Beebe, US
Brian Beebe, Detroit, MI US
Patent application number | Description | Published |
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20110252677 | FLOWING WATER DISPLAY - A flowing water display including a transparent upright backwall panel covering a graphic art sheet and water sprayed from a spray tube against a forward surface of the panel to cause a down flow of water thereover, with an open topped reservoir tank disposed beneath the panel to collect said water down flow, which is recirculated by a pump drawing water out of the reservoir tank and pumping water back into the spray tube. A pair of removable side channels and top channel frame the graphic art image and conceal the spray tube and plumbing connection to the pump. The components of a wall mounted version allow separate mounting to make a wall mount easier for large size displays. | 10-20-2011 |
Clifford A. Beebe, Snohomish, WA US
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20090192659 | AIRCRAFT MAINTENANCE LAPTOP - An apparatus comprises a portable computer, and program code stored on the portable computer. The program code is capable of being executed to establish a communications link with an aircraft network data processing system in an aircraft, obtain information about the aircraft over the communications link, display the information on a display device for the portable computer, receive user input to control a data processing system on the aircraft network data processing system in the aircraft, and send a number of commands to the data processing system in response to receiving the user input. | 07-30-2009 |
Dana C. Beebe, Houston, TX US
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20090038805 | CONTROL MODULE FOR SUBSEA EQUIPMENT - A subsea control module for providing control of subsea equipment is provided. The design allows for replacement and retrieval of a subsea control module with a single remotely operated vehicle (“ROV”) deployment from a vessel. The subsea control module can provide distributed electrical and hydraulic control functions via multiple directional control valve modules, multiple pilot valve modules, and a central electronic control module. Each directional control and pilot perform a set of functions so that replacement of a single module does not require disassembly of any other components) or hydraulic connection. Similarly, each pilot valve module can include a set of pilot valves, pressure transducers, solenoids and electronic circuitry to perform a limited set of functions so that failure of a single pilot valve module does not result in failure of the entire subsea control module. The central electronic control module can provide electrical signals to each pilot valve module which can provide hydraulic signals to each directional control valve module and to off-board hydraulics through a subsea equipment receptacle mated with the subsea control module. | 02-12-2009 |
20090194290 | CONTROL SYSTEM FOR BLOWOUT PREVENTER STACK - A modular control system consisting of multiple, remotely retrievable functional modules for controlling a blowout preventer stack. The various functional modules can be located on the lower marine riser package and blowout preventer stack positioned near the equipment with which they are associated, wherein this distribution of modules nearly eliminates the complex interface connection between the lower marine riser package and blowout preventer stack. Each of the functional modules is capable of being installed, retrieved or replaced with a single remotely operated vehicle (ROV) deployment from a vessel. The functional modules can be used to operate as a complete control system for a blowout preventer stack or can be used selectively individually or in various combinations to accommodate multiple control applications or upgrades of other control systems. | 08-06-2009 |
David Beebe, Monona, WI US
Patent application number | Description | Published |
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20120178096 | METHOD FOR ISOLATING WEAKLY INTERACTING MOLECULES FROM A FLUIDIC SAMPLE - Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps. | 07-12-2012 |
20130158240 | Method Of Extracting A Fraction From A Biological Sample - A method is provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The method includes the steps of capturing the fraction-bound solid phase substrate and bringing an isolation buffer and the fraction-bound solid phase substrate into contact to purify the captured fraction-bound solid phase substrate. | 06-20-2013 |
20130302817 | Functionalized Microfluidic Device And Method - A microfluidic device and method is provided for handheld diagnostics and assays. The device includes a base having outer surface and a channel therethough for receiving fluid therein. The channel has input and output ports communicating with the outer surface. A lid is also provided. The lid has an outer surface, a first well having a port communicating with the outer surface of the lid, and a second well having a port communicating with the outer surface. The lid moveable between a first disengaged position and a second engaged position wherein the first port of the lid is adjacent the input port of the channel and the second port is adjacent the output port of the channel. | 11-14-2013 |
