Rossmeisl
Charlotte C. Rossmeisl, Lynge DK
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20150273027 | LIQUID PHARMACEUTICAL COMPOSITION OF FACTOR VII POLYPEPTIDE - The invention relates to a liquid, aqueous pharmaceutical composition comprising a Factor VIIa polypeptide, a buffering agent suitable for keeping pH in the range of from about 5.5 to about 8.5; and an active site stabilizing agent, which is selected from the group of: (S)-2-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2′-dihydroxy-5′-sulfamoyl-biphenyl-3-yl]acetylamino}-succinic acid or a pharmaceutically acceptable salt thereof; (R)-2-{2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2′-dihydroxy-5′-sulfamoyl-biphenyl-3-yl]acetylamino}-succinic acid or a pharmaceutically acceptable salt thereof; and a mixture of the (S)- and (R)-forms or pharmaceutically acceptable salts thereof. The invention further relates to said composition for treatment of a Factor VII-responsive bleeding disorder; methods for preparing the liquid composition and for stabilizing Factor VIIa in a liquid aqueous composition; an air-tight container containing the liquid, aqueous pharmaceutical composition and optionally an inert gas; and a method of treating a Factor VII-responsive bleeding disorder in a patent. | 10-01-2015 |
Jan Rossmeisl, Vedbaek DK
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20120214083 | PLATINUM AND PALLADIUM ALLOYS SUITABLE AS FUEL CELL ELECTRODES - The present invention concerns electrode catalysts used in fuel cells, such as proton exchange membrane (PEM) fuel cells. The invention is related to the reduction of the noble metal content and the improvement of the catalytic efficiency by low level substitution of the noble metal to provide new and innovative catalyst compositions in fuel cell electrodes. The novel electrode catalysts of the invention comprise a noble metal selected from Pt, Pd and mixtures thereof alloyed with a further element selected from Sc, Y and La as well as any mixtures thereof, wherein said alloy is supported on a conductive support material. | 08-23-2012 |
Jan Rossmeisl, Lynge DK
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20150295249 | PLATINUM AND PALLADIUM ALLOYS SUITABLE AS FUEL CELL ELECTRODES - The present invention concerns electrode catalysts used in fuel cells, such as proton exchange membrane (PEM) fuel cells. The invention is related to the reduction of the noble metal content and the improvement of the catalytic efficiency by low level substitution of the noble metal to provide new and innovative catalyst compositions in fuel cell electrodes. The novel electrode catalysts of the invention comprise a noble metal selected from Pt and Pd alloyed with an alkaline earth metal. | 10-15-2015 |
John H. Rossmeisl, Blacksburg, VA US
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20100030211 | IRREVERSIBLE ELECTROPORATION TO TREAT ABERRANT CELL MASSES - The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. | 02-04-2010 |
20110106221 | TREATMENT PLANNING FOR ELECTROPORATION-BASED THERAPIES - The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue. | 05-05-2011 |
20140039489 | ACUTE BLOOD-BRAIN BARRIER DISRUPTION USING ELECTRICAL ENERGY BASED THERAPY - A method is provided for ablating brain tissue of a living mammal comprising: placing first and second electrodes in a brain of the living mammal; applying a plurality of electrical pulses through the first and second placed electrodes which are predetermined to: cause irreversible electroporation (IRE) of brain tissue of the mammal within a target ablation zone; and cause a temporary disruption of a blood brain barrier (BBB) within a surrounding zone that surrounds the target ablation zone to allow material in a blood vessel to be transferred to the surrounding zone through the temporarily disrupted BBB. Such methods are useful for delivering large molecule material within a blood vessel of the brain across the BBB, where the large molecule is otherwise blocked by the BBB from passing through the blood vessel into the brain. | 02-06-2014 |
John H. Rossmeisl, Floyd, VA US
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20130338627 | FIBER ARRAY FOR OPTICAL IMAGING AND THERAPEUTICS - The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface. Embodiments of the invention enable depth-selective and deep photothermal therapeutics and include methods of treating cancer, methods of re-shaping or removing adipose tissue, and methods of delivering drugs or co-delivering drugs and energy to selected tissue. | 12-19-2013 |
Mark E. Rossmeisl, Franklin, MA US
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20080223233 | Methods and apparatus for engaging web-material cores - A stencil printer apparatus is provided. The stencil printer apparatus may include a stencil, a material applicator to apply material on the stencil, a supply roller configured to receive a roll of web-material, the supply roller comprising a first shaft, a take-up roller to receive used web-material, the take-up roller comprising a second shaft, at least one spring-loaded protrusion element associated with one of the first shaft and the second shaft, and a drive configured to move web-material across the stencil between the supply roller and the take-up roller, and a frame to support the supply roller, the take-up roller and the drive. The at least one spring-loaded protrusion element may be configured and arranged on the at least one of the first shaft and the second shaft to resiliently engage at least one web-material core around which web-material may be disposed. Other embodiments and methods are provided. | 09-18-2008 |
Martin Rossmeisl, Prague CZ
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20100081694 | COMPOSITION COMPRISING AT LEAST ONE PPAR AGONIST AND A LIPID COMPONENT - The present invention relates to compositions comprising at least one peroxisome proliferator-activated receptor (PPAR) agonist and a lipid component and to pharmaceutical ingredients comprising said ingredients. Such compositions are particularly suitable for the prophylaxis and/or the treatment of diseases such as diabetes, obesity and hypertriglyceridemia. | 04-01-2010 |