Patent application number | Description | Published |
20100318134 | SYSTEM AND METHOD FOR PERFORMING PERCUTANEOUS SPINAL INTERBODY FUSION - A method of performing percutaneous interbody spinal fusion on adjacent vertebrae in a patient including the steps of: creating an access opening on the patient, the access opening being less than 10 mm wide, using indirect visualization: establishing a surgical path through the access opening via neural monitoring, creating a cavity in a disc space between the adjacent vertebra, evaluating the created cavity, inserting a container sized and configured to fit through the less than 10 mm access opening into the cavity and filling the container with fill material. | 12-16-2010 |
20120116515 | DEMINERALIZED CORTICAL BONE IMPLANTS - Implants comprising a plurality of separate cortical bone units, which have been at least partially demineralized and are osteoinductive, are described herein. The implants can be used in methods for treating bone. Also, disclosed are methods for treating spinal conditions using these implants. The spinal conditions include but are not limited to repairing damage to or defects in the spine, such as fractures in a vertebral body or degeneration of spinal discs. | 05-10-2012 |
20130035691 | SURGICAL BRUSH - A stainless steel bristled surgical brush for removing nucleus material from the intervertebral space and cartilage from vertebral endplates is provided herein. The surgical brush of the present invention may be dimensioned to be placed through a minimally invasive and/or percutaneous access through an access portal. In certain embodiments, the surgical brush may be straight or bent, may include a cap to contain the tines and may include a depth stop. The brush may be manually operated, powered by a wire driver or powered by other suitable means. | 02-07-2013 |
20130218278 | DEVICE AND METHOD FOR PERFORMING SPINAL INTERBODY FUSION - A system, device and method for performing a spinal interbody fusion is disclosed. The spinal fusion device may include a container that is placed in a prepared intervertebral cavity and then filled with a plurality of individual pieces or beads of PEEK or other biocompatible non-biologic material to provide mechanical support between the adjacent vertebra, and to distract the adjacent vertebrae and promote fusion. | 08-22-2013 |
20140031939 | MESH SPACER HYBRID - A modular implant for performing an intervertebral fusion on adjacent vertebral bodies in a patient including a first spacer portion, a second spacer and a container having a first end and a second end, the first end of the container constructed to operably engage a first spacer and the second end of the container constructed to operably engage the second spacer. | 01-30-2014 |
20150094811 | SYSTEM AND METHOD FOR PERFORMING PERCUTANEOUS SPINAL INTERBODY FUSION - A method of performing percutaneous interbody spinal fusion on adjacent vertebrae in a patient including the steps of: creating a percutaneous access opening on the patient, using indirect visualization to establish a surgical path through the access opening via neural monitoring, creating a cavity in a disc space between the adjacent vertebra, without retraction, evaluating the created cavity, inserting a container sized and configured to fit through the access opening into the cavity and filling the container with fill material. | 04-02-2015 |
Patent application number | Description | Published |
20090222547 | Generating Displays of Networking Addresses - Technologies for generating displays of user-defined blocks of networking addresses on a map of an associated address space are provided. Each block of networking addresses is described in a user-defined table with a start address and a map size. The display for each block of network addresses may be rendered on the map at a location based on the relative position of the start address within the associated address space and of a size based on the mask size in relation to the associated address space. | 09-03-2009 |
20090248897 | Controlling The Status Of Network Address Space - Methods, computer systems, and computer readable media provide for automated control of the status of network address space. Blocks of networking address space assigned to a network may be allocated from a free status to a new status based upon a request to allocate a particular size block. Blocks of networking address space assigned to a network that have been allocated to a new status may be deallocated to return to a free status based upon a request to deallocate the chosen block. Blocks of networking address space assigned to a network that have been allocated and otherwise manipulated such as through a lend from another network may be reclaimed for the original network upon a request to reclaim the chosen block. | 10-01-2009 |
