Palling
David Palling, Upper Montclair, NJ US
Patent application number | Description | Published |
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20100113517 | METHOD FOR THE TREATMENT OF FABRY DISEASE USING PHARMACOLOGICAL CHAPERONES - The present invention provides a method treating a patient with Fabry disease by determining whether there is an improvement of a surrogate marker that is associated with Fabry disease following administration of a specific pharmacological chaperone of α-galactosidase A. The method includes administering an effective amount of 1-deoxygalactonojirimycn to the individual, wherein the 1-deoxygalactonojirimycin binds to alpha-galactosidase A in an amount effective to increase activity of the alpha-galactosidase A. The present invention also provides a method for monitoring and increasing a therapeutic response of a patient with Fabry disease following administration of a specific pharmacological chaperone of α-galactosidase A by evaluating the effect on the cytoplasmic staining pattern of a cell from the patient, wherein detection of a staining pattern in the cell that is similar to the staining pattern in a cell from a healthy individual indicates that the individual with Fabry disease is a responder. | 05-06-2010 |
David Palling, Montclair, NJ US
Patent application number | Description | Published |
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20090176830 | TARTRATE SALT OF ISOFAGOMINE AND METHODS OF USE - A novel tartaric acid salt of Isofagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine tartrate, method for preparing the salt, a pharmaceutical composition containing the salt, and a method of treating Gaucher disease. | 07-09-2009 |
David Palling, Glen Ridge, NJ US
Patent application number | Description | Published |
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20160067218 | SECNIDAZOLE FOR USE IN THE TREATMENT OF BACTERIAL VAGINOSIS - Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV). | 03-10-2016 |
David J. Palling, Glen Ridge, NJ US
Patent application number | Description | Published |
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20160046617 | SODIUM CHANNEL MODULATORS FOR THE TREATMENT OF PAIN - Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I: | 02-18-2016 |