Lim, MA
Ai Ching Lim, Newton, MA US
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20080220049 | Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins - The present disclosure relates to novel sustained-release intraocular drug delivery systems and improvements in the treatment of retinopathies. In particular, fibronectin scaffold domain proteins that selectively inhibit VEGFR-2 are contemplated. | 09-11-2008 |
20100310549 | INHIBITORS OF TYPE 2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS - The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides. | 12-09-2010 |
20120283184 | INHIBITORS OF TYPE 2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS - The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides. | 11-08-2012 |
Bing Lim, Boston, MA US
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20090028835 | HUMAN TRANSCRIPTOME CORRESPONDING TO HUMAN OOCYTES AND USE OF SAID GENES OR THE CORRESPONDING POLYPEPTIDES TO TRANS-DIFFERENTIATE SOMATIC CELLS - The identification of 101 genes upregulated or differentially expressed by mature human oocytes is provided herein. These genes and the corresponding gene products will facilitate a greater understanding of oogenesis, folliculogenesis, fertilization, and embryonic development. In addition these genes and the corresponding gene products can be used to effect dedifferentiation and/or transdifferentiation of desired somatic cells. The resultant dedifferentiated cells and somatic cells derived therefrom can be used in cell therapies such as in the treatment of cancer, autoimmunity, and other diseases wherein specific types of cells such as hematopoietic cells may be depleted because of the underlying disease or the treatment of the disease. | 01-29-2009 |
Booyong S. Lim, Lexington, MA US
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20090291208 | ATOMIC LAYER DEPOSITION USING METAL AMIDINATES - Metal films are deposited with uniform thickness and excellent step coverage. Copper metal films were deposited on heated substrates by the reaction of alternating doses of copper(I) NN′-diispropylacetamidinate vapor and hydrogen gas. Cobalt metal films were deposited on heated substrates b the reaction of alternating doses of cobalt(II) bis(N,N′-diispropylacetamidinate) vapor and hydrogen gas. Nitrides and oxides of these metals can be formed by replacing the hydrogen with ammonia or water vapor, respectively. The films have very uniform thickness and excellent step coverage in narrow holes. Suitable applications include electrical interconnects in microelectronics and magnetoresistant layers in magnetic information storage devices. | 11-26-2009 |
20100092667 | ATOMIC LAYER DEPOSITION USING METAL AMIDINATES - Metal films are deposited with uniform thickness and excellent step coverage. Copper metal films were deposited on heated substrates by the reaction of alternating doses of copper(I) NN′-diispropylacetamidinate vapor and hydrogen gas. Cobalt metal films were deposited on heated substrates b the reaction of alternating doses of cobalt(II) bis(N,N′-diispropylacetamidinate) vapor and hydrogen gas. Nitrides and oxides of these metals can be formed by replacing the hydrogen with ammonia or water vapor, respectively. The films have very uniform thickness and excellent step coverage in narrow holes. Suitable applications include electrical interconnects in microelectronics and magnetoresistant layers in magnetic information storage devices. | 04-15-2010 |
Caeul Lim, Boston, MA US
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20160124001 | Multiple Phase Systems and Kits - Multi-phase systems and kits using these multiphase systems are described. The Multi-phase system described herein comprises multiple phase-separated phases each comprises a phase component and the phases, taken together, represent a density gradient. The kit comprising the multiphase system as described herein may be used to separate biological analytes such as cells. Non-limiting examples of the biological analytes include normal erythrocyte with hemoglobin Hb AA, Hb CC, and Hb AS, sickle cell erythrocyte with hemoglobin Hb SS and Hb SC, reticulocyte, iron deficiency anemia red blood cell, β-thalessemia trait red blood cell, and normal red blood cell. | 05-05-2016 |
Daniel Lim, Cambridge, MA US
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20090181468 | Methods and compositions for treating cellular proliferative diseases - The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, screening assays for identifying such compounds, and methods for treating such disorders. | 07-16-2009 |
Daniel Lim, Arlington, MA US
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20080285040 | Electrical Detection of Plasmon Resonances - A method includes detecting a plasmon resonance in a material based on a change in at least one electrical property of the material. For example, the material can be a sensor portion of an electrical circuit, wherein the method can further include: exposing the sensor portion to a test material; optically illuminating the sensor portion when the test material is present, and monitoring the change in the at least one electrical property of the sensor portion in response to the optical illumination. The monitored changed in the at least one electrical property of the sensor portion can provide information about the test material, such as the presence or absence of selected analytes and/or their binding affinities. In another example, the material is a part of a receiver for a plasmonic circuit. An apparatus for carrying out the method is also disclosed. | 11-20-2008 |
