Fowler, GB
Andy Fowler, Guildford GB
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20140148470 | PYRIMIDINE COMPOUNDS FOR TREATING HAIRLOSS - The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof for use in the treatment or prevention of hairloss, | 05-29-2014 |
20140148484 | PYRAZOLE COMPOUNDS FOR TREATING HAIRLOSS - The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof for use in the treatment or prevention of hairloss, | 05-29-2014 |
20140148492 | BICYCLOSUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATING HAIR LOSS - The present invention relates to compounds of formula (Ia) or (Ib) or pharmaceutically acceptable salts thereof for use in the treatment or prevention of hairloss, | 05-29-2014 |
Christabel Fowler, Essex GB
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20110256074 | NOVEL USE - A oral care composition comprising a triple polymer system and a source of fluoride ions for combating (i.e. helping to prevent, inhibit and/or treat) dental erosion and/or tooth wear is described. Such compositions are also of use in combating dental caries. | 10-20-2011 |
20140037556 | Novel Use - A oral care composition comprising a triple polymer system and a source of fluoride ions for combating (i.e. helping to prevent, inhibit and/or treat) dental erosion and/or tooth wear is described. Such compositions are also of use in combating dental caries. | 02-06-2014 |
Christabel Fowler, Surrey GB
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20100047191 | NOVEL USE - The use of an oral care composition comprising particulate zinc oxide (suitably in nanoparticulate form) optionally in the presence of a source of fluoride ions is described for combating dental erosion and/or tooth wear. Such compositions are also of use in combating dental caries. | 02-25-2010 |
20100291163 | ORAL CARE COMPOSITION COMPRISING NANOPARTICULATE TITANIUM DIOXIDE - The present invention relates to an oral care composition comprising nanoparticulate titanium dioxide, optionally together with a source of fluoride ions, for combating dental erosion and/or tooth wear. In addition such compositions may also have benefit in tooth whitening. When a source of fluoride ions is present such compositions are also of benefit in combating dental caries. | 11-18-2010 |
20100316579 | NOVEL USE OF ALKYL PHOSPHATE ESTERS - The use of an oral care composition comprising certain alkyl phosphates is described for combating dental erosion and tooth wear. | 12-16-2010 |
Christabel Fowler, Weybridge, Surrey GB
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20100068166 | ORAL COMPOSITION COMPRISING DIMETHICONE COPOLYOL - Oral compositions comprising silicone polyols are described for lubricating and hydrating the buccal cavity and are of benefit in alleviating the symptoms of xerostomia (dry mouth). | 03-18-2010 |
Christopher Edward Fowler, York Yorkshire GB
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20150117932 | DELIVERY DEVICE - A delivery device is described for intermittently delivering materials such as liquids or gels over a sustained period of time to a surface in a controlled way. The surface mountable delivery device is capable of delivering, for example, an antimicrobial agent to protect surfaces from microbial contamination and/or to disinfect surfaces, e.g. door handles, push plates, hand rails, etc. as an aid in preventing and/or hindering the spread of infectious agents. In one arrangement the device utilises a foam based reservoir in combination with a nonwoven fabric wicking layer and an elastomeric liquid delivery contact layer having valve like pore and/or slits; the combination provides for control of material delivery and longevity for the device in use. | 04-30-2015 |
Christopher John Fowler, Surrey GB
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20110169387 | FURNITURE - The invention provides a storage furniture unit ( | 07-14-2011 |
George Fowler, Wraxall GB
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20150052078 | Mapping Pension Planning to a Metaphor - A system for benefits management that includes a benefit metaphor engine that can apply a user-facing metaphor over the benefit plan, where characteristics of the benefit plan are used to identify rule sets to generate an appropriate metaphor. The metaphor presents information about the benefit plan within the metaphor setting, and allows for the user to make decisions within the metaphor that affect the benefit plan outside of the metaphor. | 02-19-2015 |
James Fowler, Ilkley GB
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20120257390 | LIGHT CURING DEVICE AND METHOD OF USE THEREOF - A light curing device is provided including a housing having a light source provided therein or associated therewith and cooling means to dissipate heat associated with or generated by the light source in use. The cooling means includes one or more heat pipes and/or vapour cooling means. | 10-11-2012 |
20120322323 | ELECTRICAL CONNECTION MEANS - Electrical connection means are provided for a first item for allowing electrical connection between the first item or a part of the first item with electrical means of at least a second item or further part of the first item. The electrical connection means include first and at least second non-linear surfaces or parts providing one or more electrical terminals for the electrical connection means. | 12-20-2012 |
James Stuart Fowler, Woking GB
