Patent application number | Description | Published |
20100098725 | METHODS FOR CULTIVATING CELLS, PROPAGATING AND PURIFYING VIRUSES - The present invention provides novel serum-free cell culture medium and methods for cultivating MDCK cells. In particular, non-tumorigenic MDCK cells. The present invention also provides methods for producing influenza viruses (e.g., particularly cold-adapted, and/or temperature sensitive, and/or attenuated influenza viruses) that eliminate the need for a cell culture medium exchange step. The novel medium and methods are useful to grow influenza viruses, in cell culture to high titer. The present invention further provides purification methods for purifying influenza viruses with high overall recovery of live virus and result in levels of host cell DNA (HCD), host cell protein (HCP) and non-specific endonuclease (e.g., Benzonase), which are below the specifications required by regulatory agencies. The immunogenic compositions can be used to actively immunize subjects or to generate antibodies for a variety of uses, including passive immunization and diagnostic immunoassays. | 04-22-2010 |
20120258136 | METHODS FOR CULTIVATING CELLS, PROPAGATING AND PURIFYING VIRUSES - The present invention provides novel serum-free cell culture medium and methods for cultivating MDCK cells. In particular, non-tumorigenic MDCK cells. The present invention also provides methods for producing influenza viruses (e.g., particularly cold-adapted, and/or temperature sensitive, and/or attenuated influenza viruses) that eliminate the need for a cell culture medium exchange step. The novel medium and methods are useful to grow influenza viruses, in cell culture to high titer. The present invention further provides purification methods for purifying influenza viruses with high overall recovery of live virus and result in levels of host cell DNA (HCD), host cell protein (HCP) and non-specific endonuclease (e.g., Benzonase), which are below the specifications required by regulatory agencies. The immunogenic compositions can be used to actively immunize subjects or to generate antibodies for a variety of uses, including passive immunization and diagnostic immunoassays. | 10-11-2012 |
Patent application number | Description | Published |
20100280411 | Transbronchial Needle Aspiration Device - Transbronchial needle aspiration (TBNA) device. In one embodiment, the device comprises a handle and a flexible catheter, the handle having a bore, the proximal end of the catheter being fixed within the handle bore. A protective tubular hub having a flared distal end is press-fit coaxially within the distal end of the catheter, the distal end of the catheter being sealed around the distal end of the hub so as to define a distal opening. A hollow needle having a sharp tip at its distal end is disposed within the catheter, the needle tip being sized for insertion through the distal opening of the catheter. The distal end of a flexible wire is coupled to the proximal end of the needle, the proximal end of the wire extending through the handle bore and coupled to a button slide accessible through a slot in the handle. The button slide is movable between a distal position in which the needle tip extends through the distal opening of the catheter and a proximal position in which the needle tip is disposed within the hub. When in either its distal position or its proximal position, a pawl on the button slide releasably engages a corresponding notch on the handle to lock the button slide in place. | 11-04-2010 |
20130053727 | Transbronchial Needle Aspiration Device - Transbronchial needle aspiration (TBNA) device. In one embodiment, the device comprises a handle and a flexible catheter, the handle having a bore, the proximal end of the catheter being fixed within the handle bore. A protective tubular hub having a flared distal end is press-fit coaxially within the distal end of the catheter, the distal end of the catheter being sealed around the distal end of the hub so as to define a distal opening. A hollow needle having a sharp tip at its distal end is disposed within the catheter, the needle tip being sized for insertion through the distal opening of the catheter. The distal end of a flexible wire is coupled to the proximal end of the needle, the proximal end of the wire extending through the handle bore and coupled to a button slide accessible through a slot in the handle. The button slide is movable between a distal position in which the needle tip extends through the distal opening of the catheter and a proximal position in which the needle tip is disposed within the hub. When in either its distal position or its proximal position, a pawl on the button slide releasably engages a corresponding notch on the handle to lock the button slide in place. | 02-28-2013 |
Patent application number | Description | Published |
20110213202 | ENDOSCOPE WORKING CHANNEL WITH MULTIPLE FUNCTIONALITY - Endoscopic instrument assemblies and methods for making and using the same. An example endoscopic instrument assembly includes an endoscope having a working channel and an endoscopic instrument slidably disposed in the working channel. The inside surface of the working channel and the outside surface of the endoscopic instrument each have a non-circular cross-sectional shape along at least a portion of their respective lengths. | 09-01-2011 |