Daryl Lim, Boston, MA US
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20150374210 | PHOTOMETRIC STEREO ENDOSCOPY - The present invention relates to systems and methods for photometric endoscope imaging. The methods can further include chromoendoscopy and computer aided detection procedures for the imaging of body lumens and cavities. | 12-31-2015 |
Daryl Lim, Brookline, MA US
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20110109736 | System and Method for Producing an Optically Sectioned Image Using Both Structured and Uniform Illumination - A first image data set of the real-world object is received at a processor where the real-world object was illuminated with substantially uniform illumination. A second image data set of the real-world object is received at the processor where the real-world object was illuminated with substantially structured illumination. A high pass filter is applied to the first-image data set to remove out-of-focus content and retrieve high-frequency in-focus content. The local contrast of the second-image data set is determined producing a low resolution local contrast data set. The local contrast provides a low resolution estimate of the in-focus content in the first-image data set. A low pass filter is applied to the estimated low resolution in-focus data set, thus making its frequency information complementary to the high-frequency in-focus data set. The low and high frequency in-focus data sets are combined to produce an optically-sectioned data set of the real-world object. | 05-12-2011 |
Jae S. Lim, Winchester, MA US
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20100165152 | Processing Images Having Different Focus - Processing images of a scene taken with different focus includes, for each of at least some of the images, determining at least one portion of the image having a predetermined characteristic. A representation of the scene is generated that includes an array of elements, where each of at least some of the elements corresponds to a determined portion of at least one of the images. An element of the array is based on a correspondence between a distance associated with a determined portion of at least one image and a focused distance associated with at least one image. The generated representation is stored or provided as output. | 07-01-2010 |
20100290520 | SELECTING TRANSFORMS FOR COMPRESSING VISUAL DATA - Encoding data includes: computing a first set of coefficients based on a plurality of transforms each computed over a different portion of an array of data, and a second set of coefficients based on a transform computed over the array of data; choosing a set of coefficients to represent the array of data from a group of multiple sets of coefficients, the group including the first set of coefficients and the second set of coefficients; and encoding the chosen coefficients and one or more parameters related to the chosen coefficients. | 11-18-2010 |
20110286525 | Selecting Transforms for Compressing Visual Data - Encoding data includes: computing a first set of coefficients based on a plurality of transforms each computed over a different portion of an array of data, a second set of coefficients based on a plurality of transforms each computed over a different portion of the array of data, and a third set of coefficients based on a transform computed over the array of data; choosing a set of coefficients to represent the array of data from a group of multiple sets of coefficients, the group including the first set of coefficients, the second set of coefficients, and the third set of coefficients; and encoding the chosen coefficients and one or more parameters related to the chosen coefficients. | 11-24-2011 |
20130169845 | PROCESSING IMAGES HAVING DIFFERENT FOCUS - Processing images of a scene taken with different focus includes, for each of at least some of the images, determining at least one portion of the image having a predetermined characteristic. A representation of the scene is generated that includes an array of elements, where each of at least some of the elements corresponds to a determined portion of at least one of the images. An element of the array is based on a correspondence between a distance associated with a determined portion of at least one image and a focused distance associated with at least one image. The generated representation is stored or provided as output. | 07-04-2013 |