20130302842 | Lid For Functionalized Microfluidic Platform And Method - A microfluidic device and method is provided for handheld diagnostics and assays. A first substance is frozen in a cryopreservation fluid in a first well of a lid. The lid includes a first surface communicating with a first port of the first well and a second surface communicating with a second port of the first well. A porous membrane is affixed to the first surface so as to overlap the first port and a non-porous membrane is affixed to the second surface so as to overlap the second port. The first substance may be dialytically freed from the cryopreservation fluid at a user desired time. Thereafter, the lid may be moved from a first position wherein the lid is spaced from a base to a second position wherein the lid is adjacent the channel in the base such that the first substance communicates with the input of the channel. | 11-14-2013 |
David James Beebe, Madison, WI US
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20150087006 | CELLULAR CIS-CO-CULTURE SYSTEMS AND METHODS - The invention relates to systems and methods for studying patient cancer samples in cis-co-culture. For example, the invention provide systems and methods for testing therapeutic agents in vitro in an environment that simulates an in vivo environment to identify agents that are therapeutically effective for the patient. | 03-26-2015 |
George Beebe, Acton, MA US
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20150192772 | DISPLAY APERTURE PIXEL CIRCUIT ARCHITECTURE INCLUDING PLANARIZATION LAYER - This disclosure provides systems, methods, and apparatus for providing pixel circuits for controlling the state of operation of light modulators in a display. A pixel circuit used to control one or more display elements of a MEMS display apparatus can include a first output node coupled to a first actuator of a display element and a second output node coupled to a second actuator of the display element. The first output node can be coupled to an actuation interconnect via a first pre-charge switch connected in parallel with a first capacitor. The second output node can be connected to the actuation interconnect via a second pre-charge switch connected in parallel with a second capacitor. Energizing the first output node or the second output node can cause the display element to enter or remain in a first state or a second state, respectively. | 07-09-2015 |
George Robert Beebe, Acton, MA US
Patent application number | Description | Published |
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20150103387 | SHUTTER-BASED LIGHT MODULATORS INCORPORATING INTEGRATED SIDEWALL REFLECTORS - This disclosure provides systems, methods, and apparatus for a MEMS display incorporating integrated sidewall reflectors. The display can include a light blocking component suspended over a substrate. The light blocking component can include an aperture in its surface that is parallel to the substrate. The display can include one or more sidewall reflectors positioned within the aperture. The one or more sidewall reflectors can be arranged at least partially normal to the surface of the light blocking component. Light that is directed through the aperture can be reflected off of the sidewall reflectors to escape from the display at a higher angle than would otherwise be possible. | 04-16-2015 |
Jane A. Beebe, Elkhorn, WI US
Patent application number | Description | Published |
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20100240080 | KINASE AND PHOSPHATASE ASSAYS - Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described. | 09-23-2010 |
20120083427 | KINASE AND PHOSPHATASE ASSAYS - Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the peptide, resulting in a change of a detectable property of the composition. Panel assays for determining substrates or modulators of kinase, phosphatase or other protein post-translational modification activity are also described. | 04-05-2012 |
Jason Beebe, Gilbert, AZ US
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20110213837 | System and Method for Evaluating and Analyzing Content - A system for evaluating content includes a plurality of client computer systems, each one of the client computer systems configured to perform the steps of playing content on a media player; capturing, while the content is playing, a plurality of ratings from a user, each one of the ratings corresponding to a different play time; and sending the plurality of ratings and the corresponding play times to a media analyzer. The system further includes the media analyzer configured to perform the steps of, from a plurality of users, receiving a plurality of ratings and corresponding play times; grouping the ratings and corresponding play times according to content being rated; and analyzing the grouped ratings. Preferably, the media analyzer can store ratings from different content being played and evaluated simultaneously. | 09-01-2011 |
Jason Beebe, Royse City, TX US
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20140162849 | LOG ROLL - A training and exercise device is provided to aid in proper positioning, technique, and muscle memory for different sports and exercise related activities. The training device includes a cylindrical barrel member. A sled or sleds are connected to the barrel member such that rotation and movement of the barrel member will in turn move the sled or sleds. The sleds are bi-directional such that they are able to move in both forward and rear directions, which will allow the training device to be used in multiple directions without having to reorient the entire device between exercises. The barrel device, sled or sleds may also be configured to adjust the weights thereof to increase or decrease the resistance of the movement of the training device to accommodate for different user's size, abilities, and intended outcome. | 06-12-2014 |
