Mark Williams
Mark Williams, Minden, NV US
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20110006076 | SYSTEM FOR DISPENSING SPRAYABLE MATERIAL - A system for dispensing sprayable material such as paint and other liquefied products. The system includes a dispenser designed to accept a flexible, crushable, container filled with sprayable material and having a valve and spray tip at one end. The container is placed into a slot in the dispenser with the valve on the container secured in the housing of the dispenser. In operation, a plunger that runs lengthwise within the housing of the dispenser exerts force on the bottom of the container crushing it as it is emptied and forcing the sprayable material out through the valve and spray tip. | 01-13-2011 |
Mark Williams, Moss Beach, CA US
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20100231400 | LIGHTING ACTIVATION SYSTEMS AND METHODS - A system and method for activating one or more lights or other devices using one or more activation devices including electronic circuitry. The electronic circuitry of the activation devices includes an activation sensor, based on which the lights or other devices are activated. Activation sensors include motion, sound or light sensors. With transmitters the activation devices can activate remote lights or other devices including receivers. Activation devices can be coupled with or apart form the lights or other devices. | 09-16-2010 |
Mark Williams, Winnipeg CA
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20090162342 | THERAPEUTIC USES OF GLANDULAR KALLIKREIN - The present invention relates to pharmaceutical compositions comprising glandular kallikrein in combination with myelin basic protein or copaxone for use in the treatment of multiple sclerosis. The present invention further relates to a method of suppressing autoimmune responses in a patient afflicted with or suffering at least one clinical sign of multiple sclerosis, comprising administering to said patient a therapeutically effective amount of glandular kallikrein in combination with a therapeutically effective amount of myelin basic protein or copaxone. | 06-25-2009 |
20090324701 | COMPOSITIONS CONTAINING (S)-BETHANECHOL AND THEIR USE IN THE TREATMENT OF INSULIN RESISTANCE, TYPE 2 DIABETES, GLUCOSE INTOLERANCE AND RELATED DISORDERS - The present invention provides pharmaceutical compositions comprising (S)-bethanechol or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier and optionally at least one diabetes drug. The use of said composition in the treatment of insulin resistance, type 2 diabetes, impaired glucose tolerance and related disorders is also provided. The invention also provides for a kit comprising the pharmaceutical compositions and instructions for its use. | 12-31-2009 |
20100008899 | METHODS OF DIAGNOSIS AND TREATMENT FOR METABOLIC DISORDERS - The invention relates to pharmaceutical compositions comprising tissue kallikrem (TK), and optionally a diabetes drug, a method of screening for a metabolic disorder by determining the concentration of TK and insulin in a biological sample from a test subject, a method of screening for a therapeutic agent for the treatment or prevention of a metabolic disorder, and a method for treating or preventing a metabolic disorder using a pharmaceutical composition comprising TK. | 01-14-2010 |
20100226910 | TISSUE KALLIKREIN FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID PROTEIN - This invention relates to methods of treating Alzheimer's disease or symptoms thereof, and amnesic mild cognitive impairment or symptoms thereof. Methods of the invention include administering a therapeutically effective amount of tissue kallikrein, variants or active fragments thereof. The invention further relates to uses of tissue kallikrein or a variant or active fragment thereof for the digesting or cleaving amyloid and the treatment of conditions benefiting from the digestion or cleavage of amyloid. The invention further relates to pharmaceutical compositions comprising a therapeutically effective amount of tissue kallikrein, variants or active fragments thereof formulated for oral or intranasal administration. | 09-09-2010 |
20120070425 | TISSUE KALLIKREIN FOR THE TREATMENT OF PANCREATIC Beta-CELL DYSFUNCTION AND FOR Beta-CELL PROLIFERATION - The invention relates to methods of administering kallikrein, a variant, or active fragment thereof to stimulate proliferation of islet cells generally and β-cells specifically. The invention also includes compositions to stimulate proliferation in vivo and in vitro. | 03-22-2012 |
20120201804 | TISSUE KALLIKREIN FOR THE TREATMENT OF SCHIZOPHRENIA AND BIPOLAR DISORDER - The invention includes methods of treating psychiatric disorders including schizophrenia, associated conditions of the schizophrenic spectrum and bipolar disorder, comprising administering tissue kallikrein (KLK1), variants or active fragments thereof. The invention also includes compositions comprising KLK1, variants, or active fragments thereof. | 08-09-2012 |
20120225051 | TISSUE KALLIKREIN FOR THE TREATMENT OF HUNTINGTON'S DISEASE - This invention relates to methods of treating the prodrome and adult onset stage of Huntington's disease or symptoms thereof, and or Juvenile Huntington's disease symptoms thereof. Methods of the invention include administering a therapeutically effective amount of tissue kallikrein, variants or active fragments thereof. The invention further relates to pharmaceutical compositions comprising a therapeutically effective amount of tissue kallikrein, variants or active fragments thereof formulated for oral or intranasal administration. | 09-06-2012 |
