the output terminal and the feedback signal line. In some embodiments, the capacitance generated between the output terminal and the feedback signal line can suffice as a capacitor in a feedback path of the amplifier and be contained in an integrated circuit die on which the amplifier is manufactured. Optionally, a structure may be provided that eliminates common mode signals on the feedback lines while simultaneously preserving the common mode signals on the amplifier output terminals. In this option, a second amplifier is provided that, in response to common mode variations at the output terminal, generates counterbalancing voltage variations on a second circuit that is coupled to the feedback lines at their source. The two variations cancel each other out at nodes from which the feedback lines originate, which substantially reduces feedback common mode variation even when there is common mode variation at the output terminals. | 10-22-2009 |
20120268204 | APPARATUS AND METHOD FOR EQUALIZATION - Apparatus and methods for equalization are provided. In one embodiment, an apparatus for equalizing an input voltage includes a first capacitor and a first resistor having a first end and a second end, the first end configured to receive the input voltage. The apparatus further includes a second resistor having a first end electrically connected to the second end of the first resistor at an output node. The apparatus further includes an inverting voltage buffer for substantially inverting the input voltage to generate an inverted input voltage. The apparatus further includes a transconductance buffer for receiving the inverted input voltage and for generating a current from a first end of the first capacitor to the output node having a magnitude equal to about the magnitude of the input voltage signal divided by the impedance of the first capacitor. | 10-25-2012 |
20130033326 | APPARATUS AND METHOD FOR DIGITALLY-CONTROLLED AUTOMATIC GAIN AMPLIFICATION - Apparatus and methods are disclosed, such as those involving a receiver device. One such apparatus includes an equalizer configured to process an input signal transmitted over a channel. The equalizer can include a programmable gain amplifier (PGA) block which includes an input node configured to receive the input signal; an output node; and a programmable gain amplifier (PGA). The PGA amplifies the input signal with an adjustable gain. The PGA block also includes a gain control block having an input electrically coupled to the input node. The gain control block is configured to adjust the gain of the PGA at least partly in response to the input signal from the input node such that the PGA generates an output signal with a substantially constant amplitude envelope to the output node. | 02-07-2013 |
20130034143 | APPARATUS AND METHOD FOR DIGITALLY-CONTROLLED ADAPTIVE EQUALIZER - Apparatus and methods are disclosed, such as those involving a receiver device. One such apparatus includes an equalizer configured to process an input signal transmitted over a channel. The equalizer includes a first node configured to receive the input signal; a second node; and a programmable gain amplifier (PGA) having an adjustable gain. The PGA has an input electrically coupled to the first node, and an output electrically coupled to a third node. The equalizer also includes a high pass filter (HPF) having an input electrically coupled to the third node, and an output electrically coupled to the second node; and a control block configured to adjust one or more of the PGA or the HPF at least partly in response to a PGA output signal from the PGA or an HPF output signal from the HPF. | 02-07-2013 |
20130043937 | APPARATUS AND METHOD FOR ELECTRICAL BIASING - As provided herein, in some embodiments, power consumption and/or chip area is reduced by bias circuits configured to provide bias conditions for more than one active circuit, thereby reducing the number of bias circuits in a design. Shared bias circuits may reduce the aggregate amount of on-chip area utilized by bias circuitry and may also reduce the total power consumption of a chip. Additionally and/or alternatively, bias circuits disclosed herein are configured to provide outputs that are less susceptible to changes in the voltage supply level. In particular, in some embodiments, bias circuits are configured to provide relatively constant bias conditions despite changes in the voltage supply level. In some embodiments, bias circuits are configured to provide bias conditions that compensate for perturbations caused by changes other inputs, in order to stabilize a particular operating point. | 02-21-2013 |
20130271219 | APPARATUS AND METHODS FOR FREQUENCY COMPENSATION OF AN AMPLIFIER - Apparatus and methods for frequency compensation of an amplifier are provided. In one embodiment, an integrated circuit (IC) includes an amplifier configured to amplify an input signal to generate an output signal. The IC further includes an output pad configured to receive an output signal from the amplifier and a control pad for controlling the closed-loop bandwidth of the amplifier. A compensation capacitor is electrically connected between an input of the inverting amplification block and an output of the inverting amplification block, and a switchable capacitor is electrically connected between the input of the inverting amplification block and the control pad. The control pad can be electrically connected to a DC voltage source or to the output pad to control the amplifier's closed-loop bandwidth. | 10-17-2013 |
20130287084 | WIDE COMMON-MODE RANGE RECEIVER - A wide common-mode range receiver includes an input module, voltage level shift module, voltage level shift control module, and output module. The receiver can also include an equalizer. The receiver translates data originating from a circuit powered from an external voltage supply to a circuit powered by an internal voltage supply. The voltage level shift may be scaled based on differences between the voltage supplies or by determining the difference between an input common-mode voltage and a reference voltage, and driving a servo based on the difference. | 10-31-2013 |
20140037031 | METHODS FOR DIGITALLY-CONTROLLED AUTOMATIC GAIN AMPLIFICATION - Apparatus and methods are disclosed, such as those involving a receiver device. One such apparatus includes an equalizer configured to process an input signal transmitted over a channel. The equalizer can include a programmable gain amplifier (PGA) block which includes an input node configured to receive the input signal; an output node; and a programmable gain amplifier (PGA). The PGA amplifies the input signal with an adjustable gain. The PGA block also includes a gain control block having an input electrically coupled to the input node. The gain control block is configured to adjust the gain of the PGA at least partly in response to the input signal from the input node such that the PGA generates an output signal with a substantially constant amplitude envelope to the output node. | 02-06-2014 |