20140126650 | USING MULTIPLE TRANSFORM/SUBBAND REPRESENTATIONS FOR VIDEO ENCODING - A method of encoding a sequence of video frames, comprising receiving a sequence of video frames, encoding at least a first portion of the sequence of frames using the first type of transform/subband representation to produce first transform/subband coefficients, encoding at least a second portion of the sequence of frames using the second type of transform/subband representation to produce second transform/subband coefficients; and providing the first and second transform/subband coefficients at an output. | 05-08-2014 |
20140126832 | SELECTING TRANSFORM PATHS FOR COMPRESSING VISUAL DATA - Encoding data includes: determining multiple patterns for computing one-dimensional transforms over a first array of data elements. Each pattern includes multiple subsets of data elements of the first array. Each subset included in a first pattern has substantially the same number of data elements as each of the other subsets included in the first pattern. Each data element of the first array is included in a single one of the subsets included in the first pattern. At least one subset included in the first pattern consists of data elements that are not in a contiguous sequence along a single dimension. Encoding the data includes: computing, for each pattern, multiple one-dimensional transforms over data elements of respective subsets included in the pattern; selecting a set of transform coefficients from a group of multiple sets of transform coefficients; and encoding the selected set of transform coefficients to represent the first array. | 05-08-2014 |
20150381993 | MANAGING TRANSFORMS FOR COMPRESSING AND DECOMPRESSING VISUAL DATA - Encoding data includes: encoding a first portion of an array of data to generate a first set of coefficients, using a first transform; decoding the first set of coefficients to generate a decoded approximation of the first portion, using the first transform; selecting a second transform from multiple candidate transforms based at least in part on a measure of encoding performance for each candidate transform used to encode the decoded approximation of the first portion; and encoding a second portion of the array of data in proximity to the first portion of the array of data to generate a second set of coefficients using the selected second transform. | 12-31-2015 |
Jeewoo Lim, Cambridge, MA US
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20120177578 | COMPOSITIONS, METHODS, AND SYSTEMS COMPRISING FLUOROUS-SOLUBLE POLYMERS - The present invention generally relates to compositions, methods, and systems comprising polymers that are fluorous-soluble and/or organize at interfaces between a fluorous phase and a non-fluorous phase. In some embodiments, emulsions or films are provided comprising a polymer. The polymers, emulsions, and films can be used in many applications, including for determining, treating, and/or imaging a condition and/or disease in a subject. The polymer may also be incorporated into various optoelectronic device such as photovoltaic cells, organic light-emitting diodes, organic field effect transistors, or the like. In some embodiments, the polymers comprise pi-conjugated backbones, and in some cases, are highly emissive. | 07-12-2012 |
Jinsoo Lim, Lexington, MA US
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20100324123 | GLMS RIBOSWITCHES, STRUCTURE-BASED COMPOUND DESIGN WITH GLMS RIBOSWITCHES, AND METHODS AND COMPOSITIONS FOR USE OF AND WITH GLMS RIBOSWITCHES - The glmS riboswitch is a target for antibiotics and other small molecule therapies. Compounds can be used to stimulate, active, inhibit and/or inactivate the glmS riboswitch. The atomic structures of the glmS riboswitch can be used to design new compounds to stimulate, active, inhibit and/or inactivate riboswitches. | 12-23-2010 |
Jong-Min Lim, Somerville, MA US
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20150174549 | HIGH-THROUGHPUT SYNTHESIS OF NANOPARTICLES - A simple and versatile coaxial turbulent jet mixer can synthesize a range of nanoparticles at high throughput, while maintaining the advantages of homogeneity, reproducibility, and tunability that are normally accessible only in specialized microscale mixing devices. Rapid mixing down to a timescale of 7 ms can be achieved by controlling the Reynolds number, providing homogeneous and controllable environments for formation of nanoparticles, for example, by precipitation. The device fabrication does not require specialized machining, making it accessible for a wide range of biomedical laboratories. | 06-25-2015 |
Jongwon Lim, Lexington, MA US
Patent application number | Description | Published |
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20090131423 | Tyrosine Kinase Inhibitors - The present invention relates to imidazo[1,2-a]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals. | 05-21-2009 |
20090197908 | Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met - The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals. | 08-06-2009 |
20090247565 | Tyrosine Kinase Inhibitors - The present invention relates to imidazo[1,2-a]pyrimidine derivatives, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals. | 10-01-2009 |
20090291941 | Tyrosine Kinase Inhibitors - The present invention relates to pyrido[3,2-c]benzazocinone derivatives and related compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals. | 11-26-2009 |