Mark Williams, Pleasant, NY US
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20100223584 | Logic Design Verification Techniques for Liveness Checking With Retiming - A technique for verification of a retimed logic design using liveness checking includes assigning a liveness gate to a liveness property for an original netlist and assigning a fairness gate to a fairness constraint for the original netlist. In this case, the fairness gate is associated with the liveness gate and is asserted for at least one time-step during any valid behavioral loop associated with the liveness gate. The original netlist is retimed, using a retiming engine, to provide a retimed netlist. The liveness and fairness gates of the retimed netlist are retimed such that a lag of the fairness gate is no greater than a lag of the liveness gate. Verification analysis is then performed on the retimed netlist. Finally, when the verification analysis yields a valid counter-example trace for the retimed netlist, a liveness violation for the original netlist is returned. | 09-02-2010 |
Mark Williams, Revere, MA US
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20090191610 | Microorganisms With Increased Efficiency for Methionine Synthesis - The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis. | 07-30-2009 |
20090221027 | Use of a bacillus meti gene to improve methionine production in microorganisms - The present invention pertains to improved microorganisms and methods for the production of methionine and other sulfur containing fine chemicals using the metI gene from | 09-03-2009 |
20090298137 | MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE - The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented. | 12-03-2009 |
20090311756 | Microorganisms with a Reactivation System for cob(I)Alamin-Dependent Methionine Synthase - The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme. | 12-17-2009 |
20100009416 | Process for the Preparation of L-Methionine - The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased. | 01-14-2010 |
Mark Williams, Seattle, WA US
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20090321857 | SYSTEMS AND METHODS FOR REDUCED STRESS ANCHORS - Anchor systems and methods anchor components of a Micro-Electro-Mechanical Systems (MEMS) device to a substrate. An exemplary embodiment has a trace anchor bonded to a substrate, a device anchor bonded to the substrate, and an anchor flexure configured flexibly couple the trace anchor and the device anchor to substantially prevent transmission of a stress induced in the trace anchor from being transmitted to the device anchor. | 12-31-2009 |
20120070931 | METHODS FOR REDUCED STRESS ANCHORS - Methods of anchoring components of a Micro-Electro-Mechanical Systems (MEMS) device to a substrate. An exemplary embodiment has a trace anchor bonded to a substrate, a device anchor bonded to the substrate, and an anchor flexure configured to flexibly couple the trace anchor and the device anchor to substantially prevent transmission of a stress induced in the trace anchor from being transmitted to the device anchor. | 03-22-2012 |
Mark Williams, Carlsbad, CA US
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20090117563 | Identification of TRPML3 (MCOLN3) as a Salty Taste Receptor and Use in Assays for Identifying Taste (Salty) Modulators and/or Therapeutics that Modulate Sodium Transport, Absorption or Excretion and/or Aldosterone and/or Vasopressin Production or Release - This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The invention also relates to the discovery that the TRPML3 gene also modulates one or more of sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion. The invention also relates to transgenic animals that have been engineered to express or knock out TRPML3 expression and assays using TRPML3 expressing animals, cells and isolated ion channel polypeptides for identifying compounds that modulate TRPML3-associated functions including salty taste, sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion. | 05-07-2009 |
20090210953 | Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release - The present invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals and based thereon high-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers. Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans. The inventive electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function. Compounds that enhance or block TRPML3 channel activity should thereby modulate salty taste. In addition, these compounds may be used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels and TRPML3 related functions. | 08-20-2009 |
Mark Williams, North Canton, OH US
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20080317058 | Accessory queue management system and method for interacting with a queuing system - A virtual queuing system and method provides for dynamic control of queue data in accordance with queue control instructions provided by a separate queue control source. The virtual queuing system comprises an interface to a queuing system and an interface to the separate queue control source. The interface to the queuing system provides for obtaining queue data and controlling the queue data in accordance with the queue control instructions provided by a separate queue control source. The interface to the separate queue control source for: i) providing the queue data to the separate queue control source; and ii) obtaining the queue control instructions there from. | 12-25-2008 |