20110295072 | IMAGING ASSEMBLY WITH TRANSPARENT DISTAL CAP - An imaging assembly for use in a medical imaging device such as an endoscope or the like. In one embodiment, the imaging assembly includes a transparent distal cap that is shaped to receive an image sensor insert. The image sensor insert has a cooling channel that supplies a cooling liquid or gas to one or more illumination sources. | 12-01-2011 |
20120010571 | CATHETER ASSEMBY AND METHOD FOR INTERNALLY ANCHORING A CATHETER IN A PATIENT - A catheter assembly and method for internally anchoring a catheter in a patient. According to one embodiment, the catheter assembly includes a catheter, a tubular fitting coupled to one end of the catheter, and an internal bolster coaxially mounted around the tubular fitting. The tubular fitting has a waist portion, and the internal bolster is secured thereto by a snap-fit. To internally anchor the catheter in a patient, one inserts the end of the catheter to which the fitting is coupled into the patient and then, while the fitting and its coupled end of the catheter are within the patient, inserts the internal bolster over the fitting until it snap-fits into place over the waist portion, thereby internally anchoring the catheter within the patient. | 01-12-2012 |
20150038784 | ENDOSCOPE WORKING CHANNEL WITH MULTIPLE FUNCTIONALITY - Endoscopic instrument assemblies and methods for making and using the same. An example endoscopic instrument assembly includes an endoscope having a working channel and an endoscopic instrument slidably disposed in the working channel. The inside surface of the working channel and the outside surface of the endoscopic instrument each have a non-circular cross-sectional shape along at least a portion of their respective lengths. | 02-05-2015 |
Patent application number | Description | Published |
20080223604 | PROCESS FOR PREPARING AN ELECTRICALLY STABLE COPPER FILLED ELECTRICALLY CONDUCTIVE ADHESIVE - A process for preparing an electrically conductive adhesive (ECA) with low and stable contact resistance by mixing at least one melt-processable reactive resin, at least one reactive diluent, at least one rheological additive, at least one curing agent, at least one organic acid catalyst, and copper particles. The ECA is useful for filling vias, and bonding together components of electronic circuit structures. | 09-18-2008 |
20080230262 | ELECTRICALLY STABLE COPPER FILLED ELECTRICALLY CONDUCTIVE ADHESIVE - An electronic device including electronic circuit structures formed with an electrically conductive adhesive (ECA) with low and stable contact resistance including at least one melt-processable reactive resin, at least one reactive diluent, at least one rheological additive, at least one curing agent, at least one organic acid catalyst, and copper particles. The ECA is useful for filling vias, and bonding together components of electronic circuit structures. | 09-25-2008 |
20090035455 | Adhesive bleed prevention method and product produced from same - A method of preventing adhesive bleed onto the metal (e.g., gold) surfaces of a plurality of electrical conductors (e.g., wire-bond pads) positioned on a dielectric substrate when positioning an electronic component onto the dielectric substrate and electrically coupling (e.g., wire-bonding) the component to the metal surfaces. The method includes contacting the metal surfaces with a chemical composition which comprises a minor amount of a surface active agent (e.g., a thiol) and the remainder substantially being a non-reactive solvent (e.g., methanol). A circuitized substrate produced using this method is also provided. | 02-05-2009 |
20110139364 | Chemical modification of chromate conversion coated aluminum work pieces - A method and assembly for chemically modifying chromate converted aluminum work pieces to improve adhesion. The chromate converted aluminum work pieces are treated with oxygen plasma within the range of 500 W to 1500 W for approximately 5 to 30 minutes to chemically modify the free cyanide in the chromate coating. The free cyanide is modified into functional groups that chemically bond with silicone based adhesives. Adhesion strength of at least 100% improvement is observed. An aluminum heat sink is attached to modules with a silicone based elastomer containing a thermally enhanced additive. The thermally enhanced adhesive is dispensed onto application specific integrated circuit (ASIC) chips, memory chips, or laminates of the modules. Subsequently, the assembled device is cured at 150° C. for approximately one hour. | 06-16-2011 |
20110260299 | METHOD FOR VIA PLATING IN ELECTRONIC PACKAGES CONTAINING FLUOROPOLYMER DIELECTRIC LAYERS - A semiconductor printed circuit board assembly (PCBA) and method for making same for use in electronic packages having a core layer of copper-invar-copper (CIC) with a layer of dielectric substrate placed on the core layer. A second layer of dielectric substrate is placed on the lower surface of the core layer of CIC. The layers are laminated together. Blind vias are laser drilled into the layers of dielectric substrate. The partially completed PCBA is subjected to a reactive ion etch (RIE) plasma as a first step to clean blind vias in the PCBA. After the plasma etch, an acidic etchant liquid solution is used on the blind vias. Pre-plating cleaning of blind vias removes a majority of oxides from the blind vias. Seed copper layers are then applied to the PCBA, followed by a layer of copper plating that can be etched to meet the requirements of the PCBA. | 10-27-2011 |