20100305091 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES - Compounds of the following formula (I) are inhibitors of microtubule affinity regulating kinase, and hence find use in the treatment of neurodegenerative diseases associated with hyperphosphorylation of tau. | 12-02-2010 |
20110245205 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 10-06-2011 |
20120010209 | IMIDAZO[1,2-A]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS - The invention encompasses imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included. | 01-12-2012 |
20120309735 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 12-06-2012 |
20130210838 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS - The invention encompasses pyrazolo[1,5-a]pyrimidine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included. | 08-15-2013 |
20140243290 | Aminopyrimidines as SYK Inhibitors - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 08-28-2014 |
20140296203 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1). | 10-02-2014 |
20140329799 | AMINOPYRIMIDINONES AS INTERLEUKIN RECEPTOR-ASSOCIATED KINASE INHIBITORS - This invention relates to aminopyrimidinone compounds of Formula (I) that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment or prevention of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease. | 11-06-2014 |
20150175575 | IMIDAZOLYL ANALOGS AS SYK INHIBITORS - The present invention provides novel imidazole analogs of Formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer. | 06-25-2015 |
20150191461 | PYRAZOLYL DERIVATIVES AS SYK INHIBITORS - The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer. | 07-09-2015 |
20150266895 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1). | 09-24-2015 |
20160068532 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (I) and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I). This invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of formula (I) and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition comprising an effective amount of at least one compound of formula (I) and an effective amount of at least one other pharmaceutically active ingredient (such as, for example, a chemotherapeutic agent), and a pharmaceutically acceptable carrier. This invention also provides a method of inhibiting ERK (i.e., inhibiting the activity of ERK2) in a patient in need of such treatment comprising administering to said patient an effective amount of at least one compound of formula (I). | 03-10-2016 |
Jongwon Lim, Lexintong, MA US
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20120277192 | AMINOPYRIMIDINES AS SYK INHIBITORS - The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis. | 11-01-2012 |
Jongwon Lim, Boston, MA US
Patent application number | Description | Published |
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20100267709 | INHIBITORS OF JANUS KINASES - The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2) and PDK1. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 TYK2 and PDK1 by administering the compound to a patient in need of treatment for myeloproliferative disorders or cancer. | 10-21-2010 |
20150266895 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS - Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1). | 09-24-2015 |
Joseph Jaewhan Lim, Cambridge, MA US
Patent application number | Description | Published |
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20140270489 | LEARNED MID-LEVEL REPRESENTATION FOR CONTOUR AND OBJECT DETECTION - Various technologies described herein pertain to constructing mid-level sketch tokens for use in tasks, such as object detection and contour detection. Sketch patches can be extracted from binary images that comprise hand-drawn contours. The hand-drawn contours in the binary images can correspond to contours in training images. The sketch patches can be clustered to form sketch token classes. Moreover, color patches from the training images can be extracted and low-level features of the color patches can be computed. Further, a classifier that labels mid-level sketch tokens can be trained. Such training of the classifier can be through supervised learning of a mapping from the low-level features of the color patches to the sketch token classes. | 09-18-2014 |
Junwoo Lim, Lynnfield, MA US
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20160061452 | CORRUGATED CYCLONE MIXER ASSEMBLY TO FACILITATE REDUCED NOX EMISSIONS AND IMPROVE OPERABILITY IN A COMBUSTOR SYSTEM - A corrugated cyclone mixer for use in a fuel injection assembly of a turbine engine. The corrugated cyclone mixer generally includes an annular housing including a flange portion and a lip portion configured downstream of the flange portion. The mixer further including a swirler disposed therein the annular housing for inducing a cyclonic motion in the corrugated cyclone mixer. The swirler is configured upstream of the flange portion and including a plurality of swirler vanes to produce a swirling air flow. The lip portion forming an outlet downstream of the swirler and including a plurality of corrugations at an aft end. The plurality of corrugations are configured to mix the swirling air flow and an injected fuel stream flowing therethrough the corrugated cyclone mixer. Additionally disclosed is a fuel injection assembly and a turbine assembly including the corrugated cyclone mixer. | 03-03-2016 |
