Patent application number | Description | Published |
20090156542 | MCP-1 Binding Nucleic Acids And Use Thereof - The present invention is related to a nucleic acid molecule capable of binding to MCP-1, whereby the nucleic acid molecule is for use as a medicament for the treatment and/or prevention of a chronic disease or chronic disorder, preferably selected from the group consisting of chronic respiratory disease, chronic kidney disease and systemic lupus erythematosus. | 06-18-2009 |
20090192100 | NOVEL USE OF SPIEGELMERS - The present invention relates to the use of a L-nucleic acid as intracellularly active agent. | 07-30-2009 |
20100062436 | Methods for Detection of a Single- or Double-Stranded Nucleic Acid Molecule - The present invention is related to a method for the detection of a nucleic acid molecule comprising at least a strand comprising a sequence of nucleotides in a sample, whereby the method comprises the following steps:
| 03-11-2010 |
20100284961 | MCP-1 binding nucleic acids - The present invention is related to a nucleic acid, preferably binding to MCP-1, selected from the group comprising type 1A nucleic acids, type 1B nucleic acids, type 2 nucleic acids, type 3 nucleic acids, type 4 nucleic acids and nucleic acids having a nucleic acid sequence according to any of SEQ. ID. No. 87 to 115. | 11-11-2010 |
20110027794 | Method for Synthesizing Nucleic Acids, and Application Thereof - The invention relates to a method for synthesizing a nucleic acid containing modified nucleotides. The method encompasses the following steps: a matrix strand is provided; —a primer which at least partially hybridizes on the matrix strand is provided; —nucleoside triphosphates, at least some of which are modified nucleoside triphosphates, are provided; —a polymerase activity is supplied; and—the matrix strand, the primer, and the nucleoside triphosphates are incubated so as to synthesize a nucleic acid that is substantially complementary to the matrix strand. The polymerase activity can be a reverse transcriptase activity. | 02-03-2011 |
20110046207 | C5a binding nucleic acids - The present invention is related to a nucleic acid, preferably binding to C5a, selected from the group comprising type A nucleic acids, type B nucleic acids, type C nucleic acids, type D nucleic acids and nucleic acids having a nucleic acid sequence according to any of SEQ.ID.No. 73 to 79. | 02-24-2011 |
20110112172 | SDF-1 Binding Nucleic Acids - The present invention is related to a nucleic acid molecule, preferably binding to SDF-1, selected from the group comprising type A nucleic acid molecules, type B nucleic acid molecules, type C nucleic acid molecules and nucleic acid molecules having a nucleic acid sequence according to any of SEQ ID NO:142, SEQ ID NO:143 or SEQ ID NO:144. | 05-12-2011 |
20110223127 | SDF-1 Binding Nucleic Acids And The Use Thereof - The present invention is related to a nucleic acid molecule binding to SDF-1, whereby the nucleic acid molecule influences migration of cells. | 09-15-2011 |
20120065254 | C5A binding nucleic acids and the use thereof - The present invention is related to a nucleic acid molecule, capable of binding to C5a, whereby the nucleic acid molecule is for use in a method for the treatment and/or prevention of tumors, the treatment and/or prevention of a respiratory disease, the treatment and/or prevention of pain and/or the treatment and/or prevention of a neurodegenerative disorder. | 03-15-2012 |
20120115937 | Ghrelin binding nucleic acids - The present invention is related to a nucleic acid, preferably binding to ghrelin, whereby the nucleic acid comprises
| 05-10-2012 |
20120258457 | Methods for Detection of a Single- or Double-Stranded Nucleic Acid Molecule - The present invention is related to a method for the detection of a nucleic acid molecule comprising at least a strand comprising a sequence of nucleotides in a sample, whereby the method comprises the following steps: providing a sample containing the nucleic acid molecule; providing a capture probe, whereby the capture probe is at least partially complementary to a part of the nucleic acid molecule; allowing the capture probe to react with the nucleic acid molecule or a part thereof; and detecting whether or not the capture probe is hybridized to the nucleic acid molecule or part thereof. | 10-11-2012 |
20130035376 | MCP-1 binding nucleic acids - The present invention is related to a nucleic acid, preferably binding to MCP-1, selected from the group consisting of Type 1A nucleic acids, type 1B nucleic acids, Type 2 nucleic acids, Type 3 nucleic acids, Type 4 nucleic acids and nucleic acids comprising SEQ ID NOs:87-115 | 02-07-2013 |
