Lee, Cambridge
Alejandro Lee, Cambridge, MA US
Patent application number | Description | Published |
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20090077809 | Shaving Razors and Other Hair Cutting Assemblies - A shaving razor blade unit including a housing having a primary guard at a front of the housing and a primary cap at an upper surface at a back of the housing, one or more primary shaving blades between the primary guard and the primary cap, a rear wall having a rear exterior surface extending downward from the upper surface at the back of the housing to a terminating surface, and a trimming blade mounted on the rear wall and having a trimming cutting edge extending at least partially beyond the terminating surface inside of an imaginary extension of the rear exterior surface, the rear exterior surface defining a secondary cap for the trimming blade. The back of the housing includes a trimming guard including spaced guard segments. | 03-26-2009 |
20110067245 | Shaving Razors and Cartridges - A shaving razor with a housing dimensioned to receive at least one blade. The housing has a pair of spaced apart opposing parallel walls each defining a fully enclosed opening that extends completely through the respective walls. | 03-24-2011 |
Alejandro Carlos Lee, Cambridge, MA US
Patent application number | Description | Published |
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20090193600 | Personal Grooming Device Handle and Method for Making the Same - A method of manufacturing a handle for a personal grooming device includes forming a substrate portion of a first material. The substrate portion has first and second walls forming a channel extending along a long axis of the substrate portion. An insert member is formed separate from the substrate portion and disposed within the channel. A grip portion of a second material is formed on the substrate portion. The second material substantially encases the insert member. | 08-06-2009 |
20100058595 | Shaving Razors and Cartridges - A shaving razor with a handle and a housing mounted to the handle. The housing has a proximal end portion, a distal end portion, and at least one blade having a cutting edge. The blade is mounted to the housing with a blade support structure. A guard is at the distal end portion of the housing and has a plurality of projections substantially perpendicular to the blade that define a plurality of slots. A washout cavity beneath the blade is defined by an inner surface of the guard and an inner surface of the blade support structure. The washout cavity has an open area of at least 80 percent for allowing unobstructed passage of water substantially along an entire length of the blade. | 03-11-2010 |
20100293789 | SHAVING CARTRIDGES HAVING ELONGATED SKIN CONTACTING MEMBERS - A razor cartridge which has a housing with a pocket defined by a front wall and a rear wall. The pocket has a seat surface and at least one of the front and rear walls include one or more flexible segments. One or more blades are mounted within the housing. An elongated skin contacting member is provided that comprises a shaving aid composite that has one or more water-leachable shaving aid materials. The elongated skin contacting member has a body portion with an upper skin contacting surface and a base portion which is disposed at least partially within the pocket. The base portion has a bottom surface spaced apart from the seat surface. The base portion extends laterally outwardly from the body portion and is in mechanical engagement with the one or more flexible segments to secure the skin contacting member to the housing. | 11-25-2010 |
20110088269 | Docking Mechanisms for Shaving Razors and Cartridges - A wet shaving razor is provided having a handle, an interconnect member and a cartridge having at least one blade for shaving. The handle has a distal gripping portion and a proximal end portion defining an open area there through. The proximal end portion of the handle has an undercut section. The interconnect member is mounted to the cartridge and includes a latch with a free end that is releasably engaged to the undercut section of the handle. The button has a distal end portion supported by the proximal end portion of the handle and a proximal end portion supported by the free end of the latch such that actuating the button deflects the free end of the latch and disengages the free end from the undercut section of the handle. | 04-21-2011 |
20110197450 | SHAVING RAZOR ADAPTER ATTACHING A SHAVING RAZOR CARTRIDGE TO A SHAVING RAZOR HANDLE - A shaving razor adapter used to attach a disposable shaving razor cartridge of a first shaving razor configuration to a shaving razor handle of a second shaving razor configuration. The shaving razor adapter comprises a first attachment portion which resembles the connecting end of the shaving razor handle of the first shaving razor configuration. The first attachment portion attaches the adapter to the shaving razor cartridge of the first shaving razor configuration. The second attachment portion of the adapter resembles the connecting member of a shaving razor cartridge of a second shaving razor configuration that interfaces with the connecting end of the handle of the second shaving razor configuration. The second attachment portion of the adapter releasably attaches the adapter to the connecting end of the shaving razor handle of the second shaving razor configuration. | 08-18-2011 |
20110247217 | SHAVING CARTRIDGE HAVING A FRONT PIVOTING HOOD WITH A BIASING MEMBER - Shaving cartridges intended for connection to handles to form shaving razors wherein the cartridges comprise pivoting hood comprising a biasing member. | 10-13-2011 |
20120233868 | SHAVING RAZORS AND CARTRIDGES - A shaving razor with a housing dimensioned to receive at least one blade. The housing has a pair of spaced apart opposing parallel walls each defining a fully enclosed opening that extends completely through the respective walls. | 09-20-2012 |
20130220087 | METHOD FOR MAKING A HANDLE FOR A PERSONAL GROOMING DEVICE - A method of manufacturing a handle for a personal grooming device includes forming a substrate portion of a first material. The substrate portion has first and second walls forming a channel extending along a long axis of the substrate portion. An insert member is formed separate from the substrate portion and disposed within the channel. A grip portion of a second material is formed on the substrate portion. The second material substantially encases the insert member. | 08-29-2013 |
Alexander Yao-Hsien Lee, Cambridge, MA US
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20120135025 | CHLAMYDIA ANTIGENS AND USES THEREOF - The present invention provides novel chlamydia antigens, nucleic acids encoding the antigens, and immunogenic compositions including the antigens. The present invention further provides methods of using the antigens to elicit immune responses (e.g., T cell-mediated and/or B cell-mediated immune responses). The present invention provides methods of prophylaxis and/or treatment of chlamydia-mediated diseases comprising administering an immunogenic composition including one or more of the novel antigens described herein. | 05-31-2012 |
Alvin W. Lee, Cambridge, MA US
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20090163177 | Guest Communication and Information Delivery User Interface - Described are computer-based methods and apparatuses, including computer program products, for providing a user interface for guest communication and information delivery. The user interface is provided on a computing device located in, for example, a guest's hotel room. The computing device is part of a system that can include internal and external networks, webportals, e-mail modules, document modules, and information storage modules. The guest uses the user interface to perform tasks that might otherwise require multiple resources. Guests may make telephone calls, send electronic messages, receive electronic messages, have electronic messages received by the hotel forwarded to other e-mail addresses, browse the Internet, and/or retrieve information on hotel services using the same computing device. | 06-25-2009 |
Ann Lee, Cambridge, MA US
Patent application number | Description | Published |
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20150286723 | IDENTIFYING DOMINANT ENTITY CATEGORIES - Systems, methods, and computer-readable storage media are provided for identifying dominant entity categories associated with target entities. A target entity is received and plural data sources are utilized to determine entity categories of which the target entity is a member and an initial confidence score for each of the entity categories. Each initial confidence score represents the likelihood that the associated entity category is a dominant category for the target entity. At least one data source includes information pertaining to plural entities arranged in a graph-based ontology that includes identifiers of respective entity categories of which the subject entities are members. Graph-based confidence score propagation is then utilized to incorporate information regarding entities determined to be related to the target entity and accolades associated with the target entity to alter the initial confidence scores provided for various entity categories of which the target entity is a member. | 10-08-2015 |
Benjamin G. Lee, Cambridge, MA US
Patent application number | Description | Published |
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20110058176 | SPECTROMETERS UTILIZING MID INFRARED ULTRA BROADBAND HIGH BRIGHTNESS LIGHT SOURCES - A mid infrared spectrometer comprises a high brightness broadband source that generates an output with a broad spectral range in the order of hundreds of wave numbers, a wavelength dispersive element and a detector. In one embodiment, the source comprises an array of semiconductor laser devices operating simultaneously. Each device emits light at wavelength different from the wavelengths emitted by the other devices in the array and the devices are arranged so that the combined output continuously covers the broad spectral range. In another embodiment, each of the lasers in the array is a quantum cascade laser device. In still another embodiment, the quantum cascade laser devices in the array are operated in the regime of Risken-Nummedal-Graham-Haken (RNGH) instabilities. In yet another embodiment, each of the lasers in the array is a mode-locked quantum cascade laser device. | 03-10-2011 |