Mark Williams, Amherst, NH US
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20080266037 | Magnetic Levitation Lithography Apparatus and Method - A magnetic levitation lithography machine having a low spring stiffness to minimize disturbances of the first structure and which is capable of dynamically controlling the first structure in one or more degrees of freedom. The machine includes a radiation source, a patterning element configured to define a pattern, a projection element, the projection element configured to project the pattern onto a substrate when radiation from the radiation source is projected through the projection element; and a substrate take configured to support the substrate. The substrate take includes a second structure, a fine stage, and a magnetic support configured to support the fine stage adjacent the second structure. The magnetic support includes a first magnet element, coupled to the fine stage, having a first magnet polarization, a second magnet element, coupled to the course stage, having a second magnet polarization, the first magnet element being separated from the second magnet element by a gap, and an adjustment mechanism configured to adjust the magnetic force used to support the fine stage by varying the gap between the first magnet element and the second magnet element. | 10-30-2008 |
Mark Williams, Saranac, MI US
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20080262988 | Vertical curve system for surface grading - A method is disclosed that generates design profiles and a surface therefrom that promote water drainage from soil in an area of interest. Topographical data describing an initial surface of the area of interest are used to form initial profiles. The method generates the design profiles using the initial profiles and desired design parameters such as minimum slope, maximum slope, optimal slope, maximum depth, optimal depth, starting elevation, ending elevation, rules of curvature, and rules of earth balancing. The method generates design surface profiles so that the cut volumes and fill volumes of the soil are at or near balance as much as possible from the available soil in the area of interest. | 10-23-2008 |
20120143572 | Vertical curve system for surface grading - A method is disclosed that generates design profiles and a surface therefrom that promote water drainage from soil in an area of interest. Topographical data describing an initial surface of the area of interest are used to form initial profiles. The method generates the design profiles using the initial profiles and desired design parameters such as minimum slope, maximum slope, optimal slope, maximum depth, optimal depth, starting elevation, ending elevation, rules of curvature, and rules of earth balancing. The method generates design surface profiles so that the cut volumes and fill volumes of the soil are at or near balance as much as possible from the available soil in the area of interest. | 06-07-2012 |
Mark Williams, Winninpeg CA
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20110150781 | TISSUE KALLIKREIN FOR THE TREATMENT OF PARKINSON'S DISEASE - The invention relates to methods of treating Parkinson's disease, dementia with Lewy bodies, and conditions associated with Parkinson's disease and dementia with Lewy bodies. Methods include administering a therapeutically effective amount of tissue kallikrein, variants or active fragments thereof. | 06-23-2011 |
Mark Williams, San Francisco, CA US
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20120325227 | PORTABLE VAPORIZER - A vaporizer and method of vaporizing a botanical material is described. Embodiments of the apparatus include a self-contained, fully enclosed, battery operated vaporizer having an air inlet and a mouthpiece. The vaporizer includes a window for viewing a botanical material contained therein and a heating element that is also visible through the window and through an air inlet. The vaporizer also includes a push-button switch that rapidly provides power to heat air, which is then drawn through the botanical material by inhaling. Embodiments of the method include utilizing a push-button switch for heating vaporizer air and viewing the glow of the heating element as a signal that the vaporizer is ready for use. | 12-27-2012 |
20150128967 | PORTABLE VAPORIZER AND METHOD FOR TEMPERATURE CONTROL - A vaporizer and method of vaporizing a botanical material is described. Embodiments of the apparatus include a self-contained, fully enclosed, battery operated vaporizer having an air inlet and a mouthpiece. The vaporizer includes a window for viewing a botanical material contained therein and a heating element that is also visible through the window and through an air inlet. The vaporizer also includes a push-button switch that rapidly provides power to heat air, which is then drawn through the botanical material by inhaling. Embodiments of the method include utilizing a push-button switch for heating vaporizer air and viewing the glow of the heating element as a signal that the vaporizer is ready for use. In certain embodiments, electric power for heating the air is varied according to the temperature of the vaporizer. Certain other embodiments measure the battery voltage and adjust a heater duty cycle according to the measured voltage. | 05-14-2015 |
Mark Williams, Victoria AU
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20130189437 | SPRAY PAINTING - An apparatus for the application of paint to an article ( | 07-25-2013 |
Mark Williams, Beaufort, SC US
