Pescatore
Brian Pescatore, Beverly, MA US
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20130330317 | Methods for Treating Lysosomal Acid Lipase Deficiency - The present invention provides compositions and methods for effective treatment of a lysosomal acid lipase deficiency (LALD) disease, in particular, Wolman's disease and Cholesteryl Ester Storage Disease (CESD). Among other things, the present invention provides a method of treating a lysosomal acid lipase deficiency (LALD) disease, including administering to an individual suffering from or susceptible to the LALD disease a therapeutic effective amount of a lysosomal acid lipase periodically at an administration interval such that lipid level in liver, spleen and/or small intestine is reduced by at least 20% as compared to an untreated control. | 12-12-2013 |
20140044697 | METHODS FOR TREATING LYSOSOMAL ACID LIPASE DEFICIENCY - The present invention provides compositions and methods for effective treatment of a lysosomal acid lipase deficiency (LALD) disease, in particular, Wolman's disease and Cholesteryl Ester Storage Disease (CESD). Among other things, the present invention provides a method of treating developmental impairment or malnutrition in an individual suffering from a lysosomal acid lipase deficiency (LALD) disease, comprising administering to the individual a therapeutic effective amount of a lysosomal acid lipase. | 02-13-2014 |
Brian H. Pescatore, Natick, MA US
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20130291086 | ENSURING NETWORK CONNECTION SECURITY BETWEEN A WRAPPED APP AND A REMOTE SERVER - A network connection between an app on a mobile device and a remote server is either enabled or denied based on whether a security wrapped app can verify that the connection is with a known and trusted server. The wrapped app uses a socket interception layer injected into the app code along with a trust store, also part of the wrapped app to determine whether a network connection attempted by the app should be allowed. The layer buffers relevant function calls from the app by intercepting them before they reach the device operating system. If the layer determines that a network connection is attempted, then it snoops the negotiation phase data stream to discern when the server sends a certificate to the app. It obtains this certificate and compares it to data in the trust store and makes a determination of whether the server is known and trusted. | 10-31-2013 |
20150052599 | GATEWAY DEVICE FOR TERMINATING A LARGE VOLUME OF VPN CONNECTIONS - A VPN gateway device is able to assign, manage, and terminate a large volume of connections from apps executing on devices, enabling a large scale per-app VPN mobile environment. When a mobile device user opens an app on a mobile device, a VPN gateway transmits a unique IP address to the app. The gateway also transmits an app federation cookie to the app. The app shares the app federation cookie with a second app. The VPN gateway then assigns the second app the same unique IP address. The gateway then transmits a range of ports to the first app. The app uses a port in the range of ports for data transmission from the device to the VPN gateway. The gateway receives a data transmission from the first app via a VPN and determines that the data transmission originated from the first app based on the source port. | 02-19-2015 |
Brian Henry Pescatore, Mansfield, MA US
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20140047535 | MULTIPLE APPLICATION CONTAINERIZATION IN A SINGLE CONTAINER - Described in an example embodiment herein is a Multiple Application Container. Various embodiments of the Multiple Application Container may include, but are not limited to: (1) managed intranet access via a dedicated Virtual Private Network (VPN) tunnel shared amongst applications within the container, (2) managed file/data encryption, (3) native look and feel applications for the base Operating System (OS), (4) isolation from any non-OS based services on the device, and/or (5) Mobile Device Management (MDM) based capabilities, such as policy enforcement. | 02-13-2014 |
Fred Pescatore, New York, NY US
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20080268075 | Herbal Composition Weight Management - Herbal extracts composition suitable for weight management in mammals is disclosed. The composition comprises a mixture of | 10-30-2008 |
20120164264 | HERBAL COMPOSITION FOR WEIGHT MANAGEMENT - Herbal extracts composition suitable for weight management in mammals is disclosed. The composition comprises a mixture of | 06-28-2012 |
Giovanna Pescatore, Pomezia IT
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20090176765 | Pyridinone and Pyridazinone Derivatives as Inhibitors of Poly (Adp-Ribose) Polymerase (Parp) - The present invention relates to compounds of formula I: | 07-09-2009 |
Giovanna Pescatore, Rome IT
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20090048228 | Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors - The present invention relates to compounds of formula I: | 02-19-2009 |
20090209523 | Pyrrolo[1,2-A] Pyrazin-1(2H)-One and Pyrrolo[1,2-D][1,2,4]Triazin-1(2H)-One Derivatives as Inhibitors of Poly(Adp-Ribose)Polymerase (Parp) - The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment. | 08-20-2009 |