Byeong-Chel Lee, Cambridge, MA US
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20120201792 | METHODS AND PRODUCTS FOR MANIPULATING HEMATOPOIETIC STEM CELLS - The invention relates to methods for manipulating hematopoietic stem cells and related products. In one aspect the invention relates to the use of stem cell G-protein coupled receptor (SC-GPR) related compositions to identify bone marrow derived hematopoietic stem cells, to enhance mobilization of hematopoietic stem cells, to improve the efficiency of targeting cells to the bone marrow and/or to modulate hematopoietic cell function. | 08-09-2012 |
Byung-Hoon Lee, Cambridge, MA US
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20130045992 | Compositions and Methods for Enhancing Proteasome Activity - Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp 14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies. | 02-21-2013 |
20130210845 | Tricyclic Proteasome Activity Enhancing Compounds - Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Usp14, enhancement of proteasome activity and treatment of proteinopathies. | 08-15-2013 |
20140199706 | Methods and Compositions for Enhancing Proteasome Activity - This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Usp14 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Usp14 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Usp14, and/or both Ubp6 and Usp14. | 07-17-2014 |
Cameron Chuck-Munn Lee, Cambridge, MA US
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20140303232 | LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS - This invention provides for a compound of formula (I): | 10-09-2014 |
Carys Eleri Lee, Cambridge GB
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20130056547 | PARTICULATE SPRAYER - A particulate sprayer includes a gas reservoir to hold a gas, a liquid reservoir to hold a product, and a low pressure section including an exit opening connected to the liquid reservoir. The product includes a liquid and solid particles. The low pressure section transports gas released from the gas reservoir over the exit opening. The product is drawn, pushed, or drawn and pushed from the exit opening into the transported gas to create a spray of the product to be sprayed from the particulate sprayer. | 03-07-2013 |
20150129674 | PARTICULATE SPRAYER - A particulate sprayer includes a gas reservoir to hold a gas, a liquid reservoir to hold a product, and a low pressure section including an exit opening connected to the liquid reservoir. The product includes a liquid and solid particles. The low pressure section transports gas released from the gas reservoir over the exit opening. The product is drawn, pushed, or drawn and pushed from the exit opening into the transported gas to create a spray of the product to be sprayed from the particulate sprayer. | 05-14-2015 |
Cerdin Lee, Cambridge GB
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20090057831 | SEMICONDUCTOR DEVICE AND METHOD OF FORMING A SEMICONDUCTOR DEVICE - A high voltage/power semiconductor device has a semiconductor layer having a high voltage terminal end and a low voltage terminal end. A drift region extends between the high and low voltage terminal ends. A dielectric layer is provided above the drift region. An electrical conductor extends across at least a part of the dielectric layer above the drift region, the electrical conductor being connected or connectable to the high voltage terminal end. The drift region has plural trenches positioned below the electrical conductor. The trenches extend laterally across at least a part of the drift region in the direction transverse the direction between the high and low voltage terminal ends of the semiconductor layer, each trench containing a dielectric material. The trenches improve the distribution of electric field in the device in the presence of the electrical conductor. | 03-05-2009 |
Chang Hyun Lee, Cambridge, MA US
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20090321811 | MEMORY CELL TRANSISTORS HAVING BANDGAP-ENGINEERED TUNNELING INSULATOR LAYERS, NON-VOLATILE MEMORY DEVICES INCLUDING SUCH TRANSISTORS, AND METHODS OF FORMATION THEREOF - A memory cell transistor comprises: an active region, the active region being elongated in a first direction of extension; a tunnel layer on the active region, the tunnel layer comprising a first tunnel insulating layer, a second tunnel insulating layer on the first tunnel insulating layer and a third tunnel insulating layer on the second tunnel insulating layer; a charge storage layer on the tunnel layer; a blocking insulating layer on the charge storage layer; and a control gate electrode on the blocking insulating layer, the control gate electrode being elongated in a second direction of extension that is transverse the first direction of extension, the active region having a first width in the second direction of extension, the second tunnel insulating layer having a second width in the second direction of extension, the second width being different than the first width. | 12-31-2009 |
20100054036 | Methods of precharging non-volatile memory devices during a programming operation and memory devices programmed thereby - Embodiments are directed to a method of programming a semiconductor memory device, the memory device including: a plurality of memory cell transistors arranged in a plurality of transistor strings; a plurality of word lines, each word line connected to a corresponding memory cell transistor of each of the transistor strings; and a plurality of bit lines, each bit line connected to at least one of the transistor strings, the method comprising: applying a first voltage, and then applying a programming voltage to a selected word line corresponding to the selected memory cell transistor; and in advance of applying the first voltage to the selected word line, applying a second voltage to at least one neighboring word line that neighbors the selected word line, the neighboring word line connected to a neighboring, unselected memory cell transistor of the selected transistor string, to ensure precharging of a channel region of another, unselected transistor string between a first, unselected transistor of the unselected transistor string connected to the neighboring word line and a second, unselected transistor of the unselected transistor string connected to the selected word line, the first, unselected transistor neighboring the second, unselected transistor in the unselected transistor string. | 03-04-2010 |
Chia Min Lee, Cambridge, MA US
Patent application number | Description | Published |
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20130280204 | Polymer-Attached Inhibitors of Influenza Virus - Antiviral compositions containing one or more antiviral agents coupled to a polymer and methods of making and using the compositions, are described herein. The one or more antiviral agents are covalently coupled to the polymer, and thereby prevent or decrease development of drug resistance. In some embodiments, the polymer is a biodegradable polymer. In particular embodiments, the polymer is a water-soluble, biodegradable polymer, which has an overall neutral charge (e.g., no charged groups or overall neutral charge). In a more particular embodiment, the neutral polymer is polyglutamine or a polymer having properties similar to polyglutamine, polyaspartate, and other homopolypeptides that can be modified to have no charge or no net charge. The compositions described herein are effective at treating a variety of viral infections, such as influenza, respiratory syncythial virus, rhinovirus, human metaneumovirus, and other respiratory diseases, while inhibiting or preventing the development of resistance. | 10-24-2013 |
Chia-Ying Lee, Cambridge, MA US
Patent application number | Description | Published |
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20150015210 | VOLTAGE-ENHANCED ENERGY STORAGE DEVICES - The present disclosure provides an energy storage device comprising at least one electrochemical cell comprising a negative current collector, a negative electrode in electrical communication with the negative current collector, an electrolyte in electrical communication with the negative electrode, a positive electrode in electrical communication with the electrolyte and a positive current collector in electrical communication with the positive electrode. The negative electrode comprises an alkali metal. Upon discharge, the electrolyte provides charged species of the alkali metal. The positive electrode can include a Group IIIA, IVA, VA and VIA of the periodic table of the elements, or a transition metal (e.g., Group 12 element). | 01-15-2015 |
20150132627 | VOLTAGE-ENHANCED ENERGY STORAGE DEVICES - The present disclosure provides an energy storage device comprising at least one electrochemical cell comprising a negative current collector, a negative electrode in electrical communication with the negative current collector, an electrolyte in electrical communication with the negative electrode, a positive electrode in electrical communication with the electrolyte and a positive current collector in electrical communication with the positive electrode. The negative electrode comprises an alkali metal. Upon discharge, the electrolyte provides charged species of the alkali metal. The positive electrode can include a Group IIIA, IVA, VA and VIA of the periodic table of the elements, or a transition metal (e.g., Group 12 element). | 05-14-2015 |
Chong Ming Gordon Lee, Cambridge GB
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20130021491 | Camera Device Systems and Methods - Disclosed are various systems and methods implemented in a camera device. An image sensor is configured to capture image data of a target scene from a lens system and a subject feedback mechanism generates framing feedback associated with the image data that includes information about a current framing of an image associated with the image data. Video capture logic also obtains motion information from motion sensors integrated into the camera device and skip frame capture when motion levels exceed a threshold. | 01-24-2013 |
Daeyeon Lee, Cambridge, MA US
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20080268229 | SUPERHYDROPHILIC COATINGS - A superhydrophilic coating on a substrate can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can include oppositely charge inorganic nanoparticles, and can be substantially free of an organic polymer. | 10-30-2008 |
