Patent application number | Description | Published |
20110125187 | Light Activated Composite Tissue Adhesives - A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin. | 05-26-2011 |
20130035629 | OPTICAL BANDAGE TO STERILIZE WOUNDS - A pad is provided that supplies light to a composite layer, which may be provided on a wound. The composite layer may include a combination including a form of collagen and a chromophore that releases a reactive oxygen species upon exposure to the light. The reactive oxygen species may then act to kill bacteria or other microorganisms in the wound. | 02-07-2013 |
20130190245 | Light Activated Composite Tissue Adhesives - A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin. | 07-25-2013 |
Patent application number | Description | Published |
20090192437 | WEARABLE PHOTOACTIVATOR FOR OCULAR THERAPEUTIC APPLICATIONS AND USES THEREOF - The invention provides a wearable device for delivery of light of a desired wavelength and power to the cornea of a subject. The device includes a frame for attachment of a light source housing which includes a light source and a lens positioned in the housing to allow light to be directed to the eye of the subject, and the light source is operably linked to a power source. The invention provides method for the prevention and treatment of ocular disease including infection, neoplasia, and corneal dystrophies. The device of the invention can be used in conjunction with photoactive therapeutic agents. | 07-30-2009 |
20130211389 | Methods and Devices for Crosslinking of Corneal Collagen and For Treatment of Disorders of the Eye - Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc. | 08-15-2013 |
20150250575 | Surgical Mesh Joining and Fixation Using Photoactivated Collagen - Consistent with the present disclosure a method is provided in which a plurality of surgical meshes are provided, each of which may include a coating that has a chromophore. Alternatively, each mesh has a plurality of rivets or tacks that include the chromophore. The meshes may then be positioned to overlap one another or be provided adjacent one another inside the body cavity such that the mesh cover the wound site. The meshes may then be exposed to light at a wavelength that activates the chromophore and causes the meshes to adhere to one another and the underlying tissue. In one example, the coating or the tacks includes a combination of relatively high concentration derivatized collagen and riboflavin, lumiflavin or lumichrome. | 09-10-2015 |
Patent application number | Description | Published |
20090261144 | CARTRIDGE FOR APPLYING VARYING AMOUNTS OF TISSUE COMPRESSION - A surgical stapling apparatus includes a staple cartridge and an anvil member. The staple cartridge includes a plurality of surgical fasteners disposed in rows of retention slots. The staple cartridge may have an annular or linear configuration of retention slots. The tissue contacting surface of the staple cartridge may be tapered or stepped. The anvil member has a tissue contacting surface that includes a number of pockets arranged for substantially aligning with the retention slots. In addition, the tissue contacting surface of the anvil member may complement the tissue contacting surface of the staple cartridge. | 10-22-2009 |
20100174236 | Single-use auto-disable syringe - A single-use auto-disable syringe device of reduced size utilizes a locking element to prevent re-use of the syringe by locking the plunger rod with respect to the barrel upon completion of an injection stroke. The plunger rod includes a plurality of teeth comprising distally facing shoulders provided on a majority of the length of an elongate portion of the plunger rod and a breakable section configured to break upon the application of excessive axial or torsional force. The breakable section is preferably provided at a distal end of the plunger rod so that a proximal end of the locking element engages the syringe barrel and plunger rod at a position more proximal than the breakable section. In this way, the locking element resists some of the force that would otherwise be applied to the breakable section if the plunger rod were twisted. The plunger rod also includes an intermediate tooth provided on a distal-most tooth to prevent the user from repeatedly drawing in doses too small to activate the safety mechanism. | 07-08-2010 |
20110224611 | MEDICAL DEVICE INCLUDING AN AIR EVACUATION SYSTEM - Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided. | 09-15-2011 |
20110224612 | MEDICAL DEVICE INCLUDING AN AIR EVACUATION SYSTEM - Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided. | 09-15-2011 |
20110315739 | Cartridge for Applying Varying Amounts of Tissue Compression - A surgical stapling apparatus includes a staple cartridge and an anvil member. The staple cartridge includes a plurality of surgical fasteners disposed in rows of retention slots. The staple cartridge may have an annular or linear configuration of retention slots. The tissue contacting surface of the staple cartridge may be tapered or stepped. The anvil member has a tissue contacting surface that includes a number of pockets arranged for substantially aligning with the retention slots. In addition, the tissue contacting surface of the anvil member may complement the tissue contacting surface of the staple cartridge. | 12-29-2011 |