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20130264494 | ARRANGEMENT OF RETICLE POSITIONING DEVICE FOR ACTINIC INSPECTION OF EUV RETICLES - A reticle positioning apparatus for actinic EUV reticle inspection including a sealed inspection chamber containing a reticle stage for holding a reticle. The reticle stage has a. magnetically suspended upper stage with a long travel in a “y” direction and a magnetically suspended lower stage with a long travel in an “x” direction; and a cable stage chamber isolated from the inspection chamber by a cable chamber wall. The cable stage chamber has a cable stage movable in the “y” direction; and a tube connected at one end to the reticle stage and to the cable stage at the other end, The tube passes from the cable stage through the inspection chamber through a seal in the chamber wail and opening into the cable entry chamber for entry of cables and hoses within the cable stage chamber, which cables and hoses pass through the tube to the reticle stage. | 10-10-2013 |
20130293865 | Linear Stage for Reflective Electron Beam Lithography - A linear stacked stage suitable for REBL may include a first upper fast stage configured to translate a first plurality of wafers in a first direction along a first axis, the first upper fast stage configured to secure a first plurality of wafers; a second upper fast stage configured to translate a second plurality of wafers in a second direction along the first axis, the second upper fast stage configured to secure the second plurality of wafers, the second direction opposite to the first direction, wherein the translation of the first upper fast stage and the translation of the second upper fast stage are configured to substantially eliminate inertial reaction forces generated by motion of the first upper fast stage and the second upper fast stage; and a carrier stage configured to translate the first and second upper fast stages along a second axis. | 11-07-2013 |
20130342827 | Linear Stage and Metrology Architecture for Reflective Electron Beam Lithography - A stage metrology suitable for REBL includes an interferometer stage metrology system configured to measure the position and rotation of a short-stroke wafer scanning stage, wherein the interferometer metrology system includes two or more interferometers for each axis of measurement, wherein a first interferometer mirror is disposed on a first surface of the short-stroke wafer scanning stage and a second interferometer mirror is disposed on a second surface of the short-stroke wafer scanning stage, and a control system configured to determine a shape error for the first interferometer mirror using two or more interferometer measurements from the two or more interferometers associated with the first interferometer mirror and a shape error for the second interferometer mirror using two or more interferometer measurements from the two or more interferometers associated with the second interferometer mirror. | 12-26-2013 |
Mark Williams, Norwalk, CT US
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20130311354 | PRODUCT LEASING SYSTEM AND METHOD - A computerized system and method for leasing products includes defining a lease of an item, for example, an electronics product. The system includes a computer database that tracks product and service items, the cost for leasing of the items, and the cost to provide updates for product items. The bundled products and services are leased at a predetermined rate calculated using the database of the computerized system. At the option of the lessee, each product may be upgraded to a newer version of the original product in the same product class. The rate does not change over the course of the lease term. In the disclosed embodiment, the upgrade product is not identified in the lease because it is not available for sale or lease at the start of the lease term. | 11-21-2013 |
Mark Williams, Plymouth, MN US
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20130323222 | HUMAN TISSUE KALLIKREIN 1 GLYCOSYLATION ISOFORMS - Provided are preparations of tissue kallikrein-1 (KLK1) glycoforms having a defined number of oligosaccharide units per KLK1 molecule. Also provided are mixtures of such glycoforms, pharmaceutical compositions containing such glycoforms or mixtures thereof, methods of obtaining the rhKLK1 glycoforms, and therapeutic uses thereof | 12-05-2013 |
20150196624 | HUMAN TISSUE KALLIKREIN 1 GLYCOSYLATION ISOFORMS - Provided are preparations of tissue kallikrein-1 (KLK1) glycoforms having a defined number of oligosaccharide units per KLK1 molecule. Also provided are mixtures of such glycoforms, pharmaceutical compositions containing such glycoforms or mixtures thereof, methods of obtaining the rhKLK1 glycoforms, and therapeutic uses thereof. | 07-16-2015 |
Mark Williams, Genoa, NV US
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20130341352 | System for Dispensing Sprayable Material - A system for dispensing sprayable material such as paint and other liquefied products. The system includes a dispenser designed to accept a flexible, crushable container filled with sprayable material and having a valve and spray tip at one end. The container is placed into an interior portion in the dispenser with the valve on the container secured in the housing of the dispenser. In operation, a pump action lever is activated causing a piston to slide lengthwise in the housing of the dispenser and exert force on the bottom of the container crushing it as it is emptied and forcing the sprayable material out through the valve and spray tip. | 12-26-2013 |