Keng Hui Lim, Cambridge, MA US
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20110319877 | APPARATUS AND METHOD FOR LASER TREATMENT WITH SPECTROSCOPIC FEEDBACK - A platform Smart Scalpel system using rapid real-time feedback for effecting laser treatment. The platform system includes an imaging system for rapid real-time detection of tissue characteristics, a processing system for processing the detected characteristics, and a treatment system for effecting treatment in accordance with results of the processing. The platform system provides for preprogramming and real-time inputting conditions and parameters for diagnosis using the imaging system and/or treatment using the treatment system. | 12-29-2011 |
Koeun Lim, Somerville, MA US
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20150064670 | DATA COLLECTION FOR VESTIBULOGRAM CONSTRUCTION - The methods, systems, and computer program products described herein enable the amount of information that can be acquired during a defined period of vestibular testing to be significantly increased while also significantly reducing the time required to collect data during such vestibular testing. These objects are achieved by intelligent data collection methods and systems configured to adaptively control a motion platform in a way that increases the amount of information gleaned from each data collection event and to achieve synergies based on the different types of, and the order of data analysis and calibration methods used. | 03-05-2015 |
Michael Lim, Lexington, MA US
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20130017634 | WAVELENGTH CONVERTING LIGHT-EMITTING DEVICES AND METHODS OF MAKING THE SAME - Wavelength converting light-emitting devices and methods of making the same are provided. In some embodiments, the devices include a phosphor material region designed to convert the wavelength of emitted light. | 01-17-2013 |
20130146932 | LIGHT-EMITTING DIODE ARCHITECTURES FOR ENHANCED PERFORMANCE - The present invention relates to light-emitting diodes (LEDs), and related components, processes, systems, and methods. In certain embodiments, an LED that provides improved optical and thermal efficiency when used in optical systems with a non-rectangular input aperture (e.g., a circular aperture) is described. In some embodiments, the emission surface of the LED and/or an emitter output aperture can be shaped (e.g., in a non-rectangular shape) such that enhanced optical and thermal efficiencies are achieved. In addition, in some embodiments, chip designs and processes that may be employed in order to produce such devices are described. | 06-13-2013 |
20130175551 | Packaging Method and System for LEDs - A slim LED package configured to handle large current, having a narrow width, an LED chip mounting area positioned centro-symmetrically within the package, mounting holes positioned equidistantly from the mounting area, wherein multiple packages may be arranged with alternating anode and cathode ends in such a manner that a high-power density radiometric flux line may be created. Some embodiments include current density management areas positioned on one more sides of the LED chip mounting area. | 07-11-2013 |
Mi Hee Lim, Cambridge, MA US
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20090017552 | FLUORESCEIN BASED SENSORS FOR TRACKING NITRIC OXIDE IN LIVE CELLS - The present invention is directed, in part, to coordination complexes for detecting analytes, and methods of making and using the same. | 01-15-2009 |
Nicholas Lim, Arlington, MA US
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20110071962 | Method and system of using network graph properties to predict vertex behavior - Network graphs are determined using data about the vertices. Vertices are clustered into community of vertices based on maximizing the density of linkages within each community. Vertex properties describing the extent to which each vertex's community has exhibited a particular behavior are determined. Vertex properties describing whether the most important vertex in each community has exhibited a particular behavior are determined. Functions describing the relationship between these two categories of vertex properties and other relevant vertex properties, and a particular behavior are determined. These functions are used to predict the likelihood of each vertex exhibiting the particular behavior. | 03-24-2011 |
Seungbum Lim, Cambridge, MA US
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20150357912 | METHOD AND APPARATUS TO PROVIDE POWER CONVERSION WITH HIGH POWER FACTOR - A power converter circuit rectifies a line voltage and applies the rectified voltage to a stack of capacitors. Voltages on the capacitors are coupled to a plurality of regulating converters to be converted to regulated output signals. The regulated output signals are combined and converted to a desired DC output voltage of the power converter. Input currents of the regulating converters are modulated in a manner that enhances the power factor of the power converter. | 12-10-2015 |