20120228013 | DEFECTIVE CONDUCTIVE SURFACE PAD REPAIR FOR MICROELECTRONIC CIRCUIT CARDS - An electrically conductive adhesive (ECA) for repairing electrically conductive pad and trace interconnects and a method of repairing interconnect locations. The method of repairing at least one defect within the area of electrically conductive circuitized substrate traces and pads outside of a pristine center area incorporates an ECA and a forming gas plasma. The ECA contains a mixture of components that allow the adhesive to be adapted to specific requirements. Curing the adhesive results in effective electrical connections being formed between the adhesive and the base pad so that the metallurgies of the conductors and of the ECA are effectively combined to engage and repair the conductor defect. | 09-13-2012 |
20120243155 | CONDUCTIVE METAL NUB FOR ENHANCED ELECTRICAL INTERCONNECTION, AND INFORMATION HANDLING SYSTEM UTILIZING SAME - A method of forming a circuitized substrate utilizing a conductive nub structure for enhanced interconnection integrity by using a joining core layer with copper outer layer on it, and forming thru-holes in the joining layer. Placing conductive adhesive in the thru-hole prior to removing the copper outer layers from the joining core layer creates an adhesive bump on joining core layer that engages a conductive secondary metal nub placed on the circuitized substrate-to-joining layer contact points, thus creating an enhanced connection between the layers. | 09-27-2012 |
20130033671 | LIQUID CRYSTAL POLYMER (LCP) SURFACE LAYER ADHESION ENHANCEMENT - A method of conditioning a liquid crystal polymer (LCP) substrate for enhanced surface adhesion accomplished by exposing an LCP substrate to oxygen plasma. The plasma will chemically alter and modify the LCP substrate surface to promote increased adhesion of metal and subsequent LCP layers during lamination. Lamination is accomplished while dwelling under the melt temperature of the LCP substrate itself. A further method is disclosed of detecting impurities modified or deposited onto the LCP surface during plasma treatment. | 02-07-2013 |
Patent application number | Description | Published |
20120258201 | ANIMAL FEED COMPOSITIONS AND PROCESSES FOR PRODUCING - The present invention relates to animal food products and methods of producing thereof. The methods of the present invention comprise mixing a binding agent with feed meal at a temperature of between about 10° C. and about 70° C. to produce a mash, passing the mash through an extruder to form an animal feed product, and drying the animal feed product. In certain embodiments, the temperature of the meal, mash and final product is kept at 70° C. or below. | 10-11-2012 |
20120263758 | PET FOOD COMPOSITIONS INCLUDING PROBIOTICS AND METHODS OF MANUFACTURE AND USE THEREOF - The present invention encompasses pet food compositions that include one or more probiotic microorganisms, which are useful to improve the health of companion animals. For example, the invention encompasses pet food compositions including a probiotic, for example, | 10-18-2012 |
20130122164 | Pet Food Compositions Having Antimicrobial Activity - The present invention relates to new food compositions, particularly pet food compositions, which are resistant to microbial contamination, and methods for making the same. The compositions comprise an ingredient in an effective amount to impart antimicrobial activity. | 05-16-2013 |
20140242228 | PROCESS FOR PREPARING A PET FOOD COMPOSITION - The disclosure provides method for preparing a food product is described which includes mixing a dry ingredient composition, a protein-containing composition, and an alginate composition to provide a first mixture, mixing the first mixture with a setting composition to effect a controlled rate gelation reaction, and processing the product of the gelation reaction to provide a food product. The disclosure also provides pet food compositions comprising food products prepared according to the disclosed process. | 08-28-2014 |
20140302226 | PET FOOD COMPOSITION WITH A SOFT TEXTURE - Provided are pet food compositions having a soft texture. Also provided are methods for preparing soft textured pet food compositions in which mixtures comprising appropriate amounts of protein, fat, and carbohydrate are contacted with an amylase at a temperature to provide the desired degree of softening of the composition. The pet food compositions exhibit increased penetrating force and are substantially unchanged with respect to digestibility and stool formation as compared to pet food compositions without added amylase. | 10-09-2014 |
