Patent application number | Description | Published |
20110077283 | MOLECULAR TARGETS AND COMPOUNDS, AND METHODS TO IDENTIFY THE SAME, USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES - The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing polyglutamine-induced protein aggregation, and/or altering huntingtin protein conformation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and protein aggregation diseases more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntington's disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these | 03-31-2011 |
20110105587 | TARGET SEQUENCES AND METHODS TO IDENTIFY THE SAME, USEFUL IN TREATMENT OF NEURODEGENERATIVE DISEASES - The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing cell death, in particular cell death associated with polyglutamine-induced protein aggregation, which inhibition is useful in the prevention, amelioration and/or treatment of neurodegenerative diseases, and Huntington's disease more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and/or treatment of Huntingtons disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETS. | 05-05-2011 |
Patent application number | Description | Published |
20090103258 | Shoulder screw and handle drive mounting system - A computer storage enclosure may comprise a mounting chassis and a computer drive apparatus. The mounting chassis may have a plurality of computer drive guides, a plurality of cam pins, and a mounting chassis disengagement ramp. The computer drive apparatus may include a computer drive, a plurality of shoulder screws, and a computer drive handle. The computer drive apparatus may be mounted on the mounting chassis utilizing the shoulder screws guided by the computer drive guides and secured by the computer drive handle, the cam pins, and the shoulder screws. The computer drive apparatus may include a blade drive and be hot-swappable. | 04-23-2009 |
20090237906 | Connector hold down and method - A device may include a connector receptacle coupled to a motherboard; a connector hold-down disposed adjacent to the connector receptacle; and/or a connector cage coupled to the motherboard and covering the connector receptacle and connector hold-down. Additionally, a computer system utilizing a connector hold-down and a method utilizing a connector hold-down are disclosed. | 09-24-2009 |
20090257186 | Horizontal drive drawer system and method - An apparatus may include drive chassis, at least one horizontal drive drawer extending from a first side of the drive chassis to a second side of the drive chassis and/or at Least one computer drive disposed on the horizontal drive drawer. Additionally, a computer server system and a method for providing the apparatus are disclosed. | 10-15-2009 |
20100058728 | CABLE CHAIN RETURN SYSTEM AND ASSOCIATED METHODS - Disclosed is a cable chain return system | 03-11-2010 |
Patent application number | Description | Published |
20090257185 | Storage Blade - A blade-system computer component with a chassis and a blade. The chassis has a housing for a blade, chassis electrical contacts for making electrical connections to the blade, and two rails for engaging the blade along two sides of a length of the blade. Each of the two rails has a slider portion and a rack portion that both engage the blade, and are both disposed along an entire length of the two rails. The blade has blade electrical contacts for making electrical connections to the chassis, two glides disposed along the entire length of the two sides of the blade, where each of the two glides engage the slider portion of each of the two rails, and provide stability to the blade during relative movement between the blade and the chassis. At least one pinion engages the rack portion of at least one of the two rails, and provides dampening to the relative movement between the blade and the chassis. | 10-15-2009 |
20100002368 | Drive Box - A rack mount drive blade system having a chassis and a drive blade. The chassis has at least one blade bay to accept a drive blade, where the chassis accepts the drive blade into the blade bay with the drive blade in a horizontal orientation. Each blade bay has chassis to blade electrical contacts including at least one cable having a length, for making electrical connections between the chassis and the drive blade. Each blade bay also has slot portions for engaging the drive blade along a length of the drive blade. The chassis has at least one module bay to accept a shared resource module, where each module bay has chassis to module electrical contacts, for making electrical connections between the chassis and the shared resource module. The drive blade has a printed circuit board for providing electrical connections to and from components on the drive blade. The drive blade has at least one hard drive, and drive blade electrical contacts for making electrical connections to the chassis through the at least one cable. The drive blade has rail portions disposed along the length of the drive blade, the rail portions for engaging the slot portions of the bay. The drive blade can be at least partially removed from the chassis without breaking the electrical connections between the chassis and the drive blade. | 01-07-2010 |