20130041019 | SDF-1 Binding Nucleic Acids - The present invention is related to an L nucleic acid that binds to an SDF-1. | 02-14-2013 |
20130310442 | SDF-1 Binding Nucleic Acids and the use Thereof in Cancer Treatment - The present invention is related to a nucleic acid molecule capable of binding to SDF-1, preferably capable of inhibiting SDF-1, whereby the nucleic acid molecule is for use in a method for the treatment and/or prevention of a disease or disorder, for use in a method for the treatment of a subject suffering from a disease or disorder or being at risk of developing a disease or disorder as an adjunct therapy, or for use as a medicament for the treatment and/or prevention of a disease or disorder, whereby the disease or disorder is cancer. | 11-21-2013 |
20130337049 | Novel Use of Spiegelmers - The present invention relates to the use of a L-nucleic acid as intracellularly active agent. | 12-19-2013 |
20140350088 | Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same - The present invention is related to a method for generating a nucleic acid molecule capable of binding to a target molecule comprising the following steps: a) providing a reference nucleic acid molecule, wherein the reference nucleic acid molecule is capable of binding to the target molecule and wherein the reference nucleic acid molecule comprises a sequence of nucleotides, wherein the sequence of nucleotides comprises n nucleotides; b) preparing a first level derivative of the reference nucleic acid molecule, wherein the first level derivative of the reference nucleic acid molecule differs from the reference nucleic acid molecule at one nucleotide position, wherein the first level derivative is prepared by replacing the ribonucleotide at the one nucleotide position by a 2′-deoxyribonucleotide in case the reference nucleic acid has a ribonucleotide at the nucleotide position and wherein the first level derivative is prepared by replacing the 2′-deoxyribonucleotide at the one nucleotide position by a ribonucleotide in case the reference nucleic acid has a 2′-deoxyribonucleotide at the nucleotide position and wherein the nucleotide position at which the replacement is made is the modified nucleotide position; and c) repeating step b) for each nucleotide position of the reference nucleic acid molecule, thus preparing a group of first level derivatives of the reference nucleic acid molecule, wherein the group of first level derivatives of the reference nucleic acid molecule consists of n first level derivatives, wherein each of the first level derivatives of the reference nucleic acid molecule differs from the reference nucleic acid molecule by a single nucleotide replacement and wherein each of the first level derivatives of the reference nucleic acid molecule has a single modified nucleotide position which is different from the single modified nucleotide of all of the single modified nucleotide positions of the other first level derivatives of the group of first level derivatives of the reference nucleic acid molecule. | 11-27-2014 |
20140370034 | SDF-1 Binding Nucleic Acids and the Use Thereof - The present invention is related to a nucleic acid molecule binding to SDF-1, whereby the nucleic acid molecule influences migration of cells. | 12-18-2014 |
20150031755 | Nucleic Acids Specifically Binding CGRP - The present invention is related to a nucleic acid molecule capable of binding to CGRP, wherein the nucleic acid molecule comprises a central stretch of nucleotides, wherein the central stretch of nucleotides comprises a nucleotide sequence of 5′ HWn | 01-29-2015 |
Patent application number | Description | Published |
20090326279 | Support for use in microchannel processing - The disclosed technology relates to an apparatus, comprising: at least one microchannel, the microchannel comprising at least one heat transfer wall; a porous thermally conductive support in the microchannel in contact with the heat transfer wall; a catalyst or a sorption medium supported by the porous support; and a heat source and/or heat sink in thermal contact with the heat transfer wall. | 12-31-2009 |