20140328896 | COMPOSITIONS AND METHODS FOR MODIFYING GASTROINTESTINAL FLORA - Provided are methods and compositions for enhancing the gastrointestinal health of an animal in need thereof by administering a gastrointestinal health maintaining or improving amount of a composition comprising an effective amount of lactic acid. The administered composition may also comprise one or more prebiotic, probiotic, symbiotic, anti bacterial, or anti-diarrhea agents. | 11-06-2014 |
Patent application number | Description | Published |
20140278791 | SYSTEM AND METHOD FOR VALIDATING LEADS IN AN INTERACTIVE DIGITAL ADVERTISING PLATFORM - An interactive digital advertising system and method may include an advertising component for generating qualified leads using interactive advertising units. The advertising system may provide “real-time” matching of leads, which may be validated based on a criteria defined by the lead requestor, to the services or products offered by the lead requestor. The advertising component may validate potential leads based in part on feedback from third-party validators. Validators may include individuals acquainted with a potential lead or other entities having a connection to the lead, which can provide references that further qualify the potential lead. The advertising component may obtain lead validation or endorsements by interacting with endorsers or validators via social media or electronic messaging services. The advertising component may also collect endorsements, references, or other information to further qualify a lead by automatically querying a third party database. | 09-18-2014 |
20140278792 | PASSIVE CANDIDATE MATCHING SYSTEM AND METHOD FOR GENERATING LEADS IN A DIGITAL ADVERTISING PLATFORM - An interactive digital advertising system and method may include an advertising component for generating qualified leads in response to a lead request using interactive advertising units. The advertising system may provide “real-time” matching of leads, which may be validated based on a criteria defined by the lead requestor, to the services or products offered by the lead requestor. Responders to the lead request may interact directly with the advertising unit to qualify themselves as a lead. Further, the advertising component may be configured to select responders that actively responded to a first lead request to present as leads to a lead requestor in response to a second lead request. | 09-18-2014 |
20140278919 | DYNAMIC INTERACTIVE ADVERTISING SYSTEM AND METHOD - A dynamic, interactive digital advertising system and method may include an advertising component for generating qualified leads in response to a lead request using interactive advertising units for engaging with responders to an advertising message. The advertising system may provide “real-time” matching of leads, which may be validated based on a criteria defined by the lead requestor, to the services or products offered by the lead requestor. The advertising component may aggregate the feedback generated from multiple interactive advertising units, including feedback received from other advertising sources, and apply various learning algorithms to optimize current and future advertising units. The advertising units may be modified in real time based on the observed aggregated performance of other advertising units across multiple advertisers. | 09-18-2014 |
20140278943 | INTERACTIVE DIGITAL ADVERTISING SYSTEM AND METHOD - An interactive digital advertising system and method may include an advertising component for generating qualified leads in response to a lead request. The advertising component may be configured to receive the lead request including user-selected pre-screening inquiries and generate an interactive advertising unit for engaging responders to an advertising message. The advertising unit may interact with responders based at least in part on the selected pre-screening inquiries to collect responder information. The advertising component may use responder information to evaluate and validate the responders based on criteria defined by a lead requestor. The advertising component may identify potential matches with lead requestor offers or services in real-time. The qualified leads generated by the advertising component may then be offered to the lead requestor. | 09-18-2014 |
20140279033 | REAL-TIME INTERACTIVE DIGITAL ADVERTISING SYSTEM AND METHOD OVER MOBILE WEB MESSAGING SERVICE - An interactive digital advertising system and method may include an advertising component for generating qualified leads in response to a lead request using interactive advertising units. The advertising system may provide “real-time” matching of leads, which may be validated based on a criteria defined by the lead requestor, to the services or products offered by the lead requestor. The interactive advertising units may communicate with leads over mobile messaging services, such as short message service (SMS), instant messaging (IM) service, or the like. The advertising component may generate a unique identification code for each lead request, which responders may use to initiate an interactive screening session with the advertising unit. The advertising component may track the unique identification code, responder's caller ID, and the state of the screening session to maintain the proper sequence of interactions. | 09-18-2014 |