Patent application number | Description | Published |
20090171077 | DELIVERY OF NUCLEIC ACID-LIKE COMPOUNDS - A process for preparing a microparticulate complex is provided. The process comprises (a) combining a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and (b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water. Also disclosed composition comprising water and particles of the microparticulate complex. According to the invention a nucleic acid-like component is delivered to a cell by (a) contacting the cell with a composition comprising water and the microparticulate complex, and (b) maintaining the contact for a time sufficient to allow the nucleic acid-based moiety to enter the cell. A therapeutic nucleic acid-like component is delivered into a patient in need thereof by administering a composition comprising water and particles of the microparticulate complex. Also disclosed is a charge-changing composition represented by the formula A-X-B, wherein X represents a chemical bond capable of irreversible dissociation in reaction to a factor in a physiological or bioprocess environment; A represents a molecular moiety that upon dissociation of the bond X produces a ionically charged product; and B represents a molecular moiety, which upon the dissociation of bond X, separates from the composition leaving the remaining ionically charged product more positive than that of A-X-B itself. | 07-02-2009 |
20090269336 | ANTI-VEGF MONOCLONAL ANTIBODY - The present invention provides novel monoclonal antibodies with a high binding affinity to all five isoforms of human VEGF. | 10-29-2009 |
20100068255 | Immunoliposomes that Optimize Internationalization into Target Cells - The present invention provides for immunoliposomes that optimizes internalization of a drug into target cells bearing a characteristic cell surface marker. The immunoliposomes comprise an Fab′ domain of an antibody that specifically binds the characteristic marker, an amphipathic vesicle-forming lipid, and a polyethylene glycol derivatized lipid. The invention also provides for growth-inhibiting immunoliposomes that lack growth-inhibiting therapeutic agents and yet are capable of inhibiting the growth and proliferation of target cells. | 03-18-2010 |
20100227877 | NEW CAMPTOTHECIN DERIVATIVES AND USES THEREOF - The present invention provides two new camptothecin derivatives, which were identified as S,R- and S,S-topotecan lactates, respectively. Both compounds have anticancer activities. Pharmaceutical compositions of the new camptothecin derivatives, and cancer therapies with the new camptothecin derivatives or their pharmaceutical compositions were also provided. | 09-09-2010 |
20110033468 | Ophthalmic Drug Delivery System Containing Phospholipid and Cholesterol - An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes. | 02-10-2011 |
20110104261 | REMOTE DETECTION OF SUBSTANCE DELIVERY TO CELLS - The present invention provides for the development of endocytosis-sensitive probes, and a remote method for measuring cellular endocytosis. These probes are based on the reduced water permeability of a nanoparticle or liposomal delivery system, and inherent degradability or disruption of barrier integrity upon endocytosis. The invention also provides for liposomes having combined therapeutic and diagnostic utilities by co-encapsulating ionically coupled diagnostic and therapeutic agents, in one embodiment, by a method using anionic chelators to prepare electrochemical gradients for loading of amphipathic therapeutic bases into liposomes already encapsulating an imaging agent. The invention provides for imaging of therapeutic liposomes by inserting a lipopolymer anchored, remotely sensing reporter molecules into liposomal lipid layer. The invention allows for an integrated delivery system capable of imaging molecular fingerprints in diseased tissues, treatment, and treatment monitoring. | 05-05-2011 |
20120171283 | Liposomes Useful for Drug Delivery - The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention. | 07-05-2012 |
20130122081 | LIPOSOMES USEFUL FOR DRUG DELIVERY - The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention. | 05-16-2013 |
20140017300 | DELIVERY OF NUCLEIC ACID-LIKE COMPOUNDS - Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleic acid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided. | 01-16-2014 |
20140154298 | LIPOSOMES USEFUL FOR DRUG DELIVERY - The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention. | 06-05-2014 |
20150140069 | DELIVERY OF NUCLEIC ACID-LIKE COMPOUNDS - Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleicacid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided. | 05-21-2015 |
20150182460 | LIPOSOMES USEFUL FOR DRUG DELIVERY - The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention. | 07-02-2015 |
Patent application number | Description | Published |
20100325568 | USER INTERFACE VISUALIZATIONS - Aspects of the invention pertain to user interface visualizations, enabling efficient display of content on a display device. At least some content is presented having diagonal views to emphasize certain portions of the content while deemphasizing other portions of the content. | 12-23-2010 |
20120042270 | USER INTERFACE VISUALIZATIONS - Aspects of the invention pertain to user interface visualizations, enabling efficient display of content on a display device. At least some content is presented having diagonal views to emphasize certain portions of the content while deemphasizing other portions of the content. | 02-16-2012 |