Daniel J. Lee, Cambridge, MA US
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20100292758 | OPTICAL STIMULATION OF THE BRAINSTEM AND/OR MIDBRAIN, INCLUDING AUDITORY AREAS - Apparatus and method for optical- or optical-and-electrical stimulation of midbrain and/or brainstem tissue (e.g., auditory nerve pathways). Peripheral neural stimulation using infrared lasers has been demonstrated in several systems; however, optical stimulation of the central nervous system (CNS) has not been previously described. In some embodiments of the present invention, radiant energy exposure of the cochlear nucleus using a mid-wavelength infrared laser generates optically-evoked auditory brainstem responses (oABRs). In an experiment, the cochlear nuclei of adult male Sprague-Dawley rats were exposed using a suboccipital craniotomy approach. In one embodiment, different regions of left cochlear nucleus were acutely stimulated with a 200- or 400-micron-diameter optical fiber placed on the surface of the brainstem, using 50- to 750-microsecond pulses of 1849-nm to 1865-nm-wavelength radiation at a rate of 10 to 40 Hz and power levels ranging from 10% to 80% of 5 watts. oABRs were recorded during the period of optical stimulation. | 11-18-2010 |
David Yue-Wei Lee, Cambridge, MA US
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20100247564 | METHODS AND COMPOSITIONS FOR THE USE OF SARGASSUM FUSIFORME FOR THE INHIBITION OF HIV-1 INFECTION - The methods, kits, articles, and compositions of the invention feature a natural product (e.g., | 09-30-2010 |
David Y-W Lee, Cambridge, MA US
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20090099099 | Isoflavone Glycosides as Peroxisome Proliferator-Activated Receptor-alpha Modulator - A method of treating or preventing diseases related to modulation of PPAR-α in comprising administering to a human or other mammals in need of such treatment an effective amount of plant material derived from plants of the genera | 04-16-2009 |
20110085975 | HYPOXIA-SELECTIVE, WEAKLY BASIC 2-NITROIMIDAZOLE DELIVERY AGENTS AND METHODS OF USE THEREOF - The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall. | 04-14-2011 |
Dongjun Lee, Cambridge, MA US
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20140363449 | METHODS, ASSAYS, AND SYSTEMS RELATING TO SAKT - The technology described herein is directed to methods, assays, and systems relating to determining the level of SAKT signaling activity in a sample obtained from a subject as well as methods relating to administering inhibitors and/or agonists of SAKT signaling. | 12-11-2014 |
E-Chiang Lee, Cambridge GB
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20120167237 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 06-28-2012 |
20120204278 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 08-09-2012 |
20130042331 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 02-14-2013 |
20130243759 | Transgenic Animals - The present invention relates inter alia to fertile non-human vertebrates such as mice and rats useful for producing antibodies bearing human variable regions, in which endogenous antibody chain expression has been inactivated. | 09-19-2013 |
20130263292 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 10-03-2013 |
20130263293 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 10-03-2013 |
20130318643 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 11-28-2013 |
20130347138 | Cells and Vertebrates for Enhanced Somatic Hypermutation and Class Switch Recombination - The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies, eg, comprising human variable region sequences. The invention provides for enhanced AID and/or AID homologue spectra, thereby providing for the increased diversity as a result of somatic hypermutation and/or class-switch recombination during in vivo antibody generation. The invention also provides methods of generating antibodies using such vertebrates, as well as the antibodies per se, therapeutic compositions thereof and uses. | 12-26-2013 |
20140041067 | ANTIBODIES, VARIABLE DOMAINS & CHAINS TAILORED FOR HUMAN USE - The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, nucleotide sequences, pharmaceutical compositions and uses are also provided by the invention. | 02-06-2014 |
20140120582 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 05-01-2014 |
20140134156 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 05-15-2014 |
20140150125 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 05-29-2014 |
20140150126 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 05-29-2014 |
20140182003 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 06-26-2014 |
20140201854 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 07-17-2014 |
20140201856 | ANIMAL MODELS AND THERAPEUTIC MOLECULES - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 07-17-2014 |
20140212416 | Manipulation of Immunoglobulin Gene Diversity and Multi-Antibody Therapeutics - The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies comprising human variable region sequences. The present invention is directed to the provision of long HCDR3s from non-human vertebrates and cells. The present invention is also directed to the provision of novel V, D and J pairings in immunoglobulin heavy and light chain loci. Novel, biased antibody diversities and potentially expanded diversities are provided. The invention also provides for novel and potentially expanded diversity or diversity that is biased towards variable gene usage common to antibodies useful for treating and/or preventing certain diseases or conditions, such as infectious diseases. The invention also provides methods of generating antibodies using such vertebrates, as well as the antibodies per se, therapeutic compositions thereof and uses. | 07-31-2014 |
20140283150 | Animal Models and Therapeutic Molecules - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 09-18-2014 |
20140323327 | ANIMALS, REPERTOIRES & METHODS - The present invention is directed to the concept of sectoring antibody gene segment repertoires in order to enable the development of novel, synthetic antibody chain repertoires not seen in nature. The present invention is also directed to the realisation of the inventors that sectoring can also alter gene segment expression by providing new arrangements of gene segment clusters relative to other gene segments and regulatory elements in transgenic immunoglobulin loci, thereby providing for new synthetic antibody chain sequence repertoires. The invention also relates to gene segment inversion. | 10-30-2014 |
20140325690 | Transgenic Non-Human Assay Vertebrates, Assays and Kits - The invention provides Assay Vertebrates comprising a human antigen or epitope knock-in for testing antibodies comprising human variable regions and generated in a related Antibody-Generating Vertebrate. The invention also provides kits and methods involving these vertebrates and antibodies. The invention provides for superior assay models and assay methods of chimaeric and other test antibodies comprising human variable regions. | 10-30-2014 |
20140331339 | Transgenic Non-Human Assay Vertebrates, Assays and Kits - The invention provides Assay Vertebrates comprising a human antigen or epitope knock-in for testing antibodies comprising human variable regions and generated in a related Antibody-Generating Vertebrate. The invention also provides kits and methods involving these vertebrates and antibodies. The invention provides for superior assay models and assay methods of chimaeric and other test antibodies comprising human variable regions. | 11-06-2014 |
20140331343 | ANTIBODIES, VARIABLE DOMAINS & CHAINS TAILORED FOR HUMAN USE - The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, nucleotide sequences, pharmaceutical compositions and uses are also provided by the invention. | 11-06-2014 |
20140331344 | Transgenic Animals - The present invention relates inter alia to fertile non-human vertebrates such as mice and rats useful for producing antibodies bearing human variable regions, in which endogenous immunoglobulin chain expression has been inactivated. | 11-06-2014 |
20140359797 | Chimaeric Surrogate Light Chains (SLC) Comprising Human VpreB - The present invention relates inter alia to improvements in the production of chimaeric antibodies in non-human transgenic vertebrates such as mice and rats bearing one or more chimaeric antibody transgenes. In particular, the invention provides for improved non-human vertebrates and cells in which VpreB has been species-matched with the variable region of the chimaeric antibodies. Also, embodiments also provide for species-matching of the entire surrogate light chain for efficient pairing with chimaeric heavy chains during B-cell development in vivo in a non-human transgenic vertebrate setting. | 12-04-2014 |
20150033369 | ANIMALS, REPERTOIRES & METHODS - The present invention is directed to the concept of sectoring antibody gene segment repertoires in order to enable the development of novel, synthetic antibody chain repertoires not seen in nature. The present invention is also directed to the realisation of the inventors that sectoring can also alter gene segment expression by providing new arrangements of gene segment clusters relative to other gene segments and regulatory elements in transgenic immunoglobulin loci, thereby providing for new synthetic antibody chain sequence repertoires. The invention also relates to gene segment inversion. | 01-29-2015 |
20150033372 | Human VpreB & Chimaeric Surrogate Light Chains in Transgenic Non-Human Vertebrates - The present invention relates inter alia to improvements in the production of chimaeric antibodies in non-human transgenic vertebrates such as mice and rats bearing one or more chimaeric antibody transgenes. In particular, the invention provides for improved non-human vertebrates and cells in which VpreB has been species-matched with the variable region of the chimaeric antibodies. Also, embodiments also provide for species-matching of the entire surrogate light chain for efficient pairing with chimaeric heavy chains during B-cell development in vivo in a non-human transgenic vertebrate setting. | 01-29-2015 |
