Hilfiker
Andres Hilfiker, Hannover DE
Patent application number | Description | Published |
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20110117163 | BIOACTIVE COATING FOR AN IMPLANTABLE DEVICE OR BIOPROSTHESIS - For an implantable device intended for use in the human body an in-vivo colonization with autologous cells is often desired. The devices, especially prosthetic devices like implant tissues, grafts, shunts, vessels, organs or a part of organs are commonly derived from animal or human origin and comprise a collagen-based tissue matrix. The invention proposes a coating deposited on a surface of the device and comprising the matrix protein CCN1 as an extracellular matrix-associated protein mediating cell adhesion or cell migration. | 05-19-2011 |
Beppo Hilfiker, Muttenz CH
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20140001728 | SENSOR APPARATUS FOR DETERMINING FORCES APPLIED TO A PEDAL OF A BICYCLE | 01-02-2014 |
Beppo Hilfiker, Riehen CH
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20090175130 | Device for operating an electronic multifunctional device - An operating mechanism of a multifunctional device which can be worn on the wrist and has a housing with integrated electronics. The operating mechanism is integrated into the housing and has an operating element which is a one-piece or multi-piece setting stem. The setting stem partly crosses the housing, and the setting stem is arranged parallel to a planar enlargement of the housing and is rotatably and linearly moveably mounted. The setting stem can be moved linearly parallel to the longitudinal axis and rotatively about the rotational axis/longitudinal axis by a first operating watch button and optionally with a second operating watch button. The movement of the setting stem triggers various contacts on a contact plate, from which contacts electronic signals are sent to the electronics, as a result of which the electronic control of the multifunctional device is effected. | 07-09-2009 |
Christian Hilfiker, Triengen CH
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20090070947 | Electrically Operated, Continuously Adjustable Personal Hygiene Device - A toothbrush has a removable end cap at its free end area directed away from the bristles, which end cap closes off an inner space of a grip element. The end cap accommodates an electrical control element, in particular a potentiometer, which can be adjusted via an adjustment element arranged rotatably on the end cap. The toothbrush also comprises an electrical power consumption unit, in particular an electric motor, which is designed to set the bristles in vibration. The energy supply from an energy reservoir arranged in the interior to the electrical power consumption unit can be adjusted continuously by means of the control element, as a result of which the vibration intensity of the bristles can be steplessly adjusted. | 03-19-2009 |
20090158540 | Handle for a Brush, In Particular a Toothbrush - The inventive handle for a brush, in particular for a toothbrush or a domestic brush, has an integral handle body with a hollow space which is surrounded by a wall. Recesses which are offset in relation to one another and open into the hollow space are formed in the wall. The handle is produced from a plastic in an injection-molding process using an injection-molding die which has finger elements, with sections of these finger elements touching in a sealing manner when the injection-molding die is in the closed state and, as a result, these finger elements forming the recesses and the hollow space in the hardened handle. | 06-25-2009 |
20090183324 | Electronic toothbrush, and transmission for an electric toothbrush - The transmission according to the invention for an electric toothbrush serves for the transmission and reforming of a rotational movement provided by an electric motor into a particularly careful and effective cleaning movement of a cleaning element. The ratio of the distance between the longitudinal mid-axis of an output shaft and the longitudinal mid-axis of a drive shaft of the transmission and of the distance between the longitudinal mid-axis of a shaft driving a cam of the transmission and the longitudinal mid-axis of the cam amounts to at least 10:1. | 07-23-2009 |
20100101037 | Toothbrush with partially coated surface - The toothbrush has a handle, a neck and a head. In the handle there is a first hard component which has a metallic covering. At least in regions, the metallic covering has a covering of a second hard component. | 04-29-2010 |
20120110768 | Toothbrush head - A toothbrush has a removable end cap at its free end area directed away from the bristles, which end cap closes off an inner space of a grip element. The end cap accommodates an electrical control element, in particular a potentiometer, which can be adjusted via an adjustment element arranged rotatably on the end cap. The toothbrush also comprises an electrical power consumption unit, in particular an electric motor, which is designed to set the bristles in vibration. The energy supply from an energy reservoir arranged in the interior to the electrical power consumption unit can be adjusted continuously by means of the control element, as a result of which the vibration intensity of the bristles can be steplessly adjusted. | 05-10-2012 |
20130097789 | ELECTRIC TOOTHBRUSH, AND TRANSMISSION FOR AN ELECTRIC TOOTHBRUSH - The transmission according to the invention for an electric toothbrush serves for the transmission and reforming of a rotational movement provided by an electric motor into a particularly careful and effective cleaning movement of a cleaning element. The ratio of the distance between the longitudinal mid-axis of an output shaft and the longitudinal mid-axis of a drive shaft of the transmission and of the distance between the longitudinal mid-axis of a shaft driving a cam of the transmission and the longitudinal mid-axis of the cam amounts to at least 10:1. | 04-25-2013 |