Jean Beebe, Salem, CT US
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20100255538 | ANTIBODIES TO INSULIN-LIKE GROWTH FACTOR I RECEPTOR - The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention. | 10-07-2010 |
20120005767 | ANTIBODIES TO INSULIN-LIKE GROWTH FACTOR I RECEPTOR - The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention. | 01-05-2012 |
Jean Beebe, Acton, MA US
Patent application number | Description | Published |
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20140286959 | Methods of Treating Inflammatory Disorders Using Anti-M-CSF Antibodies - The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies. The invention also relates to transgenic animals and transgenic plants comprising nucleic acid molecules of the present invention. | 09-25-2014 |
Jeremy Beebe, Midland, MI US
Patent application number | Description | Published |
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20140290804 | SILICON EUTECTIC ALLOY COMPOSITION AND METHOD OF MAKING BY ROTATIONAL CASTING - To carry out a rotational casting method of preparing a silicon eutectic alloy composition, silicon and one or more metallic elements M are melted together to form a eutectic alloy melt comprising the silicon and the one or more metallic elements M. A mold containing the eutectic alloy melt is rotated about a longitudinal axis thereof at a speed sufficient to form a rotating volume of the eutectic alloy melt in contact with an inner surface of the mold. Heat is directionally removed from the rotating volume of the eutectic alloy melt to directionally solidify the eutectic alloy melt, and a eutectic alloy composition, which includes the silicon, the one or more metallic elements M, and a eutectic aggregation of a first phase comprising the silicon and a second phase of formula MSi | 10-02-2014 |
20150050183 | CONTAINMENT OF MOLTEN MATERIALS HAVING SILICON - Silicon eutectic alloy compositions and methods for making the same are disclosed. In one approach, a method may include using a glass carbon container to restrict contamination of the eutectic alloy melt. In an alternative approach, a method may include using a container having aluminum. The aluminum in the container may provide aluminum that is incorporated into the silicon eutectic alloy. Silicon eutectic bodies made by such methods are also disclosed. | 02-19-2015 |
20150057145 | SILICOTHERMIC REDUCTION OF METAL OXIDES TO FORM EUTECTIC COMPOSITES - A method of making a eutectic alloy body by silicothermic reduction is provided. The method can include heating a mixture including silicon and a metal oxide comprising one or more metallic elements M and oxygen, forming a eutectic alloy melt from the mixture, and removing heat from the eutectic alloy melt, thereby forming the eutectic alloy body having a eutectic aggregation of a first phase comprising the silicon and a second phase being a silicide phase. | 02-26-2015 |
Jeremy M. Beebe, Midland, MI US
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20130178549 | SILICON-CONTAINING MATERIALS WITH CONTROLLABLE MICROSTRUCTURE - In various embodiments, provided are silicon-containing coatings; silicon-containing coatings comprising microstructures that are responsive to one or more stimuli; oxidized products of said silicon-containing coatings; bulk solids; oxidized solids and powders; methods of preparing such coatings, solids, and powders; and substrates comprising the provided coatings. | 07-11-2013 |
Joel Beebe, Columbus, OH US
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20110248127 | Display - Devices are disclosed having a magnet disposed thereon, operatively configured for retaining a ferrous element thereagainst. | 10-13-2011 |
20120175372 | HAIR STYLING DEVICE HOLSTER - A hair styling device holster includes a bottom section, a middle section, and a top section. The bottom section includes a flat bottom surface. The middle section is coupled to the bottom section and includes walls that define an interior compartment sized and configured to receive a heated end of a hair styling device. At least a portion of one of the plurality of walls including a mesh grating. The top section is coupled to the middle section and defines at least one opening in communication with the interior compartment defined by the middle section. An insulating material is disposed on an upper interior surface of the bottom section for insulating the bottom section from a hair styling device when the hair styling device is disposed within the first opening. | 07-12-2012 |
20130068802 | Media Dispenser - Media dispensers are disclosed herein for storing and dispensing course or granular dry media via a hopper and valve. | 03-21-2013 |
20130292523 | Display - Devices having a magnet disposed thereon are disclosed. The devices are operatively configured for suspending and displaying articles, such as tags, signage, clothing, and baseball caps containing ferrous elements. | 11-07-2013 |
20130305935 | Peeler - According to certain embodiments of the present disclosure, devices are described herein for providing multiple identical or varied vegetable peeler cutting heads within a single frame. | 11-21-2013 |
20140008318 | TRAVEL BOTTLE - Various embodiments of a travel bottle are disclosed. | 01-09-2014 |