20100261709 | PYRIDAZINONE DERIVATIVES AS PARP INHIBITORS - The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinaldamage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment. | 10-14-2010 |
20110034449 | N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE - N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula: | 02-10-2011 |
20110183989 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS - The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract. | 07-28-2011 |
20110207720 | QUINOLIN-4-ONE AND 4-OXODIHYRDOCINNOLINE DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) - The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo-or radiosensitizers for cancer treatment. | 08-25-2011 |
Giovanna Pescatore, Cosenza IT
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20080275004 | N-Substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase - N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula: | 11-06-2008 |
Jeannette Pescatore, Orland, CA US
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20150282646 | Bed Skirt Assembly - The present invention comprises an assembly and method for a bed skirt employing a harness and skirting panel(s) adapted for removeable attachment thereto, and includes a cinching mechanism and stabilizing tongue stays to secure the assembly in fixed horizontal alignment. | 10-08-2015 |
Jeremie Pescatore, Yvelines FR
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20080247616 | SYSTEM AND METHOD OF NAVIGATING AN OBJECT IN AN IMAGED SUBJECT - A system to navigate an image-guided object traveling in an area of interest of an imaged subject in relation to an acquired image of the imaged subject as created by an imaging system is provided. The system includes a navigation system to track movement of the object in the imaged subject in spatial relation to a navigation coordinate system, and a controller. The controller is operable in detecting an image of the object in the at least one image of the imaged subject, calculating a spatial relation between the location of the image of the object and a tracked location of the object, and modifying the spatial relation of the image coordinate system relative to the navigation coordinate system so as to reduce the difference between the location of the image of the object and the tracked location of the object by the navigation system. | 10-09-2008 |
20080267490 | SYSTEM AND METHOD TO IMPROVE VISIBILITY OF AN OBJECT IN AN IMAGED SUBJECT - A system to track movement of an object travelling through an imaged subject is provided. The system includes an imaging system to acquire a fluoroscopic image and operable to create a three-dimensional model of a region of interest of the imaged subject. A controller includes computer-readable program instructions representative of the steps of calculating a probability that an acquired image data is of the object on a per pixel basis in the fluoroscopic image, calculating a value of a blending coefficient per pixel of the fluoroscopic image dependent on the probability, adjusting the fluoroscopic image including multiplying the value of the blending coefficient with one of a greyscale value, a contrast value, and an intensity value for each pixel of the fluoroscopic image. The adjusted fluoroscopic image is combined with the three-dimensional model to create an output image illustrative of the object in spatial relation to the three-dimensional model. | 10-30-2008 |
Jeremie Pescatore, Le Chesnay FR
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20080306378 | METHOD AND SYSTEM FOR IMAGES REGISTRATION - A method for registering images acquired by at least one imaging system. The method includes:positioning at least a first sensor (S) interdependent on the imaging system; positioning at least a second sensor (P) so as to make it interdependent on the movements of an organ of a patient of which at least two images are taken; acquiring the positions of said sensors (S, P) during acquisitions of the images; and registering the images according to the positions of the sensors (S, P). A system for registering images acquired by at least one imaging system includes means for acquiring the position of at least a first sensor interdependent on the imaging system and of at least a second sensor interdependent on the movements of an organ of a patient of which two images are taken, the registration being performed according to the positions of the sensors at the moment when the images are acquired. | 12-11-2008 |
20090012390 | SYSTEM AND METHOD TO IMPROVE ILLUSTRATION OF AN OBJECT WITH RESPECT TO AN IMAGED SUBJECT - A system to generate an image dependent on tracking movement of an object travelling through an imaged subject is provided. The system comprises a tracking system operable to detect a position or an orientation of the object travelling through the imaged subject, and an imaging system operable to create a three-dimensional model of a selected anatomical structure of the imaged subject. A controller is operable to store a plurality of computer-readable program instructions for execution by a processor, the plurality of program instructions representative of the steps of: calculating at least one two-dimensional view of a volume of interest extracted from the three-dimensional model, the volume of interest dependent relative to the tracked position of the object, and generating an output image illustrative of the at least one two-dimensional view of the volume of interest. | 01-08-2009 |