20100068366 | MULTIPHASE MIXING PROCESS USING MICROCHANNEL PROCESS TECHNOLOGY - The disclosed invention relates to a process for making a multiphase mixture, comprising: flowing a first fluid stream through a process microchannel, the first fluid stream comprising at least one liquid and/or at least one gas, the process microchannel having an apertured section; flowing a second fluid stream through the apertured section into the process microchannel in contact with the first fluid stream to form the multiphase mixture, the second fluid stream comprising at least one gas and/or at least one microbody-forming material, the first fluid stream forming a continuous phase in the multiphase mixture, the second fluid stream forming a discontinuous phase dispersed in the continuous phase. | 03-18-2010 |
20100081726 | Catalytic reaction process using microchannel technology - The disclosed technology relates to a process for conducting a chemical reaction between at least one liquid reactant and at least one gaseous reactant in a process microchannel containing at least one catalyst, the catalyst comprising a solid phase catalyst or a homogeneous catalyst immobilized on a solid. In one embodiment, the process microchannel comprises a processing zone containing one or more structures for disrupting fluid flow and a reaction zone containing one or more structures for contacting and/or supporting the catalyst, the one or more structures for contacting and/or supporting the catalyst containing openings to permit the reactants to flow through the one or more structures and contact the catalyst. The process comprises: forming a reactant mixture comprising at least one liquid reactant and the at least one gaseous reactant; flowing the reactant mixture in the processing zone in contact with the one or more structures for disrupting fluid flow to enhance mixing of the liquid reactant and the gaseous reactant; flowing the reactant mixture in openings in the one or more structures for contacting and/or supporting the catalyst in contact with catalyst; and reacting the at least one liquid reactant with the at least one gaseous reactant to form at least one product. In one embodiment, the process relates to a process for conducting a Fischer-Tropsch synthesis in a process microchannel containing at least one Fischer-Tropsch synthesis catalyst, the catalyst comprising a solid phase catalyst or a homogeneous catalyst immobilized on a solid, the process comprising: flowing reactants comprising H | 04-01-2010 |
20100174124 | PROCESS AND APPARATUS EMPLOYING MICROCHANNEL PROCESS TECHNOLOGY - This invention relates to a process for conducting a hydrocracking or a hydrotreating process in a microchannel reactor. This invention also relates to a process and apparatus for flowing a vapor and liquid into a plurality of microchannels in a microchannel processing unit. | 07-08-2010 |
20110083997 | PROCESS FOR TREATING HEAVY OIL - This invention relates to a process for hydroprocessing heavy oil under process intensification conditions to form an upgraded hydrocarbon product. | 04-14-2011 |
20110112348 | PROCESS FOR MAKING STYRENE USING MIRCOHANNEL PROCESS TECHNOLOGY - The disclosed invention relates to a process for converting ethylbenzene to styrene, comprising: flowing a feed composition comprising ethylbenzene in at least one process microchannel in contact with at least one catalyst to dehydrogenate the ethylbenzene and form a product comprising styrene; exchanging heat between the process microchannel and at least one heat exchange channel in thermal contact with the process microchannel; and removing product from the process microchannel. Also disclosed is an apparatus comprising a process microchannel, a heat exchange channel, and a heat transfer wall positioned between the process microchannel and heat exchange channel wherein the heat transfer wall comprises a thermal resistance layer. | 05-12-2011 |
20120095268 | MICROCHANNEL PROCESSOR - This invention relates to an apparatus, comprising: a plurality of plates in a stack defining at least one process layer and at least one heat exchange layer, each plate having a peripheral edge, the peripheral edge of each plate being welded to the peripheral edge of the next adjacent plate to provide a perimeter seal for the stack, the ratio of the average surface area of each of the adjacent plates to the average penetration of the weld between the adjacent plates being at least about 100 cm | 04-19-2012 |
20140291204 | PROCESS AND APPARATUS EMPLOYING MICROCHANNEL PROCESS TECHNOLGOY - This invention relates to a process for conducting a hydrocracking or a hydrotreating process in a microchannel reactor. This invention also relates to a process and apparatus for flowing a vapor and liquid into a plurality of microchannels in a microchannel processing unit. | 10-02-2014 |