20140237744 | TOOTHBRUSH HEAD - A toothbrush has a removable end cap at its free end area directed away from the bristles, which end cap closes off an inner space of a grip element. The end cap accommodates an electrical control element, in particular a potentiometer, which can be adjusted via an adjustment element arranged rotatably on the end cap. The toothbrush also comprises an electrical power consumption unit, in particular an electric motor, which is designed to set the bristles in vibration. The energy supply from an energy reservoir arranged in the interior to the electrical power consumption unit can be adjusted continuously by means of the control element, as a result of which the vibration intensity of the bristles can be steplessly adjusted. | 08-28-2014 |
Harold K. Hilfiker, Eureka, CA US
Patent application number | Description | Published |
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20090285640 | METHOD FOR CONSTRUCTING A MECHANICALLY STABILIZED EARTHEN EMBANKMENT USING SEMI-EXTENSIBLE STEEL SOIL REINFORCEMENTS - A method for constructing a mechanically stabilized earthen embankment has the steps of first constructing a wall facing element. A plurality of elongate soil reinforcement elements are attached to the wall facing element. A middle portion of each of the elongate soil reinforcement elements has a plurality of semi-extensible bent segments. Fill soil is added to build the earthen embankment over the reinforcement elements. Movement of the fill soil may create sufficient force to straighten some of the plurality of semi-extensible bent segments, allowing the earthen embankment to move to an active condition thereby reducing the stress on the soil reinforcement elements. | 11-19-2009 |
20140105693 | METHOD FOR CONSTRUCTING A MECHANICALLY STABILIZED EARTHEN EMBANKMENT USING SEMI-EXTENSIBLE STEEL SOIL REINFORCEMENTS - A method for constructing a mechanically stabilized earthen embankment has the steps of constructing a wall facing element, and determining a plane of maximum force and a zone of maximum force in the earthen embankment to be formed. A plurality of elongate soil reinforcement elements are bent to form semi-extensible bent segments, but such that proximal and distal portions remain substantially straight and inextensible. The elongate soil reinforcement elements are positioned such that the semi-extensible region is within the zone of maximum force, and the proximal ends are connected to the wall facing element. Fill soil is added to build the earthen embankment, and the process is repeated until the earthen embankment is formed. | 04-17-2014 |
James N. Hilfiker, Lincoln, NE US
Patent application number | Description | Published |
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20090103094 | Ellipsometric investigation and analysis of textured samples - System for, and method of ellipsometric investigation of and analysis of samples which have, for instance, a non-random effectively “regular” textured surface, and/or a surface characterized by an irregular array of faceted structures. | 04-23-2009 |
20120057158 | Ellipsometric investigation and analysis of textured samples - System for, and method of ellipsometric investigation of and analysis of samples which have, for instance, a non-random effectively “regular” textured surface, and/or a surface characterized by an irregular array of faceted structures. | 03-08-2012 |
Mark A. Hilfiker, King Of Prussia, PA US
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20080234261 | Preparation of 1,6-Disubstituted Azabenzimidazoles as Kinase Inhibitors - Novel inhibitors of Rho-kinases are disclosed. | 09-25-2008 |
20130012499 | TRPV4 ANTAGONISTS - The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists. | 01-10-2013 |
20140113916 | TRPV4 ANTAGONISTS - The present invention relates to spirocarbamate analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists. | 04-24-2014 |
20140121206 | TRPV4 ANTAGONISTS - The present invention relates to spirocarbamate compounds of Formula (I) in which R1, (R2)Y, R3, R4, X and A have the meanings given in the specification. The invention further provides pharmaceutical compositions containing the compounds or pharmaceutically acceptable salts thereof and relates to their use of these compounds as TRPV4 antagonists in treating or preventing conditions associated with TRPV4 imbalance. | 05-01-2014 |
Rolf Hilfiker, Basel CH
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20120238556 | CRYSTALLINE METHYLTHIONINIUM CHLORIDE HYDRATES - Three dihydrate forms B, C and D and a monohydrate form E of methylthioninium chloride are described. Forms B, C, D and E can be prepared under controlled humidity and temperature from methylthioninium chloride with higher water content or conversion of a hydrate. The hydrates can be incorporated in pharmaceutical compositions. | 09-20-2012 |
20120289499 | PROCESS - Substantially pure methylthioninium chloride pentahydrate form A is prepared from methylthioninium chloride by phase equilibration of suspensions, crystallization or solvent evaporation, whereby the water content of the solvent corresponds to a water activity of at least 0.4 at 25° C., and controlled drying of said methylthioninium chloride pentahydrate form A within its stability ranges of humidity, pressure and temperature. | 11-15-2012 |
Rolf Hilfiker, Allschwil CH
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20090312430 | COLCHICINE SOLID-STATE FORMS; METHODS OF MAKING; AND METHODS OF USE THEREOF - Disclosed are new colchicine solid-state forms, methods of preparing the solid-state forms, as well as formulations prepared therefrom and uses thereof. | 12-17-2009 |
20100286254 | CRYSTALLINE FORMS OF DMXAA SODIUM SALT - The present invention relates to pharmaceutically stable crystalline forms of (5,6-Dimethyl-9-oxo-9H-xanthene-4-yl)acetic acid (DMXAA) sodium salt, processes for preparing those stable crystalline forms; pharmaceutical compositions comprising at least one of those crystalline forms in solid form or in dissolved form and a pharmaceutically acceptable carrier. Disclosed are methods of using those pharmaceutical compositions to treat tumours, optionally in combination with other active pharmaceutical agents. | 11-11-2010 |
