Patent application number | Description | Published |
20100209402 | AGENT FOR PROMOTING CORNEAL ENDOTHELIAL CELL ADHESION - The invention provides an agent for promoting adhesion of a corneal endothelial cell, containing a Rho kinase inhibitor, as well as a culture medium for a corneal endothelial cell, a solution for preservation of cornea, and a method of producing a corneal endothelial preparation, which includes culturing the corneal endothelial cell using the aforementioned culture medium. | 08-19-2010 |
20100233240 | CORNEAL ENDOTHELIAL PREPARATION WHICH ENABLES CELLS TO GROW IN VIVO - The present invention provides a graft more suitable for the transplantation of corneal endothelial cells and an application method thereof. Specifically, the present invention provides a corneal endothelial preparation capable of cell proliferation in vivo, which contains a substrate and a corneal endothelial cell layer cultured on the substrate, and a treatment method of a disease selected from the group consisting of bullous keratopathy, corneal edema, corneal leukoma and corneal endothelial inflammation, which includes a step of transplanting the preparation to patients. As the substrate, collagen is used. | 09-16-2010 |
20120300174 | OPHTHALMOLOGIC APPARATUS AND IMAGE CLASSIFICATION METHOD - An illumination light is projected onto a tear film lipid layer on a cornea of an eye to be examined, and the reflected light is received and the tear film lipid layer is imaged. The image of the tear film lipid layer that has been captured is processed, and the initial spread speed H′ of the tear film lipid layer at the time the eyelid has been opened is measured. The image of the tear film lipid layer that has been captured is processed, and the time until the tear film lipid layer is broken up after the eyelid has been opened and a dark area T appears is measured. The appearance time of the dark area is plotted on the Y-axis and the initial spread speed H′(0) of the tear film lipid layer is plotted on the X-axis, and the type of dry eye is classified. In such a configuration, since the type of dry eye can be classified and determined, diagnosis and treatment in accordance with the type of dry eye are made possible. | 11-29-2012 |
20130012408 | METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA - A method of determining the presence or the absence of a glaucoma risk by detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism, comparing the allele and/or the genotype detected with at least one of an allele and/or a genotype with a high-risk allele, wherein the presence of a glaucoma risk is determined in a case where the allele detected is the high-risk allele, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele or a heterozygote when the high-risk allele complies with a dominant genetic model, or the presence of a glaucoma risk is determined in a case where the genotype detected is a homozygote of the genotype comprising the high-risk allele when the high-risk allele complies with a recessive genetic model. | 01-10-2013 |
20130210668 | METHOD FOR DETERMINATION OF PROGRESSION RISK OF GLAUCOMA - A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk. | 08-15-2013 |
Patent application number | Description | Published |
20090175954 | Sheet-like composition - A sheet-shaped composition is provided which has an improved preservability and handling readiness, as well as a high flexibility in use. Amnion with trehalose added thereto is utilized. Addition of trehalose improves the flexibility of the amnion, and prevents basal membrane and stratum compactum from being damaged during lyophilization process. | 07-09-2009 |
20090280100 | Preventive or Therapeutic Agent for Inflammatory Ocular-Surface Diseases - [Problems] The present invention aims to provide a preventive or therapeutic agent for inflammatory ocular-surface diseases. | 11-12-2009 |
20100196895 | METHOD FOR DETERMINATION OF ONSET RISK OF GLAUCOMA - A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 514 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 514 (step B). According to the method of the present invention, the level of an onset risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention on the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk. | 08-05-2010 |