20150037337 | Manipulation of Immunoglobulin Gene Diversity and Multi-Antibody Therapeutics - The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies comprising human variable region sequences. The present invention is directed to the provision of long HCDR3s from non-human vertebrates and cells. The present invention is also directed to the provision of novel V, D and J pairings in immunoglobulin heavy and light chain loci. Novel, biased antibody diversities and potentially expanded diversities are provided. The invention also provides for novel and potentially expanded diversity or diversity that is biased towards variable gene usage common to antibodies useful for treating and/or preventing certain diseases or conditions, such as infectious diseases. The invention also provides methods of generating antibodies using such vertebrates, as well as the antibodies per se, therapeutic compositions thereof and uses. | 02-05-2015 |
20150040250 | Animal Models and Therapeutic Molecules - The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 02-05-2015 |
20150079680 | METHODS, CELLS & ORGANISMS - The invention relates to an approach for introducing one or more desired insertions and/or deletions of known sizes into one or more predefined locations in a nucleic acid (eg, in a cell or organism genome). They developed techniques to do this either in a sequential fashion or by inserting a discrete DNA fragment of defined size into the genome precisely in a predefined location or carrying out a discrete deletion of a defined size at a precise location. The technique is based on the observation that DNA single-stranded breaks are preferentially repaired through the HDR pathway, and this reduces the chances of indels (eg, produced by NHEJ) in the present invention and thus is more efficient than prior art techniques. The invention also provides sequential insertion and/or deletions using single- or double-stranded DNA cutting. | 03-19-2015 |
20150113669 | Animal Models and Therapeutic Molecules - The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods. | 04-23-2015 |
20150133641 | TRANSGENIC NON-HUMAN VERTEBRATE FOR THE IN VIVO PRODUCTION OF DUAL SPECIFICITY IMMUNOGLOBULINS OR HYPERMUTATED HEAVY CHAIN ONLY IMMUNOGLOBULINS - The invention relates, in one aspect, generally to novel concept of guided selection of antibody variable domains, combination and expression entirely in vivo. An application is to produce multivalent polypeptides. The present invention relates to multivalent (eg, multispecific) antibodies, antibody chains and polypeptides, as well as heavy chain-only antibodies (H2 antibodies) that are devoid of light chains. The invention further relates to the selection, maturation and production of these in vivo in non-human vertebrates and non-human vertebrate cells. To this end the invention also relates to such non-human vertebrates and cells. The invention also relates to the provision of means to produce and select heavy chain-only antibodies and heavy chains comprising variable domains that have undergone affinity maturation. | 05-14-2015 |
Gary Lee, Cambridge CA
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20090149983 | Quality Control System And Method Thereof - A quality control system and method for monitoring an assembly operation is provided. The method can include: (1) providing an assembly line having a plurality of machines being assembled thereon; (2) providing a tool for performing an assembly operation; (3) performing a plurality of the assembly operations with the tool; (4) measuring a measurable parameter indicative of the performance of the tool for at least a subset of the plurality of assembly operations; (5) storing the measured values in an electronic format with a data collection device; (6) analyzing the measured values; and (7) providing a signal based on the analysis with the signal indicative of at least satisfactory or unsatisfactory performance of the tool. In some instances, the data collection device can provide for storing additional information and/or data with any particular stored measured value. | 06-11-2009 |
20130110453 | STEERING WHEEL AIRBAG POSITION DETECTOR | 05-02-2013 |
20140232828 | WORK MONITORING SYSTEM - A system and methods for monitoring work processes. Once example computer-implemented method includes recording a three-dimensional work trajectory. The work trajectory comprises a representation of the actual motion of one or more markers. The method further includes comparing the work trajectory to a work template. The work template comprises a representation of the desired motion of the one or more markers. The method further includes sending a success indication to a display when the work trajectory is similar to the work template and sending a failure indication to the display when the work trajectory is dissimilar to the work template. | 08-21-2014 |
Gordon (chong Ming Gordon) Lee, Cambridge GB
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20130021483 | USING MOTION INFORMATION TO ASSIST IN IMAGE PROCESSING - Embodiments of the present application use motion information of an imaging device in encoding video or image frames captured by the imaging device. In one embodiment, a video encoding system that processes image data captured by an image sensor comprises at least one encoder that receives motion information describing motion of the imaging sensor during capturing of the image data and that encodes the image data with assistance of the motion information. | 01-24-2013 |
20130021489 | Regional Image Processing in an Image Capture Device - Disclosed are various embodiments of applying image processing techniques in an image capture device. Regions of an image can be isolated and a respective region type identified. The image capture device can apply various image processing techniques to various regions of the image based at least upon a region type that is identified for the various regions. | 01-24-2013 |
Hakho Lee, Cambridge, MA US
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20090168162 | Microscopy Methods And Apparatus For Manipulation And/Or Detection of Biological Samples And Other Objects - Microscopy methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics in connection with a microscope. In one implementation, a microscope including optics and a stage is outfitted with various components relating to the generation of electric and/or magnetic fields, which are implemented on an IC chip. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system to facilitate viewing via the microscope. | 07-02-2009 |
20100006439 | METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS - Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics. In one implementation, various components relating to the generation of electric and/or magnetic fields are implemented on an IC chip that is fabricated using standard protocols. The generated electric and/or magnetic fields are used to manipulate and/or detect one or more dielectric and/or magnetic particles and distinguish different types of particles. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system. Electric and/or magnetic field generating components also may be controlled using signals of various frequencies so as to detect one or more cells, particles or objects of interest, and even the type of particle or object of interest, by measuring resonance characteristics associated with interactions between samples and one or more of the field-generating devices. Such systems may be employed in a variety of biological and medical related applications, including cell sorting and tissue assembly. | 01-14-2010 |
20110091987 | Miniaturized Magnetic Resonance Systems and Methods - The present application describes devices, systems, and techniques related to a chip-based, miniaturized NMR diagnostic platform for rapid, quantitative and multi-channeled detection of biological targets. | 04-21-2011 |
Helen Lee, Cambridge GB
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20080206853 | SIGNAL ENHANCEMENT SYSTEM WITH MULTIPLE LABELED-MOIETIES - Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labeled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal gold labeled anti-biotin antibody is captured at a capture zone of the dipstick. Presence of colloidal gold label at the capture zone indicates the presence of analyte in the test solution. The sensitivity of analyte detection using such methods is an order of magnitude higher than for comparable methods in which biotinylated anti-analyte antibody bound to analyte is wicked up the dipstick in a first step, and a colloidal gold labeled anti-biotin antibody is wicked up the dipstick in a separate step. Kits for performing the tests of the invention are also described. | 08-28-2008 |
20120094272 | SIGNAL ENHANCEMENT SYSTEM WITH MULTIPLE LABELED-MOIETIES - Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labelled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal gold labelled anti-biotin antibody is captured at a capture zone of the dipstick. Presence of colloidal gold label at the capture zone indicates the presence of analyte in the test solution. The sensitivity of analyte detection using such methods is an order of magnitude higher than for comparable methods in which biotinylated anti-analyte antibody bound to analyte is wicked up the dipstick in a first step, and a colloidal gold labelled anti-biotin antibody is wicked up the dipstick in a separate step. Kits for performing the tests of the invention are also described. | 04-19-2012 |
20140106347 | BINDING INTERACTIONS IN DIPSTICK ASSAYS - Use of dipsticks to test for the presence of target nucleic acid in a sample solution is described. The dipsticks comprise a contact end for contacting the sample solution and a capture zone, remote from the contact end, to which a capture probe is immobilised. The capture probe is capable of hybridising to the target nucleic acid. The sample solution is contacted with the contact end of the dipstick and travels by capillary action to the capture zone. If target nucleic acid is present in the sample solution it is captured and can be detected at the capture zone. The capture probe is immobilised to the capture zone by a spacer. Use of the spacer increases the stability of the interaction between the capture probe and the target nucleic acid and thus improves the sensitivity of target nucleic acid detection. Detection probes with spacers are also described. | 04-17-2014 |