20120040337 | Conformational Epitope Initiated Signal Amplification - This invention relates to a method to generate a signal used to detect the presence or quantity of a biomarker in a sample. The signal generating reaction is initiated when the biomarker under assay interacts with a specific binding partner. The interaction produces a structural change in the binding partner that is recognized by additional binding partners capable of generating a signal. The reaction produces a localized cluster of signaling molecules that can be detected above background. The signaling cluster is detectable within minutes when interrogated in a chamber of specific dimensions. The presence of the signaling clusters is a qualitative indication of the presence of the analyte, while the number of signaling clusters detected is a direct quantification of the number of biomarker molecules in the sample. The reaction can be formatted to detect proteins, nucleic acids, cells or other informative biomarkers. | 02-16-2012 |
20130079413 | Crystalline Diacylhydrazine and the Use Thereof - The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject. | 03-28-2013 |
20130116330 | COLCHICINE SOLID-STATE FORMS; METHODS OF MAKING; AND METHODS OF USE THEREOF - Disclosed are new colchicine solid-state forms, methods of preparing the solid-state forms, as well as formulations prepared therefrom and uses thereof. | 05-09-2013 |
20150045441 | Crystalline Diacylhydrazine and the Use Thereof - The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N′-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject. | 02-12-2015 |
Thomas Hilfiker, Bunzen CH
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20110127295 | HAND APPLICATION DEVICE - The invention relates to a hand application device ( | 06-02-2011 |
William B. Hilfiker, Fortuna, CA US
Patent application number | Description | Published |
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20090285640 | METHOD FOR CONSTRUCTING A MECHANICALLY STABILIZED EARTHEN EMBANKMENT USING SEMI-EXTENSIBLE STEEL SOIL REINFORCEMENTS - A method for constructing a mechanically stabilized earthen embankment has the steps of first constructing a wall facing element. A plurality of elongate soil reinforcement elements are attached to the wall facing element. A middle portion of each of the elongate soil reinforcement elements has a plurality of semi-extensible bent segments. Fill soil is added to build the earthen embankment over the reinforcement elements. Movement of the fill soil may create sufficient force to straighten some of the plurality of semi-extensible bent segments, allowing the earthen embankment to move to an active condition thereby reducing the stress on the soil reinforcement elements. | 11-19-2009 |
William Brent Hilfiker, Fortuna, CA US
Patent application number | Description | Published |
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20140105693 | METHOD FOR CONSTRUCTING A MECHANICALLY STABILIZED EARTHEN EMBANKMENT USING SEMI-EXTENSIBLE STEEL SOIL REINFORCEMENTS - A method for constructing a mechanically stabilized earthen embankment has the steps of constructing a wall facing element, and determining a plane of maximum force and a zone of maximum force in the earthen embankment to be formed. A plurality of elongate soil reinforcement elements are bent to form semi-extensible bent segments, but such that proximal and distal portions remain substantially straight and inextensible. The elongate soil reinforcement elements are positioned such that the semi-extensible region is within the zone of maximum force, and the proximal ends are connected to the wall facing element. Fill soil is added to build the earthen embankment, and the process is repeated until the earthen embankment is formed. | 04-17-2014 |
William K. Hilfiker, Grapevine, TX US
Patent application number | Description | Published |
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20090285640 | METHOD FOR CONSTRUCTING A MECHANICALLY STABILIZED EARTHEN EMBANKMENT USING SEMI-EXTENSIBLE STEEL SOIL REINFORCEMENTS - A method for constructing a mechanically stabilized earthen embankment has the steps of first constructing a wall facing element. A plurality of elongate soil reinforcement elements are attached to the wall facing element. A middle portion of each of the elongate soil reinforcement elements has a plurality of semi-extensible bent segments. Fill soil is added to build the earthen embankment over the reinforcement elements. Movement of the fill soil may create sufficient force to straighten some of the plurality of semi-extensible bent segments, allowing the earthen embankment to move to an active condition thereby reducing the stress on the soil reinforcement elements. | 11-19-2009 |
William K. Hilfiker, Eureka, CA US
Patent application number | Description | Published |
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20140105693 | METHOD FOR CONSTRUCTING A MECHANICALLY STABILIZED EARTHEN EMBANKMENT USING SEMI-EXTENSIBLE STEEL SOIL REINFORCEMENTS - A method for constructing a mechanically stabilized earthen embankment has the steps of constructing a wall facing element, and determining a plane of maximum force and a zone of maximum force in the earthen embankment to be formed. A plurality of elongate soil reinforcement elements are bent to form semi-extensible bent segments, but such that proximal and distal portions remain substantially straight and inextensible. The elongate soil reinforcement elements are positioned such that the semi-extensible region is within the zone of maximum force, and the proximal ends are connected to the wall facing element. Fill soil is added to build the earthen embankment, and the process is repeated until the earthen embankment is formed. | 04-17-2014 |