Patent application number | Description | Published |
20130064832 | NOTCH INHIBITION IN THE TREATMENT AND PREVENTION OF A METABOLIC DISEASE OR DISORDER AND CARDIOVASCULAR COMPLICATIONS THEREOF - The present invention is directed to methods of treating or preventing a metabolic disease or disorder and cardiovascular complications and other complications thereof by administering agents that inhibit the NOTCH signaling pathway. In addition, the invention encompasses methods for determining whether a patient is at increased risk for developing these conditions by determining the amount, function, or activity of NOTCH pathway components in biological samples derived from the patient or in imaging analyses. | 03-14-2013 |
20150291963 | SORTILIN 1 IS A NOVEL INDUCER OF VASCULAR CALCIFICATION - The invention relates to methods for decreasing, inhibiting, preventing, or reducing calcification by inhibiting sortilin 1. | 10-15-2015 |
20150315577 | A METHOD FOR INHIBITING CALCIFICATION OF A MACROPHAGE-DERIVED MATRIX VESICLE - The invention relates to methods for decreasing, inhibiting, preventing, or reducing matrix vesicle induced calcification by inhibiting the amount or formation of a complex comprising phosphatidylserine (PS), annexin II, annexin V or VI, and S100A9 or S100A12 in a macrophage. | 11-05-2015 |
Patent application number | Description | Published |
20090175849 | NOTCH inhibition in the treatment or prevention of atherosclerosis - The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling pathway. In addition, the invention encompasses methods for assaying compounds for their ability to treat atherosclerosis based upon their effects on NOTCH signaling, and for measuring levels of amount, function, or activity of NOTCH pathway components in biological samples. | 07-09-2009 |
20120128697 | NOTCH Inhibition in the Treatment or Prevention of Atherosclerosis - The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling pathway. In addition, the invention encompasses methods for assaying compounds for their ability to treat atherosclerosis based upon their effects on NOTCH signaling, and for measuring levels of amount, function, or activity of NOTCH pathway components in biological samples. | 05-24-2012 |
20130064832 | NOTCH INHIBITION IN THE TREATMENT AND PREVENTION OF A METABOLIC DISEASE OR DISORDER AND CARDIOVASCULAR COMPLICATIONS THEREOF - The present invention is directed to methods of treating or preventing a metabolic disease or disorder and cardiovascular complications and other complications thereof by administering agents that inhibit the NOTCH signaling pathway. In addition, the invention encompasses methods for determining whether a patient is at increased risk for developing these conditions by determining the amount, function, or activity of NOTCH pathway components in biological samples derived from the patient or in imaging analyses. | 03-14-2013 |
20130336958 | NOTCH Inhibition In The Treatment Of Cardiovascular Disease - The present invention is directed to methods of treating or preventing atherosclerosis and other cardiovascular diseases by administering agents that inhibit or modulate the NOTCH signaling pathway. In addition, the invention encompasses methods for assaying compounds for their ability to treat atherosclerosis based upon their effects on NOTCH signaling, and for measuring levels of amount, function, or activity of NOTCH pathway components in biological samples. | 12-19-2013 |
20150291963 | SORTILIN 1 IS A NOVEL INDUCER OF VASCULAR CALCIFICATION - The invention relates to methods for decreasing, inhibiting, preventing, or reducing calcification by inhibiting sortilin 1. | 10-15-2015 |
20150315577 | A METHOD FOR INHIBITING CALCIFICATION OF A MACROPHAGE-DERIVED MATRIX VESICLE - The invention relates to methods for decreasing, inhibiting, preventing, or reducing matrix vesicle induced calcification by inhibiting the amount or formation of a complex comprising phosphatidylserine (PS), annexin II, annexin V or VI, and S100A9 or S100A12 in a macrophage. | 11-05-2015 |
Patent application number | Description | Published |
20090063126 | Validation of the consistency of automatic terminology translation - A method of determining the consistency of training data for a machine translation system is disclosed. The method includes receiving a signal indicative of a source language corpus and a target language corpus. A textual string is extracted from the source language corpus. The textual string is aligned with the target language corpus to identify a translation for the textual string from the target language corpus. A consistency index is calculated based on a relationship between the textual string from the source language corpus and the translation. An indication of the consistency index is stored on a tangible medium. | 03-05-2009 |
20100076746 | COMPUTERIZED STATISTICAL MACHINE TRANSLATION WITH PHRASAL DECODER - A computerized system for performing statistical machine translation with a phrasal decoder is provided. The system may include a phrasal decoder trained prior to run-time on a monolingual parallel corpus, the monolingual parallel corpus including a machine translation output of source language documents of a bilingual parallel corpus and a corresponding target human translation output of the source language documents, to thereby learn mappings between the machine translation output and the target human translation output. The system may further include a statistical machine translation engine configured to receive a translation input and to produce a raw machine translation output, at run-time. The phrasal decoder may be configured to process the raw machine translation output, and to produce a corrected translation output based on the learned mappings for display on a display associated with the system. | 03-25-2010 |
20100082324 | REPLACING TERMS IN MACHINE TRANSLATION - A system described herein includes a receiver component that receives an output translation from a machine translation system, wherein the output translation is in a target language and is based at least in part upon an input to the machine translation system in a source language, and wherein the input to the machine translation system includes a first term in the source language and the output translation includes a second term in the target language that corresponds to the first term. The system additionally includes a replacer component in communication with the receiver component that accesses a dictionary of term correspondences, wherein the dictionary of term correspondences includes an indication that the input first term in the source language is desirably translated to a third term in the target language, and wherein the replacer component is configured to automatically replace the second term with the third term to modify the output translation. | 04-01-2010 |
20110252316 | TRANSLATING TEXT ON A SURFACE COMPUTING DEVICE - A system described herein includes an acquirer component that acquires an electronic document that comprises text in a first language, wherein the acquirer component acquires the electronic document based at least in part upon a physical object comprising the text contacting or becoming proximate to the interactive display of the surface computing device. The system also includes a language selector component that receives an indication of a second language from a user of the surface computing device and selects the second language. A translator component translates the text in the electronic document from the first language to the second language, and a formatter component formats the electronic document for display to the user on the interactive display of the surface computing device, wherein the electronic document comprises the text in the second language. | 10-13-2011 |