20110282984 | Generating Displays of Networking Addresses - Technologies for generating displays of user-defined blocks of networking addresses on a map of an associated address space are provided. Each block of networking addresses is described in a user-defined table with a start address and a map size. The display for each block of network addresses may be rendered on the map at a location based on the relative position of the start address within the associated address space and of a size based on the mask size in relation to the associated address space. | 11-17-2011 |
20140372629 | Controlling the Status of Network Address Space - Methods, computer systems, and computer readable media provide for automated control of the status of network address space. Blocks of networking address space assigned to a network may be allocated from a free status to a new status based upon a request to allocate a particular size block. Blocks of networking address space assigned to a network that have been allocated to a new status may be deallocated to return to a free status based upon a request to deallocate the chosen block. Blocks of networking address space assigned to a network that have been allocated and otherwise manipulated such as through a lend from another network may be reclaimed for the original network upon a request to reclaim the chosen block. | 12-18-2014 |
Patent application number | Description | Published |
20090181944 | METHOD FOR CANCER THERAPY - The present invention provides a method for treating a patient having cancer comprising administering to the patient a therapeutically effective amount of compound (1), or a pharmaceutically acceptable salt thereof, having the formula: | 07-16-2009 |
20110112176 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF KIF10 GENES - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a KIF10 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a KIF10 gene using said pharmaceutical composition; and methods for inhibiting the expression of KIF10 in a cell. | 05-12-2011 |
20110287025 | COMBINATION THERAPY AND METHOD FOR ASSESSING RESISTANCE TO TREATMENT - The present invention relates to a method for determining a subject's resistance to treatment with 2,2-dimethyl-N—((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide by measuring the levels a biomarker or biomarkers present in a biological sample obtained from the subject, the biomarker being IL6 and/or IL8. The present invention also relates to a combination therapy for a patient suffering from a proliferative disorder comprising administering to the patient 2,2-Dimethyl-N—((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide and an anti-IL6 and/or an anti-IL8 agent. | 11-24-2011 |
20120159657 | Compositions and Methods for Inhibiting Expression of RRM2 Genes - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell. | 06-21-2012 |
20120225860 | METHOD FOR ADMINISTRATION OF A GAMMA SECRETASE INHIBITOR - There are provided a new dosage regimens for the gamma secretase inhibitor 2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N′-(2,2,3,3,3-pentafluoro-propyl)-malonamide which maximizes anti-tumor activity while maintaining acceptable toxicity levels. | 09-06-2012 |
20130072543 | Compounds and Compositions for Nucleic Acid Formulation and Delivery - The invention relates to compositions containing compounds of formula I: | 03-21-2013 |
20130079383 | Lipid Compounds Targeting VLA-4 - The invention relates to the compounds of formula I: | 03-28-2013 |
20140357620 | METHOD FOR ADMINISTRATION OF A GAMMA SECRETASE INHIBITOR - There are provided a new dosage regimens for the gamma secretase inhibitor 2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N-(2,2,3,3,3-pentafluoro-propyl)-malonamide which maximizes anti-tumor activity while maintaining acceptable toxicity levels. | 12-04-2014 |
20150113670 | Compositions and Methods for Inhibiting Expression of RRM2 Genes - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell. | 04-23-2015 |
20160096841 | SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH - Provided herein are Aminopurine Compounds having the following structures: | 04-07-2016 |
Patent application number | Description | Published |
20120028527 | Ultra Low Formaldehyde Binders for Nonwoven Substrates - A low-formaldehyde binder composition for increasing wet and dry tensile strength of a nonwoven substrate includes:
| 02-02-2012 |
20120214007 | Paper Coating Compositions - A composition for coating paper includes at least one pigment selected from the group consisting of polymeric pigments, aluminosilicates, calcium carbonate, titanium dioxide, talc, barium sulfate, zinc oxide, aluminum trihydrate, amorphous silica and silicates;
| 08-23-2012 |
20130149927 | LOW FORMALDEHYDE AND HIGH WET STRENGTH VINYL ACETATE ETHYLENE COPOLYMER AND VINYL ACETATE POLYMER DISPERSIONS - An aqueous composition includes polyvinyl alcohol, an acid having a pKa of at most 4.0, and a dispersion of a polymer in which vinyl acetate units constitute at least 60 wt % of the polymer. The polymer does not contain units of any N-methylol-containing monomer, and at least a portion of the polyvinyl alcohol is present in the form of an emulsion stabilizer for the polymer. The wet strength of a fibrous nonwoven substrate can be increased by applying one or more aqueous compositions that together include polyvinyl alcohol, an acid having a pKa of at most 4.0, and a dispersion of a polymer as described above, followed by a final drying step. A fibrous nonwoven article can be prepared in this way. | 06-13-2013 |