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20130279298 | MONITORING OF UNDERWATER MOORING LINES - In some aspects of the inventive subject matter, there is provided a monitor for monitoring at least one operational condition of an underwater mooring line, the monitor comprising an elongate main body, a protective shroud, at least one operational condition sensor for monitoring the, or each, operational condition, at least one acoustic transmitter, and (in some instances) a source of electrical power for powering the operation of the sensor and transmitter. The main body has at first and second ends respectively first and second mooring line connections (each configured for connection to a respective mooring line) and an intermediate portion. In use, the intermediate section is under tension between the first and second ends when the mooring line is under load. The, or each, operational condition sensor is attached to the intermediate section, the sensor having a signal output for providing a signal regarding the sensed operational condition. | 10-24-2013 |
Jason Derrick Fowler, Hereford And Worcester GB
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20160101794 | Load Transporting Apparatus - A load transporting apparatus is described including: | 04-14-2016 |
John O. Fowler, Matlock GB
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20090176419 | Submersible propulsor unit - A submersible propulsor unit, comprising: a duct defined between a duct hub and a duct wall, the duct having a water inlet and a water outlet, a propeller means rotatably mounted within the duct, and an array of stator vanes extending between the duct hub and the duct wall, wherein the array of stator vanes comprises stator vanes having a first stiffness and stator vanes having a second stiffness. | 07-09-2009 |
Katherine M. Fowler, Berkshire GB
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20150274720 | Azaquinazoline Inhibitors Of Atypical Protein Kinase C - The present application provides a compound of formula (I) | 10-01-2015 |
Katherine M. Fowler, Caversham GB
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20140113882 | Azaquinazoline Inhibitors of Atypical Protein Kinase C - The present application provides a compound of formula (I) | 04-24-2014 |
20160102094 | Azaquinazoline Inhibitors of Atypical Protein Kinase C - The present application provides a compound of formula (1) | 04-14-2016 |
Lindsay Fowler, Abingdon Oxfordshire GB
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20140073801 | PYRROLIDINE DERIVATIVES AS SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF - Disclosed are compounds of formula (I): | 03-13-2014 |
Mark Ian Fowler, Sharnbrook GB
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20140107052 | EDIBLE COMPOSITION - Foods or meals high in available carbohydrate such as sucrose or starch increase postprandial blood glucose concentrations. Repeated high post-prandial plasma glucose “spikes” are associated with an increased risk of developing type II diabetes. Unregulated glycemic excursions are undesirable, and any reduction or “blunting” of the post-prandial glucose concentration in blood is potentially beneficial. This invention relates to an edible composition for delay of intestinal glucose uptake through synergistic inhibition of both active sodium glucose co-transporter 1 (SGLT1) and passive glucose transporter 2 (GLUT2) leading to flattening or blunting of the post-prandial glucose peak. Thus in a first aspect of the invention, an edible composition is provided, the composition comprising at least 5% dry weight at least one flavonoid aglycone and at least 5% dry weight at least one flavonoid glucoside, wherein the flavonoid glucoside is at least 20%, preferably at least 40%, most preferably at least 60% more resistant to hydrolysis by lactase phloridzin hydrolase than quercetin-4-glucoside, and wherein the flavonoid aglycone is a GLUT 2 inhibitor and the flavonoid glucoside is a SGLT 1 inhibitor. | 04-17-2014 |
Mark Ian Fowler, Bedfordshire GB
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20140308392 | MEAL INTENDED FOR HUMAN CONSUMPTION - This invention relates to a plurality of compositions for dietary health management and its use in the prevention or treatment of cardiovascular disease or type 2 diabetes, and also in the prevention and/or management of obesity and generally in weight management and loss. Thus a meal intended for human consumption is provided, the meal comprising: (a) 250-650 kilocalories (1045-4180 kiloJoules); (b) 10-50, preferably 20-50, more preferably 30-50 g fibre; (c) 10-50, preferably 10-30, more preferably 10-20 g protein; (d) 0 to 5, preferably less than 3 g starch; and (e) 0 to 2, preferably 0 to 1, most preferably 0 to 0.5 g lactose; (f) at least 20, preferably at least 30, most preferably at least 40 mg of any one flavonoid aglycone; and (g) at least 30, preferably at least 40, most preferably at least 50 mg of any one flavonoid glucoside; wherein the meal comprises 75-1000 mg of total flavonoid aglycone and flavonoid glucoside, wherein the meal comprises no more than 250 mg of any one flavonoid aglycone, wherein the meal comprises no more than 250 mg of any one flavonoid glucoside. | 10-16-2014 |