20110207122 | METHOD FOR DETERMINATION OF PROGRESSION RISK OF GLAUCOMA - A method of determining the presence or the absence of a glaucoma risk, including the steps of detecting in vitro an allele and/or a genotype of a single nucleotide polymorphism which is located on a 31st base of a base sequence, in a sample from a subject, wherein the base sequence is at least one base sequence selected from the group consisting of base sequences shown in SEQ ID NOs: 203 to 752 or a complementary sequence thereto (step A), and comparing the allele and/or the genotype detected in the step A with at least one of an allele and/or a genotype, containing a high-risk allele, in the base sequences shown in SEQ ID NOs: 203 to 752 (step B). According to the method of the present invention, the level of a progressive risk of glaucoma in a sample donor can be determined by analyzing an allele or a genotype of a single nucleotide polymorphism in the present invention in the sample, so that the sample donor can take a preventive measure of glaucoma, or can receive appropriate treatments, on the basis of this risk. | 08-25-2011 |
20120190621 | CORNEAL ENDOTHELIAL CELL PROLIFERATION PROMOTER - The present invention aims to provide a corneal endothelium cell proliferation accelerator and a therapeutic agent for a disease relating to corneal endothelium damage, which are administered into the anterior chamber. bFGF is released in a sustained manner by forming bFGF sustained-release gelatin hydrogel particles wherein bFGF is carried on gelatin hydrogel. Therefore, the proliferation of corneal endothelium cells can be accelerated persistently by administration of a preparation containing the bFGF sustained-release gelatin hydrogel particles into the anterior chamber, and diseases relating to corneal endothelium damage can be treated. | 07-26-2012 |
20120276080 | SHEET-LIKE COMPOSITION - A sheet-shaped composition is provided which has an improved preservability and handling readiness, as well as a high flexibility in use. Amnion with trehalose added thereto is utilized. Addition of trehalose improves the flexibility of the amnion, and prevents basal membrane and stratum compactum from being damaged during lyophilization process. | 11-01-2012 |
20130275349 | Comprehensive Glaucoma Determination Method Utilizing Glaucoma Diagnosis Chip And Deformed Proteomics Cluster Analysis - Provided is a technique for determining a physiological attribute in a mammal, including the onset or progression of human glaucoma, with high accuracy. The results of the determination of genotype date and the results of the determination of cytokine date are consolidated by a consolidated determination unit ( | 10-17-2013 |
20140220102 | ECTOCORNEA-LIKE SHEET AND METHOD OF CONSTRUCTING THE SAME - It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells. When a layered structure of the oral mucosal epithelial cells is formed, the outermost layer is brought into contact with air, thereby inducing differentiation. Thus, an ectocornea-like sheet having an oral mucosal epithelial cell layer on the amnion is obtained. | 08-07-2014 |
Patent application number | Description | Published |
20080220546 | METHOD FOR SIMULATING DEPOSITION FILM SHAPE AND METHOD FOR MANUFACTURING ELECTRONIC DEVICE - A deposition film shape simulation method for calculating a thickness of a thin-film formed by supplying deposition species on a substrate surface, includes: changing a parameter to be used in the calculation depending on the thickness of the deposited thin-film. | 09-11-2008 |
20080244481 | METHOD FOR DESIGNING AND MANUFACTURING SEMICONDUCTOR DEVICE AND SOFTWARE THEREFOR - A method for designing a semiconductor device including a semiconductor substrate and an interconnect on the semiconductor substrate, with X-direction being one direction parallel to the semiconductor substrate, Y-direction being a direction parallel to the semiconductor substrate and perpendicular to the X-direction, and Z-direction being perpendicular to the semiconductor substrate, the method includes: determining a cross-sectional configuration in the X-Z direction; three-dimensionalizing the cross-sectional configuration with a range in the Y-direction being specified; and using the three-dimensionalized configuration as a model. | 10-02-2008 |
20080256496 | METHOD OF DESIGNING AND MANUFACTURING SEMICONDUCTOR DEVICE - A semiconductor device designing method includes calculating capacitance. The semiconductor device has a semiconductor substrate, an insulator formed on the semiconductor substrate, and an electrode formed on the insulator. The capacitance is calculated under an approximation assuming a portion of the semiconductor substrate, the insulator and a portion of the electrode to be one of a conductor and a dielectric depending on electric characteristics thereof, respectively. | 10-16-2008 |