20150053717 | System and Method for Dispensing Sprayable Material - A system and method for dispensing sprayable material such as paint and other liquefied products. The system includes a dispenser such as a marking stick or other commercially available dispenser. The dispenser is configured to accept a container housed inside a cartridge and filled with sprayable material. The sprayable material is sprayed through a valve and spray tip at one end of the cartridge. An electrically powered motor assembly is removably coupled to the cartridge. The motor is used to power a pump that is incorporated in the cartridge to draw the sprayable material from the container. The material is pumped from the container and delivered through a tube to a spray head. The pressure generated by the pump inside the container and the tube are sufficient to spray the product through the valve and spray tip when valve is opened. | 02-26-2015 |
Mark Williams, Edmonton CA
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20140217346 | SUPPORT FOR A ROOF HATCH RAIL - A support for a railing of a roof hatch having a coaming has an angle body with a first elongate member and a second elongate members that is perpendicular to the first elongate member. First and second brackets extend inward from the first and second elongate members, respectively. Each bracket has a coaming-receiving portion that is sized and shaped to directly engage the inner surface, upper surface and outer surface of the hatch coaming, and a flashing covering portion that is sized and shaped to receive the flashing. The bracket engages the coaming such that the angle body is supported laterally adjacent to the flashing of the coaming. One or more post supports connected to and extending outward from angle body. | 08-07-2014 |
Mark Williams, Brighton, MI US
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20140232145 | Assembly Comprising A Motor Vehicle Front Surface Frame Element And A Bracket Intended To Support An Actuator - An assembly comprises a framework, which is intended to be located on the front face of a motor vehicle, and a bracket. The assembly includes a means for positioning the bracket on the framework and the bracket includes a securing means for supporting an actuator that is capable of driving one or more members to be mounted onto the framework. | 08-21-2014 |
Mark Williams, Thousand Oaks, CA US
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20140260956 | CIRCUMFERENTIAL SEALING OF PISTON ASSEMBLY IN A PISTON ACTUATOR - Methods, apparatuses, and systems for circumferential sealing of piston assembly in a piston actuator. A piston assembly for a piston actuator includes a piston including an extending surface, a retracting surface, and a circumferential surface that connects the extending surface and the retracting surface. The piston is adapted to engage and seal against an interior surface of a cylinder bore of an actuator. The piston assembly includes a first unidirectional passage connecting the extending surface and the circumferential surface. The first unidirectional passage allows hydraulic fluid to flow unidirectionally from the extending surface to the circumferential surface through the piston to energize a circumferential seal disposed on a seal groove in the circumferential surface during an extension stroke of the piston | 09-18-2014 |
Mark Williams, Aberdeen GB
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20150175877 | ENVIRONMENTALLY ACCEPTABLE MULTIFUNCTIONAL ADDITIVE - A method of treating a subterranean formation penetrated by a wellbore, the method including the introduction a treatment fluid comprising an aqueous fluid composition comprising an aldehyde releasing compound. | 06-25-2015 |
Mark Williams, Tooele, UT US
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20150362155 | Rugged Lighting System - A new and innovative, rugged lighting system is provided. The problem of achieving a lighting system that optimizes ruggedness, luminosity, energy and thermal efficiency, versatility, and unbundling of key components is solved. Embodiments of the present invention include a rugged lighting system comprising a housing unit with a body with integrally formed back, sides, and a front with an opening to provide access to the interior of the housing unit; a first lens configured to substantially cover the opening; a first lens bezel configured to removeably attach to the housing unit over the first lens; a second lens configured for placement over the first lens; and a second lens bezel configured to removeably attach to the housing unit over the first lens bezel. Various embodiments further include a light module within the housing unit with a light emitting diode (LED) mounted to an electronics module having a printed circuit board for operating the LED. | 12-17-2015 |
Mark Williams, Gaines, MI US
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20160138525 | EGR DEVICE IN INTAKE MANIFOLD - A housing has an outer pipe, an inner pipe, and an EGR inlet. The inner pipe is located inside the outer pipe. The inner pipe defines an inner passage internally. The inner pipe defines an annular passage externally with the outer pipe. The EGR inlet defines an EGR channel therein to communicate with the annular passage. The inner pipe has an end surface defining a throttle passage extending circumferentially. The throttle passage communicates the annular passage with the inner passage radially inward. The throttle passage is narrow on a side of the EGR channel and is wide on an opposite side of the EGR channel. | 05-19-2016 |