20150099265 | DETECTION SIGNAL AND CAPTURE IN DIPSTICK ASSAYS - Improved dipstick assays for testing for the presence of a target nucleic acid in a sample solution are described. A dipstick is provided which comprises a contact end for contacting the sample solution and a capture zone remote from the contact end for capturing target nucleic acid. Sample solution is contacted with the contact end to cause sample solution to move by capillary action to the capture zone. Target nucleic acid in the sample solution is captured at the capture zone and is detected by a plurality of different labelled detection probes each capable of hybridizing to a different region of the target nucleic acid. The detection signal is thereby enhanced. In other methods a plurality of different capture probes are added to the sample solution which can then be bound by a capture moiety at the capture zone to indirectly capture target nucleic acid. Capture of target nucleic acid is thereby improved. Kits and dipsticks for carrying out such methods are also described. | 04-09-2015 |
Hyukjin Lee, Cambridge, MA US
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20140212503 | DELIVERY SYSTEM - The present invention provides three-dimensional, nanoscale delivery systems, particularly well adapted for delivery of nucleic acids and/or nucleic acid associated entities. | 07-31-2014 |
Hyung Woo Lee, Cambridge, MA US
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20100132080 | METHOD OF MAKING AND ASSEMBLING CAPSULATED NANOSTRUCTURES - An encapsulated nanostructure fabricated using layers of polymer material and further processed for use in a micro-scale target device is presented. The fabrication includes the formation on a substrate of an array of encapsulated nanostructures. The encapsulated nanostructures each include a nanostructure and a micro-scale, multi-block structure that encapsulates the nanostructure. Each encapsulated nanostructure can be made usable by a target device by removing, e.g., by etching, one of the layers to expose a portion of the nanostructure. | 05-27-2010 |
Jackie Chia-Hsun Lee, Cambridge, MA US
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20100268056 | Washable wearable biosensor - A washable, wearable biosensor that can gather sensor data, communicate the sensed data by wireless protocols, and permits the analysis of sensed data in real-time as a person goes about their normal lifestyle activities. The biosensor can be worn in multiple positions, can be put on or removed quickly without having to apply or remove gels and adhesives, and provides a snug, comfortable fit to gather data with minimal motion artifacts. The textile, wearable device can support integrated photoplethysmography, skin conductance, motion, and temperature sensors in a small wearable package. The supported sensors may be coupled to utilization devices by channel-sharing wireless protocols to enable the transmission of data from multiple users and multiple sensors (e.g. both sides of body, wrists or hands and feet, or multiple people). An on-board processor, or the receiving utilization device, can map patterns of the physiological and motion data to signals or alerts such as a likely seizure, drug craving, or other states that the wearer may exhibit or experience. The sensor data may be sent by wireless transmission and received by a mobile phone or other personal digital device, a computer, a favorite toy, or another wearable device. The sensors may include multiple photoplethysmographs and/or one or more EDAs which perform a time-domain measurement of skin conductance | 10-21-2010 |
Jae-Kyu Lee, Cambridge, MA US
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20100045454 | Wheelchair Alarm System and Method - A wheelchair alarm system and method for preventing falls for patients at risk by recognizing the gesture of a patient attempting to stand. The wheelchair alarm system uses an array of proximity sensors and pressure sensors to create a map of the patient's sitting position, and then uses gesture recognition algorithms to determine when a patient is attempting to stand up. The wheelchair alarm system responds with light and voice alarms that can encourage the patient to remain seated and/or to make use of the system's integrated nurse-call function. The wheelchair alarm system can be seamlessly integrated into existing hospital WiFi networks, sending messages to the nurse call system as well as providing the patient's location. | 02-25-2010 |
Janice Lee, Cambridge, MA US
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20150225422 | HETEROARYLS AND USES THEREOF - The present invention provides a compound of formula I: | 08-13-2015 |
Jeff Lee, Cambridge CA
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20100276256 | MULTI-MODE AND MULTI-PITCH CONVEYOR SYSTEM - A conveyor system comprising: a track section comprising a control system; a drive system that is controlled by the control system; a plurality of moving elements that are driven by the drive system; a pallet support apparatus; a plurality of pallets that are configured to engage with the moving elements and move on the pallet support apparatus; and a plurality of workstations provided along the track section, each workstation at a predetermined pitch from each other workstation, wherein at least some of the pitches are different among workstations, wherein the control system, drive system and moving elements are configured such that each pallet of the plurality of pallets is independently advanced through the workstations based on the pitches of the workstations. | 11-04-2010 |
20130180824 | MULTI-MODE AND MULTI-PITCH CONVEYOR SYSTEM - A conveyor system comprising: a track section comprising a control system; a drive system that is controlled by the control system; a plurality of moving elements that are driven by the drive system; a pallet support apparatus; a plurality of pallets that are configured to engage with the moving elements and move on the pallet support apparatus; and a plurality of workstations provided along the track section, each workstation at a predetermined pitch from each other workstation, wherein at least some of the pitches are different among workstations, wherein the control system, drive system and moving elements are configured such that each pallet of the plurality of pallets is independently advanced through the workstations based on the pitches of the workstations. | 07-18-2013 |
Jennifer Lee, Cambridge GB
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20130022605 | ANTAGONISTS AGAINST TNFR1 AND METHODS OF USE THEREFOR - The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands. | 01-24-2013 |
Jennifer A. Lee, Cambridge GB
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20110044979 | DOMAIN ANTIBODY CONSTRUCT - The present invention provides a domain antibody construct which binds to human TNF-α, with the construct comprising: | 02-24-2011 |
Jinha Lee, Cambridge, MA US
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20120206419 | Collapsible input device - In exemplary implementations of this invention, a handheld, collapsible input device (CID) may be employed by a user to input and manipulate 3D information. The CID telescopes in length. As a user presses the CID against a display screen, the physical length of the CID shortens, and the display screen displays a virtual end of the CID that appears to project through the screen into the virtual 3D space behind the screen. The total apparent length of the CID, comprised of a physical portion and a virtual portion, remains the same (after taking into account foreshortening). Thus, the user experience is that, as the user holds the physical CID and pushes it against the display screen, the end of the CID appears to be pushed through the display screen into the virtual 3D space beyond it. The CID housing may include a push button for user input. | 08-16-2012 |
20130241831 | Collapsible input device - In exemplary implementations of this invention, a handheld, collapsible input device (CID) may be employed by a user to input and manipulate 3D information. The CID telescopes in length. As a user presses the CID against a display screen, the physical length of the CID shortens, and the display screen displays a virtual end of the CID that appears to project through the screen into the virtual 3D space behind the screen. The total apparent length of the CID, comprised of a physical portion and a virtual portion, remains the same (after taking into account foreshortening). Thus, the user experience is that, as the user holds the physical CID and pushes it against the display screen, the end of the CID appears to be pushed through the display screen into the virtual 3D space beyond it. The CID housing may include a push button for user input. | 09-19-2013 |
Jinhyuk Lee, Cambridge, MA US
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20140099549 | High-capacity positive electrode active material - This disclosure provides a positive electrode active lithium-excess metal oxide with composition Li | 04-10-2014 |
20140141329 | MOLYBDENUM OXIDES AND USES THEREOF - The present disclosure describes, among other things, new layered molybdenum oxides for lithium ion battery cathodes from solid solutions of Li | 05-22-2014 |
Jiye Lee, Cambridge, MA US
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20140041504 | Mechanical Method For Producing Micro- Or Nano-Scale Textures - A mechanical method for producing micro-scale and nano-scale textures that facilitates, for example, the cost-effective production of nanostructures on large-scale substrates, e.g., during the large-scale production of thin-film solar cells. A “scratcher” (multi-pointed abrasion mechanism) is maintained in a precise position relative to a target substrate such that micron-level features (protrusions) extending from the scratcher's base structure are precisely positioned to contact a surface material layer of the target substrate with a predetermined amount of force, and then moved relative to the substrate (e.g., by way of a conveying mechanism) while maintaining the pressing force such that the micron-level features define elongated parallel nano-scale grooves and/or form nano-scale ridges in the surface material layer (i.e., by mechanically displacing) portions of the surface material layer to form the nano-scale grooves/ridges). | 02-13-2014 |
Jong Bum Lee, Cambridge, MA US