20120217569 | NONVOLATILE SEMICONDUCTOR MEMORY DEVICE AND METHOD FOR MANUFACTURING THE SAME - According to one embodiment, a nonvolatile semiconductor memory device includes a substrate, a tunneling insulating film, a floating gate, a leak suppression unit, an inter-gate insulating film, and a control gate. The substrate includes silicon. The tunneling insulating film is provided on the substrate. The floating gate is provided on the tunneling insulating film. The leak suppression unit is provided on the floating gate. The inter-gate insulating film is provided on the leak suppression unit. The control gate is provided on the inter-gate insulating film. The dielectric constant of the leak suppression unit is higher than a dielectric constant of the inter-gate insulating film. | 08-30-2012 |
20130193504 | SEMICONDUCTOR DEVICE AND METHOD FOR MANUFACTURING SAME - According to one embodiment, a semiconductor device includes a substrate, a plurality of interconnects, and a plurality of gap control units. The substrate includes silicon. The plurality of interconnects is provided above the substrate. The plurality of gap control units is provided respectively on the plurality of interconnects to have width dimensions greater than width dimension of the plurality of interconnects. A gap is provided between adjacent interconnects of the plurality of interconnects. An apical portion of the gap is provided between adjacent gap control units of the plurality of gap control units and between a lower surface position and an upper surface position of each of the adjacent gap control units. | 08-01-2013 |
20150055416 | NONVOLATILE SEMICONDUCTOR MEMORY DEVICE AND DATA PROGRAMMING METHOD - According to one embodiment, a nonvolatile semiconductor memory device includes memory cell units, bit lines, word lines, and a controller. Each of the memory cell units includes a plurality of memory cells connected in series. Bit lines are connected respectively to the corresponding memory cell units. Each of the word lines is commonly connected to control gates of the corresponding memory cells of the memory cell units. The controller is configured to control a programming operation of data to the memory cells. The controller is configured to execute a first procedure including programming the data to the memory cell connected to the (4n−3)th (n being a natural number) bit line and the memory cell connected to the (4n−2)th bit line, and a second procedure including programming the data to the memory cell connected to the (4n−1)th bit line and the memory cell connected to the 4nth bit line. | 02-26-2015 |
Patent application number | Description | Published |
20110284671 | METHOD AND APPARATUS FOR UPGRADING COAL - A method of upgrading coal which comprises: pulverizing low-grade coal; mixing the pulverized low-grade coal with an oil to form a slurry; heating the slurry to or above the boiling point of water to vaporize the water contained in the low-grade coal and dehydrate the coal; compressing a vapor mixture of the steam resulting from the slurry heating and that part of the oil which has vaporized simultaneously and thereby elevating the temperature and pressure of the vapor mixture; and supplying the vapor mixture increased in temperature and pressure by the compression and utilizing this vapor mixture as a high-temperature heat source to heat the slurry. In the method, the vapor mixture before being compressed is brought into contact with an oil in a liquid state. This method is a process in which low-grade coal containing water in a large proportion and hence having a low calorific value is dewatered in an oil to thereby upgrade the coal to a high-calorie fuel for thermal power generation, wherein the vapor mixture to be supplied to a compressor can be purified. | 11-24-2011 |
20120011766 | METHOD FOR PRODUCING SOLID FUEL AND SOLID FUEL PRODUCED BY THE METHOD - Provided are a modified solid fuel manufacturing method that reduces manufacturing costs and environmental impact while also realizing higher strength such as for transport, and modified solid fuels manufactured using the manufacturing method. When solid fuels are manufactured by crushing low grade coal, mixing the crushed low grade coal with solvent oil to prepare a slurry, heating the slurry to at least the boiling point of water to evaporate moisture included in the slurry, separating the solvent oil from the slurry to produce charcoal dust and compression compacting said charcoal dust, by heating the slurry to at least the boiling point of water, the non-volatile components included in the low grade coal are extracted with the solvent oil, the outer surface of the low grade coal and the internal surfaces of the pores are coated with the extracted non-volatile components, and the content of heavy oil added from the outside will be less than 0.5 mass %, and preferably essentially 0%, relative to the solid fuel after drying. | 01-19-2012 |