20140096300 | BIB WITH CUSTOMIZED DECORATIONS - A bib preferably for young children to be worn around the neck and to protect the chest from soiling usually by spilled food during feeding features a transparent window in the chest protecting area of a front facing panel. A back panel forms gap behind the front panel creating a pocket into which can be placed a detached sheet bearing a decorative graphic design. The design is positioned such that it can be seen by a viewer looking through the window when the sheet is inserted in the pocket. The back side of the bib can also be formed by a lower, middle panel partially overlapping the upper back panel. | 04-10-2014 |
20140283311 | DUAL FUNCTION TOOL - Various embodiments of a dual function tool are disclosed. | 09-25-2014 |
20140311845 | CASE COMPRISING A HANDLE - A case comprising a handle is provided. In one embodiment, the case may include a wheeled luggage case wherein at least a portion of the handle extends substantially over at least one of the centroid and center of gravity of the case. | 10-23-2014 |
20140353183 | CONTAINER WITH CALORIC MARKINGS - A container is described for holding and dispensing chilled fluids for consumption by a user. The container may include a temperature indicating device configured to indicate whether a current temperature of liquid is at or below a first temperature value. The container may include a plurality of gradations configured to indicate a plurality of liquid levels in the enclosed chamber. Each pair of the plurality of liquid level gradations may have a corresponding volume. A plurality of caloric indicia may be displayed in conjunction with the plurality of gradations. Each caloric indicia may display a caloric energy value corresponding to heating one or more of the volumes of aqueous liquid from the first temperature value to a second temperature value. The container may be included in a kit with instructions directing a user in operation of the container, for example, as part of a diet or regimen of physical fitness. | 12-04-2014 |
20150069078 | Cooking Splatter Screen - Various embodiments of a cooking splatter screen comprising an access hatch are provided. In one embodiment, a splatter screen is provided, the splatter screen comprising: a screen portion; a handle; and an access hatch, wherein the access hatch is operatively connected to the screen portion by a joint. The splatter screen may prevent splattered cooking ingredients from exiting a pan, skillet, or pot, while allowing a chef to selectively access the interior of the pan, skillet, or pot to manipulate food therein or insert additional ingredients. | 03-12-2015 |
20150103245 | TABLET MOUNT - A mounting device for housing a smart device having a user interface comprises a horizontal armature, a screen housing, and a mounting bracket. The mounting device is configured for attachment to a display unit having a plurality of posts. The horizontal armature includes coupling mechanisms disposed at each end thereof, wherein each coupling mechanism is configured to be removably coupled to one of the posts. The screen housing has a hollow interior configured to receive the smart device therein, wherein the screen housing includes at least one aperture for providing visual and tactile access to desired portions of the smart device. The mounting bracket is securely coupled to the screen housing and includes at least one projection extending therefrom and configured to be received in a corresponding opening formed in the horizontal armature to couple the screen housing to the horizontal armature. | 04-16-2015 |
20150271584 | LIGHT AND SOUND BAR SYSTEM - A system is disclosed for providing enhanced sound and additional functionality to auxiliary devices. In one embodiment, a light and sound bar system comprising an omnidirectional high fidelity speaker; an adjustable lighting device; and attachment hardware for attaching to an auxiliary device is provided to add enhanced sound capabilities and lighting functionality to auxiliary devices. | 09-24-2015 |
Kevin Beebe, Spencerport, NY US
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20090302488 | METHOD AND APPARATUS FOR THE DRY RELEASE OF A COMPLIANT OPHTHALMIC ARTICLE FROM MOLD SURFACE - An apparatus for releasing a molded lens from a deformable mold includes a shear ring for temporarily retaining an annular portion of the deformable mold outside a periphery of the lens and a plunger for deforming an annular section of the deformable mold within the periphery of the lens. The apparatus can be employed to release a non-hydrated hydrogel lens from a deformable mold section. | 12-10-2009 |
20120001353 | METHOD AND APPARATUS FOR THE DRY RELEASE OF A COMPLIANT OPHTHALMIC ARTICLE FROM A MOLD SURFACE - An apparatus for releasing a molded lens from a deformable mold includes a shear ring for temporarily retaining an annular portion of the deformable mold outside a periphery of the lens and a plunger for deforming an annular section of the deformable mold within the periphery of the lens. The apparatus can be employed to release a non-hydrated hydrogel lens from a deformable mold section. | 01-05-2012 |
Kevin D. Beebe, Spencerport, NY US
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20090135410 | Bubble reduction system - An ophthalmic device forming system includes an inspection station configured to receive a plurality of ophthalmic devices, a fluid supply fluidly connected to the inspection station, the fluid supply containing a working fluid, and a heat source fluidly connected between the fluid supply and the inspection station. The heat source includes a housing, a transfer element, and a low pressure gas region defined by the housing adjacent to the transfer element. | 05-28-2009 |