20150095133 | SYSTEMS AND METHODS FOR PROVIDING CONSUMER FACING POINT-OF-SALE INTERFACES - Systems, apparatus, methods, and non-transitory media for providing point-of-sale functionality are discussed herein. Some embodiments may include a system including a merchant device and a consumer facing device. The merchant device may include a merchant display device configured to present interactive displays of a merchant facing interface configured to be used by merchants. The consumer facing device may be configured to present interactive displays of a consumer facing interface configured to be used by consumers. The point-of-sale system may be configured to facilitate financial transactions and other forms of consumer service. For example, merchant inputs provided via the merchant facing interface (e.g., entered menu items) may be shown on the consumer facing interface. In another example, consumer inputs provided via the consumer facing interface be sent to the merchant device and/or otherwise used by the merchant device to facilitate a financial transaction, among other things. | 04-02-2015 |
20150095134 | SYSTEMS AND METHODS FOR PROVIDING CONSUMER FACING POINT-OF-SALE INTERFACES - Systems, apparatus, methods, and non-transitory media for providing point-of-sale functionality are discussed herein. Some embodiments may include a system including a merchant device and a consumer facing device. The merchant device may include a merchant display device configured to present interactive displays of a merchant facing interface configured to be used by merchants. The consumer facing device may be configured to present interactive displays of a consumer facing interface configured to be used by consumers. The point-of-sale system may be configured to facilitate financial transactions and other forms of consumer service. For example, merchant inputs provided via the merchant facing interface (e.g., entered menu items) may be shown on the consumer facing interface. In another example, consumer inputs provided via the consumer facing interface be sent to the merchant device and/or otherwise used by the merchant device to facilitate a financial transaction, among other things. | 04-02-2015 |
Patent application number | Description | Published |
20100274775 | SYSTEM AND METHOD OF DISPLAYING RELATED SITES - A system facilitates the display of thumbnail images containing images of websites related to a website currently being viewed by a user. The system may include several different components to provide the thumbnail images to the user, such as a graphical user interface, an input interface, and a processor. The graphical user interface may display a website for viewing by a user and the input interface may receive an input representative of a request for a related website. The processor may transmit the request for the related website to a search engine, and, in response, the processor may obtain a search result representative of the related website. Moreover, the search result may include several components, such as a related website image representative of the related website and a uniform resource locator (“URL”) representative of a location of the related website. | 10-28-2010 |
20130124511 | VISUAL SEARCH HISTORY - Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for presenting a visual search history. Presentation data is received indicating that a resource has been presented by a user device, the resource having been presented in response to user interaction with a search result that referenced the resource. In response to receipt of the presentation data, an image of the resource is acquired. The acquired image is associated with a search query for which the search result was provided. In response to receipt of a request for a search history for the user device, the acquired image and the associated search query are displayed. | 05-16-2013 |
20130218861 | Related Entities - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for receiving a first search query from a user device; receiving search results for the first search query provided by a search engine, wherein each of the search results identifies a respective resource; determining from the search results that the first search query relates to a first entity of a first entity type; determining that one or more entities of a second entity type have a predetermined relationship with the first entity; and transmitting information identifying the one or more entities of the second type to the user device as part of a response to the first search query. | 08-22-2013 |
20130238594 | Related Entities - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for identifying entities that are related to an entity to which a search query is directed. One of the methods includes receiving a search query, wherein the search query has been determined to relate to a first entity of a first entity type, and wherein one or more entities of a second entity type have a relationship with the first entity; receiving search results for the search query; determining that a count of search results identifying a resource containing a reference to the first entity satisfies a first threshold value; determining that a count of search results identifying a resource having the second entity type as a relevant entity type satisfies a second threshold value; and transmitting information identifying the one or more entities of the second entity type as part of the response to the search query. | 09-12-2013 |
20150242536 | Advanced Search Page with Dynamic Generation of a Search Query String - Systems, methods, and computer software for generating a search query involve displaying a search query entry page that includes multiple fields for entry of search parameters. User input defining at least a portion of a search query for at least one of the fields is received. A formatted search query having a format associated with a predetermined search engine is dynamically generated based on the received user input, and the formatted search query is displayed. | 08-27-2015 |