20130149928 | LOW FORMALDEHYDE AND HIGH WET STRENGTH POLYMER BINDER - An aqueous composition includes a blend of:
| 06-13-2013 |
20130149929 | LOW FORMALDEHYDE AND HIGH WET STRENTGH VINYL ACETATE ETHYLENE DISPERSIONS - An aqueous composition includes a blend of:
| 06-13-2013 |
Patent application number | Description | Published |
20110008604 | HARD NON-OXIDE OR OXIDE CERAMIC / HARD NON-OXIDE OR OXIDE CERAMIC COMPOSITE HYBRID ARTICLE - Embodiments of the invention include a hybrid article comprising at least one hard non-oxide or oxide ceramic component of at least 95% of theoretical density directly bonded to, and different from, a hard non-oxide or oxide ceramic composite component comprising a tribology enhancing component. The at least one hard non-oxide or oxide ceramic component comprises a member of the group consisting of silicon carbide, pressureless sintered silicon carbide, liquid phase sintered silicon carbide, reaction bonded silicon carbide, tungsten carbide, aluminum oxide, and silicon nitride. The at least one hard non-oxide or oxide ceramic composite component comprises a member of the group consisting of silicon carbide, pressureless sintered silicon carbide, liquid phase sintered silicon carbide, reaction bonded silicon carbide, tungsten carbide, aluminum oxide, and silicon nitride. In some embodiments, the hybrid article is formed by preparing at least one hard non-oxide or oxide ceramic body of at least 95% of theoretical density, preparing at least one hard non-oxide or oxide ceramic composite body comprising a tribology enhancing component, placing the bodies into contact with one another to form a hybrid article, and treating the hybrid article to directly bond the bodies. In some embodiments, treating the hybrid article may include hot isostatic pressing, pressureless sintering, liquid phase sintering, or reaction bonding. | 01-13-2011 |
Patent application number | Description | Published |
20140329913 | NANOPARTICLES WITH ENHANCED MUCOSAL PENETRATION OR DECREASED INFLAMMATION - Nanoparticles formed by emulsion of one or more core polymers, one or more surface altering materials, and one or more low molecular weight emulsifiers have been developed. The particles are made by dissolving the one or more core polymers in an organic solvent, adding the solution of the one or more core polymers to an aqueous solution or suspension of the emulsifier to form an emulsion, and then adding the emulsion to a second solution or suspension of the emulsifier to effect formation of the nanoparticles. In the preferred embodiment, the molecular weight of the emulsifiers is less than 1500, 1300, 1200, 1000, 800, 600, or 500 amu. Preferred emulsifiers include cholic acid sodium salt, dioctyl sulfosuccinate sodium, hexadecyltrimethyl ammonium bromide, saponin, TWEEN® 20, TWEEN® 80, and sugar esters. The surface altering materials are present in an amount effective to make the surface charge of the particles neutral or essentially neutral when the one or more emulsifiers are charged. The emulsifiers have an emulsification capacity of at least about 50%, preferably at least 55, 60, 65, 70, 75, 80, 85, 90, or 95%. | 11-06-2014 |
Patent application number | Description | Published |
20100228561 | COMPUTER METHOD AND SYSTEM FOR PROMOTING HEALTH, WELLNESS, AND FITNESS WITH MULTIPLE SPONSORS - Disclosed is an improved automated system and corresponding computer method of promoting and maintaining health, wellness, and fitness. Multiple sponsors per member participant are enabled. Each sponsor defines respective qualifying healthy behavior (activities, purchases, other) and reward rate for each such activity and purchase. A rewards engine operates on member accounts adding units per member completion of qualifying healthy activities or purchases, thereby encouraging members to adopt healthy habits. This, in turn, leads to better health, wellness, and fitness for the subject members. The combination of different and multiple sponsors having different qualifying activities/purchases provides increased member incentive. | 09-09-2010 |
20130117041 | COMPUTER METHOD AND SYSTEM FOR PROMOTING HEALTH, WELLNESS, AND FITNESS WITH MULTIPLE SPONSORS - Disclosed is an improved automated system and corresponding computer method of promoting and maintaining health, wellness, and fitness. Multiple sponsors per member participant are enabled. Each sponsor defines respective qualifying healthy behavior (activities, purchases, other) and reward rate for each such activity and purchase. A rewards engine operates on member accounts adding units per member completion of qualifying healthy activities or purchases, thereby encouraging members to adopt healthy habits. This, in turn, leads to better health, wellness, and fitness for the subject members. The combination of different and multiple sponsors having different qualifying activities/purchases provides increased member incentive. | 05-09-2013 |