Sung Keun Lim, Revere, MA US
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20110024723 | Nanoparticle synthesis - A noble metal nanoparticle can be grown on a semiconductor substrate by contacting a predetermined region of the substrate with a solution including noble metal ions. The predetermined region of the semiconductor substrate can be exposed by applying a polymeric layer over the substrate selectively removing a portion of the polymeric layer. The nanoparticles can be prepared in a predetermined pattern. The nanoparticle can be formed with a barrier separating it from another nanoparticle on the substrate; for example, nanoparticle can be located in a pit etched in the substrate. The size and location of the nanoparticle can be stable at elevated temperatures. | 02-03-2011 |
20130140524 | Nanoparticle Synthesis - A noble metal nanoparticle can be grown on a semiconductor substrate by contacting a predetermined region of the substrate with a solution including noble metal ions. The predetermined region of the semiconductor substrate can be exposed by applying a polymeric layer over the substrate selectively removing a portion of the polymeric layer. The nanoparticles can be prepared in a predetermined pattern. The nanoparticle can be formed with a barrier separating it from another nanoparticle on the substrate; for example, nanoparticle can be located in a pit etched in the substrate. The size and location of the nanoparticle can be stable at elevated temperatures. | 06-06-2013 |
Sungyung Lim, Acton, MA US
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20130193303 | MULTI-FUNCTIONAL STAR TRACKER WITH PRECISION FOCAL PLANE POSITION CONTROL FOR SMALL CUBESAT-CLASS SATELLITES - An optical system for use in an Earth-orbiting satellite includes a plurality of image sensors disposed on a focal plane having a reference axis orthogonal thereto, optics configured to focus incident light onto the image sensors, a piezoelectric actuator coupled to the image sensors and configured to translate the image sensors in at least two axes each orthogonal to the reference axis, and at least one controller operably coupled to the plurality of image sensors and the piezoelectric actuator. The image sensors are configured to generate at least one image frame from light detected by the plurality of image sensors, the image frame including a target star and at least one guide star. The controller is configured to stabilize the position of the target star by adjusting the position of the piezoelectric actuator based on the changes in the position of the guide star. | 08-01-2013 |
20150116155 | METHODS AND SYSTEMS FOR SELF-ALIGNING HIGH DATA RATE COMMUNICATION NETWORKS - A communication system is provided. The communication system includes a directional antenna, an antenna steering system to steer the directional antenna, a memory, and one or more processors coupled to the memory, the directional antenna, and the antenna steering system. The one or more processors are configured to identify a communication target and state information associated with the communication target, instruct the antenna steering system to steer the at least one directional antenna towards the communication target based on the state information, instruct the antenna steering system to perform a received power scan within a scan area to determine a maximum received power direction associated with a signal transmitted from the communication target, and track the maximum received power direction. | 04-30-2015 |
Wen Chen Lim, Worcester, MA US
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20130344084 | CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations. | 12-26-2013 |
20140161815 | CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations. | 06-12-2014 |
Wen Chung Lim, Worcester, MA US
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20150110799 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 04-23-2015 |
20150132801 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 05-14-2015 |
20150140006 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 05-21-2015 |
20150259410 | LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME - The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided. | 09-17-2015 |
20160039925 | CELL CULTURE METHODS TO REDUCE ACIDIC SPECIES - The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of acidic species expressed by host cells, as well as to compositions and processes for controlling the amount of acidic species present in purified preparations. | 02-11-2016 |
Wen-Chung Lim, Shrewsbury, MA US
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20120238730 | INTEGRATED APPROACH TO THE ISOLATION AND PURIFICATION OF ANTIBODIES - Disclosed herein is an integrated approach to purification process development and execution, including processes comprising particular capture and fine purification steps; processes that employ of a minimal number of buffer systems, and processes that make use of minimally-corrosive buffer systems, as well as combinations thereof. | 09-20-2012 |