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20140328931 | NUCLEIC ACID PARTICLES, METHODS AND USE THEREOF - The present invention provides, among other things, a particle which includes a core comprised of self-assembled one or more nucleic acid molecules, the core being characterized by an ability to adopt at least two configurations: a first configuration having a first greatest dimension greater than 2 μm and; a second configuration having a second greatest dimension less than 500 nm, wherein addition of a film coating converts the core from its first configuration to its second configuration. Methods of making and using of provided particles are also disclosed. | 11-06-2014 |
Jongho Lee, Cambridge, MA US
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20100176057 | Liquid Filtration Using Pressure Difference Across a Hydrophobic Membrane - Method and devices for filtering liquid are provided that rely on pressure difference to filter liquid. In one embodiment, a device for filtering liquid includes a feed chamber, a permeate chamber, and a porous membrane that is at least partially hydrophobic and has one or more pores configured to be permeable to vapor. A pressure of a liquid substance in the feed chamber is increased such that vapor of the liquid substance is transported from the feed chamber to the permeate chamber. The resistance of flow in a hydrophilic layer of the membrane can be controlled to make the membrane defect-tolerant. In another embodiment, a second porous membrane is further included and the second porous membrane is spaced apart from the first porous membrane. Various methods for filtering liquid are also provided. | 07-15-2010 |
Jun Ki Lee, Cambridge, MA US
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20090055019 | Interactive systems employing robotic companions - An interactive system for interacting with a sentient being. The system includes a robotic companion of which the sentient being may be a user and an entity which employs the robot as a participant in an activity involving the user. The robotic companion responds to inputs from an environment that includes the user during the activity. The robotic companion is capable of social and affective behavior either under control of the entity or in response to the environment. The entity may provide an interface by which an operator may control the robotic companion. Example applications for the interactive system include as a system for communicating with patients that have difficulties communicating verbally, a system for teaching remotely-located students or students with communication difficulties, a system for facilitating social interaction between a remotely-located relative and a child, and systems in which the user and the robot interact with an entity such as a smart book. Also disclosed are control interfaces for the robotic companion, techniques for rendering the robotic companion sensitive to touch and responding to those touches, and techniques for providing quiet, back-drivable motion to components of the robotic companion. | 02-26-2009 |
20130158707 | METHODS OF ROBOT BEHAVIOR GENERATION AND ROBOTS UTILIZING THE SAME - A method of generating a behavior of a robot includes measuring input data associated with a plurality of user responses, applying an algorithm to the input data of the plurality of user responses to generate a plurality of user character classes, storing the plurality of user character classes in a database, classifying an individual user into a selected one of the plurality of user character classes by generating user preference data, selecting a robot behavior based on the selected user character class, and controlling the actions of the robot in accordance with the selected robot behavior during a user-robot interaction session. The selected user character class and the user preference data are based at least in part on input data associated with the individual user. | 06-20-2013 |
Kenneth Lee, Cambridge, MA US
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20130170337 | Verifying Communication Redundancy in a Network - Apparatuses, methods, and computer-readable media support diagnosing a communications network using a network protocol that ensures a loop-free topology to prevent bridge loops. One of the network devices is identified as a selected device in a network ring, where the selected device interacts with the network ring through first and second ports. The values of some of the parameters of the selected device are modified to be distinguishable from that of any network device in the ring, and diagnostics about the functioning of the network protocol are then performed to obtain state information about the first and second ports. When one of the ports is determined to be in the blocking state, network redundancy for the network ring is verified. However, when neither of the ports is not in the blocking state, a redundancy problem may be detected. | 07-04-2013 |
20130188642 | System and Method for Deterministic I/O with Ethernet Based Industrial Networks - A networking system is discussed. The system may be used for industrial networks, where deterministic behavior is often valued. Bounded message travel times may be achieved for a first set of network traffic. Additional traffic may be routed over the networking system without interfering with the message travel times associated with the first set of network traffic. Systems and methods for assigning priority to various sets of network traffic are discussed. | 07-25-2013 |
20130265160 | Diagnostics of Hot-Standby/Redundant Owner System in an Ethernet/IP Adapter Device - Method, apparatuses, and software are described, in which an adapter in an EtherNet/IP network may determine whether a first redundant owner connection between the adapter and a first scanner is open. If it is determined that the first redundant owner connection is not open, then a network status light or other indicator of the adapter may be caused to emit a solid green color or otherwise indicate a first status if a second redundant owner connection between the adapter and a second scanner is open, and to emit a flashing red color or a flashing green color (or otherwise indicate a second or third status) if no redundant owner connection to the adapter is open. | 10-10-2013 |
20130265888 | CONNECTION TIMEOUT MANAGEMENT IN A COMMUNICATION NETWORK WITH NETWORK REDUNDANCY - A method of configuring a communication network including a network device includes obtaining a first parameter associated with a predetermined topological characteristic of the communication network, a second parameter associated with a communication protocol of the communication network and a third parameter associated with a performance characteristic of the communication network, and calculating a connection timeout value based on the first parameter, the second parameter and the third parameter. The network device is configured to determine whether a communication timeout has occurred on the communication network based on the connection timeout value. Calculating the connection timeout value may include calculating a sum of the first parameter, the second parameter and the third parameter. | 10-10-2013 |
20150032870 | UPDATING PARAMETERS IN A NETWORK - A system, method, and software product are provided for updating parameters, such as requested packet intervals (RPIs), in a network. The system may include one or more PLCs, communication controllers, and I/O devices coupled in a communication network, such as EtherNet/IP. A request to change a parameter (e.g., scanning rate or timeout value) is transmitted from the PLC to an I/O device specifying a new parameter value or time-out value. The I/O device may receive the message, use a temporary time-out value while processing the message, and transmit an acknowledgement confirming the new value to the PLC. The I/O device may use the updated parameter and new time-out value. The updated parameter may be implemented without the need to take down and re-establish network connections to the affected devices. | 01-29-2015 |
Kenneth S. Lee, Cambridge, MA US
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20090168806 | Tuning of industrial automation system performance based on device operating characteristics - Each device in an industrial automation system network or other network may have its own associated one or more performance characteristics, such as response time and/or reset time of the network device. Data may be stored representing a plurality of performance characteristics each associated with a different one of a plurality of devices in the network including a first device and a second device. The stored data may be retrieved, representing the performance characteristic of the second device. The first device may communicate over the network with the second device in accordance with the performance characteristic of the second device. | 07-02-2009 |
20090172193 | Cable Redundancy with a Networked System - Aspects of the invention provide apparatuses, systems, and methods for supporting cable redundancy in a network connecting a network controller ( | 07-02-2009 |
20090172223 | Method and Apparatus for Distributing Configuration Files in a Distributed Control System - The invention described herein provides a system and method for distributing and applying a configuration file from a master device ( | 07-02-2009 |
20090265020 | Remote Virtual Placeholder Configuration for Distributed Input/Output Modules - A modular distributed I/O system for an industrial automation network that allows one or more modules of an island to be omitted without requiring reconfiguration of the system by maintaining a consistent I/O image representation of the distributed I/O network for various physical distributed I/O configurations and managing reconfiguration changes remotely using Virtual Placeholder objects. | 10-22-2009 |
20120290759 | Virtual Placeholder Configuration for Distributed Input/Output Modules - A modular distributed I/O system for an industrial automation network that allows one or more modules of an island to be omitted without requiring reconfiguration of the system by maintaining a consistent I/O image representation of the distributed I/O network for various physical distributed I/O configurations, and managing reconfiguration changes using Virtual Placeholder objects. | 11-15-2012 |
Kwan H. Lee, Cambridge, MA US
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20090327308 | SYSTEMS AND METHODS FOR PROVIDING A CONSUMPTION NETWORK - Systems and methods for providing a consumption network are provided. A method according to the invention may include receiving purchase information on a mobile device and recording the purchasing information. The information may be transmitted to a central database. At the central database, the information may be recorded and transmitted from the central database to a pre-determined group of users. Alternatively, the information may be transmitted to a group of users directly from the mobile phone associated with the purchasing. | 12-31-2009 |