20090145456 | Ultrasonic Bubble Reduction System - An inspection system includes an inspection station configured to receive a plurality of ophthalmic devices, and a fluid supply fluidly connected to the inspection station. The fluid supply contains a working fluid. The system also includes an ultrasonic degassing assembly configured to remove at least one bubble carried by the plurality of ophthalmic devices upstream of a packaging station. | 06-11-2009 |
20090145462 | Maintaining an Ophthalmic Device in a Hydrated State - An ophthalmic device hydration system includes an inspection station configured to receive a plurality of ophthalmic devices and fluid supply fluidly connected to the inspection station. The fluid supply contains a working fluid. The ophthalmic device hydration system also includes a hydration assembly disposed proximate the inspection station and configured to vaporize a volume of the working fluid. | 06-11-2009 |
Lisa Beebe, Acton, MA US
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20140179720 | HETEROARYL COMPOUNDS AND USES THEREOF - The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. | 06-26-2014 |
20150174128 | HETEROARYL COMPOUNDS AND USES THEREOF - The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. | 06-25-2015 |
20150216865 | METHODS OF TREATING A BRUTON'S TYROSINE KINASE DISEASE OR DISORDER - The present invention provides methods of treating, stabilizing or lessening the severity or progression of a disease or disorder associated with BTK. | 08-06-2015 |
20150374690 | HETEROARYL COMPOUNDS AND USES THEREOF - The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. | 12-31-2015 |
Lou Beebe, Phoenix, AZ US
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20150057096 | VARIABLE BOUNCE CLUB HEADS AND RELATED METHODS - Some embodiments include a golf club head. The golf club head includes a top end and a bottom end opposite the top end, a front end and a rear end opposite the front end, and a toe end and a heel end opposite the toe end. Further, the golf club head includes a club head body having an aggregate sole surface. The aggregate sole surface has multiple constituent sole surfaces and at least one riser surface. The multiple constituent surfaces and the riser surface(s) extend between the toe end and the heel end. The multiple constituent sole surfaces have a first sole surface and a second sole surface, and the riser surface(s) have a first riser surface located between the first sole surface and the second sole surface. Other embodiments of related club heads and methods are also disclosed. | 02-26-2015 |
Martin C. Beebe, Standish, MI US
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20130096251 | CURABLE SILYL POLYMERS - Embodiments of the invention relate to crosslinkable silyl group-containing polymers and methods of producing them. In one embodiment a method of producing a silyl polymer is provided. The method includes reacting at least one natural oil based polyol with at least one isocyanate to form at least one prepolymer having at least one NCO group. The at least one natural oil based polyol includes the reaction product of hydroxymethylated fatty acids or esters thereof and at least one polyol initiator. The prepolymer having at least one NCO group is reacted with at least one amino functional alkoxy silane to form the silyl polymer, such that the silyl polymer includes at least one crosslinkable silyl group, at least one urethane group, and at least one urea group in each molecule. | 04-18-2013 |
Matthew W. Beebe, Zionsville, IN US
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20150136896 | Disposable Protective Covers and Associated Dispensing System for Use on Stethoscopes and Other Items - A protective cover used to cover the head of a stethoscope and other items that contact the human body. The protective cover is made from a substrate film. The substrate film has opposing curved edges and opposing flat edges. Tab material is applied to the substrate film proximate the opposing curved edges. A coating of tacky adhesive is applied to the bottom surface of the substrate film between the tab material and between the opposing flat edges. The protective covers can be interconnected as a continuous chain, whereby separate protective covers are torn away along perforations. The chain can be wound onto a roll. The roll is held in a box for storage and dispensing. A slot is formed in the box through which individual protective covers can be removed from the roll. | 05-21-2015 |
Melanie Beebe, Apex, NC US
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20100310640 | HLA-DR BINDING PEPTIDES AND THEIR USES - The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines. | 12-09-2010 |
20140377340 | HLA-DR BINDING PEPTIDES AND THEIR USES - The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines. | 12-25-2014 |
Michael Beebe, Norwalk, OH US
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20110144955 | SYSTEM FOR MODELING DYNAMIC RESPONSE CHANGES IN AN ANTHROPOMORPHIC DUMMY - A system and method for designing a crashworthiness system is taught. The system utilizes computer models of anthropomorphic dummies having material properties which change as a function of time. | 06-16-2011 |
Michael S. Beebe, Norwalk, OH US
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20130000425 | PELVIS ASSEMBLY FOR CRASH TEST DUMMY - A pelvis assembly for a crash test dummy includes a pair of pelvic bone members, the pelvic bone members being a right pelvic bone member and a left pelvic bone member both made of a thermoset plastic material. | 01-03-2013 |