20150313927 | AN EDIBLE COMPOSITION COMPRISING RESVERATROL AND FLAVONOID MONOGLUCOSIDE - Foods or meals high in available carbohydrate such as sucrose or starch increase postprandial blood glucose concentrations. Repeated high post-prandial plasma glucose “spikes” are associated with an increased risk of developing type II diabetes. Unregulated glycemic excursions are undesirable, and any reduction or “blunting” of the post-prandial glucose concentration in blood is potentially beneficial. This invention relates to an edible composition for delay of intestinal glucose uptake through synergistic inhibition of both active sodium glucose co-transporter 1 (SGLT1) and passive glucose transporter 2 (GLUT2) leading to flattening or blunting of the post-prandial glucose peak. In a first aspect of the invention, an edible composition is provided, in the form of a single serving of one or more unit dosages, wherein the edible composition comprises 20-2000, preferably 30-1000, most preferably 40-500 mg a 3,5-dihydroxy-trans-stilbene and 10-2000, preferably 20-1000, most preferably 40-500 mg flavonoid mono-glucoside or dihydrochalcone monoglucoside. | 11-05-2015 |
Matthew Fowler, London GB
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20110041006 | DISTRIBUTED TRANSACTION PROCESSING - A system and method for processing a distributed transaction for an application are disclosed. Conventionally transactions on critical data (e.g. financial information) are processed using a database architecture whereby a persistent database (typically a redundant disk array) comprises the master record. In cases where large amounts of data need to be accessed but absolute data integrity is less critical, for example search engines, processing is conducted on live in-memory data without all the data being backed up, which can be much faster but data can be lost when processors fail. There have been attempts to use data grid architectures with some backup to persistent stores for more important data but these have either introduced disk access bottlenecks or required manual intervention in the event of failure. Aspects of the invention provide committal of distributed transactions independently of persistent storage which can make the speed advantages of data grid computing available for high volume distributed transactions, without losing the reliability of conventional database systems. The methods, systems and architecture are independent of the nature of the application or data. | 02-17-2011 |
Matthew Fowler, Hillingdon GB
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20140330767 | SCALABLE DISTRIBUTED TRANSACTION PROCESSING SYSTEM - Transactional data accesses are performed in a data storage system, where the data storage system is configured to store a plurality of data objects identified by respective key values. A request is received to modify the value of a particular data object. The request specifies a modified object value and a key value identifying the data object to be modified. In response to the request, a transactional data object is created, the transactional data object specifying a transaction identifier, the original object value and the modified object value. The transactional data object is stored in the data storage system, and associated with the key value. | 11-06-2014 |
Michael William Fowler, Derbyshire GB
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20110118347 | TREATMENT Of RINGWORM - A compound of the formula CH | 05-19-2011 |
Richard Nigel Fowler, South Wales GB
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20080308182 | Fuel Tank Inlet Device - An inlet device ( | 12-18-2008 |
Richard Nigel Fowler, Newport GB
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20090050625 | FUEL INLET DEVICE AND PART THEREFOR - A fuel tank inlet device is for attachment to a fuel tank or filler neck. The fuel tank or filler neck includes a filler opening, a fuel tank or filler neck abutment surface and one or more projections extending inwardly into the filler opening. The fuel tank inlet device includes a clamping member and a mounting portion, the mounting portion being provided with a first clamping surface. The fuel tank inlet device is provided with an inlet for the ingress of fuel and an outlet for the egress of fuel into a fuel tank. One or both of the mounting portion and the clamping member is movable relative to the other of the mounting portion and the clamping member from a non-clamping configuration to a clamping configuration. In use, the clamping member engages a projection and the first clamping surface, engages with the fuel tank or filler neck abutment surface so as to secure the device to the fuel tank or filler neck. | 02-26-2009 |
Stephan Fowler, London GB
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20090019524 | System and method for network operation - A network of secure servers, requiring no central entity to administer user identities or access permissions. Each autonomous server hosts a set of user accounts. Users may link to and access the accounts of all other users in the network. Resources in accounts are private, but users may grant each other partial permissions to them. Links and permissions are independent of the location of accounts, and are cryptographically authenticated. Users may migrate their account between servers without loosing accumulated permissions, or breaking links that others have to their account. The ability to grant permissions may be delegated to reflect complex organizational structures. A permission may be configured to unlock data in a multitude of accounts. The system will support applications that require secure information sharing across multiple organizational boundaries, and provides a distributed security model which is feasible to deploy as it is wholly administered by its users. | 01-15-2009 |
Steven Fowler, Hertfordshire GB
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20130143055 | RADICALLY POLYMERIZABLE PHENOTHIAZINE MACROMONOMER FOR USE IN THE COATING OF MEDICAL DEVICES - The present invention is directed to phenothiazine-base macromonomer compounds and methods of making the same. | 06-06-2013 |