Yi-Je Lim, Boxborough, MA US
Patent application number | Description | Published |
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20120283746 | Mobile Medical Robotic System - A medical robotic system comprises a drive track unit being operable for moving the medical robotic system along a floor. An upper torso unit is joined to the drive track unit. The upper torso unit comprises at least one actuator assembly. At least one bimanual dexterous manipulator is joined to the actuator assembly in which the actuator assembly imparts torque and movement to the bimanual dexterous manipulator for lifting an object. The bimanual dexterous manipulator comprises a pair of dexterous manipulators. Each of the dexterous manipulators comprises a length being configured to support lifting an adult patient, and an end comprising a planar structure being configured for placing between the adult patient and a patient platform. The drive track unit is operable for moving the medical robotic system to the patient platform and the bimanual dexterous manipulator is operable for lifting the adult patient from the patient platform. | 11-08-2012 |
20120283872 | System for Stabilization Control of Mobile Robotics - A system comprises a platform being configured for locomotion in a plurality of directions over a surface. A robotic unit is configured for dexterous manipulation comprising at least lifting of objects. The robotic unit is joined to the platform. At least one extender unit is joined to the platform and is configured for controlled extension beyond the platform to contact the surface to stabilize the system at least during the manipulation by the robotic unit. At least one controlling unit is configured to be operable for at least determining a center of gravity and a zero moment point for the system and for at least controlling an extension of the extender unit. | 11-08-2012 |
20140100491 | Lower Extremity Robotic Rehabilitation System - To achieve “ecological” robotic rehabilitation therapy, the present invention provides the system capacity of training of patients in different ambulatory tasks utilizing motorized footplates that guide the lower limbs according to human gait trajectories generated for different ambulatory tasks of interest. A lower extremity robotic rehabilitation system comprises an active pelvic/hip device which applies series elastic actuation to achieve an intrinsically safe and desirable impedance control. A robotic unit features the telepresence operation control that allows a patient stay at home or nursing home to continue his or her rehabilitation training under a physician's remote supervision and monitoring. The robot unit utilizes an affective patient-robot interface to capture emotional information of the patient, to allow for real-time adaptation of the robotic system and adjustments of treatment protocol, and to enhance the quality and effectiveness of rehabilitation | 04-10-2014 |
20140150806 | Robotic First Responder System and Method - A robotic first responder system provides injured patients with first response medical care and extracts the injured patient from a dangerous or remote area. After assessing of the level of consciousness of an injured patient, the robotic unit utilizes an inflatable immobilization device for safe robotic rescue of injured patients. The robotic unit lifts and transfers an injured patient to an extraction vehicle, a secure, bullet-proof wheeled system that can be pulled by the robot to safe location. The extraction vehicle continues serving as the evacuation stretcher to a medical station. The robotic unit utilizes zero moment point control to maintain stability while lifting the patient. A robot first responder tows the extraction vehicle or the extraction vehicle self-navigates incorporating with power drive and autonomous navigation systems. | 06-05-2014 |
20150182403 | A Mobile Robotic Lifting and Transferring System for Bariatric Patients - Obesity has grown into one of the world's most significant health problems. The field of bariatrics and the quantity of bariatric surgical procedures is projected to continue to increase rapidly each year. This trend presents a challenge to healthcare providers and facilities striving to provide dignified care that is effective and safe both for the patient and the provider. There is a great demand for new approaches to bariatric patient care. The present invention is a robotic patient lifting system, targeted for, but not limited to, bariatric patient care. Without the need for difficult, time consuming slings and hoists associated with currently available systems, the invented lifting and transferring system utilizes rapidly deployable, articulated robotic arms with gentle conveyor belts. A unique linkage system allows powerful, safe, and flexible lifting and positioning of the patient with a minimal number of actuators. The lifting mechanism is mounted on a low profile, stable and flexible footprint, omnidirectional robotic mobile base. A simple, intuitive user interface allows control by a single caregiver with minimal training | 07-02-2015 |