Patent application number | Description | Published |
20080309409 | Balanced differential cross-coupled transconductance amplifier for a multiplexor - A balanced, differential, cross-coupled amplifier including an input stage for receiving a differential input and including an input transconductance differential pair and a feedback transconductance differential pair; and an output stage responsive to the input stage for providing a differential output; the differential input being connected to one input of the input transconductance differential pair and one input of the feedback transconductance differential pair, the differential output being fed back to one input of the input transconductance differential pair and one input of the feedback transconductance differential pair for balancing the currents in the transconductance differential pairs over the input range. | 12-18-2008 |
20090195304 | TRANSADMITTANCE AND FILTER HAVING A GAIN FUNCTION - Disclosed are a circuit and a method for tuning a programmable filter including input terminals, output terminals, a filter network and a transadmittance stage. The input terminals can receive input signals, and the output terminals output a filtered signal. The transadmittance stage, coupled to the input terminals, generates a current at its output based on the input signals. The output of the transadmittance stage can be coupled to the output terminals. The filter network can be a resistive-capacitive network connected to the input terminals. The RC network can include a capacitance respectively coupling the input terminals to output terminals, and a voltage divider network coupling the input and output terminals together. The transadmittance stage output terminals can be connected to the voltage divider, and the output terminals of the programmable filter circuit are coupled to respective intermediate nodes of the voltage divider network to provide a filtered output signal. | 08-06-2009 |
20090195311 | INDEPENDENT DOMINANT POLE COMPENSATION OF TWO LOOPS USING ONE COMPENSATION ELEMENT - Disclosed is a differential amplifier system that maintains high speed characteristics of the differential amplifier while providing stability from a common-mode loop by using dominant pole compensation. The disclosed system includes a first and second transconductance stage, a circuit having high impedance, and a compensation circuit. | 08-06-2009 |
20100277215 | Wideband Voltage Translators - In embodiments of the present invention, the problems of poor low-frequency response, slow speed, high cost and high power consumption in conventional voltage translators are addressed by processing high frequency and low frequency components of an input signal separately in two parallel stages without the use of large passive components or slow devices. At the output, the processed high frequency and low frequency components are seamlessly merged at a combining stage that maintains the integrity of the frequency response over the complete translator bandwidth. | 11-04-2010 |
20110076967 | IMPEDANCE MATCHED LANE REVERSAL SWITCHING SYSTEM - An impedance matched lane reversal switching system including first and second transceiver pairs, each of the pairs including a transmitter connected to a receiver, the output of the transmitter connected to the input of the receiver and to a node, the node of each pair interconnected with a transmission line and a switching circuit for selectively enabling one of the transmitters of one of the transceiver pairs and disabling the other and selectively utilizing one of the receivers of the other of the transceiver pairs and not the other to selectively reverse an egress side and an ingress side of the lane. | 03-31-2011 |
Patent application number | Description | Published |
20080275010 | COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS - Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs. | 11-06-2008 |
20090075956 | Genetic Risk Assessment in Heart Failure: Impact of the Genetic Variation of NOS3 - The invention provides methods for (a) reducing mortality associated with heart failure; (b) improving oxygen consumption; (c) treating heart failure; (d) treating hypertension; (e) improving the quality of life in a heart failure patient; (f) inhibiting left ventricular remodeling; (g) reducing hospitalizations related to heart failure; (h) improving exercise tolerance; (j) increasing left ventricular ejection fraction; (k) decreasing levels of B-type natriuretic protein; (l) treating renovascular diseases; (m) treating end-stage renal diseases; (n) reducing cardiomegaly; (o) treating diseases resulting from oxidative stress; (p) treating endothelial dysfunctions; (q) treating diseases caused by endothelial dysfunctions; (r) treating cardiovascular diseases; in a patient in need thereof, wherein the patient has at least one polymorphism in the endothelial nitric oxide synthase (NOS3) gene, comprising administering to the patient (i) at least one antioxidant compound or a pharmaceutically acceptable salt thereof; (ii) at least one nitric oxide enhancing compound; and (iii) optionally the best current therapy for the treatment of cardiovascular diseases. In one embodiment the antioxidant is a hydralazine compound or a pharmaceutically acceptable salt thereof and the nitric oxide enhancing compound is isosorbide dinitrate and/or isosorbide mononitrate. | 03-19-2009 |
20090088366 | NITROSATED AND NITROSYLATED PROSTAGLANDINS, COMPOSITIONS AND METHODS OF USE - The invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The invention also provides novel compositions comprising at least one prostaglandin and at least one S-nitrosothiol compound, and, optionally, at least one vasoactive agent. The prostaglandin is preferably a prostaglandin E | 04-02-2009 |
20090099139 | NITROSATED AND NITROSYLATED CYCLOOXYGENASE-2 INHIBITORS, COMPOSITIONS AND METHODS OF USE - The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or optionally, at least one therapeutic agent. The present invention also provides novel compositions comprising at least one parent COX-2 inhibitor and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The present invention also provides kits and methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity; and for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2. | 04-16-2009 |