Kwan Hong Lee, Cambridge, MA US
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20140279130 | SYSTEM AND METHOD FOR AN AFFINITY CAPTURE, USER FEEDBACK AND AFFINITY ANALYSIS - Various affinity systems and methods are provided to enable the capture of unique end-to-end purchase information. In some embodiments, the data collected through affinity systems and methods can be used to develop insights into the purchase making decision processes of users at any point of a shopping experience. The systems can host interaction platforms to facilitate the exchange of information, opinion, and/or suggestions on products, recommendations, and/or opinions. Further embodiments provide analysis of the captured data to derive insights regarding the appeal of products/services and the qualitative opinions of the users about the products/services. | 09-18-2014 |
20140279232 | SYSTEM AND METHOD FOR AN AFFINITY CAPTURE, USER FEEDBACK AND AFFINITY ANALYSIS - Various affinity systems and methods are provided to enable the capture of unique end-to-end purchase intent information. In some embodiments, the data collected through affinity systems and methods can be used to develop insights into the purchase making decision processes of users at any point of a shopping experience. The systems can host interaction platforms to facilitate the exchange of information, opinion, and/or suggestions on products, recommendations, and/or opinions. Further embodiments provide analysis of the captured data to derive insights regarding the appeal of products/services and the qualitative opinions of the users about the products/services. | 09-18-2014 |
20140279233 | SYSTEM AND METHOD FOR AN AFFINITY CAPTURE, USER FEEDBACK AND AFFINITY ANALYSIS - Provided in some embodiments is a social platform for soliciting qualified opinions and facilitating shopping, engaging shoppers, and delivering feedback. The social platform can communicate or integrate with existing sites to provide options for interacting with other qualified users. The platform can improve engagement, and increase social interaction. In some embodiments, affinity/feedback systems are provided that generate feedback for shoppers during their shopping experience. In addition to providing real-time feedback and opinions to shoppers, affinity and feedback systems can be configured to analyze and stored information on a complete purchasing experience. The complete purchasing experience can include, for example, initial identification of interest (e.g., establishing a purchase intent), specification of a product or service detail, actual identification and/or comparison of products/services, any interaction between shopping participants, conversations between participants, actual service/product purchase, and can also include after purchase conversation and/or review. | 09-18-2014 |
Mark Nackyoung Lee, Cambridge, MA US
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20150202223 | METHODS RELATING TO DNA-SENSING PATHWAY RELATED CONDITIONS - The invention provides, inter alia, methods for modulating DNA sensing pathways and the innate immune responses downstream of such pathways. The invention contemplates methods for down-regulating this pathway and/or the downstream innate immune response. The invention further contemplates methods for up-regulating this pathway and/or the downstream innate immune response. | 07-23-2015 |
Mei-Ching Lee, Cambridge GB
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20120107944 | Holographic Sensor - A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (i) | 05-03-2012 |
Michael Jungho Lee, Cambridge, MA US
Mike Lee, Cambridge CA
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20100237998 | ADAPTIVE COMMUNICATION IN AN ELECTRONIC TOLL COLLECTION SYSTEM - An adaptive communication system and method for use in an electronic toll collection system utilizing transponders located in vehicles travelling on a toll roadway. A transponder memory stores configuration type data that identifies the type of the vehicle carrying the transponder, the transponder or the transponder's mounting. The transponder transmits the configuration type data to the communication system. The communication system includes a memory which contains a database of predetermined communication parameters for various types of configuration types. The communication system looks up the predetermined communication parameters for the configuration type and adjusts variable communication parameters accordingly. Predetermined communication variables may include the transmit power of an antenna, or the receive sensitivity of the antenna or the position of the vehicle in order to maximize the likelihood of a successful communication. | 09-23-2010 |
Richard T. Lee, Cambridge, MA US
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20150111222 | GENETICALLY ENCODED BIOSENSORS - The present disclosure provides, inter alia, genetically encoded recombinant peptide biosensors comprising analyte-binding framework portions and signaling portions, wherein the signaling portions are present within the framework portions at sites or amino acid positions that undergo a conformational change upon interaction of the framework portion with an analyte. | 04-23-2015 |
Robin Lee, Cambridge GB
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20080197836 | Position Encoder - An inductive position encoder is described having first and second members which are relatively moveable over a measurement path, a magnetic device mounted on the first member; a plurality of first windings mounted on the second member; and a second winding. The magnetic device is operable to interact with the windings such that upon the energisation of either the second winding or the first windings, there is generated a plurality of sensor signals each being associated with a respective one of said first windings and varying with the relative position between said magnetic device and the associated first winding and hence with the relative position between said first and second members. Additionally, the plurality of first windings are arranged along said measurement path so that the sensor signals vary substantially in accordance with a predetermined Gray code. | 08-21-2008 |
Rosalind Trudy Lee, Cambridge GB
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20100036319 | AUTO INJECTOR - An auto injector including: a housing; an outlet portion with a needle ( | 02-11-2010 |
Stephen P. Lee, Cambridge, MA US
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20130150693 | CATHETER BALLOON METHODS AND APPARATUS EMPLOYING SENSING ELEMENTS - An apparatus for medical diagnosis and/or treatment is provides. The apparatus includes a flexible substrate forming an inflatable body and a plurality of sensing elements disposed on the flexible substrate. The plurality of sensing elements are disposed about the inflatable body such that the sensing elements are disposed at areas of minimal curvature of the inflatable body in a deflated state. | 06-13-2013 |
20130274562 | CARDIAC CATHETER EMPLOYING CONFORMAL ELECTRONICS FOR MAPPING - An apparatus for medical diagnosis and/or treatment is provided. The apparatus includes a flexible substrate, an intermediate bus disposed on the flexible substrate, and a plurality of sensing elements disposed on the flexible substrate and coupled to the intermediate bus. The plurality of sensing elements and intermediate bus are disposed on the flexible substrate such that the sensing elements are disposed at areas of minimal strain of the flexible substrate. | 10-17-2013 |
20140001058 | INTEGRATED DEVICES TO FACILITATE QUANTITATIVE ASSAYS AND DIAGNOSTICS | 01-02-2014 |
20140012242 | CATHETER DEVICE INCLUDING FLOW SENSING - Devices and methods are provided for performing an ablation procedure on tissue with flow monitoring using flow sensors. The devices include a catheter, and at least one flow sensor disposed on the catheter, and a component for applying the ablation procedure. An assessment module provides an indication of the efficacy of the ablation procedure based on the flow measurement from the flow sensor. | 01-09-2014 |
20150272652 | CARDIAC CATHETER EMPLOYING CONFORMAL ELECTRONICS FOR MAPPING - An apparatus for medical diagnosis and/or treatment is provided. The apparatus includes a flexible substrate, an intermediate bus disposed on the flexible substrate, and a plurality of sensing elements disposed on the flexible substrate and coupled to the intermediate bus. The plurality of sensing elements and intermediate bus are disposed on the flexible substrate such that the sensing elements are disposed at areas of minimal strain of the flexible substrate. | 10-01-2015 |
Sunghyuk Lee, Cambridge, MA US
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20150263606 | LEVEL-CROSSING BASED CIRCUIT AND METHOD WITH OFFSET VOLTAGE CANCELLATION - A level-crossing based circuit with offset voltage cancellation includes a first level-crossing detector section having a first output capacitor, wherein the first level-crossing section is configured to charge the first output capacitor to a first voltage corresponding to an input signal. The first voltage includes a first offset voltage. The level-crossing based circuit also includes a second level-crossing detector section having a second output capacitor, wherein the second level-crossing detector section is configured to discharge the second output capacitor to a second voltage corresponding to the input signal such that the second voltage includes a second offset voltage that is substantially equal in magnitude to the first offset voltage and opposite in polarity to the first offset voltage relative to an average of the first voltage and the second voltage. | 09-17-2015 |
Sun Hwa Lee, Cambridge, MA US
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20140186724 | MULTI-LAYER STRUCTURES PREPARED BY LAYER-BY-LAYER ASSEMBLY - A protective layer can be deposited on a surface of an porous polymer separator placing on a Li-metal electrode to protect against adverse electrochemical activity in a battery. The protective layer can be a multilayered structure including graphene oxide. | 07-03-2014 |