Steven Fowler, Cambridge, Cambridgeshire GB
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20160033340 | SENSOR CALIBRATION METHOD AND APPARATUS - Disclosed is a method for calibrating a sensor of a monitoring apparatus for monitoring an analyte concentration in a body fluid sample of a patient in which a temperature-dependent drift model is derived for the sensor. An apparatus for monitoring an analyte concentration in a body fluid sample of a patient including such a sensor and a signal processor programmed to calibrate the sensor in accordance with this method is also disclosed. | 02-04-2016 |
Steven Andrew Fowler, Cambridge GB
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20160003858 | ANALYTE EXTRACTION APPARATUS AND METHOD - Disclosed is a method and apparatus for determining a concentration of a glycopeptide antibiotic containing a phenol moiety such as Vancomycin in a complex sample matrix by extracting the glycopeptide antibiotic from a metered portion of the complex sample matrix by exposing said metered portion to an extraction material having an affinity with the glycopeptide antibiotic; and exposing the extraction material to a metered portion of an eluent for releasing the glycopeptide antibiotic from the extraction material; and by determining a concentration of the glycopeptide antibiotic by adding a Gibbs reagent (2,6 dichloroquinone-4chloroimide) to the metered portion of the complex sample matrix or the eluent; activating the Gibbs reagent and, after the reaction between the activated Gibbs reagent and the antibiotic has stabilized; detecting the reaction product of the activated Gibbs reagent and the antibiotic in said eluent; and determining the concentration of the antibiotic in the complex sample matrix from the detected reaction product. A method of designing a personalized drug administration regime using the thus obtained concentration is also disclosed. | 01-07-2016 |
Susan Fowler, Cambridge GB
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20090286745 | INHIBITION OF ALPHA-SYNUCLEIN AGGREGATION - This invention relates to the inhibition of alpha-synuclein aggregation using peptidyl compounds which are retroenantiomers of the alpha-synuclein sequence, in particular retroenantiomers of sequences in the regions between residues 1 to 60 or residues 61 to 96. Peptidyl compounds of the invention may optionally be coupled to doperminergic targeting moieties and/or blood brain barrier transport moieties and may be useful in the treatment of alpha-synucleinopathies such as Parkinson's disease. | 11-19-2009 |
Thomas Fowler, Melton Mowbray GB
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20110306542 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS - Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided. | 12-15-2011 |
20130178420 | NOVEL GLP-1 RECEPTOR MODULATORS - The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ | 07-11-2013 |
20140031290 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS - Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided. | 01-30-2014 |
20140336185 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS - Compounds that bind the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, methods of their therapeutic and/or prophylactic use, and methods of their use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor are provided. Certain compounds may have activity as modulators or potentiators with respect to glucagon receptor, GIP receptor, GLP-1 and GLP-2 receptors, and PTH receptor on their own or in the presence of receptor ligands such as GIP (1-42), PTH (1-34), Glucagon (1-29), GLP-2 (1-33), GLP-1 (7-36), GLP-1 (9-36), oxyntomodulin and exendin variants. | 11-13-2014 |
20150038416 | NOVEL GLP-1 RECEPTOR MODULATORS - The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ | 02-05-2015 |
20160038487 | NOVEL GLP-1 RECEPTOR MODULATORS - Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36), GLP-1(9-36), and oxyntomodulin, or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ | 02-11-2016 |
Vernon Fowler, Cheshire GB
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20100330054 | PREPARATION, USE OF PREPARATION FOR TREATMENT, AND METHOD OF TREATMENT OF INTESTINAL INFECTION - A preparation for use in the treatment of | 12-30-2010 |
20130071368 | PREPARATION, USE OF PREPARATION FOR TREATMENT, AND METHOD OF TREATMENT OF INTESTINAL INFECTION - A preparation for use in the treatment of | 03-21-2013 |
Veronica Fowler, Berkshire GB
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20110311568 | Vaccine - The present invention provides a foot and mouth disease (FMD) vaccine comprising or capable of expressing afoot and mouth disease virus (FMDV) VP1 polypeptide having a deletion of at least seven amino acids in the G-H loop such that the VP1 polypeptide lacks an RGD motif. The present invention also provides a method for preventing and/or treating FMD in a subject which comprises the step of administration of such a vaccine. | 12-22-2011 |
Veronica Fowler, Alton GB
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20130230549 | FOOT AND MOUTH DISEASE VIRUS WITH INCREASED STABILITY AND ITS USE AS VACCINE - The present invention provides a foot and mouth disease (FMD) virus having improved stability compared to the field isolate of the same subtype, wherein the virus comprises one or more amino acid mutations along a line of symmetry of the capsid structure. The present invention also relates to a vaccine comprising such an FMD virus and its use to prevent foot and mouth disease. | 09-05-2013 |