20140305034 | ASH-FREE COAL PRODUCTION METHOD - Provided is an ash-free coal production method that can produce an ash-free coal efficiently with a higher solvent recovery rate. The ash-free coal production method includes an extraction step of mixing coal with a solvent to give a slurry and heating the slurry to extract a solvent-soluble coal component; a separation step of separating a solution containing the coal component from the slurry containing the extracted coal component; and an ash-free coal obtaining step of separating and recovering the solvent from the separated solution to give an ash-free coal. The ash-free coal obtaining step includes a pressure-reducing substep of reducing a pressure to a level lower than the solvent vapor pressure to evaporatively separate the solvent from the solution to thereby give a solid ash-free coal; and a heating substep of heating the solid ash-free coal to evaporatively separate a residual solvent from the ash-free coal. | 10-16-2014 |
20140325901 | ASH-FREE COAL PRODUCTION METHOD - Provided is an ash-free coal production method without the need to once re-liquefy and form an ash-free coal. The ash-free coal production method includes an extraction step of mixing coal with a solvent to prepare a slurry and heating the slurry to extract a solvent-soluble coal component; a separation step of separating a solution containing the solvent-soluble coal component from the slurry obtained from the extraction step; an ash-free coal obtaining step of evaporatively separating the solvent from the solution separated in the separation step to obtain an ash-free coal. The ash-free coal obtaining step in the production method is performed so that the solvent is evaporatively separated from the solution to give a liquid ash-free coal, and the liquid ash-free coal is brought into contact with a solidifier (e.g., water) to solidify into a predetermined shape. | 11-06-2014 |
20150013215 | SOLVENT SEPARATION METHOD - A method for separating solvent-containing water, which is generated in the process for producing an ashless coal, into a solvent and water readily without using any adsorbent or the like (a solvent separation method). The solvent separation method comprises: a solvent-containing water supply step of supplying the solvent-containing water into a pressure vessel for solvent separation purposes; and a temperature retention step of retaining the temperature of the solvent-containing water that has been supplied into the pressure vessel for solvent separation purposes at a predetermined temperature (e.g., 100 to 180 DEG C. inclusive). In the pressure vessel for solvent separation purposes, water in the liquid form moves downward and the solvent moves upward due to the difference between the density of water and the density of the solvent at the predetermined temperature. In this manner, the solvent-containing water can be separated into the solvent and water. | 01-15-2015 |
Patent application number | Description | Published |
20120291342 | METHOD FOR MANUFACTURING BRIQUETTED SOLID FUEL USING POROUS COAL AS STARTING MATERIAL - Provided is a manufacturing method for a briquetted solid fuel that can reduce the briquetting cost while maintaining the strength of the briquetted product. A mixed oil that includes a heavy oil and a solvent oil, and a porous coal are mixed to obtain a slurry. The slurry is dewatered by heating to obtain a dewatered slurry. Solvent oil is separated from the dewatered slurry to obtain a cake, the cake is heated, and solvent oil is further separated from the cake to obtain a modified coal. Moisture is added to the modified coal to obtain a moist modified coal with a moisture content of 3 wt % to 10 wt %, and then the moist modified coal is briquetted under pressure. | 11-22-2012 |
20150135584 | METHOD FOR PRODUCING SOLID FUEL AND SOLID FUEL PRODUCED BY THE METHOD - Modified solid fuel manufacturing method and modified solid fuels manufactured using the manufacturing method. When solid fuels are manufactured by crushing low grade coal, mixing the crushed low grade coal with solvent oil to prepare a slurry, heating the slurry to at least the boiling point of water to evaporate moisture included in the slurry, separating the solvent oil from the slurry to produce charcoal dust and compression compacting said charcoal dust, by heating the slurry to at least the boiling point of water, the non-volatile components included in the low grade coal are extracted with the solvent oil, the outer surface of the low grade coal and the internal surfaces of the pores are coated with the extracted non-volatile components, and the content of heavy oil added from the outside will be less than 0.5 mass %, relative to the solid fuel after drying. | 05-21-2015 |