20130000426 | RIB CAGE ASSEMBLY FOR CRASH TEST DUMMY - A rib cage assembly for a crash test dummy includes a rib cage member made of a plastic material. | 01-03-2013 |
Nicole Lang Beebe, San Antonio, TX US
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20150112976 | RELEVANCY RANKING INFORMATION RETRIEVAL SYSTEM AND METHOD OF USING THE SAME - Disclosed herein is a system and method of using the same for a relevancy ranking information retrieval system. In an embodiment, the system is configured for ranking hits in text string searching. A search query for one or more hits relevant to an investigation is received from, as an example and not a limitation, a user. A set of attributes and features of each attribute are extracted related to metadata for each of the one or more hits. A score of each attribute is calculated based on the metadata features, although not limited to ‘metadata’ information as typically defined in digital forensics. Further, weights are assigned to each of the one or more attribute features and a relevancy rank is generated for each of the one or more hits based on assigned weights and the attribute score by using a predefined relevancy-ranking algorithm that may be adjusted by user input. | 04-23-2015 |
Randolph R. Beebe, Duluth, GA US
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20080282306 | Mapping Transport Streams - In a digital network that includes a plurality of devices, which include multiple devices that transmit transport streams, a system and method are provided for discovering and mapping the transport streams and the plurality of devices included in the digital network. One such method sends a transport stream map request to a plurality of network devices. The network devices include a plurality of network transport stream sources and a plurality of network transport stream handlers. The method receives a plurality of replies to the transport stream map request. Each reply includes information associated with the respective network device. The method generates a transport stream map based on the received replies. The transport stream map represents a flow of transport streams among the plurality of network devices. | 11-13-2008 |
Richard W. Beebe, Cortland, NY US
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20120160081 | RESIZING DIE FOR SPENT STRAIGHT WALL CARTRIDGES - A die for resizing spent straight wall cartridges that is suitable for use in a reloading press. The die contains a pair of spaced apart resizing rings that are arranged to size the bullet chamber of the cartridge casing to a smaller diameter than the charge chamber of the casing to improve the firing performance of the reloaded cartridge. | 06-28-2012 |
Robert M. Beebe, Raleigh, NC US
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20090221872 | Endoscope Tip Protector - The invention provides an endoscope tip protector for protecting the distal tip of an endoscope and an endoscope assembly including the tip protector affixed thereto. The endoscope tip protector can include a main body with an opening through the main body sized to accept an endoscope sheath and a white surface arranged to face a distal end of an endoscope sheath when the sheath is placed in the endoscope tip protector. Methods of making and using the tip protector and assembly are also provided. | 09-03-2009 |
Ronald Beebe, St. Petersburg, FL US
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20160036241 | WIRELESS POWER APPARATUS, SYSTEM AND METHOD - An apparatus, system and method for wirelessly powering a device. The apparatus, system and method may include a primary coil housing that houses a primary coil; a secondary coil housed within the device and suitable for having power induced therein responsive to the primary coil; an isolator that at least partially mechanically and electrically isolates the primary coil from the secondary coil; and a plurality of paired feedback sensors respectively communicatively and physically associated with, and paired as between, the primary coil housing and the device, wherein the plurality of paired feedback sensors exchanges indications regarding performance of the secondary coil, and wherein performance of the primary coil is modified responsively to the indications. | 02-04-2016 |
Ross L. Beebe, Mentor, OH US
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20100261927 | Process for Making Substituted Trithiocarbonate Derivatives - The present invention provides a low cost technique for synthesizing substituted trithiocarbonates and derivates thereof, by a one-step process which does not require solvent washes or re-crystallization steps, and results in practical yields more than double that of processes disclosed in the prior art. | 10-14-2010 |
Sarah Beebe, Herndon, VA US
Patent application number | Description | Published |
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20120030729 | COLLABORATIVE STRUCTURED ANALYSIS SYSTEM AND METHOD - Methods, systems, and apparatus for providing compartmented, collaborative, integrated, automated analytics to analysts are provided. In a first aspect, the present invention provides a computer-implemented method for providing compartmented, collaborative, integrated, automated analytics to analysts including: selecting a computer-encoded project-specific workflow; determining a computer-encoded compartment manager, said computer-encoded compartment manager including computer-encoded information about the context of said project-specific workflow; retrieving said computer-encoded information about the context; selecting a computer-implemented automated analytic using said computer-encoded project-specific workflow; providing under control of said computer-encoded compartment manager said information about the context to said automated analytic; processing said computer-encoded information using said computer-implemented automated analytic, to generate thereby analytical information representing an outcome to said analysts; and processing said analytical information in accordance with said computer-encoded compartment manager and said computer-encoded project-specific workflow. | 02-02-2012 |