20140377670 | LITHIUM ION CONDUCTING PROTECTIVE FILM AND METHOD OF USE - A lithium ion conducting protective film produced using a layer-by-layer assembly process. The lithium ion conducting protective film is assembled on a substrate by a sequential exposure of the substrate to a first poly(ethylene oxide) (PEO) layer including a cross-linking silane component on the first side of the substrate, a graphene oxide (GO) layer on the first PEO layer, a second poly(ethylene oxide) (PEO) layer including a cross-linking silane component on the GO layer and a poly(acrylic acid) (PAA) layer on the second PEO layer. The film functions as a lithium ion conducting protective film that isolates the lithium anode from the positive electrochemistry of the cathode in a lithium-air battery, thereby preventing undesirable lithium dendrite growth | 12-25-2014 |
Tong Ihn Lee, Cambridge, MA US
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20090221428 | Methods of Genome-Wide Location Analysis in Stem Cells - The invention relates to improved methods of identifying the genomic regions to which a protein of interest binds, and in particular, to methods that apply to stem cells such as but not limited to; embryonic stem cells and adult stem cells. The invention also provides methods of identifying agents which modulate differentiation of stem cells. The invention also provides methods of defining the differentiation potential of a cell and of designing array oligonucleotides. | 09-03-2009 |
Tung-Chun Lee, Cambridge GB
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20140113382 | PLASMONIC JUNCTIONS FOR SURFACE-ENHANCED SPECTROSCOPY - The invention relates to the use of a construct for the detection of an analyte using surface enhanced spectroscopic techniques. The construct includes linked surfaces, where the link is formed by a linker providing a fixed inter-surface separation between the linked surfaces, wherein the linker is a linking compound, and at least one of the surfaces is the surface of a nanoparticle. The linking compound is suitable for interacting with the analyte. The linking compound may be a cucurbituril. The surface enhanced spectroscopic technique may be surface enhanced Raman spectroscopy (SERS). | 04-24-2014 |
Victoria Lee, Cambridge, MA US
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20150053400 | APPARATUS AND METHOD FOR MIXING FLUIDS - Apparatuses and methods for mixing a first fluid with a second fluid are described herein. One such apparatus includes a chamber that contains the first fluid and the second fluid. The apparatus also includes a piston that is positioned within the chamber and that is movable within the chamber. The piston can move back and forth to mix the first fluid and the second fluid together. The apparatus further includes a restrictor that provides for controlled movement of the piston and thus protects the piston and other components of the apparatus during operation. | 02-26-2015 |
Vincent Lee, Cambridge, MA US
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20140300869 | Methods and Apparatus for Light Field Projection - In exemplary implementations of this invention, light from a light field projector is transmitted through an angle-expanding screen to create a glasses-free, 3D display. The display can be horizontal-only parallax or full parallax. In the former case, a vertical diffuser may positioned in the optical stack. The angle-expanding screen may comprise two planar arrays of optical elements (e.g., lenslets or lenticules) separated from each other by the sum of their focal distances. Alternatively, a light field projector may project light rays through a focusing lens onto a diffuse, transmissive screen. In this alternative approach, the light field projector may comprise two spatial light modulators (SLMs). A focused image of the first SLM, and a slightly blurred image of the second SLM, are optically combined on the diffuser, creating a combined image that has a higher spatial resolution and a higher dynamic range than either of two SLMs. | 10-09-2014 |
Whay C. Lee, Cambridge, MA US
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20110085562 | AGGREGATING PORTS WHILE ALLOWING ACCESS TO SINGLETON PORTS - Disclosed is a method for aggregating parallel data links connecting two end-point devices into a logical link. If one of the parallel data links is a multi-point link, then an end-point device can still access that link to route traffic to an end station on the link (that is, to a device other than the other end-point device of the logical data link). In the terminology of this disclosure, the logical aggregated link is accessed through an “aggregated port” on an end-point device, while the constituent multi-point link is accessed directly through a “singleton port.” By assigning a smaller cost to the aggregated port than to the singleton port, embodiments avoid creating routing loops. In some embodiments, the aggregation is performed at Layer 2 of the Open System Interconnection seven-layer protocol model. Then, the methods of the present invention work well with existing IEEE 802.1 bridging architectures and protocols. | 04-14-2011 |
Whay Chiou Lee, Cambridge, MA US
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20090276841 | METHOD AND DEVICE FOR DYNAMIC DEPLOYMENT OF TRUST BRIDGES IN AN AD HOC WIRELESS NETWORK - A method for deploying a trust bridge in an ad hoc wireless network can provide interoperability for multi-organizational authentication. The method includes processing at a delegate certification authority (DCA) node device authorizations received from of a plurality of certification authorities (CAs) of different organizations, where the authorizations authorize the DCA node device to serve as a DCA representing the CAs (step | 11-05-2009 |
20100014422 | Priority-Based Admission Control in a Network with Variable Channel Data Rates - A method for priority-based admission control in a network, comprises receiving an admission request for transmitting an information flow to a network through a communication channel and determining an admissible region within a range of a channel data rate of a communication channel for an information flow in response to a priority of the information flow, where the priority of the information flow is one of a plurality of priorities of information flow. The admissible region is one of a plurality of admissible regions within the channel data rate range that correspond to different ones of the plurality of priorities of information flow, respectively, and each of the plurality of admissible regions within the channel data rate range is useable for transmitting information flow with a respective one of the plurality of priorities. Further included in the method is determining an available channel data rate of the communication channel for receiving the information flow by the network, and granting the admission request for the information flow after determining that the available channel data rate of the communication channel is within the admissible region of the channel data rate range. | 01-21-2010 |
20100115266 | METHOD AND DEVICE FOR ENABLING A TRUST RELATIONSHIP USING AN UNEXPIRED PUBLIC KEY INFRASTRUCTURE (PKI) CERTIFICATE - A method and device are useful for enabling a trust relationship using an unexpired public key infrastructure (PKI) certificate, where a current status of the PKI certificate is unavailable. The method includes determining at a relying party that a certificate status update for the PKI certificate is unavailable (step | 05-06-2010 |
20100115267 | METHOD AND DEVICE FOR ENABLING A TRUST RELATIONSHIP USING AN EXPIRED PUBLIC KEY INFRASTRUCTURE (PKI) CERTIFICATE - A method and device are useful for enabling a trust relationship using an expired public key infrastructure (PKI) certificate. The method includes determining at a relying party a maximum permissible grace period during which the PKI certificate can be conditionally granted a valid status (step | 05-06-2010 |
20100250922 | METHOD AND SYSTEM FOR PROPAGATING TRUST IN AN AD HOC WIRELESS COMMUNICATION NETWORK - A method and system enable robust and scalable propagation of trust between a first organization and a second organization, both operating in an ad hoc wireless communication network. The method includes establishing at a first member node of the first organization pair-wise trust with a first member node of the second organization using a predetermined inter-organizational trust establishment device (step | 09-30-2010 |
Yi-Hsien Lee, Cambridge, MA US
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20150064471 | Seed for Metal Dichalcogenide Growth by Chemical Vapor Deposition - A metal dichalcogenide layer is produced on a transfer substrate by seeding F | 03-05-2015 |
Yuhan Lee, Cambridge, MA US
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20140348896 | Hydrophobic Tissue Adhesives - Pre-polymers for use as tissue sealants and adhesives, and methods of making and using thereof are provided. The pre-polymers have flow characteristics such that they can be applied through a syringe or catheter but are sufficiently viscous to remain in place at the site of application and not run off the tissue. The pre-polymers are also sufficiently hydrophobic to resist washout by bodily fluids. The pre-polymers are stable in bodily fluids; that is the pre-polymer does not spontaneously crosslink in bodily fluids absent the presence of an intentionally applied stimulus to initiate crosslinking. Upon crosslinking, the adhesive exhibits significant adhesive strength in the presence of blood and other bodily fluids. The adhesive is sufficiently elastic that it is able to resist movement of the underlying tissue. The adhesive can provide a hemostatic seal. The adhesive is biodegradable and biocompatible, causing minimal inflammatory response. | 11-27-2014 |
Yun Seog Lee, Cambridge, MA US
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20140166092 | Method of Fabricating Nanocone Texture on Glass and Transparent Conductors - A method of fabricating submicron textures on glass and transparent conductors includes depositing a plurality of silica or silica-coated polystyrene nanospheres onto a substrate, etching the silica coated polystyrene nanospheres and the substrate to form a plurality of nanocone projections on a first side of the substrate, and depositing a transparent conducting oxide onto the substrate on top of the nanocone projections. | 06-19-2014 |