Patent application number | Description | Published |
20080292685 | Transdermal Patch Containing Isosorbide Dinitrate and Bisoprolol - This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol. | 11-27-2008 |
20110071390 | ROTARY MEDICAL MANIFOLD - A rotary medical manifold, for delivering various fluids through a patient delivery mechanism is described. The rotary manifold can include a manifold body and a valve stem. The manifold body can include a central cavity, an output port, a first fluid port, and a second fluid port. The valve stem can include an injector port, and a single central fluid passage. The valve stem can be adapted to slibably engage the central cavity of the manifold body and provide selective fluidic connectivity between the injector port and the output port, the first fluid port and the second fluid port. | 03-24-2011 |
20110071393 | LOCKING SYRINGE WITH INTEGRATED BIAS MEMBER - A locking syringe with an integrated bias member, for delivering medical fluids at high pressure, can include a housing, a shaft, a piston, a cap assembly, a bias member, and a locking member. A distal end of the housing can interface with a patient delivery apparatus. The housing includes an internal cavity into which a distal end of the shaft can be inserted. The piston can be connected to the distal end of the shaft and can include a peripheral sealing surface that can slidably engage the inside surface of the housing to form a movable seal. The cap assembly at the proximal end of the housing can engage the shaft. A base cap can secure the piston within the housing. The bias member can have a distal end coupled to the piston and a proximal end restrained, such as to help pressurize the internal cavity. The user-actuatable locking member can user-selectively engage and inhibit unwanted movement of the shaft. | 03-24-2011 |
20120071472 | RIMINOPHENAZINES WITH 2-(HETEROARYL)AMINO SUBSTITUENTS AND THEIR ANTI-MICROBIAL ACTIVITY - The present invention relates to riminophenazines having heteroaromatic substitutions, including those with 2-heteroaryl-amino substituents, to their preparation, and to their use as drugs for treating | 03-22-2012 |
20130274682 | LOCKING SYRINGE WITH INTEGRATED BIAS MEMBER - A locking syringe with an integrated bias member, for delivering medical fluids at high pressure, can include a housing, a shaft, a piston, a cap assembly, a bias member, and a locking member. A distal end of the housing can interface with a patient delivery apparatus. The housing includes an internal cavity into which a distal end of the shaft can be inserted. The piston can be connected to the distal end of the shaft and can include a peripheral sealing surface that can slidably engage the inside surface of the housing to form a movable seal. The cap assembly at the proximal end of the housing can engage the shaft. A base cap can secure the piston within the housing. The bias member can have a distal end coupled to the piston and a proximal end restrained, such as to help pressurize the internal cavity. The user-actuatable locking member can user-selectively engage and inhibit unwanted movement of the shaft. | 10-17-2013 |
20130284292 | ROTARY MEDICAL MANIFOLD - A rotary medical manifold, for delivering various fluids through a patient delivery mechanism is described. The rotary manifold can include a manifold body and a valve stem. The manifold body can include a central cavity, an output port, a first fluid port, and a second fluid port. The valve stem can include an injector port, and a single central fluid passage. The valve stem can be adapted to slidably engage the central cavity of the manifold body and provide selective fluidic connectivity between the injector port and the output port, the first fluid port and the second fluid port. | 10-31-2013 |
20140243327 | RIMINOPHENAZINES WITH 2-(HETEROARYL) AMINO SUBSTITUENTS AND THEIR ANTI-MICROBIAL ACTIVITY - The present invention relates to riminophenazines having heteroaromatic substitutions, including those with 2-heteroaryl-amino substituents, to their preparation, and to their use as drugs for treating | 08-28-2014 |
20140243665 | MANIFOLD VALVE DEVICE - A triple three-way valve device comprises: a valve body ( | 08-28-2014 |
20140249411 | TRI-RING SYRINGE - A tri-ring syringe comprising: a barrel ( | 09-04-2014 |
20140301867 | BALLOON PRESSURE PUMP - A balloon pressure pump comprising a cavity ( | 10-09-2014 |
Patent application number | Description | Published |
20100324299 | METHOD FOR PURIFICATION OF PYRIDINE, AND METHOD FOR PRODUCTION OF CHLORINATED PYRIDINE - A method of purifying crude pyridine on an industrial scale at low cost and in a simple manner is provided. More specifically, a pyridine purification method including subjecting crude pyridine to an alkali treatment and then to distillation, or a pyridine purification method including adding an acid or water to crude pyridine, and subjecting the resulting mixture to an alkali treatment and then to distillation is provided. According to the purification method of the present invention, crude pyridine can be purified on an industrial scale at low cost and in a simple manner. Moreover, the pyridine purified by this method is useful as a starting material for various organic syntheses because of its high purity. For example, the pyridine can be reacted with chlorine to produce a chlorinated pyridine in a high yield. | 12-23-2010 |
20110257438 | SULFONE COMPOUND - It is an object of the present invention to provide an aprotic polar solvent mainly useful as a solvent for an electrochemical device, and having a comparatively low melting point and excellent thermal stability. | 10-20-2011 |
20110306797 | SULFONE COMPOUND - It is an object of the present invention to provide an aprotic polar solvent mainly useful as a solvent for an electrochemical device, and having a comparatively low melting point and excellent thermal stability. | 12-15-2011 |
20120136175 | PROCESS FOR PREPARATION OF ALKYL SULFONE COMPOUNDS - An object of the present invention is to provide a method for preparation of an alkyl sulfone compound simply and safely with high yield, and an alkyl sulfone compound. | 05-31-2012 |