Sarah Miller Beebe, Herndon, VA US
Patent application number | Description | Published |
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20150304338 | COLLABORATIVE STRUCTURED ANALYSIS SYSTEM AND METHOD - Methods, systems, and apparatus for providing compartmented, collaborative, integrated, automated analytics to analysts are provided. In a first aspect, the present invention provides a computer-implemented method for providing compartmented, collaborative, integrated, automated analytics to analysts including: selecting a computer-encoded project-specific workflow; determining a computer-encoded compartment manager, said computer-encoded compartment manager including computer-encoded information about the context of said project-specific workflow; retrieving said computer-encoded information about the context; selecting a computer-implemented automated analytic using said computer-encoded project-specific workflow; providing under control of said computer-encoded compartment manager said information about the context to said automated analytic; processing said computer-encoded information using said computer-implemented automated analytic, to generate thereby analytical information representing an outcome to said analysts; and processing said analytical information in accordance with said computer-encoded compartment manager and said computer-encoded project-specific workflow. | 10-22-2015 |
Simon Beebe, Groton, MA US
Patent application number | Description | Published |
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20110060948 | DIAGNOSTICS METHODS FOR A COMMUNICATIONS DEVICE - A method facilitating the support of a communications device via diagnostic tools on the communications device and a remote computing device of monitoring predefined data elements associated with the operation of said communications device. | 03-10-2011 |
Stephen Beebe, Norfolk, VA US
Patent application number | Description | Published |
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20090125091 | ULTRAWIDEBAND ANTENNA FOR OPERATION IN TISSUE - Method and apparatus for cellular and intracellular manipulation of cell functions with ultrashort electrical pulses and for targeted delivery of the electrical pulses into cell cultures, patients, and tissues. | 05-14-2009 |
Stephen J. Beebe, Norfolk, VA US
Patent application number | Description | Published |
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20090299417 | DELIVERY DEVICE, SYSTEM, AND METHOD FOR DELIVERING NANOSECOND PULSED ELECTRIC FIELDS - A medical instrument for delivering electrotherapy to tissue that includes an outer support member having a ground plate at a distal end of the outer support member, and a protrusive element having a tip that extends beyond the ground plate. A portion of the protrusive element proximate the ground plate can act as an electrical insulator and a portion of the protrusive element proximate the distal end of the protrusive element can include a first electrode. The protrusive element can be designed to penetrate into tissue below a tissue surface while a tissue contacting surface of the ground plate rests against the tissue surface. Also disclosed are systems incorporating the medical instrument and methods of electrotherapy to subsurface tissue using the medical instrument. | 12-03-2009 |
20110092973 | NANOSECOND PULSED ELECTRIC FIELDS CAUSE MELANOMAS TO SELF-DESTRUCT - Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nsPEFs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin. | 04-21-2011 |
20110236979 | Apparatus for Generating Electrical Pulses and Methods of Using Same - A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude. | 09-29-2011 |
20110288545 | Method and Device for Ablation of Cancer and Resistance to New Cancer Growth - Methods and devices designed to eliminate and/or ablate cancer or other abnormal growths of cells or tissues or eliminate and/or ablate cells or tissue with abnormal functions. In particular, using sub-microsecond electric pulses to treat cancer cells by, inter alia, inducing programmed cell death or other type of cell death. These methods and devices are expected to greatly improve the prevention, treatment and management of cancer by increasing the effectiveness of cancer treatments and development of resistance to new cancer growth. | 11-24-2011 |
20110318319 | ACTIVATION and AGGREGATION OF HUMAN PLATELETS AND FORMATION OF PLATELET GELS BY NANOSECOND PULSED ELECTRIC FIELDS - Methods for forming activated platelet gels using nsPEF's and applying the activated gels to wounds, such as heart tissue after myocardial infarction. The platelets are activated by applying at least one nsPEF with a duration between about 10 picoseconds to 1 microsecond and electrical field strengths between about 10 kV/cm and 350 kV/cm. | 12-29-2011 |
20120315704 | APPARATUS FOR GENERATING ELECTRICAL PULSES AND METHODS OF USING THE SAME - A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude. | 12-13-2012 |