20090022381 | METHOD TO CORRECT THE REGISTRATION OF RADIOGRAPHY IMAGES - A method for the correction of registration of radiography images comprises means to determine a residual rigid transformation in comparing the pre-operation 3D image with a fluoroscopic image. This residual transformation is determined according to a registration based on the content of the image. Once the residual transformation is computed, it is combined with a geometrical registration. The use of the geometrical registration in this combination enables the making of a real-time registration comprising the motion of the C-arm without any additional registration. And the use of the registration based on the content of the image enables the precision of said geometrical registration to be refined. | 01-22-2009 |
20150202021 | METHOD FOR PROCESSING IMAGES OF INTERVENTIONAL RADIOLOGY - An image processing method for interventional imaging in which a region of interest of a patient is viewed. The method comprises acquiring a succession of images of a region of interest of the patient. The method also comprises detecting and tracking, on the successive images, at least one surgical instrument introduced inside the region of interest of the patient, in order to isolate said instrument therein; and comparing two successive images on which the surgical instrument has been isolated in order to identify at least one common shape therein. The method further comprises estimating the displacement of said common shape between both of these successive images; and re-alignment processing of the different successive images depending on the thereby determined estimations of displacements, these displacement estimations being considered as corresponding to the displacement caused by the physiological movement of the patient with the exception of any other movement. | 07-23-2015 |
Jeremie Pescatore, La Frette FR
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20090220132 | METHOD FOR PROCESSING IMAGES OF INTERVENTIONAL RADIOLOGY - An image processing method for interventional imaging in which a region of interest of a patient is viewed. The method comprises acquiring a succession of images of a region of interest of the patient. The method also comprises detecting and tracking, on the successive images, at least one surgical instrument introduced inside the region of interest of the patient, in order to isolate said instrument therein; and comparing two successive images on which the surgical instrument has been isolated in order to identify at least one common shape therein. The method further comprises estimating the displacement of said common shape between both of these successive images; and re-alignment processing of the different successive images depending on the thereby determined estimations of displacements, these displacement estimations being considered as corresponding to the displacement caused by the physiological movement of the patient with the exception of any other movement. | 09-03-2009 |
20140153842 | METHOD FOR REDUCING NOISE IN A SEQUENCE OF FLUOROSCOPIC IMAGES BY TEMPORAL AND SPATIAL FILTERING - In the field of medical imaging using fluoroscopy, a method for reducing noise in a sequence of fluoroscopic images acquired by an X-ray detector comprises for each image (x | 06-05-2014 |
John C. Pescatore, Georgetown, TX US
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20090187806 | SYSTEM AND METHOD FOR ERROR DETECTION IN A REDUNDANT MEMORY SYSTEM - A system and method is disclosed for detecting errors in memory. A memory subsystem that includes a set of parallel memory channels is disclosed. Data is saved such that a duplicate copy of data is saved to the opposite memory channel according to a horizontal mirroring scheme or a vertical mirroring scheme. A cyclic redundancy code is generated on the basis of the data bits and address bits. The generated cyclic redundancy code and a copy of the cyclic redundancy code are saved to the memory channels according to a horizontal mirroring scheme or a vertical mirroring scheme. | 07-23-2009 |
20100037117 | DATA ERROR CORRECTION DEVICE AND METHODS THEREOF - A method of accessing a memory includes accessing multiple ECC words via a single memory channel. Portions of each ECC word are retrieved from different memory ranks, so that a failure in a memory device at one memory rank is less likely to result in uncorrectable errors in the data segment. By accessing the data segments via a single memory channel, rather than multiple memory channels, the single memory channel can be accessed independently, providing for lower cost memory modules, higher memory bandwidth, and lower power dissipation. | 02-11-2010 |
Peter F. Pescatore, Wakefield, MA US
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20140273701 | AEROGEL BLANKET AND METHOD OF PRODUCTION - A method of making a nonwoven wet laid aerogel blanket is provided. The aerogel blanket can exhibit improved thermal conductivity, lower corrosivity, lower dust production and a uniform structure. The blanket can be made from an aerogel floc that is formed from a slurry of aerogel particles. | 09-18-2014 |