Patent application number | Description | Published |
20090170131 | Agents for Imaging Apoptosis - Compositions, and methods of using such compositions, having the following Formula (I) or salt, ester, or hydrate thereof, wherein R | 07-02-2009 |
20090263485 | Targeted hollow gold nanostructures and methods of use - Provided are novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors and molecular specific photothermal coupling agents. The nanostructures can be used in laser-induced phototherapy for treatment of cancer and other disorders. The nanostructures can also be used as a sensor that detects molecules. The nanostructures are of particular use in the fields of clinical diagnosis, clinical therapy, clinical treatment, and clinical evaluation of various diseases and disorders, manufacture of compositions for use in the treatment of various diseases and disorders, for use in molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof. The hollow gold nanospheres have a unique combination of spherical shape, small size, and strong, tunable, and narrow surface plasmon resonance absorption covering the entire visible to near IR region. | 10-22-2009 |
20100034739 | Fungus-Specific Imaging Agents - The disclosure relates to an imaging composition including a fungus-specific peptide and an imaging material. Another imaging composition includes a fungus-specific peptide and a chelator able to chelate a radionuclide. The disclosure also provides to a method of detecting a fungal infection. The method includes administering an imaging agent to a patient. The imaging agent comprises a fungus-specific peptide and an imaging material. Then one may detect the imaging agent in the patient. Detecting retained imaging agent in a tissue or organ indicates fungal infection of the tissue or organ. | 02-11-2010 |
20100290997 | Imaging Agents and Methods - The disclosure includes a composition including a poly(L-glutamic acid) and a NIRF dye. It also includes a method including providing to a plurality of cells an imaging agent including poly(L-glutamic acid), a NIRF dye and then imaging the cells to detect the imaging agent. It further includes a dual functional contrast agent including an MRI agent conjugated with an optical imaging agent. A method of detecting cancer is provided including injecting a dual functional contrast agent into a patient and performing both an MRI and an optical scan. The presence of the agent may indicate cancer. A method of detecting cancer by injecting PG-DTPA-Gd-NIR813 into a patient, then detecting the presence or absence of Gd in a cell or tissue of the patient and detecting the presence or absence of NIR813 in a cell or tissue of the patient is provided. The presence of Gd and NIR813 may indicate cancer. | 11-18-2010 |
20110165611 | DUAL MODALITY DETECTION OF APOPTOSIS - To image apoptosis in vivo, small, membrane-permeable probes comprising a caspase 3 substrate, a fluorogenic dye and a radionuclide is provided. This dual-modality probe can be cleaved by caspase upon exposure to apoptotic cells, allowing imaging of caspase 3 and 7 activities using both optical and nuclear imaging techniques. The combined use of these methods provides the opportunity for a direct correlation between in vitro and in vivo biological activities and a viable method to treat disease | 07-07-2011 |
20110318415 | Hollow Gold Nanospheres (HAuNSs) and HAuNSs-Loaded Microspheres Useful in Drug Delivery - A near-infrared mediated drug delivery system comprising a plurality of microspheres made of polymeric material, each sphere containing a plurality of hollow gold nanospheres together with drug product, wherein upon NIR irradiation, the drug product is released from the microsphere. | 12-29-2011 |
20120021050 | NANOPARTICLE FORMULATED GLYCOLIPID ANTIGENS FOR IMMUNOTHERAPY - A composition for stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells includes a glycolipid antigen and a nanoparticle conjugated with the glycolipid antigen. The glycolipid antigen and the nanoparticle are not antigenic in mouse and human being. The composition can further include covalent or non-covalent connection between the glycolipid antigen and the nanoparticle. The glycolipid antigen is alpha-galactosylceramide or an analog of that. The nanoparticle can be a polymer. A production method of the composition includes preparing a nanoparticle and a glycolipid antigen and loading the glycolipid antigen to the nanoparticle. The glycolipid antigen can be coated onto the surface of the nanoparticle or encapsulated within the nanoparticle. A method of stimulating NKT cells to produce anti-cancer and anti-viral cytokines without causing anergy of NKT cells is also provided. | 01-26-2012 |
20120309691 | TUMOR TARGETED DELIVERY OF IMMUNOMODULATORS BY NANOPOLYMERS - Nanoconstructs having three components: (1) biodegradable nanopolymers and nanoparticles, (2) immunodrugs such as CpG, and a (3) tumor binding device, which are actively targeted to tumor cells such as melanoma cells through receptor-mediated uptake and methods of using the same are described. Antitumor immunity is further enhanced by combination of PG-CpG nanoconstructs with agonists of positive costimulatory signals and inhibitors of negative immune regulatory signals. | 12-06-2012 |
20140296836 | GOLD-IN-SILICON NANOASSEMBLY FOR THERMAL THERAPY AND METHODS OF USE - The present invention provides methods and compositions for the nanotechnology-based therapy of one or more mammalian diseases. Disclosed are gold-in-porous silicon nanoassemblies that are effective in the targeted and localized treatment of one or more human hyperproliferative disorders, including, for example, cancer of the breast. Methods of systemic administration of these nanoassembly vectors are disclosed that facilitate direct thermal ablative therapy of selected tissues using a localized application of near-infrared energy to the target site, wherein the gold-in-porous silicon nanoparticles release heat to destroy the surrounding cancerous tissue. | 10-02-2014 |