20140106430 | ACTIVATION AND AGGREGATION OF HUMAN PLATELETS AND FORMATION OF PLATELET GELS BY NANOSECOND PULSED ELECTRIC FIELDS - Methods for forming activated platelet gels using nsPEF's and applying the activated gels to wounds, such as heart tissue after myocardial infarction. The platelets are activated by applying at least one nsPEF with a duration between about 10 picoseconds to 1 microsecond and electrical field strengths between about 10 kV/cm and 350 kV/cm. | 04-17-2014 |
Stephen P. Beebe, Norfolk, VA US
Patent application number | Description | Published |
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20120109263 | Medical Instrument for Delivery of High Voltage Pulses and Method of Delivering the Same - An instrument | 05-03-2012 |
20140364797 | ELECTROMANIPULATION OF CELLS AND OTHER BIOLOGICALTISSUES BY PULSED ELECTRIC FIELDS AT ELEVATED TEMPERATURES - Systems and methods for treatment of a biological tissues comprising target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature. | 12-11-2014 |
Tony Beebe, Spring, TX US
W. Scott Beebe, Berkley, MA US
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20110073613 | FLUID DISPENSING SYSTEM - A fluid dispenser is disclosed where a backoff distance is determined and implemented to prevent leakage while dispensing sequentially an accurate, precise amount of fluid substantially independent of the fluid remaining in a syringe-type dispenser. The fluid characteristics of the fluid, e.g. viscosity, surface tension, etc. affect the backoff distance that may be determined heuristically for fluid type, amount of fluid remaining in the syringe and amount to be dispensed. Once the fluid characteristics are known, the dispensing may be accomplished automatically with a processor loading new drive and backoff steps to a motor controller. | 03-31-2011 |
20110101035 | PROTECTIVE SYRINGE SLEEVE - A protective sleeve placed within the cylinder of a syringe, the sleeve protects a piston and a computer controlled device or human operator pushing the piston from material leaking past a piston assembly. The sleeve has lips or ridges at either end, one that is attached to the piston assembly at the output end of the syringe and a second lip that is attached with a retention plate at the far end of the syringe. The sleeve may have a bellows or accordion configuration that slides along the inner surface of the syringe cylinder without appreciably loading the drive mechanism. | 05-05-2011 |
20110245983 | REMOTELY CONTROLLED FLUID DISPENSER - A network of fluid dispensers is disclosed where a Host controller may exchange information with local dispensers, and where local dispensers may exchange information with each other. The information may be dispensing processes, information regarding quality and reliability, problems and/or helpful information, and applications. The information may be exchanged in real time during fluid dispensing where any issues may be shared and resolved quickly even in remote locales. The applications may be developed at a local dispenser or at the Host and then shared throughout the network. The operating systems may include application software development tools, and the applications may include: monitoring deliver schedules and materials inventories; automatic issuing of purchase orders; training broadcasts; implementing industry standards for validation and approval. | 10-06-2011 |
20110245984 | VIRTUAL DISPENSING SYSTEM - A network of fluid dispenser systems is disclosed where a Host/Server is a virtual controller for a number of fluid dispensers systems. The virtual controller may exchange information with local dispenser systems, that incorporate virtual controlling functions. The information may be dispensing processes, information regarding quality and reliability, problems and/or helpful information, and applications. An application may include synchronizing multiple dispensing syringe assemblies. The information may be exchanged in real time during fluid dispensing where any issues may be shared and resolved quickly even in remote locales. Information may be distributed among the disparate locations. | 10-06-2011 |
20120247612 | System and Method for Accurately Delivering Controlled Amounts of Viscous Fluid to a Fluid Delivery Device | 10-04-2012 |
20120252242 | System and Method for Releasably Coupling a Fluid Dispenser to a Dispensing System - A system and method for releasably coupling a fluid dispenser to a structure. There is a push to connect-pull to disconnect connector system that has first and second mating connectors. A first connector is mounted to the dispenser and a second connector is mounted to the structure. The connector system accomplishes both mechanical and electrical interconnection between the dispenser and the structure. | 10-04-2012 |
20140190408 | Catheter Tip Coating System - A catheter tip coating assembly includes a housing defining a fluid reservoir and having a fluid outlet configured to dispense fluid to an end of a piece of tubing. The catheter tip coating assembly includes a valve assembly carried by the housing and at least partly disposed in fluid communication with the fluid reservoir. The valve assembly is configured to receive the piece of tubing and configured to move between a first position to limit fluid communication between the fluid reservoir and the fluid outlet and a second position to provide fluid communication between the fluid reservoir and the fluid outlet to dispense fluid to the end of the piece of tubing. The assembly provides for careful control over the amount of liquid that is applied and the depth of the wetting. | 07-10-2014 |