20120305628 | Cartridge for Applying Varying Amounts of Tissue Compression - A surgical stapling apparatus includes a staple cartridge and an anvil member. The staple cartridge includes a plurality of surgical fasteners disposed in rows of retention slots. The staple cartridge may have an annular or linear configuration of retention slots. The tissue contacting surface of the staple cartridge may be tapered or stepped. The anvil member has a tissue contacting surface that includes a number of pockets arranged for substantially aligning with the retention slots. In addition, the tissue contacting surface of the anvil member may complement the tissue contacting surface of the staple cartridge. | 12-06-2012 |
20130110076 | Single-Use Auto-Disable Syringe | 05-02-2013 |
20130299555 | CARTRIDGE FOR APPLYING VARYING AMOUNTS OF TISSUE COMPRESSION - A surgical stapling apparatus includes a staple cartridge and an anvil member. The staple cartridge includes a plurality of surgical fasteners disposed in rows of retention slots. The staple cartridge may have an annular or linear configuration of retention slots. The tissue contacting surface of the staple cartridge may be tapered or stepped. The anvil member has a tissue contacting surface that includes a number of pockets arranged for substantially aligning with the retention slots. In addition, the tissue contacting surface of the anvil member may complement the tissue contacting surface of the staple cartridge. | 11-14-2013 |
Patent application number | Description | Published |
20080197167 | SURGICAL STAPLER WITH TIMER AND FEEDBACK DISPLAY - A surgical apparatus has a clamp and a stapling mechanism. The clamp has a first jaw and a second jaw to clamp on a body tissue at a desired location for a stapling operation. The stapling mechanism is controlled by a trigger handle or a switch assembly. The surgical apparatus has a controller for providing a delay between clamping and actuating of the firing mechanism of the stapling mechanism. The delay provides for a desired amount of time for tissue compression producing a more uniform staple formation. The surgical apparatus also has an indicator. The indicator provides feedback about the status of the stapling mechanism and also displays a time of tissue compression by the clamp. | 08-21-2008 |
20100096434 | SURGICAL STAPLER WITH TIMER AND FEEDBACK DISPLAY - A surgical apparatus has a clamp and a stapling mechanism. The clamp has a first jaw and a second jaw to clamp on a body tissue at a desired location for a stapling operation. The stapling mechanism is controlled by a trigger handle or a switch assembly. The surgical apparatus has a controller for providing a delay between clamping and actuating of the firing mechanism of the stapling mechanism. The delay provides for a desired amount of time for tissue compression producing a more uniform staple formation. The surgical apparatus also has an indicator. The indicator provides feedback about the status of the stapling mechanism and also displays a time of tissue compression by the clamp. | 04-22-2010 |
20110068146 | Surgical Stapler With Timer And Feedback Display - A surgical apparatus has a clamp and a stapling mechanism. The clamp has a first jaw and a second jaw to clamp on a body tissue at a desired location for a stapling operation. The stapling mechanism is controlled by a trigger handle or a switch assembly. The surgical apparatus has a controller for providing a delay between clamping and actuating of the firing mechanism of the stapling mechanism. The delay provides for a desired amount of time for tissue compression producing a more uniform staple formation. The surgical apparatus also has an indicator. The indicator provides to feedback about the status of the stapling mechanism and also displays a time of tissue compression by the clamp. | 03-24-2011 |
20110079626 | Surgical Stapler With Timer And Feedback Display - A surgical apparatus has a clamp and a stapling mechanism. The clamp has a first jaw and a second jaw to clamp on a body tissue at a desired location for a stapling operation. The stapling mechanism is controlled by a trigger handle or a switch assembly. The surgical apparatus has a controller for providing a delay between clamping and actuating of the firing mechanism of the stapling mechanism. The delay provides for a desired amount of time for tissue compression producing a more uniform staple formation. The surgical apparatus also has an indicator. The indicator provides feedback about the status of the stapling mechanism and also displays a time of tissue compression by the clamp. | 04-07-2011 |
20120031947 | SURGICAL STAPLER WITH TIMER AND FEEDBACK DISPLAY - A surgical apparatus has a clamp and a stapling mechanism. The clamp has a first jaw and a second jaw to clamp on a body tissue at a desired location for a stapling operation. The stapling mechanism is controlled by a trigger handle or a switch assembly. The surgical apparatus has a controller for providing a delay between clamping and actuating of the firing mechanism of the stapling mechanism. The delay provides for a desired amount of time for tissue compression producing a more uniform staple formation. The surgical apparatus also has an indicator. The indicator provides feedback about the status of the stapling mechanism and also displays a time of tissue compression by the clamp. | 02-09-2012 |
20120046577 | METHOD AND SYSTEM TO DETERMINE AN OPTIMAL TISSUE COMPRESSION TIME TO IMPLANT A SURGICAL ELEMENT - An apparatus for determining an optimal amount of tissue compression for applying a surgical element to tissue is disclosed. The apparatus includes a device for compressing tissue which supports a measuring device adapted to detect a tissue parameter upon the compression of tissue. The measuring device communicates with an indicator. Upon compressing tissue, when the measuring device determines that the compressed tissue parameter reaches a predetermined threshold, the measuring device sends a signal to the indicator such that the indicator provides an indication to a surgeon that the threshold has been reached. The measuring device may include a load cell and the tissue parameter may be a viscoelastic reactive force of the tissue per unit time. | 02-23-2012 |
20120175400 | SURGICAL STAPLER WITH TIMER AND FEEDBACK DISPLAY - A surgical apparatus has a clamp and a stapling mechanism. The clamp has a first jaw and a second jaw to clamp on a body tissue at a desired location for a stapling operation. The stapling mechanism is controlled by a trigger handle or a switch assembly. The surgical apparatus has a controller for providing a delay between clamping and actuating of the firing mechanism of the stapling mechanism. The delay provides for a desired amount of time for tissue compression producing a more uniform staple formation. The surgical apparatus also has an indicator. The indicator provides feedback about the status of the stapling mechanism and also displays a time of tissue compression by the clamp. | 07-12-2012 |
20130292451 | SURGICAL STAPLER WITH TIMER AND FEEDBACK DISPLAY - A surgical apparatus has a clamp and a stapling mechanism. The clamp has a first jaw and a second jaw to clamp on a body tissue at a desired location for a stapling operation. The stapling mechanism is controlled by a trigger handle or a switch assembly. The surgical apparatus has a controller for providing a delay between clamping and actuating of the firing mechanism of the stapling mechanism. The delay provides for a desired amount of time for tissue compression producing a more uniform staple formation. The surgical apparatus also has an indicator. The indicator provides feedback about the status of the stapling mechanism and also displays a time of tissue compression by the clamp. | 11-07-2013 |
Patent application number | Description | Published |
20090192437 | WEARABLE PHOTOACTIVATOR FOR OCULAR THERAPEUTIC APPLICATIONS AND USES THEREOF - The invention provides a wearable device for delivery of light of a desired wavelength and power to the cornea of a subject. The device includes a frame for attachment of a light source housing which includes a light source and a lens positioned in the housing to allow light to be directed to the eye of the subject, and the light source is operably linked to a power source. The invention provides method for the prevention and treatment of ocular disease including infection, neoplasia, and corneal dystrophies. The device of the invention can be used in conjunction with photoactive therapeutic agents. | 07-30-2009 |
20110125187 | Light Activated Composite Tissue Adhesives - A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin. | 05-26-2011 |
20130035629 | OPTICAL BANDAGE TO STERILIZE WOUNDS - A pad is provided that supplies light to a composite layer, which may be provided on a wound. The composite layer may include a combination including a form of collagen and a chromophore that releases a reactive oxygen species upon exposure to the light. The reactive oxygen species may then act to kill bacteria or other microorganisms in the wound. | 02-07-2013 |
20130190245 | Light Activated Composite Tissue Adhesives - A light activated collagen-flavin composite layer incorporating riboflavin is applied as treatment for infected lesions caused by bacteria and as the consequence of surgical procedures. These composites have also been found to be strong tissue adhesives that are effective in closing and sealing wounds, fixation of grafts/ implants and anastomoses. Advantages include speed of closure, reduced infection due to the elimination of foreign matter, evidence of accelerated wound healing and the ease of use in complex surgery, especially when watertight seals, limited access or small repair size are important factors. The riboflavin in the collagen layer is exposed to light (e.g., light having a wavelength between 360-375 nm or 440-480 nm), decomposing the riboflavin to form reactive oxygen species (ROS). Strong crosslinks between the collagen composite and tissue results. In addition, similar exposures eradicate pathogens in the wound is eradicated resulting in a sterile wound. In other examples, the composite film may instead contain lumichrome or lumiflavin. | 07-25-2013 |
20130211389 | Methods and Devices for Crosslinking of Corneal Collagen and For Treatment of Disorders of the Eye - Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc. | 08-15-2013 |
20150250575 | Surgical Mesh Joining and Fixation Using Photoactivated Collagen - Consistent with the present disclosure a method is provided in which a plurality of surgical meshes are provided, each of which may include a coating that has a chromophore. Alternatively, each mesh has a plurality of rivets or tacks that include the chromophore. The meshes may then be positioned to overlap one another or be provided adjacent one another inside the body cavity such that the mesh cover the wound site. The meshes may then be exposed to light at a wavelength that activates the chromophore and causes the meshes to adhere to one another and the underlying tissue. In one example, the coating or the tacks includes a combination of relatively high concentration derivatized collagen and riboflavin, lumiflavin or lumichrome. | 09-10-2015 |